Abstract:
:Fractalkine/CX3C chemokine ligand 1 (CX3CL1) is a chemokine involved in the anticancer function of lymphocytes-mainly NK cells, T cells and dendritic cells. Its increased levels in tumors improve the prognosis for cancer patients, although it is also associated with a poorer prognosis in some types of cancers, such as pancreatic ductal adenocarcinoma. This work focuses on the 'hallmarks of cancer' involving CX3CL1 and its receptor CX3CR1. First, we describe signal transduction from CX3CR1 and the role of epidermal growth factor receptor (EGFR) in this process. Next, we present the role of CX3CL1 in the context of cancer, with the focus on angiogenesis, apoptosis resistance and migration and invasion of cancer cells. In particular, we discuss perineural invasion, spinal metastasis and bone metastasis of cancers such as breast cancer, pancreatic cancer and prostate cancer. We extensively discuss the importance of CX3CL1 in the interaction with different cells in the tumor niche: tumor-associated macrophages (TAM), myeloid-derived suppressor cells (MDSC) and microglia. We present the role of CX3CL1 in the development of active human cytomegalovirus (HCMV) infection in glioblastoma multiforme (GBM) brain tumors. Finally, we discuss the possible use of CX3CL1 in immunotherapy.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Korbecki J,Simińska D,Kojder K,Grochans S,Gutowska I,Chlubek D,Baranowska-Bosiacka Idoi
10.3390/ijms21103723subject
Has Abstractpub_date
2020-05-25 00:00:00issue
10issn
1422-0067pii
ijms21103723journal_volume
21pub_type
杂志文章,评审abstract::Heme oxygenase-1 (HO-1) is an intracellular enzyme that catalyzes the oxidation of heme to generate ferrous iron, carbon monoxide (CO), and biliverdin, which is subsequently converted to bilirubin. These products have anti-inflammatory, anti-oxidant, anti-apoptotic, and anti-thrombotic properties. Although HO-1 is exp...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20153628
更新日期:2019-07-24 00:00:00
abstract::The variety of metagenomes in current databases provides a rapidly growing source of information for comparative studies. However, the quantity and quality of supplementary metadata is still lagging behind. It is therefore important to be able to identify related metagenomes by means of the available sequence data alo...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms150712364
更新日期:2014-07-14 00:00:00
abstract::Earthworms express, as most animals, metallothioneins (MTs)-small, cysteine-rich proteins that bind d(10) metal ions (Zn(II), Cd(II), or Cu(I)) in clusters. Three MT homologues are known for Lumbricus rubellus, the common red earthworm, one of which, wMT-2, is strongly induced by exposure of worms to cadmium. This stu...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17010065
更新日期:2016-01-05 00:00:00
abstract::Background: Gastric glands grow and cells reach differentiation at weaning in rats. By considering that early weaning (EW) can affect the timing of development, we aimed to compare molecular and cellular markers of differentiation in pups and adults. Methods: Wistar rats were separated into suckling-control (S) and EW...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21010196
更新日期:2019-12-27 00:00:00
abstract::The glucocorticoid receptor (GR) is a transcription factor, which interacts with DNA and other cofactors to regulate gene transcription. Binding to other partners in the cell nucleus alters the diffusion properties of GR. Raster image correlation spectroscopy (RICS) was applied to quantitatively characterize the diffu...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18091855
更新日期:2017-08-25 00:00:00
abstract::Chitosan is an amino polysaccharide found in nature, which is biodegradable, nontoxic and biocompatible. It has versatile features and can be used in a variety of applications including films, packaging, and also in medical surgery. Recently a possibility to diversify chitosan properties has emerged by combining it wi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms12031908
更新日期:2011-01-01 00:00:00
abstract::Intracranial malignancies, such as primary brain cancers and brain-localized metastases derived from peripheral cancers, are particularly difficult to treat with therapeutic agents, because the blood-brain barrier (BBB) effectively minimizes brain entry of the vast majority of agents arriving from the systemic circula...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19123905
更新日期:2018-12-06 00:00:00
abstract:BACKGROUND:Nowadays, the molecular mechanisms governing TSD (temperature-dependent sex determination) or GSD + TE (genotypic sex determination + temperature effects) remain a mystery in fish. METHODS:We developed three all-female families of Nile tilapia (Oreochromis niloticus), and the family with the highest male ra...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19030689
更新日期:2018-02-28 00:00:00
abstract::The role of the collagen-platelet interaction is of crucial importance to the haemostatic response during both injury and pathogenesis of the blood vessel wall. Of particular interest is the high affinity interaction of the platelet transmembrane receptor, alpha 2 beta 1, responsible for firm attachment of platelets t...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms14022832
更新日期:2013-01-29 00:00:00
abstract::Interleukin-18 (IL-18) is a multi-functional immuno-mediator in the development and progression of many types of infectious and inflammatory diseases. In this study, we evaluated the contribution of IL-18 genotypes to renal cell carcinoma (RCC) in Taiwan via the genotyping of IL-18 -656 (A/C), -607 (A/C), and -137 (G/...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20071563
