Abstract：
:Four new labdane-type diterpenoids: hedychicoronarin (1), peroxycoronarin D (2), 7β-hydroxycalcaratarin A (3), and (E)-7β-hydroxy-6-oxo-labda-8(17),12-diene-15,16-dial (4), have been isolated from the rhizomes of Hedychium coronarium, together with 13 known compounds (5-17). The structures of these new compounds were determined through spectroscopic and MS analyses. Compounds 3, 5, 6, and 10 exhibited inhibition (IC50 values ≤4.52 μg/mL) of superoxide anion generation by human neutrophils in response to formyl-L-methionyl-L-leucyl-L-phenylalanine/cytochalasin B (fMLP/CB). Compounds 3-6, 10, and 11 inhibited fMLP/CB-induced elastase release with IC50 values ≤6.17 μg/mL.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Chen JJ,Ting CW,Wu YC,Hwang TL,Cheng MJ,Sung PJ,Wang TC,Chen JFdoi
10.3390/ijms140713063subject
Has Abstractpub_date
2013-06-25 00:00:00pages
13063-77issue
7issn
1422-0067pii
ijms140713063journal_volume
14pub_type
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