Staphylococcus aureus and MRSA Growth and Biofilm Formation after Treatment with Antibiotics and SeNPs.


:Methicillin-resistant Staphylococcus aureus (MRSA) is a dangerous pathogen resistant to β-lactam antibiotics. Due to its resistance, it is difficult to manage the infections caused by this strain. We examined this issue in terms of observation of the growth properties and ability to form biofilms in sensitive S. aureus and MRSA after the application of antibiotics (ATBs)-ampicillin, oxacillin and penicillin-and complexes of selenium nanoparticles (SeNPs) with these ATBs. The results suggest the strong inhibition effect of SeNPs in complexes with conventional ATBs. Using the impedance method, a higher disruption of biofilms was observed after the application of ATB complexes with SeNPs compared to the group exposed to ATBs without SeNPs. The biofilm formation was intensely inhibited (up to 99%±7% for S. aureus and up to 94%±4% for MRSA) after application of SeNPs in comparison with bacteria without antibacterial compounds whereas ATBs without SeNPs inhibited S. aureus up to 79%±5% and MRSA up to 16%±2% only. The obtained results provide a basis for the use of SeNPs as a tool for the treatment of bacterial infections, which can be complicated because of increasing resistance of bacteria to conventional ATB drugs.


Int J Mol Sci


Cihalova K,Chudobova D,Michalek P,Moulick A,Guran R,Kopel P,Adam V,Kizek R




Has Abstract


2015-10-16 00:00:00












  • An Isoform of Nedd4-2 Plays a Pivotal Role in Electrophysiological Cardiac Abnormalities.

    abstract::We have previously shown that neural precursor cell-expressed developmentally downregulated gene 4-2 (Nedd4-2) isoforms with a C2 domain are closely related to ubiquitination of epithelial sodium channel (ENaC), resulting in salt-sensitive hypertension by Nedd4-2 C2 targeting in mice. The sodium voltage-gated channel ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Minegishi S,Ishigami T,Kawamura H,Kino T,Chen L,Nakashima-Sasaki R,Doi H,Azushima K,Wakui H,Chiba Y,Tamura K

    更新日期:2017-06-14 00:00:00

  • Gastroprotective and Antioxidant Activity of Kalanchoe brasiliensis and Kalanchoe pinnata Leaf Juices against Indomethacin and Ethanol-Induced Gastric Lesions in Rats.

    abstract::Kalanchoe brasiliensis and Kalanchoe pinnata are used interchangeably in traditional medicine for treating peptic ulcers and inflammatory problems. In this context, this study aims to characterize the chemical constituents and evaluate the gastroprotective activity of the leaf juices of the two species in acute gastri...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: de Araújo ERD,Guerra GCB,Araújo DFS,de Araújo AA,Fernandes JM,de Araújo Júnior RF,da Silva VC,de Carvalho TG,Ferreira LS,Zucolotto SM

    更新日期:2018-04-24 00:00:00

  • Effect of long-term dietary arginyl-fructose (AF) on hyperglycemia and HbA1c in diabetic db/db mice.

    abstract::We have previously reported that Amadori compounds exert anti-diabetic effects by lowering sucrose-induced hyperglycemia in normal Sprague-Dawley rats. In the present study we extended our recent findings to evaluate whether α-glucosidase inhibitor arginyl-fructose (AF) lowers blood glucose level in diabetic db/db mic...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Lee KH,Ha KS,Jo SH,Lee CM,Kim YC,Chung KH,Kwon YI

    更新日期:2014-05-12 00:00:00

  • Inhibition of human transthyretin aggregation by non-steroidal anti-inflammatory compounds: a structural and thermodynamic analysis.

    abstract::Transthyretin (TTR) is a homotetrameric protein that circulates in plasma and cerebral spinal fluid (CSF) whose aggregation into amyloid fibrils has been associated with at least two different amyloid diseases: senile systemic amyloidosis (SSA) and familial amyloid polyneuropathy (FAP). In SSA aggregates are composed ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Sant'anna RO,Braga CA,Polikarpov I,Ventura S,Lima LM,Foguel D

