Abstract：
:In the two decades since its discovery, a large body of evidence has amassed to highlight the potential of 3-iodothyronamine (T1AM) as an antiobesity drug, whose pleiotropic signaling actions profoundly impact energy metabolism. In the present review, we recapitulate the most relevant properties of T1AM, including its structural and functional relationship to thyroid hormone, its endogenous levels, molecular targets, as well as its genomic and non-genomic effects on metabolism elicited in experimental models after exogenous administration. The physiological and pathophysiological relevance of T1AM in the regulation of energy homeostasis and metabolism is also discussed, along with its potential therapeutic applications in metabolic disturbances. Finally, we examine a number of T1AM analogs that have been recently developed with the aim of designing novel pharmacological agents for the treatment of interlinked diseases, such as metabolic and neurodegenerative disorders, as well as additional synthetic tools that can be exploited to further explore T1AM-dependent mechanisms and the physiological roles of trace amine-associated receptor 1 (TAAR1)-mediated effects.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Rutigliano G,Bandini L,Sestito S,Chiellini Gdoi
10.3390/ijms21062005subject
Has Abstractpub_date
2020-03-15 00:00:00issue
6issn
1422-0067pii
ijms21062005journal_volume
21pub_type
杂志文章,评审abstract：:Malignancy often arises from sophisticated defects in the intricate molecular mechanisms of cells, rendering a complicated molecular ground to effectively target cancers. Resistance toward cell death and enhancement of cell survival are the common adaptations in cancer due to its infinite proliferative capacity. Exist...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20020372
更新日期：2019-01-16 00:00:00
abstract：:Inflammatory bowel disease (IBD) is a chronic disorder manifested as Crohn's disease (CD) and ulcerative colitis (UC) characterized by intestinal inflammation and involves a dysregulated immune response against commensal microbiota through the activation of CD4 T helper cells. T helper cell differentiation to effector...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21093379
更新日期：2020-05-11 00:00:00
abstract：:Peroxisome proliferator-activated receptors (PPARs) are nuclear receptors that govern the expression of genes responsible for energy metabolism, cellular development, and differentiation. Their crucial biological roles dictate the significance of PPAR-targeting synthetic ligands in medical research and drug discovery....
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20205055
更新日期：2019-10-11 00:00:00
abstract：:Alpha-synuclein is considered the major pathological protein associated with Parkinson's disease, but there is still no effective immunotherapy which targets alpha-synuclein. In order to create a safer and more effective therapy against PD, we are targeting an epitope of alpha-synuclein rather than full-length alpha-s...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20092338
更新日期：2019-05-11 00:00:00
abstract：:Although most osmotic stresses are harmful to plant growth and development, certain drought- or polyethylene glycol (PEG)-induced mild osmotic stresses promote plant root growth. The underlying regulatory mechanisms of this response remain elusive. Here, we report that the GLYCOGEN SYNTHASE KINASE 3 (GSK3) genes ARABI...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21113991
更新日期：2020-06-02 00:00:00
abstract：:Skin cancer is the most common type of cancer worldwide. Ozone depletion and climate changes might cause a further increase in the incidence rate in the future. Although the early detection of skin cancer enables it to be treated successfully, some tumours can evolve and become more aggressive, especially in the case ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20225781
更新日期：2019-11-17 00:00:00
abstract：:Previous studies have shown that germin-like proteins (GLPs) are present ubiquitously in rice and Arabidopsis. However, the understanding regarding their role in development and abiotic/biotic stress resistance remains limited. In the present study, we report genome-wide identification, characterisation, subcellular l...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17101622
更新日期：2016-09-23 00:00:00
abstract：:Plant regeneration and somatic embryogenesis through interspecific hybridization among different Carica species were studied for the development of a papaya ringspot virus-resistant variety. The maximum fruit sets were recorded from the cross of the native variety C. papaya cv. Shahi with the wild species C. cauliflor...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms131217065
更新日期：2012-12-12 00:00:00
abstract：:Pterostilbene (PTE) is a natural sterbenoid contained in blueberries that has an antioxidant effect. In contrast, PTE also generates oxidative stress in cancer cells and provides an antitumor effect. Here, we examined the potential mechanism of this contrasting effect of PTE using three gastrointestinal cancer cell li...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21249347
更新日期：2020-12-08 00:00:00
abstract：:Many microbial ecology studies have demonstrated profound changes in community composition caused by environmental pollution, as well as adaptation processes allowing survival of microbes in polluted ecosystems. Soil microbial communities in polluted areas with a long-term history of contamination have been shown to m...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17060933
更新日期：2016-06-14 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228719
更新日期：2020-11-18 00:00:00
abstract：:The role of dynamic processes on self-assembled structures of 4'-([2,2':6', 2''-terpyridin]-4'-yl)-[1,1'-biphenyl]-4-carboxylic acid (l) molecules on Au(III) has been studied by scanning tunneling microscopy. The as-deposited monolayer is closed-packed and periodic in a short-range due to dipole forces. A thermal anne...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14035686
更新日期：2013-03-11 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms160715497
更新日期：2015-07-08 00:00:00
