Abstract：
:Spinal sarcopenia is a complex and multifactorial disorder associated with a loss of strength, increased frailty, and increased risks of fractures and falls. In addition, spinal sarcopenia has been associated with lumbar spine disorders and osteoporosis, which renders making decisions on treatment modalities difficult. Patients with spinal sarcopenia typically exhibit lower cumulative survival, a higher risk of in-hospital complications, prolonged hospital stays, higher postoperative costs, and higher rates of blood transfusion after thoracolumbar spine surgery. Several studies have focused on the relationships between spinal sarcopenia, appendicular muscle mass, and bone-related problems-such as osteoporotic fractures and low bone mineral density-and malnutrition and vitamin D deficiency. Although several techniques are available for measuring sarcopenia, each of them has its advantages and shortcomings. For treating spinal sarcopenia, nutrition, physical therapy, and medication have been proven to be effective; regenerative therapeutic options seem to be promising owing to their repair and regeneration potential. Therefore, in this narrative review, we summarize the characteristics, detection methodologies, and treatment options for spinal sarcopenia, as well as its role in spinal disorders.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Kuo YK,Lin YC,Lee CY,Chen CY,Tani J,Huang TJ,Chang H,Wu MHdoi
10.3390/ijms21083010subject
Has Abstractpub_date
2020-04-24 00:00:00issue
8issn
1422-0067pii
ijms21083010journal_volume
21pub_type
杂志文章,评审abstract：:Nosocomial (hospital-acquired) infections remain a serious challenge for health systems. The reason for this lies not only in the local imperfection of medical practices and protocols. The frequency of infection with antibiotic-resistant strains of bacteria is growing every year, both in developed and developing count...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21217839
更新日期：2020-10-22 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is a leading cause of cancer-related morbidity and mortality worldwide. Most patients are diagnosed with advanced disease, limiting their options for treatment. While current treatments are adequate for lower staged disease, available systemic treatments are limited, with marginal benefi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21186757
更新日期：2020-09-15 00:00:00
abstract：:We investigated the toxicity of benzo[a]pyrene (B[a]P), 1-nitropyrene (1-NP) and 3-nitrobenzanthrone (3-NBA) in A549 cells. Cells were treated for 4 h and 24 h with: B[a]P (0.1 and 1 μM), 1-NP (1 and 10 μM) and 3-NBA (0.5 and 5 μM). Bulky DNA adducts, lipid peroxidation, DNA and protein oxidation and mRNA expression o...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17091393
更新日期：2016-08-26 00:00:00
abstract：:The phenol-degrading efficiency of Pseudochrobactrum sp. was enhanced by ultraviolet (UV) irradiation. First, a bacterial strain, Pseudochrobactrum sp. XF1, was isolated from the activated sludge in a coking plant. It was subjected to mutation by UV radiation for 120 s and a mutant strain with higher phenol-degrading ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16047320
更新日期：2015-04-01 00:00:00
abstract：:A common feature of nuclear receptors (NRs) is the transformation of external cell signals into specific transcriptions of the signal molecule. Signal molecules function as ligands for NRs and, after their uptake, activated NRs form homo- or heterodimers at promoter recognition sequences of the specific genes in the n...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms150611100
更新日期：2014-06-19 00:00:00
abstract：:SECONDARY WALL-ASSOCIATED NAC DOMAIN1 (SND1) is a master regulator of fibre secondary wall deposition in Arabidopsis thaliana (Arabidopsis), with homologs in other angiosperms and gymnosperms. However, it is poorly understood to what extent the fibre-specific regulation of the SND1 promoter, and that of its orthologs,...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184623
更新日期：2019-09-18 00:00:00
abstract：:Mucopolysaccharidosis type IVA (MPS IVA) is a lysosomal storage disease caused by mutations in the N-acetylgalactosamine-6-sulfatase (GALNS) gene. Skeletal dysplasia and the related clinical features of MPS IVA are caused by disruption of the cartilage and its extracellular matrix, leading to a growth imbalance. Enzym...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22010226
更新日期：2020-12-28 00:00:00