    更新日期:2013-03-06 00:00:00

  • Influence of Cardiovascular Risk Factors, Comorbidities, Medication Use and Procedural Variables on Remote Ischemic Conditioning Efficacy in Patients with ST-Segment Elevation Myocardial Infarction.

    abstract::Remote ischemic conditioning (RIC) confers cardioprotection in patients with ST-segment elevation myocardial infarction (STEMI). Despite intense research, the translation of RIC into clinical practice remains a challenge. This may, at least partly, be due to confounding factors that may modify the efficacy of RIC. The...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Pryds K,Hjortbak MV,Schmidt MR

    更新日期:2019-07-02 00:00:00

  • AWRK6, A Synthetic Cationic Peptide Derived from Antimicrobial Peptide Dybowskin-2CDYa, Inhibits Lipopolysaccharide-Induced Inflammatory Response.

    abstract::Lipopolysaccharides (LPS) are major outer membrane components of Gram-negative bacteria and produce strong inflammatory responses in animals. Most antibiotics have shown little clinical anti-endotoxin activity while some antimicrobial peptides have proved to be effective in blocking LPS. Here, the anti-LPS activity of...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Wang Q,Jin L,Wang H,Tai S,Liu H,Zhang D

    更新日期:2018-02-17 00:00:00

  • Mitochondrial Quality Control in Age-Related Pulmonary Fibrosis.

    abstract::Idiopathic pulmonary fibrosis (IPF) is age-related interstitial lung disease of unknown etiology. About 100,000 people in the U.S have IPF, with a 3-year median life expectancy post-diagnosis. The development of an effective treatment for pulmonary fibrosis will require an improved understanding of its molecular patho...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Roque W,Cuevas-Mora K,Romero F

    更新日期:2020-01-18 00:00:00

  • Enriching Diet with n-3 PUFAs to Help Prevent Cardiovascular Diseases in Healthy Adults: Results from Clinical Trials.

    abstract::Omega-3 polyunsaturated fatty acids (n-3 PUFAs) are believed to be important for cardiovascular health. Many investigations have been carried out in an attempt to examine the effect of n-3 PUFAs intake, in the form of supplementation or fortified foods, for the management of cardiovascular disease (CVD) and risk facto...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Manuelli M,Della Guardia L,Cena H

    更新日期:2017-07-18 00:00:00

  • Decreased Expression of ZNF554 in Gliomas is Associated with the Activation of Tumor Pathways and Shorter Patient Survival.

    abstract::Zinc finger protein 554 (ZNF554), a member of the Krüppel-associated box domain zinc finger protein subfamily, is predominantly expressed in the brain and placenta in humans. Recently, we unveiled that ZNF554 regulates trophoblast invasion during placentation and its decreased expression leads to the early pathogenesi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Balogh A,Reiniger L,Hetey S,Kiraly P,Toth E,Karaszi K,Juhasz K,Gelencser Z,Zvara A,Szilagyi A,Puskas LG,Matko J,Papp Z,Kovalszky I,Juhasz C,Than NG

    更新日期:2020-08-11 00:00:00

  • Roles of Dkk2 in the Linkage from Muscle to Bone during Mechanical Unloading in Mice.

    abstract::Mechanical unloading simultaneously induces muscle and bone loss, but its mechanisms are not fully understood. The interactions between skeletal muscle and bone have been recently noted. Although canonical wingless-related integration site (Wnt)/β-catenin signaling is crucial for bone metabolism, its roles in the musc...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Kawao N,Morita H,Iemura S,Ishida M,Kaji H

    更新日期:2020-04-06 00:00:00

  • Genetic variants in human leukocyte antigen-DP influence both hepatitis C virus persistence and hepatitis C virus F protein generation in the Chinese Han population.

