Abstract：
:Abnormal filamentous aggregates that are formed by tangled tau protein turn out to be classic amyloid fibrils, meeting all the criteria defined under the fuzzy oil drop model in the context of amyloid characterization. The model recognizes amyloids as linear structures where local hydrophobicity minima and maxima propagate in an alternating manner along the fibril's long axis. This distribution of hydrophobicity differs greatly from the classic monocentric hydrophobic core observed in globular proteins. Rather than becoming a globule, the amyloid instead forms a ribbonlike (or cylindrical) structure.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Dułak D,Gadzała M,Banach M,Ptak M,Wiśniowski Z,Konieczny L,Roterman Idoi
10.3390/ijms19102910subject
Has Abstractpub_date
2018-09-25 00:00:00issue
10issn
1422-0067pii
ijms19102910journal_volume
19pub_type
杂志文章abstract：:Salidroside (Sal) is a potent antitumor drug with high water-solubility. The clinic application of Sal in cancer therapy has been significantly restricted by poor oral absorption and low tumor cell uptake. To solve this problem, lipid-shell and polymer-core nanoparticles (Sal-LPNPs) loaded with Sal were developed by a...
journal_title：International journal of molecular sciences
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abstract：:The intriguingly complex glomerular podocyte has been a recent object of intense study. Researchers have sought to understand its role in the pathogenesis of common proteinuric diseases such as minimal change disease and focal segmental glomerular sclerosis. In particular, considerable effort has been directed towards...
journal_title：International journal of molecular sciences
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doi：10.3390/ijms151121366
更新日期：2014-11-18 00:00:00
abstract：:In this work, we studied the antimicrobial properties of a nanocomposite system based on a lactose-substituted chitosan and silver nanoparticles: Chitlac-nAg. Twofold serial dilutions of the colloidal Chitlac-nAg solution were both tested on Streptococcus mitis, Streptococcus mutans, and Streptococcus oralis planktoni...
journal_title：International journal of molecular sciences
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abstract：:Acyl-CoA:glycerol-sn-3-phosphate acyltransferase (GPAT) is an enzyme responsible for the rate-limiting step in the synthesis of glycerophospholipids and triacylglycerol (TAG). The enzymes of mammalian species are classified into four isoforms; GPAT1 and GPAT2 are localized in the mitochondrial outer membrane, whereas ...
journal_title：International journal of molecular sciences
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更新日期：2019-02-22 00:00:00
abstract：:In general, a drug candidate is evaluated using 2D-cultured cancer cells followed by an animal model. Despite successful preclinical testing, however, most drugs that enter human clinical trials fail. The high failure rates are mainly caused by incompatibility between the responses of the current models and humans. He...
journal_title：International journal of molecular sciences
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doi：10.3390/ijms18112348
更新日期：2017-11-07 00:00:00
abstract：:Tuberculosis (TB) is a chronic infectious disease in which prolonged, non-resolutive inflammation of the lung may lead to metabolic and neuroendocrine dysfunction. Previous studies have reported that individuals coursing pulmonary TB experience cognitive or behavioural changes; however, the pathogenic substrate of suc...
journal_title：International journal of molecular sciences
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更新日期：2020-12-13 00:00:00
abstract：:The paper presents the synthesis of an enaminone resorcin[4]arene via a thermally activated o-quinomethide. The crystal structure indicates that in the solid state all enaminone units participate in a unidirectional seam of 12 intramolecular hydrogen bonds that are formed around the cavity. The molecule exhibits C2 sy...
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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abstract：:Traumatic brain injury (TBI) modelled by lateral fluid percussion-induction (LFPI) in rats is a widely used experimental rodent model to explore and understand the underlying cellular and molecular alterations in the brain caused by TBI in humans. Current improvements in imaging with positron emission tomography (PET)...
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abstract：:In the two decades since its discovery, a large body of evidence has amassed to highlight the potential of 3-iodothyronamine (T1AM) as an antiobesity drug, whose pleiotropic signaling actions profoundly impact energy metabolism. In the present review, we recapitulate the most relevant properties of T1AM, including its...
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journal_title：International journal of molecular sciences
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更新日期：2016-10-02 00:00:00
abstract：:The interferon α (IFN-α) has been often used as a sensitizing agent for the treatment of various malignancies such as hepatocellular carcinoma, malignant melanoma, and renal cell cancer by promoting the apoptosis of thesetumor cell types. However, the effect of IFN-α on cervical cancer remains unknown. In this study, ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17111832
更新日期：2016-11-02 00:00:00
abstract：:The presence of CD4 T lymphocytes has been described for several teleost species, while many of the main T cell subsets have not been characterized at a cellular level, because of a lack of suitable tools for their identification, e.g., monoclonal antibodies (mAbs) against cell markers. We previously described the tis...
journal_title：International journal of molecular sciences
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更新日期：2020-06-11 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms18081696
更新日期：2017-08-03 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-10-30 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-06-19 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2020-10-16 00:00:00
abstract：:The mammalian target of rapamycin (mTOR) signaling pathway plays a critical role in regulating cell growth, proliferation, and life span. mTOR signaling is a central regulator of autophagy by modulating multiple aspects of the autophagy process, such as initiation, process, and termination through controlling the acti...
journal_title：International journal of molecular sciences
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更新日期：2019-02-08 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2012-01-01 00:00:00
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journal_title：International journal of molecular sciences
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abstract：:Cardiovascular diseases (CVDs) are a major cause of health loss in the world. Prevention and treatment of this disease by traditional Chinese medicine is a promising method. Centranthera grandiflora Benth is a high-value medicinal herb in the prevention and treatment of CVDs; its main medicinal components include irid...
journal_title：International journal of molecular sciences
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doi：10.3390/ijms20236034
更新日期：2019-11-29 00:00:00
abstract：:The endoplasmic reticulum (ER) is the principal organelle responsible for correct protein folding, a step in protein synthesis that is critical for the functional conformation of proteins. ER stress is a primary feature of secretory cells and is involved in the pathogenesis of numerous human diseases, such as certain ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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