Revisiting Platelets and Toll-Like Receptors (TLRs): At the Interface of Vascular Immunity and Thrombosis.


:While platelet function has traditionally been described in the context of maintaining vascular integrity, recent evidence suggests that platelets can modulate inflammation in a much more sophisticated and nuanced manner than previously thought. Some aspects of this expanded repertoire of platelet function are mediated via expression of Toll-like receptors (TLRs). TLRs are a family of pattern recognition receptors that recognize pathogen-associated and damage-associated molecular patterns. Activation of these receptors is crucial for orchestrating and sustaining the inflammatory response to both types of danger signals. The TLR family consists of 10 known receptors, and there is at least some evidence that each of these are expressed on or within human platelets. This review presents the literature on TLR-mediated platelet activation for each of these receptors, and the existing understanding of platelet-TLR immune modulation. This review also highlights unresolved methodological issues that potentially contribute to some of the discrepancies within the literature, and we also suggest several recommendations to overcome these issues. Current understanding of TLR-mediated platelet responses in influenza, sepsis, transfusion-related injury and cardiovascular disease are discussed, and key outstanding research questions are highlighted. In summary, we provide a resource-a "researcher's toolkit"-for undertaking further research in the field of platelet-TLR biology.


Int J Mol Sci


Hally K,Fauteux-Daniel S,Hamzeh-Cognasse H,Larsen P,Cognasse F




Has Abstract


2020-08-26 00:00:00










  • Rapid Microsatellite Marker Development Using Next Generation Pyrosequencing to Inform Invasive Burmese Python-Python molurus bivittatus-Management.

    abstract::Invasive species represent an increasing threat to native ecosystems, harming indigenous taxa through predation, habitat modification, cross-species hybridization and alteration of ecosystem processes. Additionally, high economic costs are associated with environmental damage, restoration and control measures. The Bur...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Hunter ME,Hart KM

    更新日期:2013-02-28 00:00:00

  • Polymorphisms of leptin-b gene associated with growth traits in orange-spotted grouper (Epinephelus coioides).

    abstract::In mammals, leptin has been demonstrated to perform important roles in many physiological activities and to influence development, growth, metabolism and reproduction. However, in fish, its function is still unclear. Duplicate leptin genes, leptin-a and leptin-b, have been identified in the orange-spotted grouper. In ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Huang H,Wei Y,Meng Z,Zhang Y,Liu X,Guo L,Luo J,Chen G,Lin H

    更新日期:2014-07-07 00:00:00

  • The Antipsychotic D2AAK1 as a Memory Enhancer for Treatment of Mental and Neurodegenerative Diseases.

    abstract::The treatment of memory impairments associated with the central nervous system diseases remains an unmet medical need with social and economic implications. Here we show, that a multi-target ligand of aminergic G protein-coupled receptors with antipsychotic activity in vivo (D2AAK1) stimulates neuron growth and surviv...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Koszła O,Sołek P,Woźniak S,Kędzierska E,Wróbel TM,Kondej M,Archała A,Stępnicki P,Biała G,Matosiuk D,Kaczor AA

    更新日期:2020-11-23 00:00:00

  • The role of initial oligomers in amyloid fibril formation by human stefin B.

    abstract::Oligomers are commonly observed intermediates at the initial stages of amyloid fibril formation. They are toxic to neurons and cause decrease in neural transmission and long-term potentiation. We describe an in vitro study of the initial steps in amyloid fibril formation by human stefin B, which proved to be a good mo...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Taler-Verčič A,Kirsipuu T,Friedemann M,Noormägi A,Polajnar M,Smirnova J,Znidarič MT,Zganec M,Skarabot M,Vilfan A,Staniforth RA,Palumaa P,Zerovnik E

    更新日期:2013-09-05 00:00:00

  • Radiation-Induced Organizing Pneumonia: A Characteristic Disease that Requires Symptom-Oriented Management.

    abstract::Radiation-induced organizing pneumonia (RIOP) is an inflammatory lung disease that is occasionally observed after irradiation to the breast. It is a type of secondary organizing pneumonia that is characterized by infiltrates outside the irradiated volume that are sometimes migratory. Corticosteroids work acutely, but ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Otani K,Seo Y,Ogawa K

    更新日期:2017-01-27 00:00:00

  • Cancer cell cytotoxicities of 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives.

    abstract::A series of novel 1-(4-substitutedbenzoyl)-4-(4-chlorobenzhydryl)piperazine derivatives 5a-g was designed by a nucleophilic substitution reaction of 1-(4-chlorobenzhydryl)piperazine with various benzoyl chlorides and characterized by elemental analyses, IR and (1)H nuclear magnetic resonance spectra. Cytotoxicity of t...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Yarim M,Koksal M,Durmaz I,Atalay R