    abstract::Chronic hepatitis C is a serious liver disease that often results in cirrhosis or hepatocellular carcinoma. The aim of this study was to assess the association of human leukocyte antigen-DP (HLA-DP) variants with risk of chronic hepatitis C virus (HCV) or anti-F antibody generation. We selected two single nucleotide p...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Xu X,Yue M,Jiang L,Deng X,Zhang Y,Zhang Y,Zhu D,Xiao W,Zhou Z,Yao W,Kong J,Yu X,Wei J

    更新日期:2014-06-03 00:00:00

  • The contribution of the elastic reaction is severely underestimated in studies on myofibril contraction.

    abstract::We have considered the Huxley-Simmons manoeuvre. On the assumption that the quick release is an elastic process and on the basis of the isometric tension and of the stiffness of the muscle fibre we calculated that the spontaneous release of the fibre requires approximately 43 micros, which is much faster than the obse...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Grazi E,Pozzati S

    更新日期:2009-03-01 00:00:00

  • Overview of Epstein-Barr-Virus-Associated Gastric Cancer Correlated with Prognostic Classification and Development of Therapeutic Options.

    abstract::Gastric cancer (GC) is a deadly disease with poor prognosis that is characterized by heterogeneity. New classifications based on histologic features, genotypes, and molecular phenotypes, for example, the Cancer Genome Atlas subtypes and those by the Asian Cancer Research Group, help understand the carcinogenic differe...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Re V,Brisotto G,Repetto O,De Zorzi M,Caggiari L,Zanussi S,Alessandrini L,Canzonieri V,Miolo G,Puglisi F,Belluco C,Steffan A,Cannizzaro R

    更新日期:2020-12-10 00:00:00

  • Interplay between Autophagy and the Ubiquitin-Proteasome System and Its Role in the Pathogenesis of Age-Related Macular Degeneration.

    abstract::Age-related macular degeneration (AMD) is a complex eye disease with many pathogenesis factors, including defective cellular waste management in retinal pigment epithelium (RPE). Main cellular waste in AMD are: all-trans retinal, drusen and lipofuscin, containing unfolded, damaged and unneeded proteins, which are degr...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Blasiak J,Pawlowska E,Szczepanska J,Kaarniranta K

    更新日期:2019-01-08 00:00:00

  • Endoglin Targeting: Lessons Learned and Questions That Remain.

    abstract::Approximately 30 years ago, endoglin was identified as a transforming growth factor (TGF)-β coreceptor with a crucial role in developmental biology and tumor angiogenesis. Its selectively high expression on tumor vessels and its correlation with poor survival in cancer patients led to the exploration of endoglin as a ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Liu Y,Paauwe M,Nixon AB,Hawinkels LJAC

    更新日期:2020-12-25 00:00:00

  • Differences in Liver TFAM Binding to mtDNA and mtDNA Damage between Aged and Extremely Aged Rats.

    abstract::While mitochondrial dysfunction is acknowledged as a major feature of aging, much less is known about the role of mitochondria in extended longevity. Livers from aged (28-month-old) and extremely aged (32-month-old) rats were analyzed for citrate synthase activity, mitochondrial transcription factor A (TFAM) amount, m...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Chimienti G,Picca A,Fracasso F,Marzetti E,Calvani R,Leeuwenburgh C,Russo F,Lezza AMS,Pesce V

    更新日期:2019-05-27 00:00:00

  • Synthesis of spongy-like mesoporous hydroxyapatite from raw waste eggshells for enhanced dissolution of ibuprofen loaded via supercritical CO2.

    abstract::The use of cheaper and recyclable biomaterials (like eggshells) to synthesize high purity hydroxyapatite (HAp) with better properties (small particle size, large surface area and pore volume) for applications (in environmental remediation, bone augmentation and replacement, and drug delivery systems) is vital since hi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Ibrahim AR,Li X,Zhou Y,Huang Y,Chen W,Wang H,Li J

