Abstract:
:Genomic DNA is constantly damaged by factors produced during natural metabolic processes as well as agents coming from the external environment. Considering such a wide array of damaging agents, eukaryotic cells have evolved a DNA damage response (DRR) that opposes the influence of deleterious factors. Despite the broad knowledge regarding DNA damage and repair, new areas of research are emerging. New players in the field of DDR are constantly being discovered. The aim of this study is to review current knowledge regarding the roles of sirtuins, heat shock proteins, long-noncoding RNAs and the circadian clock in DDR and distinguish new agents that may have a prominent role in DNA damage response and repair.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Kciuk M,Bukowski K,Marciniak B,Kontek Rdoi
10.3390/ijms21113934subject
Has Abstractpub_date
2020-05-30 00:00:00issue
11issn
1422-0067pii
ijms21113934journal_volume
21pub_type
杂志文章,评审abstract::Radiation has a wide variety of effects on the liver. Fibrosis is a concern in medical fields as one of the acute effects of high-dose irradiation, such as with cancer radiotherapies. Cancer is also an important concern following exposure to radiation. The liver has an active metabolism and reacts to radiations. In ad...
journal_title:International journal of molecular sciences
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