Filamentous Aggregates of Tau Proteins Fulfil Standard Amyloid Criteria Provided by the Fuzzy Oil Drop (FOD) Model.


:Abnormal filamentous aggregates that are formed by tangled tau protein turn out to be classic amyloid fibrils, meeting all the criteria defined under the fuzzy oil drop model in the context of amyloid characterization. The model recognizes amyloids as linear structures where local hydrophobicity minima and maxima propagate in an alternating manner along the fibril's long axis. This distribution of hydrophobicity differs greatly from the classic monocentric hydrophobic core observed in globular proteins. Rather than becoming a globule, the amyloid instead forms a ribbonlike (or cylindrical) structure.


Int J Mol Sci


Dułak D,Gadzała M,Banach M,Ptak M,Wiśniowski Z,Konieczny L,Roterman I




Has Abstract


2018-09-25 00:00:00










  • Hepatoprotective Effect of Kombucha Tea in Rodent Model of Nonalcoholic Fatty Liver Disease/Nonalcoholic Steatohepatitis.

    abstract::Kombucha tea (KT) has emerged as a substance that protects the liver from damage; however, its mechanisms of action on the fatty liver remain unclear. Therefore, we investigated the potential role of KT and its underlying mechanisms on nonalcoholic fatty liver disease (NAFLD). db/db mice that were fed methionine/choli...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Lee C,Kim J,Wang S,Sung S,Kim N,Lee HH,Seo YS,Jung Y

    更新日期:2019-05-13 00:00:00

  • Insights into the Antimicrobial Mechanism of Action of Human RNase6: Structural Determinants for Bacterial Cell Agglutination and Membrane Permeation.

    abstract::Human Ribonuclease 6 is a secreted protein belonging to the ribonuclease A (RNaseA) superfamily, a vertebrate specific family suggested to arise with an ancestral host defense role. Tissue distribution analysis revealed its expression in innate cell types, showing abundance in monocytes and neutrophils. Recent evidenc...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Pulido D,Arranz-Trullén J,Prats-Ejarque G,Velázquez D,Torrent M,Moussaoui M,Boix E

    更新日期:2016-04-13 00:00:00

  • CRISPR/Cas9 Editing for Gaucher Disease Modelling.

    abstract::Gaucher disease (GD) is an autosomal recessive lysosomal storage disorder caused by mutations in the acid β-glucosidase gene (GBA1). Besides causing GD, GBA1 mutations constitute the main genetic risk factor for developing Parkinson's disease. The molecular basis of neurological manifestations in GD remain elusive. Ho...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Pavan E,Ormazabal M,Peruzzo P,Vaena E,Rozenfeld P,Dardis A

    更新日期:2020-05-05 00:00:00

  • Kynurenine Aminotransferase Isozyme Inhibitors: A Review.

    abstract::Kynurenine aminotransferase isozymes (KATs 1-4) are members of the pyridoxal-5'-phosphate (PLP)-dependent enzyme family, which catalyse the permanent conversion of l-kynurenine (l-KYN) to kynurenic acid (KYNA), a known neuroactive agent. As KATs are found in the mammalian brain and have key roles in the kynurenine pat...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Nematollahi A,Sun G,Jayawickrama GS,Church WB

    更新日期:2016-06-15 00:00:00

  • Regulatory Role of MicroRNAs in Muscle Atrophy during Exercise Intervention.

    abstract::Skeletal muscle comprising approximately 40% of body weight is highly important for locomotion and metabolic homeostasis. The growth and regeneration of skeletal muscle are highly organized processes; thus, it is not surprising to reveal certain complexity during these regulatory processes. Recently, a large number of...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Zhang S,Chen N

    更新日期:2018-01-30 00:00:00

  • Anti-Obesity Effects of Dietary Calcium: The Evidence and Possible Mechanisms.

    abstract::Obesity is a serious health challenge worldwide and is associated with various comorbidities, including dyslipidemia, type 2 diabetes, and cardiovascular disease. Developing effective strategies to prevent obesity is therefore of paramount importance. One potential strategy to reduce obesity is to consume calcium, whi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Zhang F,Ye J,Zhu X,Wang L,Gao P,Shu G,Jiang Q,Wang S

    更新日期:2019-06-23 00:00:00

  • TCF2 attenuates FFA-induced damage in islet β-cells by regulating production of insulin and ROS.

