Abstract:
:Bone adaptation or integration of an implant is characterized by a series of biological reactions that start with bone turnover at the interface (a process of localized necrosis), followed by rapid repair. The wound healing response is guided by a complex activation of macrophages leading to tissue turnover and new osteoblast differentiation on the implant surface. The complex role of implant surface topography and impact on healing response plays a role in biological criteria that can guide the design and development of future tissue-implant surface interfaces.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Stanford CMdoi
10.3390/ijms11010354subject
Has Abstractpub_date
2010-01-25 00:00:00pages
354-69issue
1issn
1422-0067journal_volume
11pub_type
杂志文章,评审abstract::Glioblastoma is a highly aggressive primary brain tumour, renowned for its infiltrative growth and varied genetic profiles. The current treatment options are insufficient, and their off-target effects greatly reduce patient quality of life. The major challenge in improving glioblastoma diagnosis and treatment involves...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18122576
更新日期:2017-11-30 00:00:00
abstract::The adult mammalian central nervous system (CNS) is generally considered as repair restricted organ with limited capacities to regenerate lost cells and to successfully integrate them into damaged nerve tracts. Despite the presence of endogenous immature cell types that can be activated upon injury or in disease cell ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20020455
更新日期:2019-01-21 00:00:00
abstract::Marine sponges remain representative of a unique source of renewable biological materials. The demosponges of the family Ianthellidae possess chitin-based skeletons with high biomimetic potential. These three-dimensional (3D) constructs can potentially be used in tissue engineering and regenerative medicine. In this s...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20205105
更新日期:2019-10-15 00:00:00
abstract::Cell proliferation is an important biological process during myogenesis. Tob1 encoded a member of the Tob/BTG family of anti-proliferative proteins. Our previous LongSAGE (Long Serial Analysis of Gene Expression) analysis suggested that Tob1 was differentially expressed during prenatal skeletal muscle development. In ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms12074315
更新日期:2011-01-01 00:00:00
abstract::Platycodin D (PD), a major saponin (platycoside) in Platycodi radix (balloon flower root), has higher pharmacological activity than the other major platycosides; however, its content in the plant root is only approximately 10% (w/w) and the productivities of PD by several enzymes are still too low for industrial appli...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20163854
更新日期:2019-08-07 00:00:00
abstract::Many studies have provided evidence suggesting that caspases not only contribute to the neurodegeneration associated with Alzheimer's disease (AD) but also play essential roles in promoting the underlying pathology of this disease. Studies regarding the caspase inhibition draw researchers' attention through time due t...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20194850
更新日期:2019-09-29 00:00:00
abstract::Although platelet-rich fibrin (PRF) has been used in clinical practice for some time, to date, few studies reveal its role as a bioactive scaffold in facilitating meniscal repair. Here, the positive anabolic effects of PRF on meniscocytes harvested from the primary culture of a rabbit meniscus were revealed. The rabbi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18081722
更新日期:2017-08-07 00:00:00
abstract::Aging is the major risk factor in the development of cardiovascular diseases (CVDs), including hypertension, atherosclerosis, and myocardial infarction. Oxidative stress caused by overproduction of reactive oxygen species (ROS) and/or by reduced expression of antioxidant enzymes is a major contributor to the progressi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19051327
更新日期:2018-04-29 00:00:00
abstract::Shellfish allergy affects 2% of the world's population and persists for life in most patients. The diagnosis of shellfish allergy, in particular shrimp, is challenging due to the similarity of allergenic proteins from other invertebrates. Despite the clinical importance of immunological cross-reactivity among shellfis...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22010032
更新日期:2020-12-22 00:00:00
abstract::The G protein-coupled cannabinoid receptors type 1 (CB1R) and type 2 (CB2R), and their endocannabinoid (eCBs) ligands, have been implicated in several aspects of brain wiring during development. Here we aim to assess whether interfering with CB1R affects development, neuritogenesis and pathfinding of GnRH and AgRP neu...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21010168
更新日期:2019-12-25 00:00:00
abstract::Alternative splicing plays an important role in numerous cellular processes and aberrant splice decisions are associated with cancer. Although some studies point to a regulation of alternative splicing and its effector mechanisms in a time-dependent manner, the extent and consequences of such a regulation remains poor...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20051182
更新日期:2019-03-08 00:00:00
abstract::Salinity is considered as one of the most important abiotic challenges that affect crop productivity. Plant hormones, including salicylic acid (SA), are key factors in the defence signalling output triggered during plant responses against environmental stresses. We have previously reported in peach a new SA biosynthet...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19113519
更新日期:2018-11-08 00:00:00
abstract::Speckle-type BTB/POZ protein (SPOP) is a substrate recognition receptor of the cullin-3 (CUL3)/RING type ubiquitin E3 complex. To date, approximately 30 proteins have been identified as ubiquitinated substrates of the CUL3/SPOP complex. Pathologically, missense mutations in the substrate-binding domain of SPOP have be...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21197293
更新日期:2020-10-02 00:00:00
abstract::The analgesic effect of venlafaxine (VLX), which is a selective serotonin and noradrenaline reuptake inhibitor (SNRI), has been observed on oxaliplatin-induced neuropathic pain in mice. Significant allodynia was shown after oxaliplatin treatment (6 mg/kg, i.p.); acetone and von Frey hair tests were used to assess cold...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20071652
更新日期:2019-04-03 00:00:00
