Abstract:
:The engineering of T cells through expression of chimeric antigen receptors (CARs) against tumor-associated antigens (TAAs) has shown significant potential for use as an anti-cancer therapeutic. The development of strategies for flexible and modular CAR T systems is accelerating, allowing for multiple antigen targeting, precise programming, and adaptable solutions in the field of cellular immunotherapy. Moving beyond the fixed antigen specificity of traditional CAR T systems, the modular CAR T technology splits the T cell signaling domains and the targeting elements through use of a switch molecule. The activity of CAR T cells depends on the presence of the switch, offering dose-titratable response and precise control over CAR T cells. In this review, we summarize developments in universal or modular CAR T strategies that expand on current CAR T systems and open the door for more customizable T cell activity.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Sutherland AR,Owens MN,Geyer CRdoi
10.3390/ijms21197222subject
Has Abstractpub_date
2020-09-30 00:00:00issue
19issn
1422-0067pii
ijms21197222journal_volume
21pub_type
杂志文章,评审abstract::The Kv4 family of voltage-gated K⁺ channels underlie the fast transient (A-type) outward K⁺ current. Although A-type currents are critical to determine somato-dendritic integration in central neurons, relatively little is known about the precise subcellular localisation of the underlying channels in hippocampal circui...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20020246
更新日期:2019-01-09 00:00:00
abstract::The high affinity immunoglobulin E (IgE) receptor-FcεR1 is mainly expressed on the surface of effector cells. Cross-linking of IgE Abs bound to FcεR1 by multi-valent antigens can induce the activation of these cells and the secretion of inflammatory mediators. Since FcεR1 plays a central role in the induction and main...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms16059504
更新日期:2015-04-27 00:00:00
abstract::Platelet extracellular vesicles (PEVs) are potential new biomarkers of platelet activation which may allow us to predict and/or diagnose developing coronary thrombosis before myocardial necrosis occurs. The P2Y1 and P2Y12 receptors play a key role in platelet activation and aggregation. Whereas the P2Y1 antagonists ar...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21176065
更新日期:2020-08-23 00:00:00
abstract::This review provides a current summary of plant resistance inducers (PRIs) that have been successfully used in the Solanaceae plant family to protect against pathogens by activating the plant's own defence. Solanaceous species include many important crops such as potato and tomato. We also present findings regarding t...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms17101673
更新日期:2016-10-02 00:00:00
abstract::Hibiscus aridicola (Malvaceae) is an endangered ornamental shrub endemic to the dry-hot valleys of Jinsha River in southwest China. Only four natural populations of H. aridicola exist in the wild according to our field investigation. It can be inferred that H. aridicola is facing a very high risk of extinction in the ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms12095698
更新日期:2011-01-01 00:00:00
abstract::Studies conducted on Zebrafish embryos in our laboratory have allowed for the identification of precise moments of organogenesis in which a lot of genes are switched on and off, a sign that the genome is undergoing substantial changes in gene expression. Stem cell growth and differentiation stage-factors present in di...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21144914
更新日期:2020-07-12 00:00:00
abstract::Increased plasma homocysteinemia is considered a risk factor of dementia, including Alzheimer's disease (AD) and vascular dementia. However, the reason elevated plasma homocysteinemia increases the risk of dementia remains unknown. A pathological hallmark of AD is neurofibrillary tangles (NFTs) that consist of patholo...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19030891
更新日期:2018-03-17 00:00:00
abstract::Colorectal cancer (CRC) is one of the most common malignant diseases worldwide, but the involved signaling pathways and driven-genes are largely unclear. This study integrated four cohorts profile datasets to elucidate the potential key candidate genes and pathways in CRC. Expression profiles GSE28000, GSE21815, GSE44...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18040722
更新日期:2017-03-28 00:00:00
abstract::In a recent study, we investigated the antimicrobial activity of a collection of resveratrol-derived monomers and dimers against a series of foodborne pathogens. Out of the tested molecules, dehydro-δ-viniferin and dehydro-ε-viniferin emerged as the most promising derivatives. To define the structural elements essenti...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21062168
更新日期:2020-03-21 00:00:00
abstract::Curcumin diglutaric acid (CurDG), an ester prodrug of curcumin, has the potential to be developed as an anti-inflammatory agent due to its improved solubility and stability. In this study, the anti-inflammatory effects of CurDG were evaluated. The effects of CurDG on inflammatory mediators were evaluated in LPS-stimul...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21165700
更新日期:2020-08-09 00:00:00
abstract::Serotonin (5-HT) is a critical player in brain development and neuropsychiatric disorders. Fetal 5-HT levels can be influenced by several gestational factors, such as maternal genotype, diet, stress, medication, and immune activation. In this review, addressing both human and animal studies, we discuss how these gesta...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21165850
更新日期:2020-08-14 00:00:00
abstract::By integrating ATP aptamer into the linker DNA, a novel DNA hydrogel was designed, with mechanical properties that could be tuned into three phases. Based on the unique interaction between ATP and its aptamer, the mechanical strength of the hydrogel increased from 204 Pa to 380 Pa after adding ATP. Furthermore, with t...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19061633
更新日期:2018-05-31 00:00:00
abstract::Ischemic preconditioning (IPre) reduces ischemia/reperfusion (I/R) injury in the heart. The non-coding microRNA miR-125b-1-3p has been demonstrated to play a role in the mechanism of IPre. Hypercholesterolemia is known to attenuate the cardioprotective effect of preconditioning; nevertheless, the exact underlying mech...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21113744
更新日期:2020-05-26 00:00:00
abstract::Adult Renal Stem/Progenitor Cells (ARPCs) have been recently identified in the human kidney and several studies show their active role in kidney repair processes during acute or chronic injury. However, little is known about their immunomodulatory properties and their capacity to regulate specific T cell subpopulation...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22010274
