Staphylococcus aureus and MRSA Growth and Biofilm Formation after Treatment with Antibiotics and SeNPs.


:Methicillin-resistant Staphylococcus aureus (MRSA) is a dangerous pathogen resistant to β-lactam antibiotics. Due to its resistance, it is difficult to manage the infections caused by this strain. We examined this issue in terms of observation of the growth properties and ability to form biofilms in sensitive S. aureus and MRSA after the application of antibiotics (ATBs)-ampicillin, oxacillin and penicillin-and complexes of selenium nanoparticles (SeNPs) with these ATBs. The results suggest the strong inhibition effect of SeNPs in complexes with conventional ATBs. Using the impedance method, a higher disruption of biofilms was observed after the application of ATB complexes with SeNPs compared to the group exposed to ATBs without SeNPs. The biofilm formation was intensely inhibited (up to 99%±7% for S. aureus and up to 94%±4% for MRSA) after application of SeNPs in comparison with bacteria without antibacterial compounds whereas ATBs without SeNPs inhibited S. aureus up to 79%±5% and MRSA up to 16%±2% only. The obtained results provide a basis for the use of SeNPs as a tool for the treatment of bacterial infections, which can be complicated because of increasing resistance of bacteria to conventional ATB drugs.


Int J Mol Sci


Cihalova K,Chudobova D,Michalek P,Moulick A,Guran R,Kopel P,Adam V,Kizek R




Has Abstract


2015-10-16 00:00:00












  • A Pathological Study of Acute Pulmonary Toxicity Induced by Inhaled Kanto Loam Powder.

    abstract::The frequency and volume of Asian sand dust (ASD) (Kosa) are increasing in Japan, and it has been reported that ASD may cause adverse respiratory effects. The pulmonary toxicity of ASD has been previously analyzed in mice exposed to ASD particles by intratracheal instillation. To study the pulmonary toxicity induced b...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Kobayashi Y,Shimada A,Morita T,Inoue K,Takano H

    更新日期:2018-01-31 00:00:00

  • Rapid synthesis and antiviral activity of (quinazolin-4-ylamino)methyl-phosphonates through microwave irradiation.

    abstract::This study describes the simple synthesis of new (quinazolin-4-ylamino) methylphosphonates via microwave irradiation. Substituted-2-aminobenzonitrile reacted with 1,1-dimethoxy-N,N-dimethylmethanamine at a reflux condition to obtain N'-(substituted-2-cyanophenyl)-N,N-dimethylformamidine (1). The subsequent reaction of...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Luo H,Hu D,Wu J,He M,Jin L,Yang S,Song B

    更新日期:2012-01-01 00:00:00

  • Chrysin Attenuates VCAM-1 Expression and Monocyte Adhesion in Lipopolysaccharide-Stimulated Brain Endothelial Cells by Preventing NF-κB Signaling.

    abstract::Adhesion of leukocytes to endothelial cells plays an important role in neuroinflammation. Therefore, suppression of the expression of adhesion molecules in brain endothelial cells may inhibit neuroinflammation. Chrysin (5,7-dihydroxyflavone) is a flavonoid component of propolis, blue passion flowers, and fruits. In th...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Lee BK,Lee WJ,Jung YS

    更新日期:2017-07-03 00:00:00

  • Vitamin D Supplementation in Central Nervous System Demyelinating Disease-Enough Is Enough.

    abstract::The exact cause of multiple sclerosis (MS) remains elusive. Various factors, however, have been identified that increase an individual's risk of developing this central nervous system (CNS) demyelinating disease and are associated with an acceleration in disease severity. Besides genetic determinants, environmental fa...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Häusler D,Weber MS

    更新日期:2019-01-08 00:00:00

  • The Effect of the Chorion on Size-Dependent Acute Toxicity and Underlying Mechanisms of Amine-Modified Silver Nanoparticles in Zebrafish Embryos.

    abstract::As the worldwide application of nanomaterials in commercial products increases every year, various nanoparticles from industry might present possible risks to aquatic systems and human health. Presently, there are many unknowns about the toxic effects of nanomaterials, especially because the unique physicochemical pro...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Chen ZY,Li NJ,Cheng FY,Hsueh JF,Huang CC,Lu FI,Fu TF,Yan SJ,Lee YH,Wang YJ

    更新日期:2020-04-20 00:00:00

  • GSK-3β-Targeting Fisetin Promotes Melanogenesis in B16F10 Melanoma Cells and Zebrafish Larvae through β-Catenin Activation.

