Staphylococcus aureus and MRSA Growth and Biofilm Formation after Treatment with Antibiotics and SeNPs.


:Methicillin-resistant Staphylococcus aureus (MRSA) is a dangerous pathogen resistant to β-lactam antibiotics. Due to its resistance, it is difficult to manage the infections caused by this strain. We examined this issue in terms of observation of the growth properties and ability to form biofilms in sensitive S. aureus and MRSA after the application of antibiotics (ATBs)-ampicillin, oxacillin and penicillin-and complexes of selenium nanoparticles (SeNPs) with these ATBs. The results suggest the strong inhibition effect of SeNPs in complexes with conventional ATBs. Using the impedance method, a higher disruption of biofilms was observed after the application of ATB complexes with SeNPs compared to the group exposed to ATBs without SeNPs. The biofilm formation was intensely inhibited (up to 99%±7% for S. aureus and up to 94%±4% for MRSA) after application of SeNPs in comparison with bacteria without antibacterial compounds whereas ATBs without SeNPs inhibited S. aureus up to 79%±5% and MRSA up to 16%±2% only. The obtained results provide a basis for the use of SeNPs as a tool for the treatment of bacterial infections, which can be complicated because of increasing resistance of bacteria to conventional ATB drugs.


Int J Mol Sci


Cihalova K,Chudobova D,Michalek P,Moulick A,Guran R,Kopel P,Adam V,Kizek R




Has Abstract


2015-10-16 00:00:00












  • Immunogenomic Classification of Colorectal Cancer and Therapeutic Implications.

    abstract::The immune system has a substantial effect on colorectal cancer (CRC) progression. Additionally, the response to immunotherapeutics and conventional treatment options (e.g., chemotherapy, radiotherapy and targeted therapies) is influenced by the immune system. The molecular characterization of colorectal cancer (CRC) ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Roelands J,Kuppen PJK,Vermeulen L,Maccalli C,Decock J,Wang E,Marincola FM,Bedognetti D,Hendrickx W

    更新日期:2017-10-24 00:00:00

  • Platelet Proteasome Activity and Metabolism Is Upregulated during Bacterial Sepsis.

    abstract::Dysregulation of platelet function can contribute to the disease progression in sepsis. The proteasome represents a critical and vital element of cellular protein metabolism in platelets and its proteolytic activity has been associated with platelet function. However, the role of the platelet proteasome as well as its...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Grundler Groterhorst K,Mannell H,Pircher J,Kraemer BF

    更新日期:2019-11-27 00:00:00

  • Genetic and Molecular Control of Floral Organ Identity in Cereals.

    abstract::Grasses represent a major family of monocots comprising mostly cereals. When compared to their eudicot counterparts, cereals show a remarkable morphological diversity. Understanding the molecular basis of floral organ identity and inflorescence development is crucial to gain insight into the grain development for yiel...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Ali Z,Raza Q,Atif RM,Aslam U,Ajmal M,Chung G

    更新日期:2019-06-04 00:00:00

  • Anti-Metastatic Effects of Antrodan with and without Cisplatin on Lewis Lung Carcinomas in a Mouse Xenograft Model.

    abstract::Antrodan, a unique protein-bound polysaccharide derived from the fungal mycelia of Antrodia cinnamomea, has been reported to exhibit antitumor and anti-metastatic effects on Lewis lung carcinoma (LLC) cells through direct action and immunomodulation in vitro. In this study, we investigated the combined treatment of an...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Chen PC,Chen CC,Ker YB,Chang CH,Chyau CC,Hu ML

    更新日期:2018-05-24 00:00:00

  • Cannabinoids Reduce Inflammation but Inhibit Lymphocyte Recovery in Murine Models of Bone Marrow Transplantation.

    abstract::Cannabinoids, the biologically active constituents of Cannabis, have potent neuronal and immunological effects. However, the basic and medical research dedicated to medical cannabis and cannabinoids is limited. The influence of these treatments on hematologic reconstitution and on the development of graft versus host ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Khuja I,Yekhtin Z,Or R,Almogi-Hazan O

    更新日期:2019-02-04 00:00:00

  • Linking LOXL2 to Cardiac Interstitial Fibrosis.

    abstract::Cardiovascular diseases (CVDs) are the leading causes of death worldwide. CVD pathophysiology is often characterized by increased stiffening of the heart muscle due to fibrosis, thus resulting in diminished cardiac function. Fibrosis can be caused by increased oxidative stress and inflammation, which is strongly linke...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Erasmus M,Samodien E,Lecour S,Cour M,Lorenzo O,Dludla P,Pheiffer C,Johnson R