更新日期:2020-12-29 00:00:00
abstract::Alzheimer's disease (AD) is characterized by extracellular accumulation of amyloid-β peptide (Aβ), generated by proteolytic processing of the amyloid precursor protein (APP) by β- and γ-secretase. Aβ generation is inhibited when the initial ectodomain shedding is caused by α-secretase, cleaving APP within the Aβ domai...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms14035879
更新日期:2013-03-13 00:00:00
abstract::Vascular cell adhesion molecule-1 (VCAM-1) is closely associated with tumor progression and metastasis. However, the relevance and role of VCAM-1 in lung cancer have not been clearly elucidated. In this study, we found that VCAM-1 was highly overexpressed in lung cancer tissue compared with that of normal lung tissue,...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18030566
更新日期:2017-03-06 00:00:00
abstract::The mammalian HSP90 family of proteins is a cluster of highly conserved molecules that are involved in myriad cellular processes. Their distribution in various cellular compartments underlines their essential roles in cellular homeostasis. HSP90 and its co-chaperones orchestrate crucial physiological processes such as...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19092560
更新日期:2018-08-29 00:00:00
abstract::Inflammatory bowel diseases (IBD) are chronic, inflammatory processes that affect the gastrointestinal tract and are mainly represented by ulcerative colitis (UC) and Crohn's disease (CD). Omega 3 (ω3) fatty acids (eicosapentanoic acid and docosahexaenoic acid) show an indispensable role in the inflammatory processes ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,meta分析,评审
doi:10.3390/ijms20194851
更新日期:2019-09-30 00:00:00
abstract::We characterized Schistosoma japonicum HSP40 (Sjp40) and HSP90α (Sjp90α) in this study. Western blot analysis revealed both are present in soluble egg antigens and egg secretory proteins, implicating them in triggering the host immune response after secretion from eggs into host tissues. These observations were confir...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21114034
更新日期:2020-06-04 00:00:00
abstract::Monoterpenoids are a diverse class of natural products and contribute to the important varietal aroma of certain Vitis vinifera grape cultivars. Among the typical monoterpenoids, linalool exists in almost all grape varieties. A gene coding for a nerolidol/linalool (NES/LINS) synthase was evaluated in the role of linal...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms151221992
更新日期:2014-12-01 00:00:00
abstract::The presence of abnormal ovarian ratios of myo-inositol (MI) to D-chiro-inositol (DCI) is a recurrent feature in PCOS. Available evidence suggests that MI and DCI may modulate steroid biosynthesis, likely in an opposite manner. Specifically, MI seems to induce estrogen production, while DCI has a role in the synthesis...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21197157
更新日期:2020-09-28 00:00:00
abstract::Decades of study on the role of mitochondria in living cells have evidenced the importance of the 18 kDa mitochondrial translocator protein (TSPO), first discovered in the 1977 as an alternative binding site for the benzodiazepine diazepam in the kidneys. This protein participates in a variety of cellular functions, i...
journal_title:International journal of molecular sciences
pub_type: 社论
doi:10.3390/ijms18122640
更新日期:2017-12-06 00:00:00
abstract::The current emergence of multi-, extensively-, extremely-, and total-drug resistant strains of Mycobacterium tuberculosis poses a major health, social, and economic threat, and stresses the need to develop new therapeutic strategies. The notion of phage therapy against bacteria has been around for more than a century ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms22020735
更新日期:2021-01-13 00:00:00
abstract::The involvement of microRNAs in the control of repressors of human γ-globin gene transcription has been firmly demonstrated, as described for the miR-486-3p mediated down-regulation of BCL11A. On the other hand, we have reported that miR-210 is involved in erythroid differentiation and, possibly, in γ-globin gene up-r...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18122530
更新日期:2017-11-26 00:00:00
abstract::Geopropolis is a resin mixed with mud, produced only by stingless bees. Despite being popularly known for its medicinal properties, few scientific studies have proven its biological activities. In this context, the objective of this study was to determine the chemical composition and antioxidant, anti-inflammatory, an...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18050953
更新日期:2017-05-03 00:00:00
abstract::The aim of the study was to verify if quantification of placental specific C19MC microRNAs in plasma exosomes would be able to differentiate during the early stages of gestation between patients subsequently developing pregnancy-related complications and women with the normal course of gestation and if this differenti...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20122972
更新日期:2019-06-18 00:00:00
abstract::Reactive oxygen species (ROS) are highly reactive signaling molecules that maintain redox homeostasis in mammalian cells. Dysregulation of redox homeostasis under pathological conditions results in excessive generation of ROS, culminating in oxidative stress and the associated oxidative damage of cellular components. ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20153791
更新日期:2019-08-03 00:00:00
abstract::Renal proximal tubular epithelial cells are significantly damaged during acute kidney injury. Renal proximal tubular cell-specific autophagy-deficient mice show increased sensitivity against renal injury, while showing few pathological defects under normal fed conditions. Considering that autophagy protects the proxim...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21010155
更新日期:2019-12-25 00:00:00
abstract::Impairment of skeletal muscle function causes disabilities in elderly people. Therefore, in an aged society, prevention and treatment of sarcopenia are important for expanding healthy life expectancy. In addition to aging, adipose tissue disfunction and inflammation also contribute to the pathogenesis of sarcopenia by...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21093182
更新日期:2020-04-30 00:00:00
abstract::Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their expression is misregulated in a wide variety of tumors, and ample data prove their involvement in cancer progression, angiogenesis, metastasis, and in the occurrence of drug resistance. However, while their overexpression is usually associ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20143602
更新日期:2019-07-23 00:00:00