Abstract：
:Humans express an expansive and detailed response to wavelength differences within the electromagnetic (EM) spectrum. This is most clearly manifest, and most studied, with respect to a relatively small range of electromagnetic radiation that includes the visible wavelengths with abutting ultraviolet and infrared, and mostly with respect to the visual system. Many aspects of our biology, however, respond to wavelength differences over a wide range of the EM spectrum. Further, humans are now exposed to a variety of modern lighting situations that has, effectively, increased our exposure to wavelengths that were once likely minimal (e.g., "blue" light from devices at night). This paper reviews some of those biological effects with a focus on visual function and to a lesser extent, other body systems.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Buch J,Hammond Bdoi
10.3390/ijms21218020subject
Has Abstractpub_date
2020-10-28 00:00:00issue
21issn
1422-0067pii
ijms21218020journal_volume
21pub_type
杂志文章,评审abstract：:Diabetic nephropathy (DN) is the main cause of end-stage renal disease, which remains incurable. The progression of DN is associated with progressive and irreversible renal fibrosis and also high levels of adenosine. Our aim was to evaluate the effects of ADORA3 antagonism on renal injury in streptozotocin-induced dia...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184531
更新日期：2019-09-13 00:00:00
abstract：:Neurodegenerative proteinopathies are complex diseases that share some pathogenetic processes. One of these is the failure of the proteostasis network (PN), which includes all components involved in the synthesis, folding, and degradation of proteins, thus leading to the aberrant accumulation of toxic protein aggregat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21176405
更新日期：2020-09-03 00:00:00
abstract：:Mesenchymal stem cells (MSCs) are a promising therapy to improve vascular repair, yet their role in ischemic retinopathy is not fully understood. The aim of this study is to investigate the impact of modulating the neurotrophin receptor; p75NTR on the vascular protection of MSCs in an acute model of retinal ischemia/r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22020829
更新日期：2021-01-15 00:00:00
abstract：:Gain-of-function mutations in human androgen receptor (AR) are among the major causes of drug resistance in prostate cancer (PCa). Identifying mutations that cause resistant phenotype is of critical importance for guiding treatment protocols, as well as for designing drugs that do not elicit adverse responses. However...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21165847
更新日期：2020-08-14 00:00:00
abstract：:Lonicera japonica Thunb. is a widely used medicinal plant and is rich in a variety of active ingredients. Flavonoids are one of the important components in L. japonica and their content is an important indicator for evaluating the quality of this herb. To study the regulation of flavonoid biosynthesis in L. japonica, ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184494
更新日期：2019-09-11 00:00:00
abstract：:The lack of effective Alzheimer's disease treatment is becoming a challenge for researchers and prompts numerous attempts to search for and develop better therapeutic solutions. Compounds that affect several routes of the neurodegeneration cascade leading to the development of disease are of particular interest. An ex...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21082749
更新日期：2020-04-15 00:00:00
abstract：:Synthesis of the CCA end of essential tRNAs is performed either by CCA-adding enzymes or as a collaboration between enzymes restricted to CC- and A-incorporation. While the occurrence of such tRNA nucleotidyltransferases with partial activities seemed to be restricted to Bacteria, the first example of such split CCA-a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21020462
更新日期：2020-01-10 00:00:00
abstract：:Auxin plays crucial roles in multiple developmental processes, such as embryogenesis, organogenesis, cell determination and division, as well as tropic responses. These processes are finely coordinated by the auxin, which requires the polar distribution of auxin within tissues and cells. The intercellular directionali...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19092759
更新日期：2018-09-14 00:00:00
abstract：:Most pharmaceutical substances interact with several or even many molecular targets in the organism, determining the complex profiles of their biological activity. Moreover, due to biotransformation in the human body, they form one or several metabolites with different biological activity profiles. Therefore, the deve...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21207492
更新日期：2020-10-11 00:00:00
abstract：:p-Sulfonatocalixarenes are a special class of water soluble macrocyclic molecules made of 4-hydroxybenzenesulfonate units linked by methylene bridges. One of the main features of these compounds relies on their ability to form inclusion complexes with cationic and neutral species. This feature, together with their wat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14023140
更新日期：2013-02-04 00:00:00
abstract：:Kinetic studies of the early events in cytochrome c folding are reviewed with a focus on the evidence for folding intermediates on the submillisecond timescale. Evidence from time-resolved absorption, circular dichroism, magnetic circular dichroism, fluorescence energy and electron transfer, small-angle X-ray scatteri...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms10041476
更新日期：2009-04-01 00:00:00
abstract：:Bradyrhizobium japonicum is a nitrogen-fixing symbiont of soybean. In previous studies, transcriptomic profiling of B. japonicum USDA110, grown under various environmental conditions, revealed the highly induced gene aceA, encoding isocitrate lyase (ICL). The ICL catalyzes the conversion of isocitrate to succinate and...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160716695
更新日期：2015-07-22 00:00:00
abstract：:Oxidative damages induced by a redox imbalance cause age-related changes in cells and tissues. Superoxide dismutase (SOD) enzymes play a major role in the antioxidant system and they also catalyze superoxide radicals (O2·-). Since the loss of cytoplasmic SOD (SOD1) resulted in aging-like phenotypes in several types of...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140610998
更新日期：2013-05-24 00:00:00
abstract：:Antibacterial bonding agents and composites containing dimethylaminododecyl methacrylate (DMADDM) have been recently developed. The objectives of this study were to investigate the antibacterial effect of novel adhesives containing different mass fractions of DMADDM on Streptococcus mutans (S. mutans) biofilm at diffe...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms150712791