    abstract::Fisetin is found in many fruits and plants such as grapes and onions, and exerts anti-inflammatory, anti-proliferative, and anticancer activity. However, whether fisetin regulates melanogenesis has been rarely studied. Therefore, we evaluated the effects of fisetin on melanogenesis in B16F10 melanoma cell and zebrafis...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Molagoda IMN,Karunarathne WAHM,Park SR,Choi YH,Park EK,Jin CY,Yu H,Jo WS,Lee KT,Kim GY

    更新日期:2020-01-02 00:00:00

  • The yin and yang of VEGF and PEDF: multifaceted neurotrophic factors and their potential in the treatment of Parkinson's Disease.

    abstract::Over the last few decades, vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) have emerged as multifaceted players in not only the pathogenesis, but potential treatment, of numerous diseases. They activate diverse intracellular signaling cascades known to have extensive crosstalk, a...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Falk T,Gonzalez RT,Sherman SJ

    更新日期:2010-08-05 00:00:00

  • Unveiling the Actual Functions of Awns in Grasses: From Yield Potential to Quality Traits.

    abstract::Awns, which are either bristles or hair-like outgrowths of lemmas in the florets, are one of the typical morphological characteristics of grass species. These stiff structures contribute to grain dispersal and burial and fend off animal predators. However, their phenotypic and genetic associations with traits deciding...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Ntakirutimana F,Xie W

    更新日期:2020-10-14 00:00:00

  • Molecular Dynamics Simulations to Investigate How PZM21 Affects the Conformational State of the μ-Opioid Receptor Upon Activation.

    abstract::Opioid analgesics such as morphine have indispensable roles in analgesia. However, morphine use can elicit side effects such as respiratory depression and constipation. It has been reported that G protein-biased agonists as substitutes for classic opioid agonists can alleviate (or even eliminate) these side effects. T...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Zhao Z,Huang T,Li J

    更新日期:2020-07-01 00:00:00

  • Effects of Fullerenol Nanoparticles on Rat Oocyte Meiosis Resumption.

    abstract::The excellent biocompatibility and biological effects of fullerenol and its derivatives make their biomedical application promising. The potential effects of fullerenol in mammals have been extensively studied, but little is known about its effects on female reproduction. Using canonical oocyte-granulosa cell complexe...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Lei R,Bai X,Chang Y,Li J,Qin Y,Chen K,Gu W,Xia S,Zhang J,Wang Z,Xing G

    更新日期:2018-03-01 00:00:00

  • Recognizing Depression from the Microbiota⁻Gut⁻Brain Axis.

    abstract::Major depression is one of the leading causes of disability, morbidity, and mortality worldwide. The brain⁻gut axis functions are disturbed, revealed by a dysfunction of the brain, immune system, endocrine system, and gut. Traditional depression treatments all target the brain, with different drugs and/or psychotherap...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Liang S,Wu X,Hu X,Wang T,Jin F

    更新日期:2018-05-29 00:00:00

  • A Gene Signature of Survival Prediction for Kidney Renal Cell Carcinoma by Multi-Omic Data Analysis.

    abstract::Kidney renal cell carcinoma (KIRC), which is the most common subtype of kidney cancer, has a poor prognosis and a high mortality rate. In this study, a multi-omics analysis is performed to build a multi-gene prognosis signature for KIRC. A combination of a DNA methylation analysis and a gene expression data analysis r...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Hu F,Zeng W,Liu X

    更新日期:2019-11-14 00:00:00

  • Combined Metabolome and Transcriptome Analyses Reveal the Effects of Mycorrhizal Fungus Ceratobasidium sp. AR2 on the Flavonoid Accumulation in Anoectochilus roxburghii during Different Growth Stages.

    abstract::Anoectochilus roxburghii is a traditional Chinese herb with high medicinal value, with main bioactive constituents which are flavonoids. It commonly associates with mycorrhizal fungi for its growth and development. Moreover, mycorrhizal fungi can induce changes in the internal metabolism of host plants. However, its r...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Zhang Y,Li Y,Chen X,Meng Z,Guo S

    更新日期:2020-01-15 00:00:00

  • Classical Soybean (Glycine max (L.) Merr) Symbionts, Sinorhizobium fredii USDA191 and Bradyrhizobium diazoefficiens USDA110, Reveal Contrasting Symbiotic Phenotype on Pigeon Pea (Cajanus cajan (L.) Millsp).

    abstract::Pigeon pea (Cajanus cajan (L.) Millspaugh) is cultivated widely in semiarid agricultural regions in over 90 countries around the world. This important legume can enter into symbiotic associations with a wide range of rhizobia including Bradyrhizobium and fast-growing rhizobia. In comparison with other major legumes su...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Alaswad AA,Oehrle NW,Krishnan HB

    更新日期:2019-03-03 00:00:00

  • Dietary Salt Accelerates Orthodontic Tooth Movement by Increased Osteoclast Activity.

