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Anti-inflammatory effect of emodin via attenuation of NLRP3 inflammasome activation.

Abstract：

:Emodin, an active constituent of oriental herbs, is widely used to treat allergy, inflammation, and other symptoms. This study provides the scientific basis for the anti-inflammasome effects of emodin on both in vitro and in vivo experimental models. Bone marrow-derived macrophages were used to study the effects of emodin on inflammasome activation by using inflammasome inducers such as ATP, nigericin, and silica crystals. The lipopolysaccharide (LPS)-induced endotoxin shock model was employed to study the effect of emodin on in vivo efficacy. Emodin treatment attenuated interleukin (IL)-1β secretion via the inhibition of NOD-like receptor family, pyrin domain containing 3 (NLRP3) inflammasome activation induced by ATP, nigericin, and silica crystals. Further, emodin ameliorated the severity of NLRP3 inflammasome-mediated symptoms in LPS-induced endotoxin mouse models. This study is the first to reveal mechanism-based evidence, especially with respect to regulation of inflammasome activation, substantiating traditional claims of emodin in the treatment of inflammation-related disorders.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Han JW,Shim DW,Shin WY,Heo KH,Kwak SB,Sim EJ,Jeong JH,Kang TB,Lee KH

doi

10.3390/ijms16048102

subject

Has Abstract

pub_date

2015-04-10 00:00:00

pages

8102-9

issue

4

issn

1422-0067

pii

ijms16048102

journal_volume

16

pub_type

杂志文章

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