Abstract:
:Colorectal cancer (CRC) is one of the most common malignant diseases worldwide, but the involved signaling pathways and driven-genes are largely unclear. This study integrated four cohorts profile datasets to elucidate the potential key candidate genes and pathways in CRC. Expression profiles GSE28000, GSE21815, GSE44076 and GSE75970, including 319 CRC and 103 normal mucosa, were integrated and deeply analyzed. Differentially expressed genes (DEGs) were sorted and candidate genes and pathways enrichment were analyzed. DEGs-associated protein-protein interaction network (PPI) was performed. Firstly, 292 shared DEGs (165 up-regulated and 127 down-regulated) were identified from the four GSE datasets. Secondly, the DEGs were clustered based on functions and signaling pathways with significant enrichment analysis. Thirdly, 180 nodes/DEGs were identified from DEGs PPI network complex. Lastly, the most significant 2 modules were filtered from PPI, 31 central node genes were identified and most of the corresponding genes are involved in cell cycle process, chemokines and G protein-coupled receptor signaling pathways. Taken above, using integrated bioinformatical analysis, we have identified DEGs candidate genes and pathways in CRC, which could improve our understanding of the cause and underlying molecular events, and these candidate genes and pathways could be therapeutic targets for CRC.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Guo Y,Bao Y,Ma M,Yang Wdoi
10.3390/ijms18040722subject
Has Abstractpub_date
2017-03-28 00:00:00issue
4issn
1422-0067pii
ijms18040722journal_volume
18pub_type
杂志文章abstract::Enzymes containing flavin cofactors are predominantly involved in redox reactions in numerous cellular processes where the protein environment modulates the chemical reactivity of the flavin to either transfer one or two electrons. Some flavoenzymes catalyze reactions with no net redox change. In these reactions, the ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms131114219
更新日期:2012-11-05 00:00:00
abstract::Previously, we developed a novel microRNA (miRNA) delivery system based on bacteriophage MS2 virus-like particles (MS2 VLPs). In this current study, we used this system to transport miR-146a into human peripheral blood mononuclear cells (PBMCs), and demonstrated the inhibition of osteoclastogenesis in precursors. Two ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms16048337
更新日期:2015-04-14 00:00:00
abstract::Fabry disease (FD) is a lysosomal storage disorder caused by mutations of the GLA gene that lead to a deficiency of the enzymatic activity of α-galactosidase A. Available therapies for FD include enzyme replacement therapy (ERT) (agalsidase alfa and agalsidase beta) and the chaperone migalastat. Despite the large body...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms22010206
更新日期:2020-12-28 00:00:00
abstract::Frizzled receptors (FZDs) are a family of seven-span transmembrane receptors with hallmarks of G protein-coupled receptors (GPCRs) that serve as receptors for secreted Wingless-type (WNT) ligands in the WNT signaling pathway. Functionally, FZDs play crucial roles in regulating cell polarity, embryonic development, cel...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19051543
更新日期:2018-05-22 00:00:00
abstract::Humans express an expansive and detailed response to wavelength differences within the electromagnetic (EM) spectrum. This is most clearly manifest, and most studied, with respect to a relatively small range of electromagnetic radiation that includes the visible wavelengths with abutting ultraviolet and infrared, and ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21218020
更新日期:2020-10-28 00:00:00
abstract::Fetal programming implies that the maternal diet during pregnancy affects the long-term health of offspring. Although maternal diet influences metabolic disorders and non-alcoholic fatty liver disease in offspring, the hepatic mechanisms related to metabolites are still unknown. Here, we investigated the maternal diet...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21239060
更新日期:2020-11-28 00:00:00
abstract::The phototoxic effect of hypericin can be utilized for Photodynamic Therapy (PDT) of cancer. After intravenous application and systemic distribution of the drug in the patient's body, the tumor site is exposed to light. Subsequently, toxic reactive oxygen species (ROS) are generated, inducing tumor cell death. To prev...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18071388
更新日期:2017-06-29 00:00:00
abstract::Frataxin is a highly conserved protein whose deficiency results in the neurodegenerative disease Friederich's ataxia. Frataxin's actual physiological function has been debated for a long time without reaching a general agreement; however, it is commonly accepted that the protein is involved in the biosynthetic iron-su...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21249619
