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ADMA/SDMA in elderly subjects with asymptomatic carotid atherosclerosis: values and site-specific association.

Abstract：

:Asymmetric dimethylarginine (ADMA) is an endogenous nitric oxide synthase (NOS) inhibitor known as a mediator of endothelial dysfunction and atherosclerosis. Circulating ADMA levels are correlated with cardiovascular risk factors such as hypercholesterolemia, arterial hypertension, diabetes mellitus, hyperhomocysteinemia, age and smoking. We assessed the relationship between ADMA values and site-specific association of asymptomatic carotid atherosclerosis (intima-media thickness (CIMT) and plaque) in elderly subjects. One hundred and eighty subjects underwent a complete history and physical examination, determination of serum chemistries and ADMA levels, and carotid ultrasound investigation (CUI). All subjects had no acute or chronic symptoms of carotid atherosclerosis. Statistical analyses showed that high plasma levels of ADMA/SDMA were positively correlated to carotid atherosclerosis (CIMT and plaque) (p<0.001), with significant site-specific association. Total cholesterol, low density lipoprotein cholesterol, triglycerides and C-reactive protein plasma concentrations were significantly associated with asymptomatic carotid atherosclerosis (p<0.001). High serum concentrations of ADMA and SDMA were associated with carotid atherosclerotic lesions as measured by CIMT ad plaque and may represent a new marker of asymptomatic carotid atherosclerosis in elderly subjects.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Riccioni G,Scotti L,D'Orazio N,Gallina S,Speziale G,Speranza L,Bucciarelli T

doi

10.3390/ijms15046391

subject

Has Abstract

pub_date

2014-04-15 00:00:00

pages

6391-8

issue

4

issn

1422-0067

pii

ijms15046391

journal_volume

15

pub_type

杂志文章

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