abstract:BACKGROUND:Recently a greater interest in tissue engineering for the treatment of large bone defect has been reported. The aim of the present systematic review and meta-analysis was to investigate the effectiveness of dental pulp stem cells and synthetic block complexes for bone defect treatment in preclinical in vivo ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21249765
更新日期:2020-12-21 00:00:00
abstract::Poly(glutamic acid) has been studied with a nanosecond T-jump experiment. A new experimental set-up based on the frequency-quadrupling of an 82 MHz Titanium-Sapphire laser allows rapid CD measurements to be performed. Combining time-resolved absorption and circular dichroism at 204 and 220 nm, we are able to measure p...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms13022239
更新日期:2012-01-01 00:00:00
abstract::Hepatocytes are key players in the innate immune response to liver pathogens but are challenging to study because of inaccessibility and a short half-life. Recent advances in in vitro differentiation of hepatocyte-like cells (HLCs) facilitated studies of hepatocyte-pathogen interactions. Here, we aimed to define the a...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21113831
更新日期:2020-05-28 00:00:00
abstract::Molecular characterization of Circulating Tumor Cells (CTCs) is still challenging, despite attempts to minimize the drawbacks of Whole Genome Amplification (WGA). In this paper, we propose a Next-Generation Sequencing (NGS) optimized protocol based on molecular tagging technology, in order to detect CTCs mutations whi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21124364
更新日期:2020-06-19 00:00:00
abstract::Several studies showed that hydroxyethyl starch (HES), a synthetic colloid used in volume replacement therapies, interferes with leukocyte-endothelium interactions. Although still unclear, the mechanism seems to involve the inhibition of neutrophils' integrin. With the aim to provide direct evidence of the binding of ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20040817
更新日期:2019-02-14 00:00:00
abstract::MicroRNAs are tiny but powerful regulators of gene expression at the post-transcriptional level. Aberrant expression of oncogenic and tumor-suppressor microRNAs has been recognized as a common feature of human cancers. Colorectal cancer represents a major clinical challenge in the developed world and the design of inn...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21072423
更新日期:2020-03-31 00:00:00
abstract::CZ48, chemically camptothecin-20-O-propionate hydrate, is currently under clinical investigation. The kinetics of the metabolite camptothecin (CPT) formation and of CZ48 depletion in mouse and human liver microsomes in the presence or absence of NADPH was examined. The formation rate of camptothecin in human liver mic...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms13055498
更新日期:2012-01-01 00:00:00
abstract::Pigment nephropathy is an acute decline in renal function following the deposition of endogenous haem-containing proteins in the kidneys. Haem pigments such as myoglobin and haemoglobin are filtered by glomeruli and absorbed by the proximal tubules. They cause renal vasoconstriction, tubular obstruction, increased oxi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20081997
更新日期:2019-04-23 00:00:00
abstract::The aim of this study was to determine the effect and mechanism of tamoxifen (TAM)-induced steatosis in vitro. HepG 2 (Human hepatocellular liver carcinoma cell line) cells were treated with different concentrations of TAM for 72 h. Steatosis of hepatocytes was determined after Oil Red O staining and measurement of tr...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms15034019
更新日期:2014-03-05 00:00:00
abstract::The WRKY transcription factor superfamily is known to participate in plant growth and stress response. However, the role of this family in wheat (Triticum aestivum L.) is largely unknown. Here, a salt-induced gene TaWRKY13 was identified in an RNA-Seq data set from salt-treated wheat. The results of RT-qPCR analysis s...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20225712
更新日期:2019-11-14 00:00:00
abstract::The role of E-cadherin in Hereditary Diffuse Gastric Cancer (HDGC) is unequivocal. Germline alterations in its encoding gene (CDH1) are causative of HDGC and occur in about 40% of patients. Importantly, while in most cases CDH1 alterations result in the complete loss of E-cadherin associated with a well-established cl...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18122687
更新日期:2017-12-12 00:00:00
abstract::The purpose of this study is to clinically validate a series of circulating miRNAs that distinguish between the 4 most prevalent tumor types (lung cancer (LC); breast cancer (BC); colorectal cancer (CRC); and prostate cancer (PCa)) and healthy donors (HDs). A total of 18 miRNAs and 3 housekeeping miRNA genes were eval...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21082783
更新日期:2020-04-16 00:00:00
abstract::The ongoing pandemic of coronavirus disease-2019 (COVID-19) is being caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). The disease continues to present significant challenges to the health care systems around the world. This is primarily because of the lack of vaccines to protect against the infe...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21155224
更新日期:2020-07-23 00:00:00
abstract::Squamous cell carcinoma (SCC) is the second commonest type of skin cancer, and SCCs make up about 90% of head and neck cancers (HNSCCs). HNSCCs harbor two frequent molecular alterations, namely, gain-of-function alterations of phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha (PIK3CA) and loss-of-...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21186585
更新日期:2020-09-09 00:00:00
abstract::Targeting protein for Xenopus kinesin-like protein 2 (TPX2), a microtubule-associated protein, impacts spindle assembly in human cells. Several studies have demonstrated that TPX2 is overexpressed in different types of human cancers and promotes tumor growth and metastasis. In this study, we found that the expression ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms151018148
更新日期:2014-10-09 00:00:00
abstract::Plants are able to synthesize all essential metabolites from minerals, water, and light to complete their life cycle. This plasticity comes at a high energy cost, and therefore, plants need to tightly allocate resources in order to control their economy. Being sessile, plants can only adapt to fluctuating environmenta...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21082771
更新日期:2020-04-16 00:00:00