    更新日期:2015-04-09 00:00:00

  • cGMP Signaling in the Cardiovascular System-The Role of Compartmentation and Its Live Cell Imaging.

    abstract::The ubiquitous second messenger 3',5'-cyclic guanosine monophosphate (cGMP) regulates multiple physiologic processes in the cardiovascular system. Its intracellular effects are mediated by stringently controlled subcellular microdomains. In this review, we will illustrate the current techniques available for real-time...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Bork NI,Nikolaev VO

    更新日期:2018-03-10 00:00:00

  • AMP-Activated Protein Kinase as a Reprogramming Strategy for Hypertension and Kidney Disease of Developmental Origin.

    abstract::Suboptimal early-life conditions affect the developing kidney, resulting in long-term programming effects, namely renal programming. Adverse renal programming increases the risk for developing hypertension and kidney disease in adulthood. Conversely, reprogramming is a strategy aimed at reversing the programming proce...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Tain YL,Hsu CN

    更新日期:2018-06-12 00:00:00

  • Heat Shock Proteins and Autophagy Pathways in Neuroprotection: from Molecular Bases to Pharmacological Interventions.

    abstract::Neurodegenerative diseases (NDDs) such as Alzheimer's disease, Parkinson's disease and Huntington's disease (HD), amyotrophic lateral sclerosis, and prion diseases are all characterized by the accumulation of protein aggregates (amyloids) into inclusions and/or plaques. The ubiquitous presence of amyloids in NDDs sugg...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Penke B,Bogár F,Crul T,Sántha M,Tóth ME,Vígh L

    更新日期:2018-01-22 00:00:00

  • The self-assembled behavior of DNA bases on the interface.

    abstract::A successful example of self-assembly in a biological system is that DNA can be an excellent agent to self-assemble into desirable two and three-dimensional nanostructures in a well-ordered manner by specific hydrogen bonding interactions between the DNA bases. The self-assembly of DNA bases have played a significant ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Liu L,Xia D,Klausen LH,Dong M

    更新日期:2014-01-27 00:00:00

  • Salivary MicroRNA for Diagnosis of Cancer and Systemic Diseases: A Systematic Review.

    abstract::: Background: The aberrant expression of microRNAs (miRNAs) has been associated with several diseases, including cancer, inflammatory, and autoimmune conditions. Interest in salivary miRNAs as non-invasive tools for the diagnosis of malignancies and systemic diseases is rapidly increasing. The present systematic revie...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Setti G,Pezzi ME,Viani MV,Pertinhez TA,Cassi D,Magnoni C,Bellini P,Musolino A,Vescovi P,Meleti M

    更新日期:2020-01-30 00:00:00

  • Time, Concentration, and pH-Dependent Transport and Uptake of Anthocyanins in a Human Gastric Epithelial (NCI-N87) Cell Line.

    abstract::Anthocyanins are the largest class of water soluble plant pigments and a common part of the human diet. They may have many potential health benefits, including antioxidant, anti-inflammatory, anti-cancer, and cardioprotective activities. However, anthocyanin metabolism is not well understood. Studies suggest that anth...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Atnip AA,Sigurdson GT,Bomser J,Giusti MM

    更新日期:2017-02-18 00:00:00

  • miR-27b Modulates Insulin Signaling in Hepatocytes by Regulating Insulin Receptor Expression.

    abstract::Insulin resistance (IR) is one of the key contributing factors in the development of type 2 diabetes mellitus (T2DM). However, the molecular mechanisms leading to IR are still unclear. The implication of microRNAs (miRNAs) in the pathophysiology of multiple cardiometabolic pathologies, including obesity, atherosclerot...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Benito-Vicente A,Uribe KB,Rotllan N,Ramírez CM,Jebari-Benslaiman S,Goedeke L,Canfrán-Duque A,Galicia-García U,Saenz De Urturi D,Aspichueta P,Suárez Y,Fernández-Hernando C,Martín C

