Abstract：
:Hedgehog signaling pathway is physiologically activated during embryogenesis, especially in lung development. It is also reactivated in many solid tumors. In lung cancer, Hedgehog pathway is closely associated with cancer stem cells (CSCs). Recent works have shown that CSCs produced a full-length Sonic Hedgehog (Shh) protein, with paracrine activity and induction of tumor development. Hedgehog pathway is also involved in tumor drug resistance in lung cancer, as cytotoxic chemotherapy, radiotherapy, and targeted therapies. This review proposes to describe the activation mechanisms of Hedgehog pathway in lung cancer, the clinical implications for overcoming drug resistance, and the perspectives for further research.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Giroux-Leprieur E,Costantini A,Ding VW,He Bdoi
10.3390/ijms19092835subject
Has Abstractpub_date
2018-09-19 00:00:00issue
9issn
1422-0067pii
ijms19092835journal_volume
19pub_type
杂志文章,评审abstract：:Colorectal cancer (CRC) is one of the most common malignant diseases worldwide, but the involved signaling pathways and driven-genes are largely unclear. This study integrated four cohorts profile datasets to elucidate the potential key candidate genes and pathways in CRC. Expression profiles GSE28000, GSE21815, GSE44...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18040722
更新日期：2017-03-28 00:00:00
abstract：:Advances in the use of targeted and immune therapies have revolutionized the clinical management of melanoma patients, prolonging significantly their overall and progression-free survival. However, both targeted and immune therapies suffer limitations due to genetic mutations and epigenetic modifications, which determ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21124544
更新日期：2020-06-26 00:00:00
abstract：:Accumulation of glycogen in the kidney and liver is the main feature of Fanconi-Bickel Syndrome (FBS), a rare disorder of carbohydrate metabolism inherited in an autosomal recessive manner due to SLC2A2 gene mutations. Missense, nonsense, frame-shift (fs), in-frame indels, splice site, and compound heterozygous varian...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21176286
更新日期：2020-08-31 00:00:00
abstract：:Cannabinoids, the biologically active constituents of Cannabis, have potent neuronal and immunological effects. However, the basic and medical research dedicated to medical cannabis and cannabinoids is limited. The influence of these treatments on hematologic reconstitution and on the development of graft versus host ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20030668
更新日期：2019-02-04 00:00:00
abstract：:Reactive oxygen species (ROS) are not only harmful to cell survival but also essential to cell signaling through cysteine-based redox switches. In fact, ROS triggers the potential activation of mitogen-activated protein kinases (MAPKs). The 90 kDa ribosomal S6 kinase 1 (RSK1), one of the downstream mediators of the MA...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21228750
更新日期：2020-11-19 00:00:00
abstract：:Phostensin is encoded by KIAA1949. 5'-RACEanalysis has been used to identify the translation start site of phostensin mRNA, indicating that it encodes 165 amino acids with an apparent molecular weight of 26 kDa on SDS-PAGE. This low-molecular-weight phostensin is present in human peripheral blood mononuclear cells and...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15011068
更新日期：2014-01-15 00:00:00
abstract：:Recently, we used a recombinant produced C-terminus (D194-F319) of the Clostridium perfringens enterotoxin (C-CPE) to functionalize gold nanoparticles (AuNPs) for a subsequent specific killing of claudin expressing tumor cells using the gold nanoparticle-mediated laser perforation (GNOME-LP) technique. For a future in...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20174248
更新日期：2019-08-30 00:00:00
abstract：:CDK5RAP3 was regarded as the most significant regulator of cellular responses against heat stress, which is associated with dysfunctions of the immune system and animal susceptibility to disease. Despite this, little known about how CDK5RAP3 regulates heat stress response. In this study, CDK5RAP3 conditional Knockout ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218400
更新日期：2020-11-09 00:00:00
abstract：:Adsorption of precious metals in acidic aqueous solutions using thiourea modified magnetic magnetite nanoparticle (MNP-Tu) was examined. The MNP-Tu was synthesized, characterized and examined as a reusable adsorbent for the recovery of precious metals. The adsorption kinetics were well fitted with pseudo second-order e...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14059834
更新日期：2013-05-08 00:00:00
abstract：:This study describes the simple synthesis of new (quinazolin-4-ylamino) methylphosphonates via microwave irradiation. Substituted-2-aminobenzonitrile reacted with 1,1-dimethoxy-N,N-dimethylmethanamine at a reflux condition to obtain N'-(substituted-2-cyanophenyl)-N,N-dimethylformamidine (1). The subsequent reaction of...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13066730
更新日期：2012-01-01 00:00:00
abstract：:Plants have evolved strategies to tightly regulate metabolism during acclimation to a changing environment. Low temperature significantly constrains distribution, growth and yield of many temperate plant species. Exposing plants to low but non-freezing temperature induces a multigenic processes termed cold acclimation...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20215411
更新日期：2019-10-30 00:00:00
abstract：BACKGROUND:Vinegars based on fruit juices could conserve part of the health-associated compounds present in the fruits. However, in general very limited knowledge exists on the consequences of vinegar-making on different antioxidant compounds from fruit. In this study vinegars derived from apple and grape are studied. ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17101658
更新日期：2016-09-29 00:00:00
abstract：:Dietary guidelines recommended by key health agencies are generally designed for a global population. However, ethnicity affects human disease and environment-gene interactions, including nutrient intake. Historically, isolated human populations with different genetic backgrounds have adapted to distinct environments ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20143516
更新日期：2019-07-18 00:00:00
abstract：:The paper presents a detailed study of the biological effects of two amino acid hydroxyurea derivatives that showed selective antiproliferative effects in vitro on the growth of human tumor cell line SW620. Tested compounds induced cell cycle perturbations and apoptosis. Proteins were identified by proteomics analyses...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms141223654
