Surface modification of biomedical and dental implants and the processes of inflammation, wound healing and bone formation.

Abstract:

:Bone adaptation or integration of an implant is characterized by a series of biological reactions that start with bone turnover at the interface (a process of localized necrosis), followed by rapid repair. The wound healing response is guided by a complex activation of macrophages leading to tissue turnover and new osteoblast differentiation on the implant surface. The complex role of implant surface topography and impact on healing response plays a role in biological criteria that can guide the design and development of future tissue-implant surface interfaces.

journal_name

Int J Mol Sci

authors

Stanford CM

doi

10.3390/ijms11010354

subject

Has Abstract

pub_date

2010-01-25 00:00:00

pages

354-69

issue

1

issn

1422-0067

journal_volume

11

pub_type

杂志文章,评审
  • Aptamers and Glioblastoma: Their Potential Use for Imaging and Therapeutic Applications.

    abstract::Glioblastoma is a highly aggressive primary brain tumour, renowned for its infiltrative growth and varied genetic profiles. The current treatment options are insufficient, and their off-target effects greatly reduce patient quality of life. The major challenge in improving glioblastoma diagnosis and treatment involves...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms18122576

    authors: Hays EM,Duan W,Shigdar S

    更新日期:2017-11-30 00:00:00

  • Do Neural Stem Cells Have a Choice? Heterogenic Outcome of Cell Fate Acquisition in Different Injury Models.

    abstract::The adult mammalian central nervous system (CNS) is generally considered as repair restricted organ with limited capacities to regenerate lost cells and to successfully integrate them into damaged nerve tracts. Despite the presence of endogenous immature cell types that can be activated upon injury or in disease cell ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms20020455

    authors: Beyer F,Samper Agrelo I,Küry P

    更新日期:2019-01-21 00:00:00

  • Naturally Prefabricated Marine Biomaterials: Isolation and Applications of Flat Chitinous 3D Scaffolds from Ianthella labyrinthus (Demospongiae: Verongiida).

    abstract::Marine sponges remain representative of a unique source of renewable biological materials. The demosponges of the family Ianthellidae possess chitin-based skeletons with high biomimetic potential. These three-dimensional (3D) constructs can potentially be used in tissue engineering and regenerative medicine. In this s...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20205105

    authors: Schubert M,Binnewerg B,Voronkina A,Muzychka L,Wysokowski M,Petrenko I,Kovalchuk V,Tsurkan M,Martinovic R,Bechmann N,Ivanenko VN,Fursov A,Smolii OB,Fromont J,Joseph Y,Bornstein SR,Giovine M,Erpenbeck D,Guan K,Ehrlich

    更新日期:2019-10-15 00:00:00

  • Molecular characterization of Tob1 in muscle development in pigs.

    abstract::Cell proliferation is an important biological process during myogenesis. Tob1 encoded a member of the Tob/BTG family of anti-proliferative proteins. Our previous LongSAGE (Long Serial Analysis of Gene Expression) analysis suggested that Tob1 was differentially expressed during prenatal skeletal muscle development. In ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms12074315

    authors: Yuan J,Cao JY,Tang ZL,Wang N,Li K

    更新日期:2011-01-01 00:00:00

  • Enzymatic Biotransformation of Balloon Flower Root Saponins into Bioactive Platycodin D by Deglucosylation with Caldicellulosiruptor bescii β-Glucosidase.

    abstract::Platycodin D (PD), a major saponin (platycoside) in Platycodi radix (balloon flower root), has higher pharmacological activity than the other major platycosides; however, its content in the plant root is only approximately 10% (w/w) and the productivities of PD by several enzymes are still too low for industrial appli...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20163854

    authors: Kil TG,Kang SH,Kim TH,Shin KC,Oh DK

    更新日期:2019-08-07 00:00:00

  • Application of the Movable Type Free Energy Method to the Caspase-Inhibitor BindingAffinity Study.

    abstract::Many studies have provided evidence suggesting that caspases not only contribute to the neurodegeneration associated with Alzheimer's disease (AD) but also play essential roles in promoting the underlying pathology of this disease. Studies regarding the caspase inhibition draw researchers' attention through time due t...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20194850

    authors: Xue S,Liu H,Zheng Z

    更新日期:2019-09-29 00:00:00

  • Platelet-Rich Fibrin Facilitates Rabbit Meniscal Repair by Promoting Meniscocytes Proliferation, Migration, and Extracellular Matrix Synthesis.