    更新日期:2020-08-18 00:00:00

  • Differential Regulation of Thermodynamic Binding Forces of Levocetirizine and (S)-Cetirizine by Lys191 in Human Histamine H₁ Receptors.

    abstract::Cetirizine is a zwitterionic second-generation antihistamine containing R- and S-enantiomers, levocetirizine, and (S)-cetirizine. Levocetirizine is known to have a higher affinity for the histamine H₁ receptors than (S)-cetirizine; ligand-receptor docking simulations have suggested the importance of the formation of a...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Hishinuma S,Tamura Y,Kobayashi C,Akatsu C,Shoji M

    更新日期:2018-12-15 00:00:00

  • Radiation-sensitising effects of antennapedia proteins (ANTP)-SmacN7 on tumour cells.

    abstract::The objective of this study was to investigate the underlying mechanisms behind the radiation-sensitising effects of the antennapedia proteins (ANTP)-smacN7 fusion protein on tumour cells. ANTP-SmacN7 fusion proteins were synthesised, and the ability of this fusion protein to penetrate cells was observed. Effects of r...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Du LQ,Wang Y,Xu C,Cao J,Wang Q,Zhao H,Fan FY,Wang B,Katsube T,Fan SJ,Liu Q

    更新日期:2013-12-11 00:00:00

  • Molecular Aspects and Prognostic Significance of Microcalcifications in Human Pathology: A Narrative Review.

    abstract::The presence of calcium deposits in human lesions is largely used as imaging biomarkers of human diseases such as breast cancer. Indeed, the presence of micro- or macrocalcifications is frequently associated with the development of both benign and malignant lesions. Nevertheless, the molecular mechanisms involved in t...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Bonfiglio R,Granaglia A,Giocondo R,Scimeca M,Bonanno E

    更新日期:2020-12-24 00:00:00

  • Anti-Angiogenic and Anti-Proliferative Graphene Oxide Nanosheets for Tumor Cell Therapy.

    abstract::Graphene oxide (GO) is a bidimensional novel material that exhibits high biocompatibility and angiogenic properties, mostly related to the intracellular formation of reactive oxygen species (ROS). In this work, we set up an experimental methodology for the fabrication of GO@peptide hybrids by the immobilization, via i...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Verde V,Longo A,Cucci LM,Sanfilippo V,Magrì A,Satriano C,Anfuso CD,Lupo G,La Mendola D

    更新日期:2020-08-04 00:00:00

  • Fluence Rate Differences in Photodynamic Therapy Efficacy and Activation of Epidermal Growth Factor Receptor after Treatment of the Tumor-Involved Murine Thoracic Cavity.

    abstract::Photodynamic therapy (PDT) of the thoracic cavity can be performed in conjunction with surgery to treat cancers of the lung and its pleura. However, illumination of the cavity results in tissue exposure to a broad range of fluence rates. In a murine model of intrathoracic PDT, we studied the efficacy of 2-(1-hexyloxye...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Grossman CE,Carter SL,Czupryna J,Wang L,Putt ME,Busch TM

    更新日期:2016-01-14 00:00:00

  • Synthesis and Characterization of Tissue Plasminogen Activator-Functionalized Superparamagnetic Iron Oxide Nanoparticles for Targeted Fibrin Clot Dissolution.

    abstract::Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted great attention in many biomedical fields and are used in preclinical/experimental drug delivery, hyperthermia and medical imaging. In this study, biocompatible magnetite drug carriers, stabilized by a dextran shell, were developed to carry tissue plas...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Heid S,Unterweger H,Tietze R,Friedrich RP,Weigel B,Cicha I,Eberbeck D,Boccaccini AR,Alexiou C,Lyer S

    更新日期:2017-08-24 00:00:00

  • Aging and Intermittent Fasting Impact on Transcriptional Regulation and Physiological Responses of Adult Drosophila Neuronal and Muscle Tissues.

    abstract::The progressive decline of the nervous system, including protein aggregate formation, reflects the subtle dysregulation of multiple functional pathways. Our previous work has shown intermittent fasting (IF) enhances longevity, maintains adult behaviors and reduces aggregates, in part, by promoting autophagic function ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Zhang S,Ratliff EP,Molina B,El-Mecharrafie N,Mastroianni J,Kotzebue RW,Achal M,Mauntz RE,Gonzalez A,Barekat A,Bray WA,Macias AM,Daugherty D,Harris GL,Edwards RA,Finley KD

    更新日期:2018-04-10 00:00:00

  • Inducible Nitric Oxide Synthase (iNOS) Mediates Vascular Endothelial Cell Apoptosis in Grass Carp Reovirus (GCRV)-Induced Hemorrhage.

