Abstract：
:Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the main therapeutic strategy for patients with both malignant and nonmalignant disorders. The therapeutic benefits of allo-HSCT in malignant disorders are primarily derived from the graft-versus-leukemia (GvL) effect, in which T cells in the donor graft recognize and eradicate residual malignant cells. However, the same donor T cells can also recognize normal host tissues as foreign, leading to the development of graft-versus-host disease (GvHD), which is difficult to separate from GvL and is the most frequent and serious complication following allo-HSCT. Inhibition of donor T cell toxicity helps in reducing GvHD but also restricts GvL activity. Therefore, developing a novel therapeutic strategy that selectively suppresses GvHD without affecting GvL is essential. Recent studies have shown that inhibition of histone deacetylases (HDACs) not only inhibits the growth of tumor cells but also regulates the cytotoxic activity of T cells. Here, we compile the known therapeutic potential of HDAC inhibitors in preventing several stages of GvHD pathogenesis. Furthermore, we will also review the current clinical features of HDAC inhibitors in preventing and treating GvHD as well as maintaining GvL.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Kim S,Santhanam S,Lim S,Choi Jdoi
10.3390/ijms21124281subject
Has Abstractpub_date
2020-06-16 00:00:00issue
12issn
1422-0067pii
ijms21124281journal_volume
21pub_type
杂志文章,评审abstract：:Broad Copy Number Gains (BCNGs) are copy-number increases of chromosomes or large segments of chromosomal arms. Publicly-available single-nucleotide polymorphism (SNP) array and RNA-Seq data of colon adenocarcinoma (COAD) samples from The Cancer Genome Atlas (TCGA) consortium allowed us to design better control groups...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184652
更新日期：2019-09-19 00:00:00
abstract：:This review, one in a series on myotonic dystrophy (DM), is focused on the development and potential use of small molecules as therapeutics for DM. The complex mechanisms and pathogenesis of DM are covered in the associated reviews. Here, we examine the various small molecule approaches taken to target the DNA, RNA, a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20164017
更新日期：2019-08-17 00:00:00
abstract：:Alpha-synuclein is considered the major pathological protein associated with Parkinson's disease, but there is still no effective immunotherapy which targets alpha-synuclein. In order to create a safer and more effective therapy against PD, we are targeting an epitope of alpha-synuclein rather than full-length alpha-s...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20092338
更新日期：2019-05-11 00:00:00
abstract：:KCND3 encodes the voltage-gated potassium ion channel subfamily D member 3, a six trans-membrane protein (Kv4.3), involved in the transient outward K+ current. KCND3 defect causes both cardiological and neurological syndromes. From a neurological perspective, Kv4.3 defect has been associated to SCA type 19/22, a compl...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21165802
更新日期：2020-08-13 00:00:00
abstract：:Mucin1 (MUC1) is aberrantly glycosylated and overexpressed in various cancers, and it plays a crucial role in cancerogenesis. MUC1 is a type I membranous protein composed of α and β subunits. MUC1-α can be cleaved in cancers, exposing MUC1-β (MUC1-C). MUC1-C is involved with multiple cancer cellular functions, which m...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21093258
更新日期：2020-05-05 00:00:00
abstract：:Kaempferol, a flavonoid compound, is derived from the rhizome of Kaempferia galanga L., which is used in traditional medicine in Asia. Autophagy has pleiotropic functions that are involved in cell growth, survival, nutrient supply under starvation, defense against pathogens, and antigen presentation. There are many st...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19010125
更新日期：2018-01-02 00:00:00
abstract：:The frequency and volume of Asian sand dust (ASD) (Kosa) are increasing in Japan, and it has been reported that ASD may cause adverse respiratory effects. The pulmonary toxicity of ASD has been previously analyzed in mice exposed to ASD particles by intratracheal instillation. To study the pulmonary toxicity induced b...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19020416
更新日期：2018-01-31 00:00:00
abstract：:Evolution of reactive oxygen species (ROS), generated during the patho-physiological stress of nervous tissue, has been implicated in the etiology of several progressive human neurological disorders including Alzheimer's disease (AD) and amylotrophic lateral sclerosis (ALS). In this brief communication we used mixed i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13089615