abstract：:Tumors often show intra-tumor heterogeneity because of genotypic differences between all the cells that compose it and that derive from it. Recent studies have shown significant aspects of neuroblastoma heterogeneity that may affect the diagnostic-therapeutic strategy. Therefore, we developed a laboratory protocol, ba...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20040893
更新日期：2019-02-19 00:00:00
abstract：:Our laboratory and others have previously shown that cannabinoid receptor type-1 (CB1r) activity is neuroprotective and a modulator of brain ageing; a genetic disruption of CB1r signaling accelerates brain ageing, whereas the pharmacological stimulation of CB1r activity had the opposite effect. In this study, we have ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22010005
更新日期：2020-12-22 00:00:00
abstract：:Metabolic reprogramming that favors high glycolytic flux with lactate production in normoxia is among cancer hallmarks. Lactate is an essential oncometabolite regulating cellular redox homeostasis, energy substrate partitioning, and intracellular signaling. Moreover, malignant phenotype's chief characteristics are dep...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21249676
更新日期：2020-12-18 00:00:00
abstract：INTRODUCTION:Targeted agents such as bevacizumab (BEV) or poly (ADP-ribose) polymerase inhibitors (PARPi) which have been added as concomitant or maintenance therapies have been shown to improve progression-free survival (PFS) in patients with platinum-sensitive recurrent ovarian cancer (PS rOC). In the absence of dire...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21113805
更新日期：2020-05-27 00:00:00
abstract：:One of the most striking features occurring in the root-knot nematode Meloidogyne incognita induced galls is the reorganization of the vascular tissues. During the interaction of the model tree species Populus and M. incognita, a pronounced xylem proliferation was previously described in mature galls. To better charac...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21020406
更新日期：2020-01-09 00:00:00
abstract：:It has been shown that saturated fatty acids (FAs) have a detrimental effect on pancreatic β-cells function and survival, leading to apoptosis, whereas unsaturated FAs are well tolerated and are even capable of inhibiting the pro-apoptotic effect of saturated FAs. Molecular mechanisms of apoptosis induction and regula...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18112313
更新日期：2017-11-02 00:00:00
abstract：:Since the European Union (EU) announced their animal testing ban in 2013, all animal experiments related to cosmetics have been prohibited, creating a demand for alternatives to animal experiments for skin studies. Here, we investigated whether an ex vivo live porcine skin model can be employed to study the safety and...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22020657
更新日期：2021-01-11 00:00:00
abstract：:Erythropoiesis is a complex process driving the production of red blood cells. During homeostasis, adult erythropoiesis takes place in the bone marrow and is tightly controlled by erythropoietin (EPO), a central hormone mainly produced in renal EPO-producing cells. The expression of EPO is strictly regulated by local ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21218131
更新日期：2020-10-30 00:00:00
abstract：:Genetic analysis of "InochinoIchi," an exceptionally large grain rice variety, was conducted through five continuous backcrosses with Koshihikari as a recurrent parent using the large grain F3 plant in Koshihikari × Inochinoichi as a nonrecurrent parent. Thorough the F2 and all BCnF2 generations, large, medium, and sm...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20215442
更新日期：2019-10-31 00:00:00
abstract：:In this report, the use of fluorescence detection coupled capillary electrophoresis (CE-FL) allowed us to fully characterize the antigen-antibody interaction. CE-FL allowed separation of unbound quantum dots (QDs) and ligand bound QDs and also revealed an ordered assembly of biomolecules on QDs. Further, we observed F...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140919146
更新日期：2013-09-17 00:00:00
abstract：:Trichoderma reesei is a biotechnologically important filamentous fungus with the remarkable ability to secrete large amounts of enzymes, whose production is strongly affected by both the carbon and nitrogen sources. While the carbon metabolism regulators are extensively studied, the regulation of enzyme production by ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20174100
更新日期：2019-08-22 00:00:00
abstract：:It is widely recognized that many chronic infections of the human body have a polymicrobial etiology. These include diabetic foot ulcer infections, lung infections in cystic fibrosis patients, periodontitis, otitis, urinary tract infections and even a proportion of systemic infections. The treatment of mixed infection...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms22020482