    abstract::Hemorrhage is one of the most obvious pathological phenomena in grass carp reovirus (GCRV) infection. The etiology of GCRV-induced hemorrhage is unclear. We found inducible nitric oxide synthase (iNOS) may relate to viral hemorrhage according to the previous studies, which is expressed at high levels after GCRV infect...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Liang B,Su J

    更新日期:2019-12-16 00:00:00

  • Effect of Artocarpus communis Extract on UVB Irradiation-Induced Oxidative Stress and Inflammation in Hairless Mice.

    abstract::Administration of antioxidants and anti-inflammatory agents is an effective strategy for preventing ultraviolet (UV) irradiation-induced skin damage. Artocarpus communis possesses several pharmacological activities, such as antioxidant, anticancer and anti-inflammation. However, the photoprotective activity of methan...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Lee CW,Ko HH,Chai CY,Chen WT,Lin CC,Yen FL

    更新日期:2013-02-12 00:00:00

  • Targeting Protein Kinases to Enhance the Response to anti-PD-1/PD-L1 Immunotherapy.

    abstract::The interaction between programmed cell death protein (PD-1) and its ligand (PD-L1) is one of the main pathways used by some tumors to escape the immune response. In recent years, immunotherapies based on the use of antibodies against PD-1/PD-L1 have been postulated as a great promise for cancer treatment, increasing ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: García-Aranda M,Redondo M

    更新日期:2019-05-09 00:00:00

  • Pigment Epithelium-Derived Factor (PEDF) Receptors Are Involved in Survival of Retinal Neurons.

    abstract::The demise of retinal ganglion cells (RGCs) is characteristic of diseases of the retina such as glaucoma and diabetic or ischemic retinopathies. Pigment epithelium-derived factor (PEDF) is a multifunctional secreted protein that mediates neuroprotection and inhibition of angiogenesis in the retina. We have studied exp...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Bürger S,Meng J,Zwanzig A,Beck M,Pankonin M,Wiedemann P,Eichler W,Unterlauft JD

    更新日期:2020-12-31 00:00:00

  • Plant flavonoids--biosynthesis, transport and involvement in stress responses.

    abstract::This paper aims at analysing the synthesis of flavonoids, their import and export in plant cell compartments, as well as their involvement in the response to stress, with particular reference to grapevine (Vitis vinifera L.). A multidrug and toxic compound extrusion (MATE) as well as ABC transporters have been demonst...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Petrussa E,Braidot E,Zancani M,Peresson C,Bertolini A,Patui S,Vianello A

    更新日期:2013-07-17 00:00:00

  • Transcriptome-Wide Identification and Expression Profiling Analysis of Chrysanthemum Trihelix Transcription Factors.

    abstract::Trihelix transcription factors are thought to feature a typical DNA-binding trihelix (helix-loop-helix-loop-helix) domain that binds specifically to the GT motif, a light-responsive DNA element. Members of the trihelix family are known to function in a number of processes in plants. Here, we characterize 20 trihelix f...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Song A,Wu D,Fan Q,Tian C,Chen S,Guan Z,Xin J,Zhao K,Chen F

    更新日期:2016-02-02 00:00:00

  • Renal Sympathetic Nerve-Derived Signaling in Acute and Chronic kidney Diseases.

    abstract::The kidney is innervated by afferent sensory and efferent sympathetic nerve fibers. Norepinephrine (NE) is the primary neurotransmitter for post-ganglionic sympathetic adrenergic nerves, and its signaling, regulated through adrenergic receptors (AR), modulates renal function and pathophysiology under disease condition...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Noh MR,Jang HS,Kim J,Padanilam BJ

    更新日期:2020-02-28 00:00:00

  • Brusatol Enhances the Radiosensitivity of A549 Cells by Promoting ROS Production and Enhancing DNA Damage.

    abstract::NF-E2-related factor 2 (Nrf2) has been identified as a master regulatory factor in the protection of cells from oxidative and electrophilic stress. However, overexpression of Nrf2 in lung cancer may cause chemoresistance, as well as radioresistance. In this study, we examined the relationship between radioresistance a...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Sun X,Wang Q,Wang Y,Du L,Xu C,Liu Q

    更新日期:2016-06-24 00:00:00

  • Impact of tRNA Modifications and tRNA-Modifying Enzymes on Proteostasis and Human Disease.

    abstract::Transfer RNAs (tRNAs) are key players of protein synthesis, as they decode the genetic information organized in mRNA codons, translating them into the code of 20 amino acids. To be fully active, tRNAs undergo extensive post-transcriptional modifications, catalyzed by different tRNA-modifying enzymes. Lack of these mod...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Pereira M,Francisco S,Varanda AS,Santos M,Santos MAS,Soares AR