更新日期：2012-01-01 00:00:00
abstract：:Tomato cell wall-associated kinase 1 (SlWAK1) has only been studied in biotic stress response and hence its function in abiotic stress remains unknown. In a screening under salinity of an insertional mutant collection of tomato (Solanum lycopersicum L.), a mutant exhibiting lower degree of leaf chlorosis than wild typ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21176308
更新日期：2020-08-31 00:00:00
abstract：:Red fluorescent genetically encoded calcium indicators (GECIs) have expanded the available pallet of colors used for the visualization of neuronal calcium activity in vivo. However, their calcium-binding domain is restricted by calmodulin from metazoans. In this study, we developed red GECI, called FRCaMP, using calmo...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22010111
更新日期：2020-12-24 00:00:00
abstract：:Bacterial exopolysaccharides produced by lactic acid bacteria are of increasing interest in the food industry, since they might enhance the technological and functional properties of some edible matrices. In this work, Pediococcus parvulus 2.6, which produces an O2-substituted (1,3)-β-d-glucan exopolysaccharide only s...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18071588
更新日期：2017-07-21 00:00:00
abstract：:Adolescence represents a vulnerable period for the psychiatric consequences of delta9-tetrahydrocannabinol (Δ⁸-THC) exposure, however, the molecular underpinnings of this vulnerability remain to be established. Histone modifications are emerging as important epigenetic mechanisms involved in the etiopathogenesis of ps...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18102094
更新日期：2017-10-04 00:00:00
abstract：:Traumatic brain injury (TBI) can cause biochemical and metabolomic alterations in the brain tissue and serum. These alterations can be used for diagnosis and prognosis of TBI. Here, the serum concentrations of seventeen amino acids (AA) were studied for their potential utility as biomarkers of TBI. Twenty-five female,...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051786
更新日期：2020-03-05 00:00:00
abstract：:Ceramide and diacylglycerol are linked to insulin resistance in rodents, but in humans the data are inconsistent. Insulin resistance is frequently observed with aging, but the role of ceramide and diacylglycerol is not clarified. Training improves metabolic health and, therefore, we aimed to elucidate the influence of...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20051240
更新日期：2019-03-12 00:00:00
abstract：:Thrombin is an essential procoagulant and profibrotic mediator. However, its implication in tuberculous pleural effusion (TBPE) remains unknown. The effusion thrombin and plasminogen activator inhibitor-1 (PAI-1) levels were measured among transudative pleural effusion (TPE, n = 22) and TBPE (n = 24) patients. Pleural...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20205076
更新日期：2019-10-13 00:00:00
abstract：:The only curative treatment for hepatic failure is liver transplantation. Unfortunately, this treatment has several major limitations, as for example donor organ shortage. A previous report demonstrated that transplantation of induced pluripotent stem cells without reprogramming factor c-Myc (3-genes iPSCs) attenuates...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13033598
更新日期：2012-01-01 00:00:00
abstract：:SECONDARY WALL-ASSOCIATED NAC DOMAIN1 (SND1) is a master regulator of fibre secondary wall deposition in Arabidopsis thaliana (Arabidopsis), with homologs in other angiosperms and gymnosperms. However, it is poorly understood to what extent the fibre-specific regulation of the SND1 promoter, and that of its orthologs,...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184623
更新日期：2019-09-18 00:00:00
abstract：:The physiological and pathological roles of nascent amyloid beta (Aβ) monomers are still debated in the literature. Their involvement in the pathological route of Alzheimer's Disease (AD) is currently considered to be the most relevant, triggered by their aggregation into structured oligomers, a toxic species. Recentl...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218295
更新日期：2020-11-05 00:00:00
abstract：:We have been made aware that text, figures and experimental data reported in the title paper [1] are duplicated in another publication by Zihan Xu et al. [2].[...]. ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,撤回出版物
doi：10.3390/ijms17050768
更新日期：2016-05-20 00:00:00
abstract：:Legume root nodules develop as a result of a symbiotic relationship between the plant and nitrogen-fixing rhizobia bacteria in soil. Auxin activity is detected in different cell types at different stages of nodule development; as well as an enhanced sensitivity to auxin inhibits, which could affect nodule development....