    abstract::Dietary salt uptake and inflammation promote sodium accumulation in tissues, thereby modulating cells like macrophages and fibroblasts. Previous studies showed salt effects on periodontal ligament fibroblasts and on bone metabolism by expression of nuclear factor of activated T-cells-5 (NFAT-5). Here, we investigated ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Schröder A,Gubernator J,Leikam A,Nazet U,Cieplik F,Jantsch J,Neubert P,Titze J,Proff P,Kirschneck C

    更新日期:2021-01-09 00:00:00

  • Cloning and Functional Characterization of Dihydroflavonol 4-Reductase Gene Involved in Anthocyanidin Biosynthesis of Grape Hyacinth.

    abstract::Grape hyacinth (Muscari spp.) is a popular ornamental plant with bulbous flowers noted for their rich blue color. Muscari species have been thought to accumulate delphinidin and cyanidin rather than pelargonidin-type anthocyanins because their dihydroflavonol 4-reductase (DFR) does not efficiently reduce dihydrokaempf...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Liu H,Lou Q,Ma J,Su B,Gao Z,Liu Y

    更新日期:2019-09-24 00:00:00

  • Genotypic Homogeneity in Distinctive Transforming Growth Factor-Beta Induced (TGFBI) Protein Phenotypes.

    abstract::Background: To evaluate the distribution of the transforming growth factor-beta induced (TGFBI) corneal dystrophies in a multi-ethnic population in Singapore, and to present the different phenotypes with the same genotype. Methods: This study included 32 patients. Slit lamp biomicroscopy was performed for each patient...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Han SB,Anandalakshmi V,Wong CW,Ng SR,Mehta JS

    更新日期:2021-01-27 00:00:00

  • Homocysteine Increases Tau Phosphorylation, Truncation and Oligomerization.

    abstract::Increased plasma homocysteinemia is considered a risk factor of dementia, including Alzheimer's disease (AD) and vascular dementia. However, the reason elevated plasma homocysteinemia increases the risk of dementia remains unknown. A pathological hallmark of AD is neurofibrillary tangles (NFTs) that consist of patholo...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Shirafuji N,Hamano T,Yen SH,Kanaan NM,Yoshida H,Hayashi K,Ikawa M,Yamamura O,Kuriyama M,Nakamoto Y

    更新日期:2018-03-17 00:00:00

  • Adenosine Receptor Profiling Reveals an Association between the Presence of Spare Receptors and Cardiovascular Disorders.

    abstract::Adenosine and its receptors exert a potent control on the cardiovascular system. This review aims to present emerging experimental evidence supporting the existence and implication in cardiovascular disorders of specific adenosinergic pharmacological profiles, conforming to the concept of "receptor reserve", also know...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Fenouillet E,Mottola G,Kipson N,Paganelli F,Guieu R,Ruf J

    更新日期:2019-11-27 00:00:00

  • Therapeutic Potential of Tauroursodeoxycholic Acid for the Treatment of Osteoporosis.

    abstract::Tauroursodeoxycholic acid (TUDCA) is a US FDA-approved hydrophilic bile acid for the treatment of chronic cholestatic liver disease. In the present study, we investigate the effects of TUDCA on the proliferation and differentiation of osteoblasts and its therapeutic effect on a mice model of osteoporosis. Following tr...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Ahn TK,Kim KT,Joshi HP,Park KH,Kyung JW,Choi UY,Sohn S,Sheen SH,Shin DE,Lee SH,Han IB

    更新日期:2020-06-16 00:00:00

  • Zinc Inhibits Expression of Androgen Receptor to Suppress Growth of Prostate Cancer Cells.

    abstract::The prostate gland contains a high level of intracellular zinc, which is dramatically diminished during prostate cancer (PCa) development. Owing to the unclear role of zinc in this process, therapeutic applications using zinc are limited. This study aimed to clarify the role of zinc and its underlying mechanism in the...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: To PK,Do MH,Cho YS,Kwon SY,Kim MS,Jung C

    更新日期:2018-10-08 00:00:00

  • miR-211 Plays a Critical Role in Cnidium officinale Makino Extract-Induced, ROS/ER Stress-Mediated Apoptosis in U937 and U266 Cells.

    abstract::Though Cnidium officinale Makino (COM) was known to have anti-angiogenic, anti-oxidant, neuroprotective, and anti-cancer effects, the underlying anticancer mechanism of COM using endoplasmic reticulum (ER) stress and miRNA remained unclear until now. Thus, in the current study, the inhibitory mechanism of COM in lymph...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Cha JA,Song HS,Kang B,Park MN,Park KS,Kim SH,Shim BS,Kim B

