当前位置： SCI文献检索 > INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES期刊下所有文献 > Aβ Beyond the AD Pathology: Exploring the Structural Response of Membranes Exposed to Nascent Aβ Peptide.

Aβ Beyond the AD Pathology: Exploring the Structural Response of Membranes Exposed to Nascent Aβ Peptide.

Abstract：

:The physiological and pathological roles of nascent amyloid beta (Aβ) monomers are still debated in the literature. Their involvement in the pathological route of Alzheimer's Disease (AD) is currently considered to be the most relevant, triggered by their aggregation into structured oligomers, a toxic species. Recently, it has been suggested that nascent Aβ, out of the amyloidogenic pathway, plays a physiological and protective role, especially in the brain. In this emerging perspective, the study presented in this paper investigated whether the organization of model membranes is affected by contact with Aβ in the nascent state, as monomers. The outcome is that, notably, the rules of engagement and the resulting structural outcome are dictated by the composition and properties of the membrane, rather than by the Aβ variant. Interestingly, Aβ monomers are observed to favor the tightening of adjacent complex membranes, thereby affecting a basic structural event for cell-cell adhesion and cell motility.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Rondelli V,Salmona M,Colombo L,Fragneto G,Fadda GC,Cantu' L,Del Favero E

doi

10.3390/ijms21218295

subject

Has Abstract

pub_date

2020-11-05 00:00:00

issue

21

issn

1422-0067

pii

ijms21218295

journal_volume

21

pub_type

杂志文章

相关文献

INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES文献大全
  • Nanoparticle-Mediated Combination Therapy: Two-in-One Approach for Cancer.

    abstract：:Cancer represents a group of heterogeneous diseases characterized by uncontrolledgrowth and spread of abnormal cells, ultimately leading to death. Nanomedicine plays a significantrole in the development of nanodrugs, nanodevices, drug delivery systems and nanocarriers. Someof the major issues in the treatment of cance...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19103264

    authors： Gurunathan S,Kang MH,Qasim M,Kim JH

    更新日期：2018-10-20 00:00:00

  • Novel microwave-assisted synthesis of the immunomodulator organotellurium compound ammonium trichloro(dioxoethylene-O,O')tellurate (AS101).

    abstract：:Ammonium trichloro[1,2-ethanediolato-O,O']-tellurate (AS101) is the most important synthetic Te compound from the standpoint of its biological activity. It is a potent immunomodulator with a variety of potential therapeutic applications and antitumoral action in several preclinical and clinical studies. An experimenta...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms15023287

    authors： Vázquez-Tato MP,Mena-Menéndez A,Feás X,Seijas JA

    更新日期：2014-02-21 00:00:00

  • In Vivo and In Vitro Mechanical Loading of Mouse Achilles Tendons and Tenocytes-A Pilot Study.

    abstract：:Mechanical force is a key factor for the maintenance, adaptation, and function of tendons. Investigating the impact of mechanical loading in tenocytes and tendons might provide important information on in vivo tendon mechanobiology. Therefore, the study aimed at understanding if an in vitro loading set up of tenocytes...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21041313

    authors： Fleischhacker V,Klatte-Schulz F,Minkwitz S,Schmock A,Rummler M,Seliger A,Willie BM,Wildemann B

    更新日期：2020-02-15 00:00:00

  • Hedgehog Signaling in Lung Cancer: From Oncogenesis to Cancer Treatment Resistance.

    abstract：:Hedgehog signaling pathway is physiologically activated during embryogenesis, especially in lung development. It is also reactivated in many solid tumors. In lung cancer, Hedgehog pathway is closely associated with cancer stem cells (CSCs). Recent works have shown that CSCs produced a full-length Sonic Hedgehog (Shh) ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19092835

    authors： Giroux-Leprieur E,Costantini A,Ding VW,He B

    更新日期：2018-09-19 00:00:00

  • Hsa-let-7g miRNA targets caspase-3 and inhibits the apoptosis induced by ox-LDL in endothelial cells.