    abstract::Although platelet-rich fibrin (PRF) has been used in clinical practice for some time, to date, few studies reveal its role as a bioactive scaffold in facilitating meniscal repair. Here, the positive anabolic effects of PRF on meniscocytes harvested from the primary culture of a rabbit meniscus were revealed. The rabbi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms18081722

    authors: Wong CC,Kuo TF,Yang TL,Tsuang YH,Lin MF,Chang CH,Lin YH,Chan WP

    更新日期:2017-08-07 00:00:00

  • NADPH Oxidases and Mitochondria in Vascular Senescence.

    abstract::Aging is the major risk factor in the development of cardiovascular diseases (CVDs), including hypertension, atherosclerosis, and myocardial infarction. Oxidative stress caused by overproduction of reactive oxygen species (ROS) and/or by reduced expression of antioxidant enzymes is a major contributor to the progressi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms19051327

    authors: Salazar G

    更新日期:2018-04-29 00:00:00

  • Novel Allergen Discovery through Comprehensive De Novo Transcriptomic Analyses of Five Shrimp Species.

    abstract::Shellfish allergy affects 2% of the world's population and persists for life in most patients. The diagnosis of shellfish allergy, in particular shrimp, is challenging due to the similarity of allergenic proteins from other invertebrates. Despite the clinical importance of immunological cross-reactivity among shellfis...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms22010032

    authors: Karnaneedi S,Huerlimann R,Johnston EB,Nugraha R,Ruethers T,Taki AC,Kamath SD,Wade NM,Jerry DR,Lopata AL

    更新日期:2020-12-22 00:00:00

  • Interference with the Cannabinoid Receptor CB1R Results in Miswiring of GnRH3 and AgRP1 Axons in Zebrafish Embryos.

    abstract::The G protein-coupled cannabinoid receptors type 1 (CB1R) and type 2 (CB2R), and their endocannabinoid (eCBs) ligands, have been implicated in several aspects of brain wiring during development. Here we aim to assess whether interfering with CB1R affects development, neuritogenesis and pathfinding of GnRH and AgRP neu...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21010168

    authors: Zuccarini G,D'Atri I,Cottone E,Mackie K,Shainer I,Gothilf Y,Provero P,Bovolin P,Merlo GR

    更新日期:2019-12-25 00:00:00

  • Temporal Splicing Switches in Elements of the TNF-Pathway Identified by Computational Analysis of Transcriptome Data for Human Cell Lines.

    abstract::Alternative splicing plays an important role in numerous cellular processes and aberrant splice decisions are associated with cancer. Although some studies point to a regulation of alternative splicing and its effector mechanisms in a time-dependent manner, the extent and consequences of such a regulation remains poor...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20051182

    authors: Genov N,Basti A,Abreu M,Relógio A

    更新日期:2019-03-08 00:00:00

  • The Salt-Stress Response of the Transgenic Plum Line J8-1 and Its Interaction with the Salicylic Acid Biosynthetic Pathway from Mandelonitrile.

    abstract::Salinity is considered as one of the most important abiotic challenges that affect crop productivity. Plant hormones, including salicylic acid (SA), are key factors in the defence signalling output triggered during plant responses against environmental stresses. We have previously reported in peach a new SA biosynthet...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms19113519

    authors: Bernal-Vicente A,Cantabella D,Petri C,Hernández JA,Diaz-Vivancos P

    更新日期:2018-11-08 00:00:00

  • The Roles of SPOP in DNA Damage Response and DNA Replication.

    abstract::Speckle-type BTB/POZ protein (SPOP) is a substrate recognition receptor of the cullin-3 (CUL3)/RING type ubiquitin E3 complex. To date, approximately 30 proteins have been identified as ubiquitinated substrates of the CUL3/SPOP complex. Pathologically, missense mutations in the substrate-binding domain of SPOP have be...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21197293

    authors: Maekawa M,Higashiyama S

    更新日期:2020-10-02 00:00:00

  • The Analgesic Effect of Venlafaxine and Its Mechanism on Oxaliplatin-Induced Neuropathic Pain in Mice.

    abstract::The analgesic effect of venlafaxine (VLX), which is a selective serotonin and noradrenaline reuptake inhibitor (SNRI), has been observed on oxaliplatin-induced neuropathic pain in mice. Significant allodynia was shown after oxaliplatin treatment (6 mg/kg, i.p.); acetone and von Frey hair tests were used to assess cold...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20071652

    authors: Li D,Lee JH,Choi CW,Kim J,Kim SK,Kim W

    更新日期:2019-04-03 00:00:00

  • Synthetic Scaffold/Dental Pulp Stem Cell (DPSC) Tissue Engineering Constructs for Bone Defect Treatment: An Animal Studies Literature Review.

