Structural Insights into Ankyrin Repeat-Containing Proteins and Their Influence in Ubiquitylation.

Abstract:

:Ankyrin repeat (AR) domains are considered the most abundant repeat motif found in eukaryotic proteins. AR domains are predominantly known to mediate specific protein-protein interactions (PPIs) without necessarily recognizing specific primary sequences, nor requiring strict conformity within its own primary sequence. This promiscuity allows for one AR domain to recognize and bind to a variety of intracellular substrates, suggesting that AR-containing proteins may be involved in a wide array of functions. Many AR-containing proteins serve a critical role in biological processes including the ubiquitylation signaling pathway (USP). There is also strong evidence that AR-containing protein malfunction are associated with several neurological diseases and disorders. In this review, the structure and mechanism of key AR-containing proteins are discussed to suggest and/or identify how each protein utilizes their AR domains to support ubiquitylation and the cascading pathways that follow upon substrate modification.

journal_name

Int J Mol Sci

authors

Kane EI,Spratt DE

doi

10.3390/ijms22020609

subject

Has Abstract

pub_date

2021-01-09 00:00:00

issue

2

issn

1422-0067

pii

ijms22020609

journal_volume

22

pub_type

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