Cell Death Conversion under Hypoxic Condition in Tumor Development and Therapy.


:Hypoxia, which is common during tumor progression, plays important roles in tumor biology. Failure in cell death in response to hypoxia contributes to progression and metastasis of tumors. On the one hand, the metabolic and oxidative stress following hypoxia could lead to cell death by triggering signal cascades, like LKB1/AMPK, PI3K/AKT/mTOR, and altering the levels of effective components, such as the Bcl-2 family, Atg and p62. On the other hand, hypoxia-induced autophagy can serve as a mechanism to turn over nutrients, so as to mitigate the adverse condition and then avoid cell death potentially. Due to the effective role of hypoxia, this review focuses on the crosstalk in cell death under hypoxia in tumor progression. Additionally, the illumination of cell death in hypoxia could shed light on the clinical applications of cell death targeted therapy.


Int J Mol Sci


Qiu Y,Li P,Ji C




Has Abstract


2015-10-23 00:00:00












  • Proteostasis and Proteotoxicity in the Network Medicine Era.

    abstract::Neurodegenerative proteinopathies are complex diseases that share some pathogenetic processes. One of these is the failure of the proteostasis network (PN), which includes all components involved in the synthesis, folding, and degradation of proteins, thus leading to the aberrant accumulation of toxic protein aggregat...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Lualdi M,Alberio T,Fasano M

    更新日期:2020-09-03 00:00:00

  • A Rice B-Box Protein, OsBBX14, Finely Regulates Anthocyanin Biosynthesis in Rice.

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Kim DH,Park S,Lee JY,Ha SH,Lee JG,Lim SH

    更新日期:2018-07-27 00:00:00

  • Antibacterial Free Fatty Acids and Monoglycerides: Biological Activities, Experimental Testing, and Therapeutic Applications.

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Yoon BK,Jackman JA,Valle-González ER,Cho NJ

    更新日期:2018-04-08 00:00:00

  • Gut Microbiota and Type 1 Diabetes.

    abstract::Recently, the onset of type 1 diabetes (T1D) has increased rapidly and became a major public health concern worldwide. Various factors are associated with the development of T1D, such as diet, genome, and intestinal microbiota. The gastrointestinal (GI) tract harbors a complex and dynamic population of microorganisms,...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Han H,Li Y,Fang J,Liu G,Yin J,Li T,Yin Y

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Cohen SI,Vendruscolo M,Dobson CM,Knowles TP

    更新日期:2011-01-01 00:00:00

  • Verification of the Saccharina japonica Translocon Tic20 and its Localization in the Chloroplast Membrane in Diatoms.

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Chen Z,Wang X,Li S,Yao J,Shao Z,Duan D

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Wei J,Han L,Song J,Chen M

    更新日期:2015-06-25 00:00:00

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Cheng D,Kong H,Li Y

    更新日期:2013-07-12 00:00:00

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Kur P,Kolasa-Wołosiuk A,Grabowska M,Kram A,Tarnowski M,Baranowska-Bosiacka I,Rzeszotek S,Piasecka M,Wiszniewska B

    更新日期:2021-01-27 00:00:00

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Baumann L,Segner H,Ros A,Knapen D,Vergauwen L

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Ambrosi N,Guerrieri D,Caro F,Sanchez F,Haeublein G,Casadei D,Incardona C,Chuluyan E

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Mou S,Shi L,Lin W,Liu Y,Shen L,Guan D,He S

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    pub_type: 杂志文章


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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Furukawa Y,Watanabe S,Okuyama S,Nakajima M

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Lanzilli M,Esercizio N,Vastano M,Xu Z,Nuzzo G,Gallo C,Manzo E,Fontana A,d'Ippolito G

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Brunkhorst R,Pfeilschifter W,Patyna S,Büttner S,Eckes T,Trautmann S,Thomas D,Pfeilschifter J,Koch A

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Koga F,Takemura K,Fukushima H

    更新日期:2018-09-15 00:00:00

  • Benzothiophenone Derivatives Targeting Mutant Forms of Estrogen Receptor-α in Hormone-Resistant Breast Cancers.

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Singh K,Munuganti RSN,Lallous N,Dalal K,Yoon JS,Sharma A,Yamazaki T,Cherkasov A,Rennie PS

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Leite AF,Janke L,Lv Z,Harms H,Richnow HH,Nikolausz M

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  • Formation of α-Farnesene in Tea (Camellia sinensis) Leaves Induced by Herbivore-Derived Wounding and Its Effect on Neighboring Tea Plants.

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Wang X,Zeng L,Liao Y,Li J,Tang J,Yang Z

    更新日期:2019-08-25 00:00:00

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Thiruvengadam M,Rekha K,Rajakumar G,Lee TJ,Kim SH,Chung IM

    更新日期:2016-11-16 00:00:00

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Yang X,Palasuberniam P,Kraus D,Chen B

    更新日期:2015-10-28 00:00:00

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    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Monserrat Sanz J,Bohórquez C,Gómez AM,Movasat A,Pérez A,Ruíz L,Diaz D,Sánchez AI,Albarrán F,Sanz I,Álvarez-Mon M

    更新日期:2020-09-18 00:00:00