更新日期：2021-01-06 00:00:00
abstract：:Bacteria generate membrane vesicles, which are structures known as extracellular vesicles (EVs), reported to be involved in different pathogenic mechanisms, as it has been demonstrated that EVs participate in biofilm formation, cell-to-cell communication, bacteria-host interactions, and nutrients supply. EVs deliver n...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20215307
更新日期：2019-10-25 00:00:00
abstract：:During the last few years, diverse studies have shown that tumors can actively interact with the lymphatic system and promote metastases development. In order to examine the molecular mechanisms involved in this interaction, we co-cultured tumor and lymphatic endothelial cells (LEC) and subsequently analyzed the molec...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21020602
更新日期：2020-01-17 00:00:00
abstract：:Protein-protein interactions are important for the molecular understanding of the biological processes of proteins. The dimerization of bZIPs (basic leucine zipper proteins) is involved in modifying binding site specificities, altering dimer stability, and permitting a new set of specific protein-to-protein interactio...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms150610005
更新日期：2014-06-04 00:00:00
abstract：:Engineering rubber composites have been widely used as main components in many fields including vehicle engineering and biomedical applications. However, when a rubber composite surface area is exposed to heat or sunlight and over a long-term accelerated exposure and lifecycle of test, the rubber becomes hard, thus in...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21239007
更新日期：2020-11-27 00:00:00
abstract：:Adenosine triphosphate (ATP) has been well established as an important extracellular ligand of autocrine signaling, intercellular communication, and neurotransmission with numerous physiological and pathophysiological roles. In addition to the classical exocytosis, non-vesicular mechanisms of cellular ATP release have...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19030808
更新日期：2018-03-11 00:00:00
abstract：:A variety of studies have suggested that the 4b/a polymorphism in the endothelial nitric oxide synthase (eNOS) was associated with coronary artery disease (CAD) risk. However, the data remain conflicting. The aim of the present meta-analysis was to estimate the overall association between risk of CAD and eNOS 4b/a pol...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,meta分析
doi：10.3390/ijms15057987
更新日期：2014-05-07 00:00:00
abstract：:Duloxetine (DLX) is a potent drug investigated for the treatment of depression and urinary incontinence. DLX is extensively metabolized in the liver by two P450 isozymes, CYP2D6 and CYP1A2. Propolis (PPL) is one of the popular functional foods known to have effects on activities of CYPs, including CYP1A2. Due to the h...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051862
更新日期：2020-03-09 00:00:00
abstract：:Immunosenescence defines the decline in immune function that occurs with aging. This has been associated, at least in part, with defective cellular signaling via protein kinase C (PKC) signal transduction pathways. Our data suggest reduced PKC activation and consequently reduced response to lipopolysaccharide (LPS) st...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18071453
更新日期：2017-07-06 00:00:00
abstract：:Inherited bone marrow failure syndromes (IBMFS) are a group of cancer-prone genetic diseases characterized by hypocellular bone marrow with impairment in one or more hematopoietic lineages. The pathogenesis of IBMFS involves mutations in several genes which encode for proteins involved in DNA repair, telomere biology ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21134672
更新日期：2020-06-30 00:00:00
abstract：:We have been made aware that text, figures and experimental data reported in the title paper [1] are duplicated in another publication by Zihan Xu et al. [2].[...]. ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,撤回出版物
doi：10.3390/ijms17050768
更新日期：2016-05-20 00:00:00
abstract：:Astrocytomas and, in particular, their most severe form, glioblastoma, are the most aggressive primary brain tumors and those with the poorest vital prognosis. Standard treatment only slightly improves patient survival. Therefore, new therapies are needed. Very few risk factors have been clearly identified but many ep...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21239114
更新日期：2020-11-30 00:00:00
