Prevalence of Quinolone Resistance of Extended-Spectrum β-Lactamase-Producing Escherichia coli with ST131-fimH30 in a City Hospital in Hyogo, Japan.

abstract：:donor⁻acceptorDonor⁻acceptor⁻π⁻acceptor⁻donor (D1-A1-π-A2/A3-D2)-type small molecules, such TPA-MC-2 and TPA-MC-3, were designed and synthesized starting from donor-substituted alkynes (TPA-MC-1) via [2 + 2] cycloaddition-retroelectrocyclization reaction with tetracyanoethylene (TCNE) and 7,7,8,8-tetracyanoquinodimeth...

journal_title：International journal of molecular sciences

authors： Srinivasa Rao P,L Puyad A,V Bhosale S,V Bhosale S

更新日期：2019-04-01 00:00:00

abstract：:Ankyrin repeat (AR) domains are considered the most abundant repeat motif found in eukaryotic proteins. AR domains are predominantly known to mediate specific protein-protein interactions (PPIs) without necessarily recognizing specific primary sequences, nor requiring strict conformity within its own primary sequence....

journal_title：International journal of molecular sciences

authors： Kane EI,Spratt DE

更新日期：2021-01-09 00:00:00

abstract：:Detection and recovery of heavy metals from environmental sources is a major task in environmental protection and governance. Based on previous research into cell-based visual detection and biological adsorption, we have developed a novel system combining these two functions by the BioBrick technique. The gold-specifi...

journal_title：International journal of molecular sciences

authors： Yan L,Sun P,Xu Y,Zhang S,Wei W,Zhao J

更新日期：2018-11-24 00:00:00

abstract：:Recovered blood supply after cerebral ischemia for a certain period of time fails to restore brain function, with more severe dysfunctional problems developing, called cerebral ischemia-reperfusion injury (CIR). CIR involves several extremely complex pathophysiological processes in which the interactions between key f...

journal_title：International journal of molecular sciences

authors： Su J,Liu J,Yan XY,Zhang Y,Zhang JJ,Zhang LC,Sun LK

更新日期：2017-07-24 00:00:00

abstract：:The turnover of the RNA molecules is determined by the rates of transcription and RNA degradation. Several methods have been developed to study RNA turnover since the beginnings of molecular biology. Here we summarize the main methods to measure RNA half-life: transcription inhibition, gene control, and metabolic labe...

journal_title：International journal of molecular sciences

authors： Wada T,Becskei A

更新日期：2017-12-15 00:00:00

abstract：:ALG-2 is a penta-EF-hand Ca(2+)-binding protein and interacts with a variety of intracellular proteins. Two types of ALG-2-binding motifs have been determined: type 1, PXYPXnYP (X, variable; n = 4), in ALIX and PLSCR3; type 2, PXPGF, in Sec31A and PLSCR3. The previously solved X-ray crystal structure of the complex be...

journal_title：International journal of molecular sciences

authors： Takahashi T,Suzuki H,Inuzuka T,Shibata H,Maki M

更新日期：2012-01-01 00:00:00

abstract：:The let-7 family is the second microRNA found in C. elegans. Recent researches have found it is highly expressed in the cardiovascular system. Studies have revealed the aberrant expression of let-7 members in cardiovascular diseases, such as heart hypertrophy, cardiac fibrosis, dilated cardiomyopathy (DCM), myocardial...

journal_title：International journal of molecular sciences

authors： Bao MH,Feng X,Zhang YW,Lou XY,Cheng Y,Zhou HH

更新日期：2013-11-21 00:00:00

abstract：:Infectious diseases caused by parasites are a major threat for the entire mankind, especially in the tropics. More than 1 billion people world-wide are directly exposed to tropical parasites such as the causative agents of trypanosomiasis, leishmaniasis, schistosomiasis, lymphatic filariasis and onchocerciasis, which ...

journal_title：International journal of molecular sciences

authors： Ndjonka D,Rapado LN,Silber AM,Liebau E,Wrenger C

更新日期：2013-02-06 00:00:00

abstract：:The prostate gland contains a high level of intracellular zinc, which is dramatically diminished during prostate cancer (PCa) development. Owing to the unclear role of zinc in this process, therapeutic applications using zinc are limited. This study aimed to clarify the role of zinc and its underlying mechanism in the...

journal_title：International journal of molecular sciences

authors： To PK,Do MH,Cho YS,Kwon SY,Kim MS,Jung C

更新日期：2018-10-08 00:00:00

abstract：:Colon cancer constitutes 33% of all cancer cases in humans and the majority of patients with metastatic colon cancer still have poor prognosis. An important role in cancer development is the communication between cancer and normal cells. This may occur, among others, through extracellular vesicles (including microvesi...

journal_title：International journal of molecular sciences

authors： Depciuch J,Klębowski B,Stec M,Szatanek R,Węglarczyk K,Baj-Krzyworzeka M,Parlińska-Wojtan M,Baran J

