Cell Death Conversion under Hypoxic Condition in Tumor Development and Therapy.

Abstract:

:Hypoxia, which is common during tumor progression, plays important roles in tumor biology. Failure in cell death in response to hypoxia contributes to progression and metastasis of tumors. On the one hand, the metabolic and oxidative stress following hypoxia could lead to cell death by triggering signal cascades, like LKB1/AMPK, PI3K/AKT/mTOR, and altering the levels of effective components, such as the Bcl-2 family, Atg and p62. On the other hand, hypoxia-induced autophagy can serve as a mechanism to turn over nutrients, so as to mitigate the adverse condition and then avoid cell death potentially. Due to the effective role of hypoxia, this review focuses on the crosstalk in cell death under hypoxia in tumor progression. Additionally, the illumination of cell death in hypoxia could shed light on the clinical applications of cell death targeted therapy.

journal_name

Int J Mol Sci

authors

Qiu Y,Li P,Ji C

doi

10.3390/ijms161025536

subject

Has Abstract

pub_date

2015-10-23 00:00:00

pages

25536-51

issue

10

issn

1422-0067

pii

ijms161025536

journal_volume

16

pub_type

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