    更新日期:2012-01-01 00:00:00

  • Application of Chromatographic and Spectroscopic Methods towards the Quality Assessment of Ginger (Zingiber officinale) Rhizomes from Ecological Plantations.

    abstract::The usefulness of ginger in the food industry and pharmacotherapy is strictly related to its content of various components. The study elucidates the chemical composition of Zingiber officinale rhizomes cultivated on ecological plantations on Shikoku Island (Japan). GC-MS analysis of terpene content, LC-MS determinatio...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Koch W,Kukula-Koch W,Marzec Z,Kasperek E,Wyszogrodzka-Koma L,Szwerc W,Asakawa Y

    更新日期:2017-02-20 00:00:00

  • Role of the Novel Hsp90 Co-Chaperones in Dynein Arms' Preassembly.

    abstract::The outer and inner dynein arms (ODAs and IDAs) are composed of multiple subunits including dynein heavy chains possessing a motor domain. These complex structures are preassembled in the cytoplasm before being transported to the cilia. The molecular mechanism(s) controlling dynein arms' preassembly is poorly understo...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Fabczak H,Osinka A

    更新日期:2019-12-07 00:00:00

  • Synthesis and biological evaluation of 2-aminobenzamide derivatives as antimicrobial agents: opening/closing pharmacophore site.

    abstract::A series of new 2-aminobenzamide derivatives (1-10) has been synthesized in good to excellent yields by adopting both conventional and/or a time-efficient microwave assisted methodologies starting from isatoic anhydride (ISA) and characterized on the basis of their physical, spectral and microanalytical data. Selected...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Mabkhot YN,Al-Majid AM,Barakat A,Al-Showiman SS,Al-Har MS,Radi S,Naseer MM,Hadda TB

    更新日期:2014-03-21 00:00:00

  • A Review on the Current Knowledge on ZIKV Infection and the Interest of Organoids and Nanotechnology on Development of Effective Therapies against Zika Infection.

    abstract::Zika virus (ZIKV) acquired a special relevance due to the pandemic that occurred in the Americas in 2015, when an important number of fetal microcephaly cases occurred. Since then, numerous studies have tried to elucidate the pathogenic mechanisms and the potential therapeutic approaches to combat the virus. Cellular ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Gasco S,Muñoz-Fernández MÁ

    更新日期:2020-12-22 00:00:00

  • Carbonic Anhydrase Sensitivity to Pesticides: Perspectives for Biomarker Development.

    abstract::Carbonic anhydrase (CA) is a widespread metalloenzyme playing a pivotal role in several physiological processes. Many studies have demonstrated the in vitro and in vivo sensitivity of CA to the exposure to several classes of pesticides in both humans and wildlife. This review aims to analyze and to discuss the literat...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Lionetto MG,Caricato R,Giordano ME

    更新日期:2020-05-18 00:00:00

  • First Identification of RNA-Binding Proteins That Regulate Alternative Exons in the Dystrophin Gene.

    abstract::The Duchenne muscular dystrophy (DMD) gene has a complex expression pattern regulated by multiple tissue-specific promoters and by alternative splicing (AS) of the resulting transcripts. Here, we used an RNAi-based approach coupled with DMD-targeted RNA-seq to identify RNA-binding proteins (RBPs) that regulate splicin...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Miro J,Bougé AL,Murauer E,Beyne E,Da Cunha D,Claustres M,Koenig M,Tuffery-Giraud S

    更新日期:2020-10-21 00:00:00

  • Pre-Analytical Considerations for Successful Next-Generation Sequencing (NGS): Challenges and Opportunities for Formalin-Fixed and Paraffin-Embedded Tumor Tissue (FFPE) Samples.

    abstract::In cancer drug discovery, it is important to investigate the genetic determinants of response or resistance to cancer therapy as well as factors that contribute to adverse events in the course of clinical trials. Despite the emergence of new technologies and the ability to measure more diverse analytes (e.g., circulat...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Arreaza G,Qiu P,Pang L,Albright A,Hong LZ,Marton MJ,Levitan D

    更新日期:2016-09-20 00:00:00

  • MYC-Associated Factor MAX is a Regulator of the Circadian Clock.

    abstract::The circadian transcriptional network is based on a competition between transcriptional activator and repressor complexes regulating the rhythmic expression of clock-controlled genes. We show here that the MYC-associated factor X, MAX, plays a repressive role in this network and operates through a MYC-independent bind...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Blaževitš O,Bolshette N,Vecchio D,Guijarro A,Croci O,Campaner S,Grimaldi B