abstract：:Aquaporins (AQPs) are among the best structural-characterized membrane proteins, fulfilling the role of allowing water flux across cellular membranes. Thus far, 34 single amino acid polymorphisms have been reported in HUMSAVAR for human aquaporins as disease-related. They affect AQP2, AQP5 and AQP8, where they are ass...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19061577
更新日期：2018-05-25 00:00:00
abstract：:The relationship between antiphospholipid antibodies (aPL) and autoimmune haemolytic anaemia (AIHA) has never been systematically addressed. The aim of this study is to assess the link between aPL and AIHA in adult systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). This study performed an EMBASE/P...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21114120
更新日期：2020-06-09 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20061417
更新日期：2019-03-20 00:00:00
abstract：:Hepatic disorders have been increasing in recent years because of high carbohydrate diets. Hepatocytes depend mainly on the basal autophagy to maintain hepatic glucose/lipid homeostasis in mammals. However, the regulatory mechanisms of autophagy in hepatic energy metabolism are still unknown in fish species. According...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041533
更新日期：2020-02-24 00:00:00
abstract：:Relaxin is known to play an important role in animal pregnancies, including those of humans. It is suggested that relaxin induces aggressive cell growth and invasiveness in several types of cancer, including endometrial cancer. However, the mechanisms of relaxin remain largely unclear. In this study, we examined the e...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19082438
更新日期：2018-08-18 00:00:00
abstract：:The prognosis of patients with pancreatic cancer remains poor; only patients with small tumors and complete resection have a chance of a complete cure. Pancreatic cancer responds poorly to conventional therapies, including chemotherapy and irradiation. Snail is a transcription factor that has been associated with anti...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,收录出版
doi：10.3390/ijms11124891
更新日期：2010-01-01 00:00:00
abstract：:The pathogenesis of type 2 diabetes (T2D) involves chronic hyperinsulinemia due to systemic and hepatic insulin resistance (IR), which if uncorrected, will lead to progressive pancreatic beta cell failure in predisposed individuals. Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of fatty (simple stea...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17030355
更新日期：2016-03-09 00:00:00
abstract：:In a previous phylogenetic study of the family of pyruvate kinase, we found one cluster with Glu117 and another with Lys117. Those sequences with Glu117 have Thr113 and are K+-dependent, whereas those with Lys117 have Leu113 and are K+-independent. The carbonyl oxygen of Thr113 is one of the residues that coordinate K...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms151222214
更新日期：2014-12-02 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,meta分析
doi：10.3390/ijms15057987
更新日期：2014-05-07 00:00:00
abstract：:Inflammation is the body's response to injury or infection. As early as 2000 years ago, the Roman encyclopaedist Aulus Cornelius Celsus recognised four cardinal signs of this response-redness, heat, swelling and pain; a fifth sign is loss of function.[...]. ...
journal_title：International journal of molecular sciences
pub_type： 社论
doi：10.3390/ijms18112415
更新日期：2017-11-14 00:00:00
abstract：:The cholinergic efferent network from the medial septal nucleus to the hippocampus has an important role in learning and memory processes. This cholinergic projection can generate theta oscillations in the hippocampus to efficiently encode novel information. Hippocampal cholinergic neurostimulating peptide (HCNP) indu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20215367
更新日期：2019-10-28 00:00:00
abstract：:Acute myeloid leukemia (AML) is caused by malignant transformation of hematopoietic stem or progenitor cells and displays the most frequent acute leukemia in adults. Although some patients can be cured with high dose chemotherapy and allogeneic hematopoietic stem cell transplantation, the majority still succumbs to ch...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17122080
更新日期：2016-12-10 00:00:00
abstract：:The authors are sorry to report that some of the HPLC data reported in their recently published paper [...]. ...
journal_title：International journal of molecular sciences
pub_type： 已发布勘误
doi：10.3390/ijms20174178
更新日期：2019-08-26 00:00:00
abstract：:Aquaporin-5 (AQP5) is a membrane water channel widely distributed in human tissues that was found up-regulated in different tumors and considered implicated in carcinogenesis in different organs and systems. Despite its wide distribution pattern and physiological importance, AQP5 short-term regulation was not reported...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17122090
更新日期：2016-12-13 00:00:00
abstract：:Volumetric strain can be divided into two parts: strain due to bond distance change and strain due to vacancy sources and sinks. In this paper, efforts are focused on studying the atomic lattice strain due to a vacancy in an FCC metal lattice with molecular dynamics simulation (MDS). The result has been compared with ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms10062798
更新日期：2009-06-19 00:00:00
abstract：:Chemosensitivity is a crucial feature for all tumours so that they can be successfully treated, but the huge heterogeneity of these diseases, to be intended both inter- and intra-tumour, makes it a hard-to-win battle. Indeed, this genotypic and phenotypic variety, together with the adaptability of tumours, results in ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20071776
更新日期：2019-04-10 00:00:00
abstract：:Human stem cells are promising sources for bladder regeneration. Among several possible sources, pluripotent stem cells are the most fascinating because they can differentiate into any cell type, and proliferate limitlessly in vitro. Here, we developed a protocol for differentiation of human pluripotent stem cells (hP...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15057139
更新日期：2014-04-25 00:00:00