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18122547
更新日期：2017-11-28 00:00:00
abstract：:CX3CL1 can function as both an adhesion molecule and a chemokine for CX3CR1+ cells, such as T cells, monocytes, and NK cells. Recent studies have demonstrated that CX3CL1-CX3CR1 interaction is associated with the development of various inflammatory skin diseases. In this study, we examined CX3CR1 involvement in 2,4-di...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21197401
更新日期：2020-10-07 00:00:00
abstract：:This study aimed to examine whether inhibition of hexokinase (HK)-II activity enhances the efficacy of sorafenib in in-vivo models of hepatocellular carcinoma (HCC), and to evaluate the prognostic implication of HK-II expression in patients with HCC. We used 3-bromopyruvate (3-BP), a HK-II inhibitor to target HK-II. T...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20061292
更新日期：2019-03-14 00:00:00
abstract：:In inflammatory bowel diseases (IBD), the therapeutic benefit and mucosal healing from specific probiotics may relate to the modulation of dendritic cells (DCs). Herein, we assessed the immunomodulatory effects of four probiotic strains including Lactobacillus salivarius, Bifidobacterium bifidum, Bacillus coagulans an...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21176266
更新日期：2020-08-29 00:00:00
abstract：:In allergic bronchial asthma, an increased smooth muscle contractility of the airways is one of the causes of the airway hyperresponsiveness (AHR). Increasing evidence also suggests a possible involvement of microRNAs (miRNAs) in airway diseases, including asthma, although their roles in function and pathology largely...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21217982
更新日期：2020-10-27 00:00:00
abstract：:Various strategies have been employed to speed tissue regeneration using bioactive molecules. Interestingly, platelet concentrates derived from a patient's own blood have been utilized as a regenerative strategy in recent years. In the present study, a novel liquid platelet formulation prepared without the use of anti...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020331
更新日期：2017-02-04 00:00:00
abstract：:Breast cancer is the most common cancer type among women worldwide. With breast cancer patients and survivors being reported to experience a repertoire of symptoms that are detrimental to their quality of life, the development of breast cancer treatment strategies that are effective with minimal side effects is theref...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18112423
更新日期：2017-11-15 00:00:00
abstract：:NW-G01, produced by Streptomyces alboflavus 313, is a novel cyclic hexapeptide antibiotic with many potential applications, including antimicrobial activity and antitumor agents. This study developed a system for optimizing medium components in order to enhance NW-G01 production. In this study, Plackett-Burman design ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13045230
更新日期：2012-01-01 00:00:00
abstract：:The aging kidney is a marked by a number of structural and functional changes, including an increased susceptibility to acute kidney injury (AKI). Previous studies from our laboratory have shown that aging male Fischer 344 rats (24 month) are more susceptible to apoptosis-mediated injury than young counterparts. In th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020368
更新日期：2017-02-10 00:00:00
abstract：:Glu-1Ay, one of six genes encoding a high molecular weight glutenin subunit (HMW-GS), is frequently silenced in hexaploid common wheat. Here, an active allele of Glu-1Ay was integrated from wild emmer wheat (Triticum turgidum ssp. dicoccoides) accession D97 into the common wheat (Triticum aestivum) cultivar Chuannong ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19040923
更新日期：2018-03-21 00:00:00
abstract：:Various sulfonamide derivatives are intensively studied as anticancer agents owing to their inhibitory activity against human tumor-associated carbonic anhydrase isoforms. In this work, different synthetic procedures for the series of 1,3,5-triazinyl-aminobenzenesulfonamide conjugates with amino acids, possessing pola...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21103661
更新日期：2020-05-22 00:00:00