    更新日期:2020-03-26 00:00:00

  • Recent Advances in SELEX Technology and Aptamer Applications in Biomedicine.

    abstract::Aptamers are short DNA/RNA oligonucleotides capable of binding to target molecules with high affinity and specificity. The process of selecting an aptamer is called Systematic Evolution of Ligands by Exponential Enrichment (SELEX). Thanks to the inherit merits, aptamers have been used in a wide range of applications, ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Zhuo Z,Yu Y,Wang M,Li J,Zhang Z,Liu J,Wu X,Lu A,Zhang G,Zhang B

    更新日期:2017-10-14 00:00:00

  • Circulating Long Noncoding RNA LNC-EPHA6 Associates with Acute Rejection after Kidney Transplantation.

    abstract::Acute rejection (AR) of a kidney graft in renal transplant recipients is associated with microvascular injury in graft dysfunction and, ultimately, graft failure. Circulating long noncoding RNAs (lncRNAs) may be suitable markers for vascular injury in the context of AR. Here, we first investigated the effect of AR aft...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Groeneweg KE,Duijs JMGJ,Florijn BW,van Kooten C,de Fijter JW,van Zonneveld AJ,Reinders MEJ,Bijkerk R

    更新日期:2020-08-05 00:00:00

  • Growth Factors in the Carotid Body-An Update.

    abstract::The carotid body may undergo plasticity changes during development/ageing and in response to environmental (hypoxia and hyperoxia), metabolic, and inflammatory stimuli. The different cell types of the carotid body express a wide series of growth factors and corresponding receptors, which play a role in the modulation ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Stocco E,Barbon S,Tortorella C,Macchi V,De Caro R,Porzionato A

    更新日期:2020-10-01 00:00:00

  • Immunotherapies and Future Combination Strategies for Head and Neck Squamous Cell Carcinoma.

    abstract::Head and neck squamous cell carcinoma (HNSCC) is often diagnosed at an advanced stage and has a dismal prognosis. Nearly 10 years after the approval of cetuximab, anti-PD1/PD-L1 checkpoint inhibitors are the first drugs that have shown any survival benefit for the treatment on platinum-refractory recurrent/metastatic ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Cristina V,Herrera-Gómez RG,Szturz P,Espeli V,Siano M

    更新日期:2019-10-30 00:00:00

  • Membrane Repair Deficit in Facioscapulohumeral Muscular Dystrophy.

    abstract::Deficits in plasma membrane repair have been identified in dysferlinopathy and Duchenne Muscular Dystrophy, and contribute to progressive myopathy. Although Facioscapulohumeral Muscular Dystrophy (FSHD) shares clinicopathological features with these muscular dystrophies, it is unknown if FSHD is characterized by plasm...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Bittel AJ,Sreetama SC,Bittel DC,Horn A,Novak JS,Yokota T,Zhang A,Maruyama R,Rowel Q Lim K,Jaiswal JK,Chen YW

    更新日期:2020-08-04 00:00:00

  • Cadmium and Lead Decrease Cell-Cell Aggregation and Increase Migration and Invasion in Renca Mouse Renal Cell Carcinoma Cells.

    abstract::Metastatic renal cell carcinoma (RCC) remains an important clinical issue; the 5-year survival rate of patients with metastasis is approximately 12%, while it is 93% in those with localized disease. There is evidence that blood cadmium and lead levels are elevated in RCC. The current studies were designed to assess th...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Akin R,Hannibal D,Loida M,Stevens EM,Grunz-Borgmann EA,Parrish AR

    更新日期:2019-12-14 00:00:00

  • Toward the understanding of the metabolism of levodopa I. DFT investigation of the equilibrium geometries, acid-base properties and levodopa-water complexes.

    abstract::Levodopa (LD) is used to increase dopamine level for treating Parkinson's disease. The major metabolism of LD to produce dopamine is decarboxylation. In order to understand the metabolism of LD; the electronic structure of levodopa was investigated at the Density Functional DFT/B3LYP level of theory using the 6-311+G*...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Elroby SA,Makki MS,Sobahi TR,Hilal RH

    更新日期:2012-01-01 00:00:00

  • Leucine-Rich Repeat Kinase 2 Controls Inflammatory Cytokines Production through NF-κB Phosphorylation and Antigen Presentation in Bone Marrow-Derived Dendritic Cells.

    abstract::Leucine-rich repeat kinase 2 (LRRK2) is the causal molecule of familial Parkinson's disease. Although the characteristics of LRRK2 have gradually been revealed, its true physiological functions remain unknown. LRRK2 is highly expressed in immune cells such as B2 cells and macrophages, suggesting that it plays importan...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Kubo M,Nagashima R,Kurihara M,Kawakami F,Maekawa T,Eshima K,Ohta E,Kato H,Obata F