更新日期：2020-03-06 00:00:00

abstract：:RNA interference (RNAi) has emerged as a powerful tool for studying target identification and holds promise for the development of therapeutic gene silencing. Recent advances in RNAi delivery and target selection provide remarkable opportunities for translational medical research. The induction of RNAi relies on small...

journal_title：International journal of molecular sciences

authors： Fujita Y,Kuwano K,Ochiya T

更新日期：2015-03-06 00:00:00

abstract：:Abnormal filamentous aggregates that are formed by tangled tau protein turn out to be classic amyloid fibrils, meeting all the criteria defined under the fuzzy oil drop model in the context of amyloid characterization. The model recognizes amyloids as linear structures where local hydrophobicity minima and maxima prop...

journal_title：International journal of molecular sciences

authors： Dułak D,Gadzała M,Banach M,Ptak M,Wiśniowski Z,Konieczny L,Roterman I

更新日期：2018-09-25 00:00:00

abstract：:Liquid biopsy-based methods to test biomarkers (e.g., serum proteins and extracellular vesicles) may help to monitor brain tumors. In this proteomics-based study, we aimed to identify a characteristic protein fingerprint associated with central nervous system (CNS) tumors. Overall, 96 human serum samples were obtained...

journal_title：International journal of molecular sciences

authors： Dobra G,Bukva M,Szabo Z,Bruszel B,Harmati M,Gyukity-Sebestyen E,Jenei A,Szucs M,Horvath P,Biro T,Klekner A,Buzas K

更新日期：2020-07-28 00:00:00

abstract：:Consumption of a high-fat diet (HFD) promotes the development of obesity, a disease resulting from an imbalance between energy intake and energy expenditure. Brown adipose tissue (BAT) has thermogenic capacity that burns calories to produce heat, and it is a potential target for the treatment and prevention of obesity...

journal_title：International journal of molecular sciences

authors： Cao J,Zhu Q,Liu L,Glazier BJ,Hinkel BC,Liang C,Shi H

更新日期：2018-04-06 00:00:00

abstract：:Diabetic retinopathy (DR) is a severe and recurrent microvascular complication in diabetes. The multifunctional response gene to complement 32 (RGC-32) is involved in the regulation of cell cycle, proliferation, and apoptosis. To investigate the role of RGC-32 in the development of DR, we used human retinal microvascu...

journal_title：International journal of molecular sciences

authors： Liao WL,Lin JM,Liu SP,Chen SY,Lin HJ,Wang YH,Lei YJ,Huang YC,Tsai FJ

更新日期：2018-11-17 00:00:00

abstract：:Amyloid precursor protein (APP) is processed along both the nonamyloidogenic pathway preventing amyloid beta peptide (Aβ) production and the amyloidogenic pathway, generating Aβ, whose accumulation characterizes Alzheimer's disease. Items of evidence report that the intracellular trafficking plays a key role in the ge...

journal_title：International journal of molecular sciences

authors： Bhattacharya A,Limone A,Napolitano F,Cerchia C,Parisi S,Minopoli G,Montuori N,Lavecchia A,Sarnataro D

更新日期：2020-03-04 00:00:00

abstract：:During their lifespan, Red blood cells (RBC), due to their inability to self-replicate, undergo an ageing degradation phenomenon. This pathway, both in vitro and in vivo, consists of a series of chemical and morphological modifications, which include deviation from the biconcave cellular shape, oxidative stress, membr...

journal_title：International journal of molecular sciences

authors： Ruggeri FS,Marcott C,Dinarelli S,Longo G,Girasole M,Dietler G,Knowles TPJ

更新日期：2018-08-30 00:00:00

abstract：:The pandemic of coronavirus disease 2019 (COVID-19), with rising numbers of patients worldwide, presents an urgent need for effective treatments. To date, there are no therapies or vaccines that are proven to be effective against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Several potential candidate...

journal_title：International journal of molecular sciences

authors： Zhand S,Saghaeian Jazi M,Mohammadi S,Tarighati Rasekhi R,Rostamian G,Kalani MR,Rostamian A,George J,Douglas MW

更新日期：2020-08-03 00:00:00

abstract：:The liver has a wide range of physiological functions in the body, and its health is maintained by complex cross-talk among hepatic cells, including parenchymal hepatocytes and nonparenchymal cells. Exosomes, which are one method of cellular communication, are endosomal-derived small vesicles that are released by dono...

journal_title：International journal of molecular sciences

authors： Sung S,Kim J,Jung Y

更新日期：2018-11-22 00:00:00

abstract：:Earthworms express, as most animals, metallothioneins (MTs)-small, cysteine-rich proteins that bind d(10) metal ions (Zn(II), Cd(II), or Cu(I)) in clusters. Three MT homologues are known for Lumbricus rubellus, the common red earthworm, one of which, wMT-2, is strongly induced by exposure of worms to cadmium. This stu...