更新日期：2014-07-18 00:00:00
abstract：:We recently isolated stem cells derived from the brain of a bovine fetus, utilizing a particular mechanical separation method. After improving our experimental conditions, we obtained neural stem cells using an optimized culture medium system. The cells were expanded, established in continuous cell culture and used fo...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16035990
更新日期：2015-03-13 00:00:00
abstract：:Omega-3 fatty acids are important to pregnancy and neonatal development and health. One mechanism by which omega-3 fatty acids exert their protective effects is through serving as substrates for the generation of specialized pro-resolving lipid mediators (SPM) that potently limit and resolve inflammatory processes. We...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184402
更新日期：2019-09-07 00:00:00
abstract：:Human chorionic gonadotropin (hCG) is no longer a single, omnipotent ovulation triggering option. Gonadotropin releasing hormone (GnRH) agonist, initially presented as a substitute for hCG, has led to a new era of administering GnRH agonist followed by hCG triggering. According to this new concept, GnRH agonist enable...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18051075
更新日期：2017-05-17 00:00:00
abstract：BACKGROUND:Autologous fat transfer in the form of lipoaspirates for the reconstruction of the breast after breast cancer surgery is a commonly used procedure in plastic surgery. However, concerns regarding the oncologic risk of nutrient-rich fat tissue are widely debated. Previous studies have primarily focused on stud...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21239171
更新日期：2020-12-01 00:00:00
abstract：:SDS-gradient mini-gel electrophoresis and immunoblotting of urine of rats given ochratoxin A (OTA), showed OTA binding to an alpha2u-globulin. Perceived potential internalised delivery of OTA to proximal tubule epithelia by the carrier, specific only to adult male rats and augmenting other uptake mechanisms, suggests ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms9050719
更新日期：2008-05-01 00:00:00
abstract：:General cognitive (intelligence) function is substantially heritable, and is a major determinant of economic and health-related life outcomes. Cognitive impairments and intelligence decline are core features of schizophrenia which are evident before the onset of the illness. Genetic overlaps between cognitive impairme...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19123822
更新日期：2018-11-30 00:00:00
abstract：:Aluminum-activated malate transporters (ALMTs) play an important role in aluminum tolerance, stomatal opening, and fruit acidity in plants. However, the evolutionary pattern of the ALMT gene family in apples remains relatively unknown. In this study, a total of 25 MdALMT genes were identified from the apple reference ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092807
更新日期：2018-09-18 00:00:00
abstract：:Aurora kinases have emerged as attractive targets for the design of anticancer drugs. 3D-QSAR (comparative molecular field analysis (CoMFA) and comparative molecular similarity indices analysis (CoMSIA)) and Surflex-docking studies were performed on a series of pyrrole-indoline-2-ones as Aurora A inhibitors. The CoMFA...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12031605
更新日期：2011-01-01 00:00:00
abstract：:A novel camptothecin analogue, (20S)-10,11-methylenedioxy-camptothecin (FL118), has been proven to show significant antitumor efficacy for a wide variety of solid tumors. However, the further development of FL118 is severely hindered due to its extremely poor water solubility and adverse side effects. Here, two series...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228495
更新日期：2020-11-11 00:00:00
abstract：:LEAFY (LFY) and UNUSUAL FLORAL ORGANS (UFO) homologous genes have been reported to play key roles in promoting the initiation of floral meristems in raceme- and cyme-type plants. Asteraceae, a large family of plants with more than 23,000 species, has a unique head-like inflorescence termed capitulum. Here, we report a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20102503
更新日期：2019-05-21 00:00:00
abstract：:Diabetes and respiratory diseases are frequently comorbid conditions. However, the mechanistic links between hyperglycemia and lung dysfunction are not entirely understood. This study examined the effects of high sucrose intake on lung mechanics and alveolar septal composition and tested voluntary activity as an inter...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20102438
更新日期：2019-05-17 00:00:00
abstract：:Endonuclease IV (EndoIV) is a DNA damage-specific endonuclease that mainly hydrolyzes the phosphodiester bond located at 5' of an apurinic/apyrimidinic (AP) site in DNA. EndoIV also possesses 3'-exonuclease activity for removing 3'-blocking groups and normal nucleotides. Here, we report that Thermococcus eurythermalis...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20010069
更新日期：2018-12-24 00:00:00
abstract：:3,3'-Diindolylmethane (DIM) is a naturally derived chemopreventive compound. It comes from glucobrassicin, an indole glucosinolate enriched in cruciferous vegetables, and is formed in the acidic environment of the stomach after ingestion. Mouse double minute 2 homolog (MDM2) is an important, multi-functional oncogenic...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21134642
更新日期：2020-06-30 00:00:00
abstract：:Neurodegenerative diseases are characterized by adverse cellular environments and pathological alterations causing neurodegeneration in distinct brain regions. This development is triggered or facilitated by conditions such as hypoxia, ischemia or inflammation and is associated with disruptions of fundamental cellular...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms22020582
更新日期：2021-01-08 00:00:00
abstract：:Triple-negative breast cancer (TNBC) is characterized by the lack of immunohistochemical staining for estrogen receptors (ER), progesterone receptors (PR), and lack of overexpression or amplification of human epidermal growth factor receptor 2 (HER2). Our aim was to investigate the expression of transmembrane protease...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140714659
更新日期：2013-07-12 00:00:00
abstract：:The regeneration of dental tissues is a still an unmet clinical need; in fact, no therapies have been completely successful in regenerating dental tissue complexes such as periodontium, which is also due to the lack of scaffolds that are able to guide and direct cell fate towards the reconstruction of different minera...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19113604
更新日期：2018-11-15 00:00:00