    abstract:BACKGROUND:Recently a greater interest in tissue engineering for the treatment of large bone defect has been reported. The aim of the present systematic review and meta-analysis was to investigate the effectiveness of dental pulp stem cells and synthetic block complexes for bone defect treatment in preclinical in vivo ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21249765

    authors: Lorusso F,Inchingolo F,Dipalma G,Postiglione F,Fulle S,Scarano A

    更新日期:2020-12-21 00:00:00

  • Nanosecond T-jump experiment in poly(glutamic acid): a circular dichroism study.

    abstract::Poly(glutamic acid) has been studied with a nanosecond T-jump experiment. A new experimental set-up based on the frequency-quadrupling of an 82 MHz Titanium-Sapphire laser allows rapid CD measurements to be performed. Combining time-resolved absorption and circular dichroism at 204 and 220 nm, we are able to measure p...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms13022239

    authors: Mendonça L,Hache F

    更新日期:2012-01-01 00:00:00

  • Human PSC-Derived Hepatocytes Express Low Levels of Viral Pathogen Recognition Receptors, but Are Capable of Mounting an Effective Innate Immune Response.

    abstract::Hepatocytes are key players in the innate immune response to liver pathogens but are challenging to study because of inaccessibility and a short half-life. Recent advances in in vitro differentiation of hepatocyte-like cells (HLCs) facilitated studies of hepatocyte-pathogen interactions. Here, we aimed to define the a...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21113831

    authors: Fischer L,Lucendo-Villarin B,Hay DC,O'Farrelly C

    更新日期:2020-05-28 00:00:00

  • Optimization of a WGA-Free Molecular Tagging-Based NGS Protocol for CTCs Mutational Profiling.

    abstract::Molecular characterization of Circulating Tumor Cells (CTCs) is still challenging, despite attempts to minimize the drawbacks of Whole Genome Amplification (WGA). In this paper, we propose a Next-Generation Sequencing (NGS) optimized protocol based on molecular tagging technology, in order to detect CTCs mutations whi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21124364

    authors: De Luca G,Cardinali B,Del Mastro L,Lastraioli S,Carli F,Ferrarini M,Calin GA,Garuti A,Mazzitelli C,Zupo S,Dono M

    更新日期:2020-06-19 00:00:00

  • Hydroxyethyl Starch 130/0.4 Binds to Neutrophils Impairing Their Chemotaxis through a Mac-1 Dependent Interaction.

    abstract::Several studies showed that hydroxyethyl starch (HES), a synthetic colloid used in volume replacement therapies, interferes with leukocyte-endothelium interactions. Although still unclear, the mechanism seems to involve the inhibition of neutrophils' integrin. With the aim to provide direct evidence of the binding of ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20040817

    authors: Trentini A,Murganti F,Rosta V,Cervellati C,Manfrinato MC,Spadaro S,Dallocchio F,Volta CA,Bellini T

    更新日期:2019-02-14 00:00:00

  • miR-1285-3p Controls Colorectal Cancer Proliferation and Escape from Apoptosis through DAPK2.

    abstract::MicroRNAs are tiny but powerful regulators of gene expression at the post-transcriptional level. Aberrant expression of oncogenic and tumor-suppressor microRNAs has been recognized as a common feature of human cancers. Colorectal cancer represents a major clinical challenge in the developed world and the design of inn...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21072423

    authors: Villanova L,Barbini C,Piccolo C,Boe A,De Maria R,Fiori ME

    更新日期:2020-03-31 00:00:00

  • Metabolic difference of CZ48 in human and mouse liver microsomes.

    abstract::CZ48, chemically camptothecin-20-O-propionate hydrate, is currently under clinical investigation. The kinetics of the metabolite camptothecin (CPT) formation and of CZ48 depletion in mouse and human liver microsomes in the presence or absence of NADPH was examined. The formation rate of camptothecin in human liver mic...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms13055498

    authors: Liu X,Dejesus A,Cao Z,Vardeman D,Giovanella B

    更新日期:2012-01-01 00:00:00

  • Pigment Nephropathy: Novel Insights into Inflammasome-Mediated Pathogenesis.

    abstract::Pigment nephropathy is an acute decline in renal function following the deposition of endogenous haem-containing proteins in the kidneys. Haem pigments such as myoglobin and haemoglobin are filtered by glomeruli and absorbed by the proximal tubules. They cause renal vasoconstriction, tubular obstruction, increased oxi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms20081997

    authors: Giuliani KTK,Kassianos AJ,Healy H,Gois PHF

    更新日期:2019-04-23 00:00:00

  • The effect and mechanism of tamoxifen-induced hepatocyte steatosis in vitro.