journal_title：International journal of molecular sciences

authors： Kowald GR,Stürzenbaum SR,Blindauer CA

更新日期：2016-01-05 00:00:00

abstract：:Aeromonas veronii is a pathogen capable of infecting humans, livestock and aquatic animals, resulting in serious economic losses. In this study, two recombinant Lactobacillus casei expressing flagellin A (FlaA) of A. veronii, Lc-pPG-1-FlaA (surface-displayed) and Lc-pPG-2-FlaA (secretory) were constructed. The immune ...

journal_title：International journal of molecular sciences

authors： Tian JX,Kang YH,Chu GS,Liu HJ,Kong YD,Zhao LH,Kong YX,Shan XF,Wang GQ

更新日期：2019-12-19 00:00:00

abstract：:Free fatty acids (FFAs) are cytotoxic to pancreatic islet β-cells and play a crucial role in the diabetes disease process. A recent study revealed a down-regulation of transcription factor 2 (TCF2) levels during FFA-mediated cytotoxicity in pancreatic β-cells. However, its function during this process and the underlyi...

journal_title：International journal of molecular sciences

authors： Quan X,Zhang L,Li Y,Liang C

更新日期：2014-07-30 00:00:00

abstract：:Lung squamous cell carcinoma (LUSC) has a poor prognosis, in part due to poor therapeutic response and limited therapeutic alternatives. Lichens are symbiotic organisms, producing a variety of substances with multiple biological activities. (+)-Usnic acid, an important biologically active metabolite of lichens, has be...

journal_title：International journal of molecular sciences

authors： Qi W,Lu C,Huang H,Zhang W,Song S,Liu B

更新日期：2020-01-29 00:00:00

abstract：:SECONDARY WALL-ASSOCIATED NAC DOMAIN1 (SND1) is a master regulator of fibre secondary wall deposition in Arabidopsis thaliana (Arabidopsis), with homologs in other angiosperms and gymnosperms. However, it is poorly understood to what extent the fibre-specific regulation of the SND1 promoter, and that of its orthologs,...

journal_title：International journal of molecular sciences

authors： Tonfack LB,Hussey SG,Veale A,Myburg AA,Mizrachi E

更新日期：2019-09-18 00:00:00

abstract：:We prepared thermoresponsive hydrogels by mixing poly(N-isopropylacrylamide) (PNIPAAm) derivatives as the main chain components, octa-arm polyethylene glycol (PEG) as a crosslinker, and the Arg-Gly-Asp-Ser (RGDS) peptides as cell adhesion units. Human bone marrow-derived mesenchymal stem cells (hbmMSCs) were cultured ...

journal_title：International journal of molecular sciences

authors： Akimoto AM,Niitsu EH,Nagase K,Okano T,Kanazawa H,Yoshida R

更新日期：2018-04-21 00:00:00

abstract：:Wild barley eibi1 mutant with HvABCG31 gene mutation has low capacity to retain leaf water, a phenotype associated with reduced cutin deposition and a thin cuticle. To better understand how such a mutant plant survives, we performed a genome-wide gene expression analysis. The leaf transcriptomes between the near-isoge...

journal_title：International journal of molecular sciences

authors： Yang Z,Zhang T,Lang T,Li G,Chen G,Nevo E

更新日期：2013-10-14 00:00:00

abstract：:Akt acts as a pivotal regulator in the PI3K/Akt signaling pathway and represents a potential drug target for cancer therapy. To search for new inhibitors of Akt kinase, we performed a structure-based virtual screening using the DOCK 4.0 program and the X-ray crystal structure of human Akt kinase. From the virtual scre...

journal_title：International journal of molecular sciences

authors： Chuang CH,Cheng TC,Leu YL,Chuang KH,Tzou SC,Chen CS

更新日期：2015-02-02 00:00:00

abstract：:Oral squamous cell carcinoma (OSCC) is one of the leading presentations of head and neck cancer (HNC). The first part of this review will describe the highlights of the oral microbiome in health and normal development while demonstrating how both the oral and gut microbiome can map OSCC development, progression, treat...

journal_title：International journal of molecular sciences

authors： Sami A,Elimairi I,Stanton C,Ross RP,Ryan CA

更新日期：2020-10-29 00:00:00

abstract：:Chondral or osteochondral defects are still controversial problems in orthopedics. Here, chondrocytes labeled with magnetic nanoparticles were cultivated on a biphasic, type II collagen-chitosan/poly(lactic-co-glycolic acid) scaffold in an attempt to develop cultures with trackable cells exhibiting growth, differentia...

journal_title：International journal of molecular sciences

authors： Su JY,Chen SH,Chen YP,Chen WC

更新日期：2017-01-04 00:00:00

abstract：:With the development of molecular cloning technology and the deep understanding of antibody engineering, there are diverse bispecific antibody formats from which to choose to pursue the optimal biological activity and clinical purpose. The single-chain-based bispecific antibodies usually bridge tumor cells with immune...

journal_title：International journal of molecular sciences

authors： Yang F,Wen W,Qin W

更新日期：2016-12-28 00:00:00