    更新日期:2020-11-17 00:00:00

  • Differential Function of Endogenous and Exogenous Abscisic Acid during Bacterial Pattern-Induced Production of Reactive Oxygen Species in Arabidopsis.

    abstract::Abscisic acid (ABA) plays important roles in positively or negatively regulating plant disease resistance to pathogens. Here, we reassess the role of endogenous and exogenous ABA by using: 35S::ABA2, a previously reported transgenic Arabidopsis line with increased endogenous ABA levels; aba2-1, a previously reported A...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Tan L,Liu Q,Song Y,Zhou G,Luan L,Weng Q,He C

    更新日期:2019-05-23 00:00:00

  • ArtinM Mediates Murine T Cell Activation and Induces Cell Death in Jurkat Human Leukemic T Cells.

    abstract::The recognition of cell surface glycans by lectins may be critical for the innate and adaptive immune responses. ArtinM, a d-mannose-binding lectin from Artocarpus heterophyllus, activates antigen-presenting cells by recognizing TLR2 N-glycans and induces Th1 immunity. We recently demonstrated that ArtinM stimulated C...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: da Silva TA,Oliveira-Brito PKM,Gonçalves TE,Vendruscolo PE,Roque-Barreira MC

    更新日期:2017-06-30 00:00:00

  • Oxidative Stress and Immune System Dysfunction in Autism Spectrum Disorders.

    abstract::Autism Spectrum Disorders (ASDs) represent a group of neurodevelopmental disorders associated with social and behavioral impairments. Although dysfunctions in several signaling pathways have been associated with ASDs, very few molecules have been identified as potentially effective drug targets in the clinic. Classica...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Pangrazzi L,Balasco L,Bozzi Y

    更新日期:2020-05-06 00:00:00

  • M1 Macrophages Promote TRAIL Expression in Adipose Tissue-Derived Stem Cells, Which Suppresses Colitis-Associated Colon Cancer by Increasing Apoptosis of CD133+ Cancer Stem Cells and Decreasing M2 Macrophage Population.

    abstract::We have previously reported that adipose tissue-derived stem cells (ASCs) cultured at high cell density can induce cancer cell death through the expression of type I interferons and tumor necrosis factor (TNF)-related apoptosis-inducing ligands (TRAIL). Here, we investigated whether TRAIL-expressing ASCs induced by M1...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Eom YW,Akter R,Li W,Lee S,Hwang S,Kim J,Cho MY

    更新日期:2020-05-29 00:00:00

  • Structural Identification of Antibacterial Lipids from Amazonian Palm Tree Endophytes through the Molecular Network Approach.

    abstract::A library of 197 endophytic fungi and bacteria isolated from the Amazonian palm tree Astrocaryum sciophilum was extracted and screened for antibacterial activity against methicillin-resistant Staphylococcus aureus (MRSA). Four out of five antibacterial ethyl acetate extracts were also cytotoxic for the MRC-5 cells lin...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Barthélemy M,Elie N,Pellissier L,Wolfender JL,Stien D,Touboul D,Eparvier V

    更新日期:2019-04-24 00:00:00

  • Astaxanthin, a Carotenoid, Stimulates Immune Responses by Enhancing IFN-γ and IL-2 Secretion in Primary Cultured Lymphocytes in Vitro and ex Vivo.

    abstract::Astaxanthin, a potent antioxidant carotenoid, plays a major role in modulating the immune response. In this study, we examined the immunomodulatory effects of astaxanthin on cytokine production in primary cultured lymphocytes both in vitro and ex vivo. Direct administration of astaxanthin (70-300 nM) did not produce c...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Lin KH,Lin KC,Lu WJ,Thomas PA,Jayakumar T,Sheu JR

    更新日期:2015-12-29 00:00:00