    abstract::The aim of this study was to determine the effect and mechanism of tamoxifen (TAM)-induced steatosis in vitro. HepG 2 (Human hepatocellular liver carcinoma cell line) cells were treated with different concentrations of TAM for 72 h. Steatosis of hepatocytes was determined after Oil Red O staining and measurement of tr...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms15034019

    authors: Zhao F,Xie P,Jiang J,Zhang L,An W,Zhan Y

    更新日期:2014-03-05 00:00:00

  • Characterizing the Role of TaWRKY13 in Salt Tolerance.

    abstract::The WRKY transcription factor superfamily is known to participate in plant growth and stress response. However, the role of this family in wheat (Triticum aestivum L.) is largely unknown. Here, a salt-induced gene TaWRKY13 was identified in an RNA-Seq data set from salt-treated wheat. The results of RT-qPCR analysis s...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms20225712

    authors: Zhou S,Zheng WJ,Liu BH,Zheng JC,Dong FS,Liu ZF,Wen ZY,Yang F,Wang HB,Xu ZS,Zhao H,Liu YW

    更新日期:2019-11-14 00:00:00

  • Predicting the Functional Impact of CDH1 Missense Mutations in Hereditary Diffuse Gastric Cancer.

    abstract::The role of E-cadherin in Hereditary Diffuse Gastric Cancer (HDGC) is unequivocal. Germline alterations in its encoding gene (CDH1) are causative of HDGC and occur in about 40% of patients. Importantly, while in most cases CDH1 alterations result in the complete loss of E-cadherin associated with a well-established cl...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms18122687

    authors: Melo S,Figueiredo J,Fernandes MS,Gonçalves M,Morais-de-Sá E,Sanches JM,Seruca R

    更新日期:2017-12-12 00:00:00

  • A Tetra-Panel of Serum Circulating miRNAs for the Diagnosis of the Four Most Prevalent Tumor Types.

    abstract::The purpose of this study is to clinically validate a series of circulating miRNAs that distinguish between the 4 most prevalent tumor types (lung cancer (LC); breast cancer (BC); colorectal cancer (CRC); and prostate cancer (PCa)) and healthy donors (HDs). A total of 18 miRNAs and 3 housekeeping miRNA genes were eval...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21082783

    authors: Pastor-Navarro B,García-Flores M,Fernández-Serra A,Blanch-Tormo S,Martínez de Juan F,Martínez-Lapiedra C,Maia de Alcantara F,Peñalver JC,Cervera-Deval J,Rubio-Briones J,García-Rupérez J,López-Guerrero JA

    更新日期:2020-04-16 00:00:00

  • Potential Anti-COVID-19 Therapeutics that Block the Early Stage of the Viral Life Cycle: Structures, Mechanisms, and Clinical Trials.

    abstract::The ongoing pandemic of coronavirus disease-2019 (COVID-19) is being caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The disease continues to present significant challenges to the health care systems around the world. This is primarily because of the lack of vaccines to protect against the infe...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21155224

    authors: Al-Horani RA,Kar S,Aliter KF

    更新日期:2020-07-23 00:00:00

  • Deletion of p53 and Hyper-Activation of PIK3CA in Keratin-15+ Stem Cells Lead to the Development of Spontaneous Squamous Cell Carcinoma.

    abstract::Squamous cell carcinoma (SCC) is the second commonest type of skin cancer, and SCCs make up about 90% of head and neck cancers (HNSCCs). HNSCCs harbor two frequent molecular alterations, namely, gain-of-function alterations of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) and loss-of-...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms21186585

    authors: Chen SMY,Li B,Nicklawsky AG,Krinsky AL,Brunetti T,Woolaver RA,Wang X,Chen Z,Young CD,Gao D,Wang XJ,Wang JH

    更新日期:2020-09-09 00:00:00

  • TPX2 is a prognostic marker and contributes to growth and metastasis of human hepatocellular carcinoma.

    abstract::Targeting protein for Xenopus kinesin-like protein 2 (TPX2), a microtubule-associated protein, impacts spindle assembly in human cells. Several studies have demonstrated that TPX2 is overexpressed in different types of human cancers and promotes tumor growth and metastasis. In this study, we found that the expression ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章

    doi:10.3390/ijms151018148

    authors: Huang Y,Guo W,Kan H

    更新日期:2014-10-09 00:00:00

  • The Role of Selective Protein Degradation in the Regulation of Iron and Sulfur Homeostasis in Plants.

    abstract::Plants are able to synthesize all essential metabolites from minerals, water, and light to complete their life cycle. This plasticity comes at a high energy cost, and therefore, plants need to tightly allocate resources in order to control their economy. Being sessile, plants can only adapt to fluctuating environmenta...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审

    doi:10.3390/ijms21082771

    authors: Wawrzyńska A,Sirko A

    更新日期:2020-04-16 00:00:00