    abstract：:It has been well confirmed ox-LDL plays key roles in the development of atherosclerosis via binding to LOX-1 and inducing apoptosis in vascular endothelial cells. Recent studies have shown ox-LDL can suppress microRNA has-let-7g, which in turn inhibits the ox-LDL induced apoptosis. However, details need to be uncovere...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms141122708

    authors： Zhang Y,Chen N,Zhang J,Tong Y

    更新日期：2013-11-18 00:00:00

  • Vortioxetine Subchronically Activates Serotonergic Transmission via Desensitization of Serotonin 5-HT1A Receptor with 5-HT3 Receptor Inhibition in Rats.

    abstract：:Vortioxetine is a novel, multimodal antidepressant with unique targets, including the inhibition of the serotonin transporter (SET), of serotonin 5-HT3 (5-HT3R), and of 5-HT7 (5-HT7R) receptors and partial agonism to serotonin 5-HT1A (5-HT1AR) receptors in humans. Vortioxetine has a lower affinity to 5-HT1AR and 5-HT7...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20246235

    authors： Okada M,Okubo R,Fukuyama K

    更新日期：2019-12-10 00:00:00

  • Combined 3D-QSAR modeling and molecular docking studies on pyrrole-indolin-2-ones as Aurora A kinase inhibitors.

    abstract：:Aurora kinases have emerged as attractive targets for the design of anticancer drugs. 3D-QSAR (comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA)) and Surflex-docking studies were performed on a series of pyrrole-indoline-2-ones as Aurora A inhibitors. The CoMFA...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms12031605

    authors： Ai Y,Wang ST,Sun PH,Song FJ

    更新日期：2011-01-01 00:00:00

  • Impact of Mechanical Load on the Expression Profile of Synovial Fibroblasts from Patients with and without Osteoarthritis.

    abstract：:Osteoarthritis (OA) affects the integrity of the entire joint including the synovium. The most abundant cells in the synovium are fibroblasts (SF). Excessive mechanical loading might contribute to OA pathogenesis. Here, we investigate the effects of mechanical loading on SF derived from non-OA (N-SF) and OA patients (...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20030585

    authors： Schröder A,Nazet U,Muschter D,Grässel S,Proff P,Kirschneck C

    更新日期：2019-01-30 00:00:00

  • Gut Microbiota and Type 1 Diabetes.

    abstract：:Recently, the onset of type 1 diabetes (T1D) has increased rapidly and became a major public health concern worldwide. Various factors are associated with the development of T1D, such as diet, genome, and intestinal microbiota. The gastrointestinal (GI) tract harbors a complex and dynamic population of microorganisms,...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms19040995

    authors： Han H,Li Y,Fang J,Liu G,Yin J,Li T,Yin Y

    更新日期：2018-03-27 00:00:00

  • Evolutionary Toxicogenomics of the Striped Killifish (Fundulus majalis) in the New Bedford Harbor (Massachusetts, USA).

    abstract：:In this paper, we used a Genotyping-by-Sequencing (GBS) approach to find and genotype more than 4000 genome-wide SNPs (Single Nucleotide Polymorphisms) from striped killifish exposed to a variety of polychlorinated biphenyls (PCBs) and other aromatic pollutants in New Bedford Harbor (NBH, Massachusetts, USA). The aims...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms20051129

    authors： Ruggeri P,Du X,Crawford DL,Oleksiak MF

    更新日期：2019-03-05 00:00:00

  • Downregulation of FOXP1 Inhibits Cell Proliferation in Hepatocellular Carcinoma by Inducing G1/S Phase Cell Cycle Arrest.