    更新日期:2018-03-15 00:00:00

  • CSPG4 as Target for CAR-T-Cell Therapy of Various Tumor Entities-Merits and Challenges.

    abstract::Targeting cancer cells using chimeric-antigen-receptor (CAR-)T cells has propelled adoptive T-cell therapy (ATT) to the next level. A plentitude of durable complete responses using CD19-specific CAR-T cells in patients suffering from various lymphoid malignancies resulted in the approval by the food and drug administr...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Harrer DC,Dörrie J,Schaft N

    更新日期:2019-11-26 00:00:00

  • Identification of Proteins Modulated in the Date Palm Stem Infested with Red Palm Weevil (Rhynchophorus ferrugineus Oliv.) Using Two Dimensional Differential Gel Electrophoresis and Mass Spectrometry.

    abstract::A state of the art proteomic methodology using Matrix Assisted Laser Desorption/Ionization-Time of Flight (MALDI TOF) has been employed to characterize peptides modulated in the date palm stem subsequent to infestation with red palm weevil (RPW). Our analyses revealed 32 differentially expressed peptides associated wi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Rasool KG,Khan MA,Aldawood AS,Tufail M,Mukhtar M,Takeda M

    更新日期:2015-08-17 00:00:00

  • Growth Hormone Deficiency Following Traumatic Brain Injury.

    abstract::Traumatic brain injury (TBI) is fairly common and annually affects millions of people worldwide. Post traumatic hypopituitarism (PTHP) has been increasingly recognized as an important and prevalent clinical entity. Growth hormone deficiency (GHD) is the most common pituitary hormone deficit in long-term survivors of T...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Kgosidialwa O,Hakami O,Muhammad Zia-Ul-Hussnain H,Agha A

    更新日期:2019-07-06 00:00:00

  • IKKβ Kinase Promotes Stemness, Migration, and Invasion in KRAS-Driven Lung Adenocarcinoma Cells.

    abstract::KRAS oncogenic mutations are widespread in lung cancer and, because direct targeting of KRAS has proven to be challenging, KRAS-driven cancers lack effective therapies. One alternative strategy for developing KRAS targeted therapies is to identify downstream targets involved in promoting important malignant features, ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Rodrigues FS,Miranda VS,Carneiro-Lobo TC,Scalabrini LC,Kruspig B,Levantini E,Murphy DJ,Bassères DS

    更新日期:2020-08-13 00:00:00

  • Toward the understanding of the metabolism of levodopa I. DFT investigation of the equilibrium geometries, acid-base properties and levodopa-water complexes.

    abstract::Levodopa (LD) is used to increase dopamine level for treating Parkinson's disease. The major metabolism of LD to produce dopamine is decarboxylation. In order to understand the metabolism of LD; the electronic structure of levodopa was investigated at the Density Functional DFT/B3LYP level of theory using the 6-311+G*...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Elroby SA,Makki MS,Sobahi TR,Hilal RH

    更新日期:2012-01-01 00:00:00

  • EPAS-1 mediates SP-1-dependent FBI-1 expression and regulates tumor cell survival and proliferation.

    abstract::Factor binding IST-1 (FBI-1) plays an important role in oncogenic transformation and tumorigenesis. As FBI-1 is over-expressed in multiple human cancers, the regulation of itself would provide new effective options for cancer intervention. In this work, we aimed to study the role that EPAS-1 plays in regulating FBI-1....

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Wang X,Cao P,Li Z,Wu D,Wang X,Liang G

    更新日期:2014-09-04 00:00:00

  • Type 2 Diabetes in Non-Alcoholic Fatty Liver Disease and Hepatitis C Virus Infection--Liver: The "Musketeer" in the Spotlight.

    abstract::The pathogenesis of type 2 diabetes (T2D) involves chronic hyperinsulinemia due to systemic and hepatic insulin resistance (IR), which if uncorrected, will lead to progressive pancreatic beta cell failure in predisposed individuals. Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of fatty (simple stea...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Ballestri S,Nascimbeni F,Romagnoli D,Baldelli E,Targher G,Lonardo A

    更新日期:2016-03-09 00:00:00

  • Intestinal Preservation Injury: A Comparison Between Rat, Porcine and Human Intestines.

    abstract::Advanced preservation injury (PI) after intestinal transplantation has deleterious short- and long-term effects and constitutes a major research topic. Logistics and costs favor rodent studies, whereas clinical translation mandates studies in larger animals or using human material. Despite diverging reports, no direct...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Søfteland JM,Casselbrant A,Biglarnia AR,Linders J,Hellström M,Pesce A,Padma AM,Jiga LP,Hoinoiu B,Ionac M,Oltean M

    更新日期:2019-06-27 00:00:00