    abstract::Free fatty acids (FFAs) are cytotoxic to pancreatic islet β-cells and play a crucial role in the diabetes disease process. A recent study revealed a down-regulation of transcription factor 2 (TCF2) levels during FFA-mediated cytotoxicity in pancreatic β-cells. However, its function during this process and the underlyi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Quan X,Zhang L,Li Y,Liang C

    更新日期:2014-07-30 00:00:00

  • Biased Ligands Differentially Shape the Conformation of the Extracellular Loop Region in 5-HT2B Receptors.

    abstract::G protein-coupled receptors are linked to various intracellular transducers, each pathway associated with different physiological effects. Biased ligands, capable of activating one pathway over another, are gaining attention for their therapeutic potential, as they could selectively activate beneficial pathways whilst...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Denzinger K,Nguyen TN,Noonan T,Wolber G,Bermudez M

    更新日期:2020-12-20 00:00:00

  • Hormonal Responses to Plasmodiophora brassicae Infection in Brassica napus Cultivars Differing in Their Pathogen Resistance.

    abstract::Hormonal dynamics after Plasmodiophora brassicae infection were compared in two Brassica napus cultivars-more resistant SY Alister and more sensitive Hornet, in order to elucidate responses associated with efficient defense. Both cultivars responded to infection by the early transient elevation of active cytokinins (p...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Prerostova S,Dobrev PI,Konradyova V,Knirsch V,Gaudinova A,Kramna B,Kazda J,Ludwig-Müller J,Vankova R

    更新日期:2018-12-13 00:00:00

  • Eicosanoids in Skin Wound Healing.

    abstract::Wound healing is an important process in the human body to protect against external threats. A dysregulation at any stage of the wound healing process may result in the development of various intractable ulcers or excessive scar formation. Numerous factors such as growth factors, cytokines, and chemokines are involved...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Yasukawa K,Okuno T,Yokomizo T

    更新日期:2020-11-10 00:00:00

  • Dp71 Expression in Human Glioblastoma.

    abstract:BACKGROUND:Dp71 is the most abundant dystrophin (DMD) gene product in the nervous system. Mutation in the Dp71 coding region is associated with cognitive disturbances in Duchenne muscular dystrophy (DMD) patients, but the function of dystrophin Dp71 in tumor progression remains to be established. This study investigate...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Ruggieri S,De Giorgis M,Annese T,Tamma R,Notarangelo A,Marzullo A,Senetta R,Cassoni P,Notarangelo M,Ribatti D,Nico B

    更新日期:2019-10-31 00:00:00

  • New Therapeutic Implications of Endothelial Nitric Oxide Synthase (eNOS) Function/Dysfunction in Cardiovascular Disease.

    abstract::The Global Burden of Disease Study identified cardiovascular risk factors as leading causes of global deaths and life years lost. Endothelial dysfunction represents a pathomechanism that is associated with most of these risk factors and stressors, and represents an early (subclinical) marker/predictor of atheroscleros...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Daiber A,Xia N,Steven S,Oelze M,Hanf A,Kröller-Schön S,Münzel T,Li H

    更新日期:2019-01-07 00:00:00

  • The cloning and characterization of the enolase2 gene of Gekko japonicus and its polyclonal antibody preparation.

    abstract::The enolase2 gene is usually expressed in mature neurons and also named neuron specific enolase (NSE). In the present study, we first obtained the NSE gene cDNA sequence by using the RACE method based on the expressed sequence tag (EST) fragment from the cDNA library of Gekko japonicus and identified one transcript of...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Li J,Wu R,Chen H,Zhou Y,Li Y,Wang Y,Liu Y,Liu M

    更新日期:2013-04-24 00:00:00

  • MOS1 Negatively Regulates Sugar Responses and Anthocyanin Biosynthesis in Arabidopsis.

    abstract::Sugars, which are important signaling molecules, regulate diverse biological processes in plants. However, the convergent regulatory mechanisms governing these physiological activities have not been fully elucidated. MODIFIER OF snc1-1 (MOS1), a modulator of plant immunity, also regulates floral transition, cell cycle...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Zhang N,Wang M,Huang J,Yang L,Wang Z,Wu D,Shu X

    更新日期:2020-09-26 00:00:00

  • A Novel Mutation of the NARROW LEAF 1 Gene Adversely Affects Plant Architecture in Rice (Oryza sativa L.).

    abstract::Plant architecture is critical for enhancing the adaptability and productivity of crop plants. Mutants with an altered plant architecture allow researchers to elucidate the genetic network and the underlying mechanisms. In this study, we characterized a novel nal1 rice mutant with short height, small panicle, and narr...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Subudhi PK,Garcia RS,Coronejo S,De Leon TB