更新日期:2020-12-17 00:00:00
abstract::Intravenous iron preparations are typically classified as non-dextran-based or dextran/dextran-based complexes. The carbohydrate shell for each of these preparations is unique and is key in determining the various physicochemical properties, the metabolic pathway, and the immunogenicity of the iron-carbohydrate comple...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17071185
更新日期:2016-07-21 00:00:00
abstract::Fragile X syndrome (FXS) is a leading genetic disorder of intellectual disability caused by the loss of the functional fragile X mental retardation protein (FMRP). To date, there is no efficacious mechanism-based medication for FXS. With regard to potential disease mechanisms in FXS, it is widely accepted that the lac...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21239327
更新日期:2020-12-07 00:00:00
abstract::The micronutrients iron (Fe) and zinc (Zn) are not only essential for plant survival and proliferation but are crucial for human health. Increasing Fe and Zn levels in edible parts of plants, known as biofortification, is seen a sustainable approach to alleviate micronutrient deficiency in humans. Wheat, as one of the...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21239280
更新日期:2020-12-05 00:00:00
abstract::One of the hallmarks of the acute toxicity of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is a drastically reduced feed intake by an unknown mechanism. To further elucidate this wasting syndrome, we followed the effects of a single large dose (100 μg/kg) of TCDD on the serum levels of several energy balance-influencing...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms150813938
更新日期:2014-08-12 00:00:00
abstract::Patients with advanced skeletal metastases arising from primary cancers including breast, lung, and prostate suffer from extreme pain, bone loss, and frequent fractures. While the importance of interactions between bone and tumors is well-established, our understanding of complex cell-cell and cell-microenvironment in...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21186913
更新日期:2020-09-21 00:00:00
abstract::Ionic liquids, considered "green" chemicals, are widely used in many areas of analytical chemistry due to their unique properties. Recently, ionic liquids have been used as a kind of novel additive in separation and combined with silica to synthesize new stationary phase as separation media. This review will focus on ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms10062591
更新日期:2009-06-04 00:00:00
abstract::The paper presents a detailed study of the biological effects of two amino acid hydroxyurea derivatives that showed selective antiproliferative effects in vitro on the growth of human tumor cell line SW620. Tested compounds induced cell cycle perturbations and apoptosis. Proteins were identified by proteomics analyses...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms141223654
更新日期:2013-12-04 00:00:00
abstract::Hypoxia, which is common during tumor progression, plays important roles in tumor biology. Failure in cell death in response to hypoxia contributes to progression and metastasis of tumors. On the one hand, the metabolic and oxidative stress following hypoxia could lead to cell death by triggering signal cascades, like...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms161025536
更新日期:2015-10-23 00:00:00
abstract::G protein-coupled receptors are linked to various intracellular transducers, each pathway associated with different physiological effects. Biased ligands, capable of activating one pathway over another, are gaining attention for their therapeutic potential, as they could selectively activate beneficial pathways whilst...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21249728
更新日期:2020-12-20 00:00:00
abstract::It has been shown that activation of adenosine monophosphate-activated protein kinase (AMPK) suppresses proliferation of a variety of tumor cells as well as nonmalignant cells. In this study, we used post-transcriptional gene silencing with small interfering RNA (siRNA) to specifically examine the effect of AMPK on pu...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17060844
更新日期:2016-05-31 00:00:00
abstract::Powdery mildew caused by Blumeria graminis f. sp. hordei (Bgh) is one of the most serious diseases in barley. The numerous barley varieties across China provide valuable genetic resources to screen the resistant germplasm and to discover the primary genes of resistance to powdery mildew. In this study, Chinese barley ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21010151
更新日期:2019-12-24 00:00:00
abstract::Among serotonin receptors, the 5-HT6 subtype is the most controversial and the least known in the field of molecular mechanisms. The 5-HT6R ligands can be pivotal for innovative treatment of cognitive impairment, but none has reached pharmacological market, predominantly, due to insufficient "druglikeness" properties....