    abstract：:Forkhead box P1 (FOXP1) belongs to a family of winged-helix transcription factors that are involved in the processes of cellular proliferation, differentiation, metabolism, and longevity. FOXP1 can affect cell proliferation and migratory ability in hepatocellular carcinoma (HCC) in vitro. However, little is known abou...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms17091501

    authors： Wang X,Sun J,Cui M,Zhao F,Ge C,Chen T,Yao M,Li J

    更新日期：2016-09-08 00:00:00

  • Hypercholesterolemia Interferes with Induction of miR-125b-1-3p in Preconditioned Hearts.

    abstract：:Ischemic preconditioning (IPre) reduces ischemia/reperfusion (I/R) injury in the heart. The non-coding microRNA miR-125b-1-3p has been demonstrated to play a role in the mechanism of IPre. Hypercholesterolemia is known to attenuate the cardioprotective effect of preconditioning; nevertheless, the exact underlying mech...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21113744

    authors： Szabó MR,Gáspár R,Pipicz M,Zsindely N,Diószegi P,Sárközy M,Bodai L,Csont T

    更新日期：2020-05-26 00:00:00

  • Antimicrobial Resistance Profile of Planktonic and Biofilm Cells of Staphylococcus aureus and Coagulase-Negative Staphylococci.

    abstract：:The objective of the present study was to determine the antimicrobial resistance profile of planktonic and biofilm cells of Staphylococcus aureus and coagulase-negative staphylococci (CoNS). Two hundred Staphylococcus spp. strains were studied, including 50 S. aureus and 150 CoNS strains (50 S. epidermidis, 20 S. haem...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms17091423

    authors： de Oliveira A,Cataneli Pereira V,Pinheiro L,Moraes Riboli DF,Benini Martins K,Ribeiro de Souza da Cunha Mde L

    更新日期：2016-09-01 00:00:00

  • Alpha-Smooth Muscle Actin-Positive Perivascular Cells in Diabetic Retina and Choroid.

    abstract：:Structural alterations of pericytes in microvessels are important features of diabetic retinopathy. Although capillary pericytes had been known not to have α-smooth muscle actin (αSMA), a recent study revealed that a specific fixation method enabled the visualization of αSMA along retinal capillaries. In this study, w...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21062158

    authors： Kim SJ,Kim SA,Choi YA,Park DY,Lee J

    更新日期：2020-03-20 00:00:00

  • Synergy between Readthrough and Nonsense Mediated Decay Inhibition in a Murine Model of Cystic Fibrosis Nonsense Mutations.

    abstract：:Many heritable genetic disorders arise from nonsense mutations, which generate premature termination codons (PTCs) in transcribed mRNA. PTCs ablate protein synthesis by prematurely terminating the translation of mutant mRNA, as well as reducing mutant mRNA quantity through targeted degradation by nonsense-mediated dec...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22010344

    authors： McHugh DR,Cotton CU,Hodges CA

    更新日期：2020-12-31 00:00:00

  • Fatty Acids Composition of Vegetable Oils and Its Contribution to Dietary Energy Intake and Dependence of Cardiovascular Mortality on Dietary Intake of Fatty Acids.

    abstract：:Characterizations of fatty acids composition in % of total methylester of fatty acids (FAMEs) of fourteen vegetable oils--safflower, grape, silybum marianum, hemp, sunflower, wheat germ, pumpkin seed, sesame, rice bran, almond, rapeseed, peanut, olive, and coconut oil--were obtained by using gas chromatography (GC). S...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms160612871

    authors： Orsavova J,Misurcova L,Ambrozova JV,Vicha R,Mlcek J

    更新日期：2015-06-05 00:00:00

  • Combined Transcriptome and Proteome Analysis of Masson Pine (Pinus massoniana Lamb.) Seedling Root in Response to Nitrate and Ammonium Supplementations.

    abstract：:Nitrogen (N) is an essential nutrient for plant growth and development. Plant species respond to N fluctuations and N sources, i.e., ammonium or nitrate, differently. Masson pine (Pinus massoniana Lamb.) is one of the pioneer plants in the southern forests of China. It shows better growth when grown in medium containi...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21207548

    authors： Ren Q,Zhou Y,Zhou X

    更新日期：2020-10-13 00:00:00

  • Toward Drug-Like Multispecific Antibodies by Design.