    更新日期:2020-10-30 00:00:00

  • Melatonin Non-Linearly Modulates Bull Spermatozoa Motility and Physiology in Capacitating and Non-Capacitating Conditions.

    abstract::Bull spermatozoa physiology may be modulated by melatonin. We washed ejaculated spermatozoa free of melatonin and incubated them (4 h, 38 °C) with 0-pM, 1-pM, 100-pM, 10-nM and 1-µM melatonin in TALP-HEPES (non-capacitating) and TALP-HEPES-heparin (capacitating). This range of concentrations encompassed the effects me...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Fernández-Alegre E,Álvarez-Fernández I,Domínguez JC,Casao A,Martínez-Pastor F

    更新日期:2020-04-13 00:00:00

  • Genistein induces increase in fluid pH, Na+ and HCO3(-) concentration, SLC26A6 and SLC4A4 (NBCe1)-B expression in the uteri of ovariectomized rats.

    abstract::Genistein has been reported to stimulate luminal HCO3(-) secretion. We hypothesized that genistein mediates this effect via SLC26A6 and SLC4A4 (NBCe1) transporters. Our study aimed to: investigate changes in uterine fluid pH, Na+ and HCO3(-) concentration and expression of uterine SLC26A6 and NBCe1 under genistein eff...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Chinigarzadeh A,Kasim NF,Muniandy S,Kassim NM,Salleh N

    更新日期:2014-01-10 00:00:00

  • Liver Cirrhosis and Sarcopenia from the Viewpoint of Dysbiosis.

    abstract::Sarcopenia in patients with liver cirrhosis (LC) has been attracting much attention these days because of the close linkage to adverse outcomes. LC can be related to secondary sarcopenia due to protein metabolic disorders and energy metabolic disorders. LC is associated with profound alterations in gut microbiota and ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Nishikawa H,Enomoto H,Nishiguchi S,Iijima H

    更新日期:2020-07-24 00:00:00

  • Quercetin in Animal Models of Alzheimer's Disease: A Systematic Review of Preclinical Studies.

    abstract::Alzheimer's disease (AD) is the leading cause of dementia worldwide. It involves progressive impairment of cognitive function. A growing number of neuroprotective compounds have been identified with potential anti-AD properties through in vitro and in vivo models of AD. Quercetin, a natural flavonoid contained in a wi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Zhang XW,Chen JY,Ouyang D,Lu JH

    更新日期:2020-01-13 00:00:00

  • Muscle-Saturated Bioactive Lipids Are Increased with Aging and Influenced by High-Intensity Interval Training.

    abstract::Ceramide and diacylglycerol are linked to insulin resistance in rodents, but in humans the data are inconsistent. Insulin resistance is frequently observed with aging, but the role of ceramide and diacylglycerol is not clarified. Training improves metabolic health and, therefore, we aimed to elucidate the influence of...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Søgaard D,Baranowski M,Larsen S,Taulo Lund M,Munk Scheuer C,Vestergaard Abildskov C,Greve Dideriksen S,Dela F,Wulff Helge J

    更新日期:2019-03-12 00:00:00

  • Design, Synthesis, and Cytotoxic Analysis of Novel Hederagenin⁻Pyrazine Derivatives Based on Partial Least Squares Discriminant Analysis.

    abstract::Hederagenin (He) is a novel triterpene template for the development of new antitumor compounds. In this study, 26 new He⁻pyrazine derivatives were synthetized in an attempt to develop potent antitumor agents; they were screened for in vitro cytotoxicity against tumor and non-tumor cell lines. The majority of these der...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Fang K,Zhang XH,Han YT,Wu GR,Cai DS,Xue NN,Guo WB,Yang YQ,Chen M,Zhang XY,Wang H,Ma T,Wang PL,Lei HM

    更新日期:2018-09-30 00:00:00

  • Screening for Cholesterol-Lowering Probiotics from Lactic Acid Bacteria Isolated from Corn Silage Based on Three Hypothesized Pathways.

    abstract::A total of 85 strains of lactic acid bacteria were isolated from corn silage in this study and analyzed in vitro for their cholesterol removal, NPC1L1 protein down-regulation and bile salt deconjugation ability, respectively. Nineteen strains were selected for further analysis for their probiotic potential. Finally, 3...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Ma C,Zhang S,Lu J,Zhang C,Pang X,Lv J