    更新日期:2018-11-24 00:00:00

  • Physiological and proteomic responses of diploid and tetraploid black locust (Robinia pseudoacacia L.) subjected to salt stress.

    abstract::Tetraploid black locust (Robinia pseudoacacia L.) is adaptable to salt stress. Here, we compared morphological, physiological, ultrastructural, and proteomic traits of leaves in tetraploid black locust and its diploid relatives under salt stress. The results showed that diploid (2×) plants suffered from greater negati...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Wang Z,Wang M,Liu L,Meng F

    更新日期:2013-10-14 00:00:00

  • Evolutionary Toxicogenomics of the Striped Killifish (Fundulus majalis) in the New Bedford Harbor (Massachusetts, USA).

    abstract::In this paper, we used a Genotyping-by-Sequencing (GBS) approach to find and genotype more than 4000 genome-wide SNPs (Single Nucleotide Polymorphisms) from striped killifish exposed to a variety of polychlorinated biphenyls (PCBs) and other aromatic pollutants in New Bedford Harbor (NBH, Massachusetts, USA). The aims...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Ruggeri P,Du X,Crawford DL,Oleksiak MF

    更新日期:2019-03-05 00:00:00

  • SAHBNET, an accessible surface-based elastic network: an application to membrane protein.

    abstract::Molecular Dynamics is a method of choice for membrane simulations and the rising of coarse-grained forcefields has opened the way to longer simulations with reduced calculations times. Here, we present an elastic network, SAHBNET (Surface Accessibility Hydrogen-Bonds elastic NETwork), that will maintain the structure ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Dony N,Crowet JM,Joris B,Brasseur R,Lins L

    更新日期:2013-05-30 00:00:00

  • Novel Antibodies Targeting MUC1-C Showed Anti-Metastasis and Growth-Inhibitory Effects on Human Breast Cancer Cells.

    abstract::Mucin1 (MUC1) is aberrantly glycosylated and overexpressed in various cancers, and it plays a crucial role in cancerogenesis. MUC1 is a type I membranous protein composed of α and β subunits. MUC1-α can be cleaved in cancers, exposing MUC1-β (MUC1-C). MUC1-C is involved with multiple cancer cellular functions, which m...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Kim MJ,Choi JR,Tae N,Wi TM,Kim KM,Kim DH,Lee ES

    更新日期:2020-05-05 00:00:00

  • Fusion of Mitochondria to 3-D Networks, Autophagy and Increased Organelle Contacts are Important Subcellular Hallmarks during Cold Stress in Plants.

    abstract::Low temperature stress has a severe impact on the distribution, physiology, and survival of plants in their natural habitats. While numerous studies have focused on the physiological and molecular adjustments to low temperatures, this study provides evidence that cold induced physiological responses coincide with dist...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Steiner P,Buchner O,Andosch A,Wanner G,Neuner G,Lütz-Meindl U

    更新日期:2020-11-19 00:00:00

  • The Endocrine Function of Osteocalcin Regulated by Bone Resorption: A Lesson from Reduced and Increased Bone Mass Diseases.

    abstract::Bone is a peculiar tissue subjected to a continuous process of self-renewal essential to assure the integrity of the skeleton and to explicate the endocrine functions. The study of bone diseases characterized by increased or reduced bone mass due to osteoclast alterations has been essential to understand the great rol...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Rossi M,Battafarano G,Pepe J,Minisola S,Del Fattore A

    更新日期:2019-09-11 00:00:00

  • Trypanosoma brucei Interaction with Host: Mechanism of VSG Release as Target for Drug Discovery for African Trypanosomiasis.

    abstract::The protozoan Trypanosoma brucei, responsible for animal and human trypanosomiasis, has a family of major surface proteases (MSPs) and phospholipase-C (PLC), both involved in some mechanisms of virulence during mammalian infections. During parasitism in the mammalian host, this protozoan is exclusively extracellular a...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Moreno CJG,Temporão A,Torres T,Sousa Silva M

    更新日期:2019-03-25 00:00:00

  • Targeting Age-Dependent Functional and Metabolic Decline of Human Skeletal Muscle: The Geroprotective Role of Exercise, Myokine IL-6, and Vitamin D.

    abstract::In the elderly, whole-body health largely relies on healthy skeletal muscle, which controls body stability, locomotion, and metabolic homeostasis. Age-related skeletal muscle structural/functional deterioration is associated with a higher risk of severe comorbid conditions and poorer outcomes, demanding major socioeco...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Crescioli C

    更新日期:2020-02-04 00:00:00