Abstract：
:Abnormal filamentous aggregates that are formed by tangled tau protein turn out to be classic amyloid fibrils, meeting all the criteria defined under the fuzzy oil drop model in the context of amyloid characterization. The model recognizes amyloids as linear structures where local hydrophobicity minima and maxima propagate in an alternating manner along the fibril's long axis. This distribution of hydrophobicity differs greatly from the classic monocentric hydrophobic core observed in globular proteins. Rather than becoming a globule, the amyloid instead forms a ribbonlike (or cylindrical) structure.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Dułak D,Gadzała M,Banach M,Ptak M,Wiśniowski Z,Konieczny L,Roterman Idoi
10.3390/ijms19102910subject
Has Abstractpub_date
2018-09-25 00:00:00issue
10issn
1422-0067pii
ijms19102910journal_volume
19pub_type
杂志文章abstract：:Kombucha tea (KT) has emerged as a substance that protects the liver from damage; however, its mechanisms of action on the fatty liver remain unclear. Therefore, we investigated the potential role of KT and its underlying mechanisms on nonalcoholic fatty liver disease (NAFLD). db/db mice that were fed methionine/choli...
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