    更新日期:2020-03-10 00:00:00

  • Establishing a Split Luciferase Assay for Proteinkinase G (PKG) Interaction Studies.

    abstract::Nitric oxide (NO/cyclic guanosine monophosphate (cGMP)-regulated cellular mechanisms are involved in a variety of (patho-) physiological processes. One of the main effector molecules in this system, proteinkinase G (PKG), serves as a molecular switch by phosphorylating different target proteins and thereby turning the...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Schramm A,Mueller-Thuemen P,Littmann T,Harloff M,Ozawa T,Schlossmann J

    更新日期:2018-04-12 00:00:00

  • Intrapancreatic Parenchymal Injection of Cells as a Useful Tool for Allowing a Small Number of Proliferative Cells to Grow In Vivo.

    abstract::In vivo inoculation of cells such as tumor cells and induced pluripotent stem (iPS)/embryonic stem (ES) cells into immunocompromised mice has been considered as a powerful technique to evaluate their potential to proliferate or differentiate into various cell types originating from three germ cell layers. Subcutaneous...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Sato M,Saitoh I,Murakami T,Kubota N,Nakamura S,Watanabe S,Inada E

    更新日期:2017-08-02 00:00:00

  • Ultrasound tissue characterization of vulnerable atherosclerotic plaque.

    abstract::A thrombotic occlusion of the vessel fed by ruptured coronary atherosclerotic plaque may result in unstable angina, myocardial infarction or death, whereas embolization from a plaque in carotid arteries may result in transient ischemic attack or stroke. The atherosclerotic plaque prone to such clinical events is terme...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Picano E,Paterni M

    更新日期:2015-05-05 00:00:00

  • MT-Feeding-Induced Impermanent Sex Reversal in the Orange-Spotted Grouper during Sex Differentiation.

    abstract::In this study, we systematically investigated the process of sex reversal induced by 17-methyltestosterone (MT) feeding and MT-feeding withdrawal at the ovary differentiation stage in orange-spotted groupers, Epinephelus coioides. Gonadal histology showed that MT feeding induced a precocious sex reversal from immature...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Wang Q,Huang M,Peng C,Wang X,Xiao L,Wang D,Chen J,Zhao H,Zhang H,Li S,Yang H,Liu Y,Lin H,Zhang Y

    更新日期:2018-09-19 00:00:00

  • At the Crossroads of Clinical and Preclinical Research for Muscular Dystrophy-Are We Closer to Effective Treatment for Patients?

    abstract::Among diseases affecting skeletal muscle, muscular dystrophy is one of the most devastating and complex disorders. The term 'muscular dystrophy' refers to a heterogeneous group of genetic diseases associated with a primary muscle defect that leads to progressive muscle wasting and consequent loss of muscle function. M...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Gawlik KI

    更新日期:2018-05-16 00:00:00

  • Effects of Non-Starch Polysaccharides on Inflammatory Bowel Disease.

    abstract::The incidence of inflammatory bowel disease (IBD) has increased considerably over the past few decades. In the present review, we discuss several disadvantages existing in the treatment of IBD and current understandings of the structures, sources, and natures of various kinds of non-starch polysaccharides (NSPs). Avai...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Nie Y,Lin Q,Luo F

    更新日期:2017-06-27 00:00:00

  • The Molecular Mechanisms of Iron Metabolism and Its Role in Cardiac Dysfunction and Cardioprotection.

    abstract::Iron is an essential mineral participating in different functions of the organism under physiological conditions. Numerous biological processes, such as oxygen and lipid metabolism, protein production, cellular respiration, and DNA synthesis, require the presence of iron, and mitochondria play an important role in the...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Ravingerová T,Kindernay L,Barteková M,Ferko M,Adameová A,Zohdi V,Bernátová I,Ferenczyová K,Lazou A

    更新日期:2020-10-24 00:00:00

  • Mitochondrial AOX Supports Redox Balance of Photosynthetic Electron Transport, Primary Metabolite Balance, and Growth in Arabidopsis thaliana under High Light.

    abstract::When leaves receive excess light energy, excess reductants accumulate in chloroplasts. It is suggested that some of the reductants are oxidized by the mitochondrial respiratory chain. Alternative oxidase (AOX), a non-energy conserving terminal oxidase, was upregulated in the photosynthetic mutant of Arabidopsis thalia...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Jiang Z,Watanabe CKA,Miyagi A,Kawai-Yamada M,Terashima I,Noguchi K

    更新日期:2019-06-23 00:00:00