Cell Death Conversion under Hypoxic Condition in Tumor Development and Therapy.


:Hypoxia, which is common during tumor progression, plays important roles in tumor biology. Failure in cell death in response to hypoxia contributes to progression and metastasis of tumors. On the one hand, the metabolic and oxidative stress following hypoxia could lead to cell death by triggering signal cascades, like LKB1/AMPK, PI3K/AKT/mTOR, and altering the levels of effective components, such as the Bcl-2 family, Atg and p62. On the other hand, hypoxia-induced autophagy can serve as a mechanism to turn over nutrients, so as to mitigate the adverse condition and then avoid cell death potentially. Due to the effective role of hypoxia, this review focuses on the crosstalk in cell death under hypoxia in tumor progression. Additionally, the illumination of cell death in hypoxia could shed light on the clinical applications of cell death targeted therapy.


Int J Mol Sci


Qiu Y,Li P,Ji C




Has Abstract


2015-10-23 00:00:00












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    pub_type: 杂志文章


    authors: Merlos Rodrigo MA,Molina-López J,Jimenez Jimenez AM,Planells Del Pozo E,Adam P,Eckschlager T,Zitka O,Richtera L,Adam V

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  • A Rice B-Box Protein, OsBBX14, Finely Regulates Anthocyanin Biosynthesis in Rice.

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    journal_title:International journal of molecular sciences

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    journal_title:International journal of molecular sciences

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Sgrignani J,Garofalo M,Matkovic M,Merulla J,Catapano CV,Cavalli A

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    pub_type: 杂志文章,评审


    authors: Zhang S,Chen N

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    journal_title:International journal of molecular sciences

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    journal_title:International journal of molecular sciences

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    pub_type: 杂志文章,评审


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    pub_type: 杂志文章,评审


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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Gupta A,Perez M,Lee KJ,Taylor JM,Farrow KN

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    pub_type: 杂志文章


    authors: Nørskov-Lauritsen L,Thomsen AR,Bräuner-Osborne H

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    pub_type: 杂志文章


    authors: Merolle M,Mongiardi MP,Piras M,Levi A,Falchetti ML

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Ko SY,Naora H

    更新日期:2020-07-30 00:00:00

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Korbecki J,Simińska D,Kojder K,Grochans S,Gutowska I,Chlubek D,Baranowska-Bosiacka I

    更新日期:2020-05-25 00:00:00

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Romano A,Feola A,Porcellini A,Gigantino V,Di Bonito M,Di Mauro A,Caggiano R,Faraonio R,Zuchegna C

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Bhattacharya A,Ashouri R,Fangman M,Mazur A,Garett T,Doré S

    更新日期:2021-01-23 00:00:00