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Design, synthesis and antiviral activity studies of schizonepetin derivatives.

Abstract：

:A series of schizonepetin derivatives have been designed and synthesized in order to obtain potent antivirus agents. The antiviral activity against HSV-1 and influenza virus H3N2 as well as the cytotoxicity of these derivatives was evaluated by using cytopathic effect (CPE) inhibition assay in vitro. Compounds M2, M4, M5 and M34 showed higher inhibitory activity against HSV-1 virus with the TC50 values being in micromole. Compounds M28, M33, and M35 showed higher inhibitory activity against influenza virus H3N2 with their TC50 values being 96.4, 71.0 and 75.4 μM, respectively. Preliminary biological activity evaluation indicated that the anti-H3N2 and anti-HSV-1 activities improved obviously through the introduction of halogen into the structure of schizonepetin.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Bao B,Meng Z,Li N,Meng Z,Zhang L,Cao Y,Yao W,Shan M,Ding A

doi

10.3390/ijms140817193

subject

Has Abstract

pub_date

2013-08-20 00:00:00

pages

17193-203

issue

8

issn

1422-0067

pii

ijms140817193

journal_volume

14

pub_type

杂志文章

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