Abstract：
:The paper presents a detailed study of the biological effects of two amino acid hydroxyurea derivatives that showed selective antiproliferative effects in vitro on the growth of human tumor cell line SW620. Tested compounds induced cell cycle perturbations and apoptosis. Proteins were identified by proteomics analyses using two-dimensional gel electrophoresis coupled to mass spectrometry, which provided a complete insight into the most probable mechanism of action on the protein level. Molecular targets for tested compounds were analyzed by cheminformatics tools. Zinc-dependent histone deacetylases were identified as potential targets responsible for the observed antiproliferative effect.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Saban N,Stepanić V,Vučinić S,Horvatić A,Cindrić M,Perković I,Zorc B,Oršolić N,Mintas M,Pavelić K,Pavelić SKdoi
10.3390/ijms141223654subject
Has Abstractpub_date
2013-12-04 00:00:00pages
23654-71issue
12issn
1422-0067pii
ijms141223654journal_volume
14pub_type
杂志文章abstract：BACKGROUND:Carbapenems (ertapenem, imipenem, meropenem) are used to treat multidrug-resistant (MDR-) and extensively drug-resistant tuberculosis (XDR-TB), even if the published evidence is limited, particularly when it is otherwise difficult to identify the recommended four active drugs to be included in the regimen. N...
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abstract：:The author wishes to make a change to the published paper [1].[...]. ...
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