    abstract：:The success of antibody therapeutics is strongly influenced by their multifunctional nature that couples antigen recognition mediated by their variable regions with effector functions and half-life extension mediated by a subset of their constant regions. Nevertheless, the monospecific IgG format is not optimal for ma...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21207496

    authors： Sawant MS,Streu CN,Wu L,Tessier PM

    更新日期：2020-10-12 00:00:00

  • Long-Lived Epidermal Cancer-Initiating Cells.

    abstract：:Non-melanomatous skin cancers (NMSCs), which include basal and squamous cell carcinoma (BCC and SCC respectively), represent a significant burden on the population, as well as an economic load to the health care system; yet treatments of these preventable cancers remain ineffective. Studies estimate that there has bee...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms18071369

    authors： Youssef M,Cuddihy A,Darido C

    更新日期：2017-06-27 00:00:00

  • Mesenchylmal Stem Cell Culture on Poly(N-isopropylacrylamide) Hydrogel with Repeated Thermo-Stimulation.

    abstract：:We prepared thermoresponsive hydrogels by mixing poly(N-isopropylacrylamide) (PNIPAAm) derivatives as the main chain components, octa-arm polyethylene glycol (PEG) as a crosslinker, and the Arg-Gly-Asp-Ser (RGDS) peptides as cell adhesion units. Human bone marrow-derived mesenchymal stem cells (hbmMSCs) were cultured ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19041253

    authors： Akimoto AM,Niitsu EH,Nagase K,Okano T,Kanazawa H,Yoshida R

    更新日期：2018-04-21 00:00:00

  • The Proteome and Citrullinome of Hippoglossus hippoglossus Extracellular Vesicles-Novel Insights into Roles of the Serum Secretome in Immune, Gene Regulatory and Metabolic Pathways.

    abstract：:Extracellular vesicles (EVs) are lipid bilayer vesicles which are released from cells and play multifaceted roles in cellular communication in health and disease. EVs can be isolated from various body fluids, including serum and plasma, and are usable biomarkers as they can inform health status. Studies on EVs are an ...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms22020875

    authors： Magnadóttir B,Kraev I,Dodds AW,Lange S

    更新日期：2021-01-16 00:00:00

  • Programming Effects of Prenatal Glucocorticoid Exposure with a Postnatal High-Fat Diet in Diabetes Mellitus.

    abstract：:Increasing evidence has shown that many chronic diseases originate from early life, even before birth, through what are termed as fetal programming effects. Glucocorticoids are frequently used prenatally to accelerate the maturation of the lungs of premature infants. High-fat diets are associated with insulin resistan...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms17040533

    authors： Sheen JM,Hsieh CS,Tain YL,Li SW,Yu HR,Chen CC,Tiao MM,Chen YC,Huang LT

    更新日期：2016-04-08 00:00:00

  • The Function of Transthyretin Complexes with Metallothionein in Alzheimer's Disease.

    abstract：:Alzheimer's disease (AD) is one of the most frequently diagnosed types of dementia in the elderly. An important pathological feature in AD is the aggregation and deposition of the β-amyloid (Aβ) in extracellular plaques. Transthyretin (TTR) can cleave Aβ, resulting in the formation of short peptides with less activity...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms21239003

    authors： Zaręba N,Kepinska M

    更新日期：2020-11-26 00:00:00

  • The Histone Deacetylase Inhibitor BML-210 Influences Gene and Protein Expression in Human Promyelocytic Leukemia NB4 Cells via Epigenetic Reprogramming.