    更新日期:2019-04-26 00:00:00

  • Cell Reprogramming in Tumorigenesis and Its Therapeutic Implications for Breast Cancer.

    abstract::Breast cancer is the most common malignancy in women worldwide and can be categorized into several subtypes according to histopathological parameters or genomic signatures. Such heterogeneity of breast cancer can arise from the reactivation of mammary stem cells in situ during tumorigenesis. Moreover, different breast...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Chu PY,Hou MF,Lai JC,Chen LF,Lin CS

    更新日期:2019-04-12 00:00:00

  • The Role of Vitamin D in Thyroid Diseases.

    abstract::The main role of vitamin D is regulating bone metabolism and calcium and phosphorus homeostasis. Over the past few decades, the importance of vitamin D in non-skeletal actions has been studied, including the role of vitamin D in autoimmune diseases, metabolic syndromes, cardiovascular disease, cancers, and all-cause m...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Kim D

    更新日期:2017-09-12 00:00:00

  • miR-7 Knockdown by Peptide Nucleic Acids in the Ascidian Ciona intestinalis.

    abstract::Peptide Nucleic Acids (PNAs) are synthetic mimics of natural oligonucleotides, which bind complementary DNA/RNA strands with high sequence specificity. They display numerous advantages, but in vivo applications are still rare. One of the main drawbacks of PNAs application is the poor cellular uptake that could be over...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Mercurio S,Cauteruccio S,Manenti R,Candiani S,Scarì G,Licandro E,Pennati R

    更新日期:2019-10-16 00:00:00

  • Time, Concentration, and pH-Dependent Transport and Uptake of Anthocyanins in a Human Gastric Epithelial (NCI-N87) Cell Line.

    abstract::Anthocyanins are the largest class of water soluble plant pigments and a common part of the human diet. They may have many potential health benefits, including antioxidant, anti-inflammatory, anti-cancer, and cardioprotective activities. However, anthocyanin metabolism is not well understood. Studies suggest that anth...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Atnip AA,Sigurdson GT,Bomser J,Giusti MM

    更新日期:2017-02-18 00:00:00

  • TCF4 Is a Molecular Target of Resveratrol in the Prevention of Colorectal Cancer.

    abstract::The Wnt/β-catenin pathway plays an essential role in the tumorigenesis of colorectal cancer. T-cell factor-4 (TCF4) is a member of the TCF/LEF (lymphoid enhancer factor) family of transcription factors, and dysregulation of β-catenin is decisive for the initiation and progression of colorectal cancer. However, the rol...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Jeong JB,Lee J,Lee SH

    更新日期:2015-05-07 00:00:00

  • Statin, calcium channel blocker and Beta blocker therapy may decrease the incidence of tuberculosis infection in elderly Taiwanese patients with type 2 diabetes.

    abstract:BACKGROUND:It is well known that diabetes mellitus impairs immunity and therefore is an independent risk factor for tuberculosis. However, the influence of associated metabolic factors, such as hypertension, dyslipidemia and gout has yet to be confirmed. This study aimed to investigate whether the strong association be...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Lee MY,Lin KD,Hsu WH,Chang HL,Yang YH,Hsiao PJ,Shin SJ

    更新日期:2015-05-18 00:00:00

  • Increased ROS Scavenging and Antioxidant Efficiency of Chlorogenic Acid Compound Delivered via a Chitosan Nanoparticulate System for Efficient In Vitro Visualization and Accumulation in Human Renal Adenocarcinoma Cells.

    abstract::Naturally existing Chlorogenic acid (CGA) is an antioxidant-rich compound reported to act a chemopreventive agent by scavenging free radicals and suppressing cancer-causing mechanisms. Conversely, the compound's poor thermal and pH (neutral and basic) stability, poor solubility, and low cellular permeability have been...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Kavi Rajan R,Hussein MZ,Fakurazi S,Yusoff K,Masarudin MJ

    更新日期:2019-09-20 00:00:00

  • Ethanol versus Phytochemicals in Wine: Oral Cancer Risk in a Light Drinking Perspective.

    abstract::This narrative review aims to summarize the current controversy on the balance between ethanol and phytochemicals in wine, focusing on light drinking and oral cancer. Extensive literature search included PUBMED and EMBASE databases to identify in human studies and systematic reviews (up to March 2015), which contribut...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Varoni EM,Lodi G,Iriti M

    更新日期:2015-07-27 00:00:00