更新日期：2013-12-04 00:00:00
abstract：:Genistein has been reported to stimulate luminal HCO3(-) secretion. We hypothesized that genistein mediates this effect via SLC26A6 and SLC4A4 (NBCe1) transporters. Our study aimed to: investigate changes in uterine fluid pH, Na+ and HCO3(-) concentration and expression of uterine SLC26A6 and NBCe1 under genistein eff...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15010958
更新日期：2014-01-10 00:00:00
abstract：:Drought stress is a major obstacle to agriculture. Although many studies have reported on plant drought tolerance achieved via genetic modification, application of plant growth-promoting rhizobacteria (PGPR) to achieve tolerance has rarely been studied. In this study, the ability of three isolates, including Bacillus ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246271
更新日期：2019-12-12 00:00:00
abstract：:Copper is an essential microelement that plays an important role in a wide variety of biological processes. Copper concentration has to be finely regulated, as any imbalance in its homeostasis can induce abnormalities. In particular, excess copper plays an important role in the etiopathogenesis of the genetic disease ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21031069
更新日期：2020-02-06 00:00:00
abstract：:Hepatic diseases, like viral hepatitis, autoimmune hepatitis, hereditary hemochromatosis, non-alcoholic fatty liver disease (NAFLD) and Wilson's disease, play an important role in the development of liver cirrhosis and, hence, hepatocellular carcinoma. In this review, the current treatment options and the molecular me...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms15057500
更新日期：2014-04-30 00:00:00
abstract：:Adolescence represents a vulnerable period for the psychiatric consequences of delta9-tetrahydrocannabinol (Δ⁸-THC) exposure, however, the molecular underpinnings of this vulnerability remain to be established. Histone modifications are emerging as important epigenetic mechanisms involved in the etiopathogenesis of ps...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18102094
更新日期：2017-10-04 00:00:00
abstract：:Human leukocyte antigen (HLA) class I ligands and Killer immunoglobulin-like receptors (KIRs) regulate the cytolytic activity of natural killer (NK) cells and certain T cells. We examined their genetic predisposition to disease susceptibility and clinical phenotypes in Taiwanese ankylosing spondylitis (AS) patients. K...
journal_title：International journal of molecular sciences
pub_type： 临床试验,杂志文章
doi：10.3390/ijms18081775
更新日期：2017-08-16 00:00:00
abstract：:During plant-pathogen interactions, plants have to relocate their resources including energy to defend invading organisms; as a result, plant growth and development are usually reduced. Arabidopsis signal responsive1 (AtSR1) has been documented as a negative regulator of plant immune responses and could serve as a pos...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19061764
更新日期：2018-06-14 00:00:00
abstract：:Notwithstanding the widespread use and promising clinical value of chemotherapy, the pharmacokinetics, toxicology, and mechanism of mitoxantrone remains unclear. To promote the clinical value in the treatment of human diseases and the exploration of potential subtle effects of mitoxantrone, zebrafish embryos were empl...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19113516
更新日期：2018-11-08 00:00:00
abstract：:Lupus nephritis (LN) is one of the most common and severe complications of lupus. However, the mechanisms for renal damage have not been well elucidated. There are evidences show that glomerular endothelial cells (GECs) are damaged in LN. Immune complexes can deposit in subendothelial area and could affect GEC functio...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20215281
更新日期：2019-10-24 00:00:00
abstract：:Pectin methylesterase inhibitor genes (PMEIs) are a large multigene family and play crucial roles in cell wall modifications in plant growth and development. Here, a comprehensive analysis of the PMEI gene family in Brassicacampestris, an important leaf vegetable, was performed. We identified 100 BrassicacampestrisPME...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19051338
更新日期：2018-05-02 00:00:00
abstract：:Multiple sclerosis is a potentially debilitating disease of the central nervous system. A concerted program of research by many centers around the world has consistently demonstrated the importance of the immune system in its pathogenesis. This knowledge has led to the formal testing of a number of therapeutic agents ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms131012665
更新日期：2012-10-04 00:00:00
abstract：:Cisplatin is one of the most widely used chemical drugs for anticancer treatment. Recent studies have focused on the ability of cisplatin to retain the high mobility group box 1 (HMGB1) protein in cisplatin-DNA adducts, thereby preventing its release from the nucleus. Because HMGB1 is a powerful inflammatory mediator ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140611224
更新日期：2013-05-27 00:00:00
abstract：:Platelets (PLT) are the second most abundant cell type in human blood and exert various immune-regulatory functions under both physiological and pathological conditions. In fact, immune cell regulation via platelets has been demonstrated in several studies within the past decade. However, the exact mechanisms behind T...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21207507
更新日期：2020-10-12 00:00:00
abstract：:The emergence of multidrug resistance is always associated with more rapid tumor recurrence and metastasis. P-glycoprotein (P-gp), which is a well-known multidrug-efflux transporter, confers enhanced invasion ability in drug-resistant cells. Previous studies have shown that P-gp probably exerts its tumor-promoting fun...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17101718
更新日期：2016-10-13 00:00:00
abstract：:Pancreatic cancer remains one of the deadliest cancers in the world, as a consequence of late diagnosis, early metastasis and limited response to chemotherapy, under which conditions the potential mechanism of pancreatic cancer progression requires further study. Exosomes are membrane vesicles which are important in t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20184332
更新日期：2019-09-04 00:00:00
abstract：:Human leukocyte antigen (HLA) class II molecule influences host antigen presentation and anti-viral immune response. The aim of this study was to investigate whether single nucleotide polymorphisms (SNPs) within HLA class II gene were associated with different clinical outcomes of hepatitis C virus (HCV) infection. Th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160816792
更新日期：2015-07-23 00:00:00