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20143420
更新日期:2019-07-12 00:00:00
abstract::Traumatic brain injury (TBI) modelled by lateral fluid percussion-induction (LFPI) in rats is a widely used experimental rodent model to explore and understand the underlying cellular and molecular alterations in the brain caused by TBI in humans. Current improvements in imaging with positron emission tomography (PET)...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22020951
更新日期:2021-01-19 00:00:00
abstract::Emodin, an active constituent of oriental herbs, is widely used to treat allergy, inflammation, and other symptoms. This study provides the scientific basis for the anti-inflammasome effects of emodin on both in vitro and in vivo experimental models. Bone marrow-derived macrophages were used to study the effects of em...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms16048102
更新日期:2015-04-10 00:00:00
abstract::Cell therapy is an innovative strategy for tissue repair, since adult stem cells could have limited regenerative ability as in the case of myocardial damage. This leads to a local contractile dysfunction due to scar formation. For these reasons, refining strategy approaches for "in vitro" stem cell commitment, prepara...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19082324
更新日期:2018-08-08 00:00:00
abstract::Serotonin (5-HT) is a critical player in brain development and neuropsychiatric disorders. Fetal 5-HT levels can be influenced by several gestational factors, such as maternal genotype, diet, stress, medication, and immune activation. In this review, addressing both human and animal studies, we discuss how these gesta...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21165850
更新日期:2020-08-14 00:00:00
abstract::Nonylphenol polyethoxylates (NPnEOs), a major class of nonionic surfactants, can easily enter into aquatic environments through various pathways due to their wide applications, which leads to the extensive existence of their relative stable metabolites, namely nonylphenol (NP) and mono- to tri-ethoxylates. This study ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms15011255
更新日期:2014-01-17 00:00:00
abstract::In the endoplasmic reticulum (ER), misfolded and unfolded proteins are eliminated by a process called ER-associated protein degradation (ERAD) in order to maintain cell homeostasis. In the ERAD pathway, several ER-localized E3 ubiquitin ligases target ERAD substrate proteins for ubiquitination and subsequent proteasom...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17111829
更新日期:2016-11-02 00:00:00
abstract::The diagnosis and treatment of prostate cancer (PCa) is a major health-care concern worldwide. This cancer can manifest itself in many distinct forms and the transition from clinically indolent PCa to the more invasive aggressive form remains poorly understood. It is now universally accepted that glycan expression pat...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21239233
更新日期:2020-12-03 00:00:00
abstract::The maintenance of ordinal cell cycle phases is a critical biological process in cancer genesis, which is a crucial target for anti-cancer drugs. As an important natural isoquinoline alkaloid from Chinese herbal medicine, Berberine (BBR) has been reported to possess anti-cancer potentiality to induce cell cycle arrest...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19020327
更新日期:2018-01-23 00:00:00
abstract::Parkinson's disease (PD) is the second most common neurodegenerative disorder worldwide, mainly affecting the elderly. The disease progresses gradually, with core motor presentations and a multitude of non-motor manifestations. There are two neuropathological hallmarks of PD, the dopaminergic neuronal loss and the alp...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20215312
更新日期:2019-10-25 00:00:00
abstract:BACKGROUND:Gadolinium chloride (GdCl3) has been reported to attenuate liver injury caused by a variety of toxicants. Gap junctional intercellular communication (GJIC) is thought to be essential in controlling liver homeostasis and pathology. Here we evaluate the effects of GdCl3 on functional GJIC and connexin expressi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20153748
更新日期:2019-07-31 00:00:00