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Experimental Pulmonary Tuberculosis in the Absence of Detectable Brain Infection Induces Neuroinflammation and Behavioural Abnormalities in Male BALB/c Mice.

Abstract：

:Tuberculosis (TB) is a chronic infectious disease in which prolonged, non-resolutive inflammation of the lung may lead to metabolic and neuroendocrine dysfunction. Previous studies have reported that individuals coursing pulmonary TB experience cognitive or behavioural changes; however, the pathogenic substrate of such manifestations have remained unknown. Here, using a mouse model of progressive pulmonary TB, we report that, even in the absence of brain infection, TB is associated with marked increased synthesis of both inflammatory and anti-inflammatory cytokines in discrete brain areas such as the hypothalamus, the hippocampal formation and cerebellum accompanied by substantial changes in the synthesis of neurotransmitters. Moreover, histopathological findings of neurodegeneration and neuronal death were found as infection progressed with activation of p38, JNK and reduction in the BDNF levels. Finally, we perform behavioural analysis in infected mice throughout the infection, and our data show that the cytokine and neurochemical changes were associated with a marked onset of cognitive impairment as well as depressive- and anxiety-like behaviour. Altogether, our results suggest that besides pulmonary damage, TB is accompanied by an extensive neuroinflammatory and neurodegenerative state which explains some of the behavioural abnormalities found in TB patients.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Lara-Espinosa JV,Santana-Martínez RA,Maldonado PD,Zetter M,Becerril-Villanueva E,Pérez-Sánchez G,Pavón L,Mata-Espinosa D,Barrios-Payán J,López-Torres MO,Marquina-Castillo B,Hernández-Pando R

doi

10.3390/ijms21249483

subject

Has Abstract

pub_date

2020-12-13 00:00:00

issue

24

issn

1422-0067

pii

ijms21249483

journal_volume

21

pub_type

杂志文章

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