Abstract：
:The growth and vascularization of prostate cancer is dependent on interactions between cancer cells and supporting stromal cells. The primary stromal cell type found in prostate tumors is the carcinoma-associated fibroblast, which produces placental growth factor (PlGF). PlGF is a member of the vascular endothelial growth factor (VEGF) family of angiogenic molecules and PlGF mRNA levels increase after androgen deprivation therapy in prostate cancer. In this study, we show that PlGF has a direct dose-dependent proliferative effect on human PC-3 prostate cancer cells in vitro and fibroblast-derived PlGF increases PC-3 proliferation in co-culture. In xenograft tumor models, intratumoral administration of murine PlGF siRNA reduced stromal-derived PlGF expression, reduced tumor burden and decreased the number of Ki-67 positive proliferating cells associated with reduced vascular density. These data show that targeting stromal PlGF expression may represent a therapeutic target for the treatment of prostate cancer.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Zins K,Thomas A,Lucas T,Sioud M,Aharinejad S,Abraham Ddoi
10.3390/ijms140917958subject
Has Abstractpub_date
2013-09-03 00:00:00pages
17958-71issue
9issn
1422-0067pii
ijms140917958journal_volume
14pub_type
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