    abstract：:Today, cancer is understood as an epigenetic as well as genetic disease. The main epigenetic hallmarks of the cancer cell are DNA methylation and histone modifications. Proteins such as histone deacetylases (HDACs) that cause modifications of histones and other proteins can be targets for novel anticancer agents. Rece...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms160818252

    authors： Borutinskaitė V,Navakauskienė R

    更新日期：2015-08-06 00:00:00

  • Potential of the NKG2D/NKG2DL Axis in NK Cell-Mediated Clearance of the HIV-1 Reservoir.

    abstract：:Viral persistency in latently infected CD4+ T cells despite antiretroviral therapy (ART) represents a major drawback in the fight against HIV-1. Efforts to purge latent HIV-1 have been attempted using latency reversing agents (LRAs) that activate expression of the quiescent virus. However, initial trials have shown th...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20184490

    authors： Desimio MG,Covino DA,Doria M

    更新日期：2019-09-11 00:00:00

  • Identification and biochemical characterization of protein phosphatase 5 from the cantharidin-producing blister beetle, Epicauta chinensis.

    abstract：:Protein phosphatase 5 (PP5) is a unique member of serine/threonine phosphatases which has been recognized in regulation of diverse cellular processes. A cDNA fragment encoding PP5 (EcPP5) was cloned and characterized from the cantharidin-producing blister beetle, E. chinensis. EcPP5 contains an open reading frame of 1...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms141224501

    authors： Chen X,Lü S,Zhang Y

    更新日期：2013-12-16 00:00:00

  • In Vitro Antitumor Active Gold(I) Triphenylphosphane Complexes Containing 7-Azaindoles.

    abstract：:A series of gold(I) complexes of the general composition [Au(naza)(PPh₃)] (1-8) was prepared and thoroughly characterized (e.g., electrospray ionization (ESI) mass spectrometry and multinuclear nuclear magnetic resonance (NMR) spectroscopy). The N1-deprotonated anions of 7-azaindole or its derivatives (naza) are coord...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms17122084

    authors： Štarha P,Trávníček Z,Drahoš B,Dvořák Z

    更新日期：2016-12-11 00:00:00

  • Circulating Cell-Free DNA as a Prognostic and Molecular Marker for Patients with Brain Tumors under Perillyl Alcohol-Based Therapy.

    abstract：:Tumor infiltration into brain tissue usually remains undetected even by high-resolution imaging. Molecular markers are used to increase diagnostic accuracy, but with limited continuous monitoring application. We evaluated the potential of circulating cell-free DNA (cfDNA) as a molecular indicator of the response to th...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms19061610

    authors： Faria G,Silva E,Da Fonseca C,Quirico-Santos T

    更新日期：2018-05-30 00:00:00

  • Protective Effect of CXCR4 Antagonist CX807 in a Rat Model of Hemorrhagic Stroke.

    abstract：:Intracerebral hemorrhage (ICH) is a major cause of stroke, with high mortality and morbidity. There is no effective pharmacological therapy for ICH. Previous studies have indicated that CXCR4 antagonists reduced microglia activation, attenuated infiltration of T cells, and improved functional recovery in ischemic stro...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章

    doi：10.3390/ijms21197085

    authors： Yu SJ,Wu KJ,Wang YS,Song JS,Wu CH,Jan JJ,Bae E,Chen H,Shia KS,Wang Y

    更新日期：2020-09-25 00:00:00

  • Regulation of Dual-Specificity Phosphatase (DUSP) Ubiquitination and Protein Stability.

    abstract：:Mitogen-activated protein kinases (MAPKs) are key regulators of signal transduction and cell responses. Abnormalities in MAPKs are associated with multiple diseases. Dual-specificity phosphatases (DUSPs) dephosphorylate many key signaling molecules, including MAPKs, leading to the regulation of duration, magnitude, or...

    journal_title：International journal of molecular sciences

    pub_type： 杂志文章,评审

    doi：10.3390/ijms20112668

    authors： Chen HF,Chuang HC,Tan TH

    更新日期：2019-05-30 00:00:00