更新日期:2019-03-28 00:00:00
abstract::Microglia are first-line defense antigen-presenting phagocytes in the central nervous system. Activated microglial cells release pro-inflammatory cytokines and can trigger an oxidative burst. The amino acid glycine exerts anti-inflammatory, immunomodulatory and cytoprotective effects and influences cell volume regulat...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21030804
更新日期:2020-01-26 00:00:00
abstract::Intravenous administration of high-dose ascorbic acid (AA) has been reported as a treatment for cancer patients. However, cancer patients with renal failure cannot receive this therapy because high-dose AA infusion can have side effects. To solve this problem, we evaluated the antitumor activity of a lipophilic stable...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19020535
更新日期:2018-02-10 00:00:00
abstract::The regeneration of neurons is an important goal of neuroscience and clinical medicine. The electrical stimulation of cells is a promising technique to meet this goal. However, its efficiency highly depends on the electrochemical properties of the stimulation electrodes used. This work reports on the preparation and u...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20082013
更新日期:2019-04-24 00:00:00
abstract::As one of the major abiotic stresses, salinity stress may affect the physiology and biochemical components of Apocynum venetum L. To systematically evaluate the quality of Apocyni Veneti Folium (AVF) from the perspective of physiological and the wide variety of bioactive components response to various concentrations o...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19103042
更新日期:2018-10-05 00:00:00
abstract::Activated carbon honeycomb-monoliths with different textural properties were prepared by chemical activation of African palm shells with H(3)PO(4), ZnCl(2) and CaCl(2) aqueous solutions of various concentrations. The adsorbents obtained were characterized by N(2) adsorption at 77 K, and their carbon dioxide adsorption...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms13078388
更新日期:2012-01-01 00:00:00
abstract::Recovered blood supply after cerebral ischemia for a certain period of time fails to restore brain function, with more severe dysfunctional problems developing, called cerebral ischemia-reperfusion injury (CIR). CIR involves several extremely complex pathophysiological processes in which the interactions between key f...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18071599
更新日期:2017-07-24 00:00:00
abstract::Sarcopenia is primarily characterized by skeletal muscle disturbances such as loss of muscle mass, quality, strength, and physical performance. It is commonly seen in elderly patients with chronic diseases. The prevalence of sarcopenia in chronic heart failure (HF) patients amounts to up to 20% and may progress into c...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21186549
更新日期:2020-09-08 00:00:00
abstract::The dried roots of Euphorbia kansui (kansui) have been used for centuries in China as a herbal medicine for edema, ascites, and asthma. The 95% ethanol extract showed a significant inhibition of cell proliferation against human normal cell lines L-O2 and GES-1. Bioassay-guided separation of the 95% ethanol extract fro...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms130911247
更新日期:2012-01-01 00:00:00
abstract::This study aimed to express heterologously the lipase LipA from Pseudomonas aeruginosa PSA01 obtained from palm fruit residues. In previous approaches, LipA was expressed in Escherichia coli fused with its signal peptide and without its disulfide bond, displaying low activity. We cloned the mature LipA with its trunca...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21113925
更新日期:2020-05-30 00:00:00
abstract::The MAP kinase ERK5 contains an N-terminal kinase domain and a unique C-terminal tail including a nuclear localization signal and a transcriptional activation domain. ERK5 is activated in response to growth factors and stresses and regulates transcription at the nucleus by either phosphorylation or interaction with tr...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21062203
更新日期:2020-03-23 00:00:00
abstract::A sound ocular surface microbiota has been recognized as a part of ocular surface health following a growing body of evidence from next-generation sequencing technique and metagenomic analysis. However, even from the perspective of contemporary precision medicine, it is difficult to directly apply these new technologi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21218299
更新日期:2020-11-05 00:00:00
abstract::Adhesion molecules are known to play an important role in endothelial activation and angiogenesis. Here we determined the functional role of IQGAP1 in the regulation of endothelial adherens junctions. VE-cadherin is found to be associated with actin filaments and thus stable, but IQGAP1 at intercellular junctions is n...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms140713377
更新日期:2013-06-27 00:00:00
abstract::Serine protease dipeptidyl peptidase 4 (DPP-4) is involved in self/non-self-recognition and insulin sensitivity. DPP-4 inhibitors are conventional choices for diabetic treatment; however, side effects such as headache, bronchus infection, and nasopharyngitis might affect the daily lives of diabetic patients. Notably, ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20030530
更新日期:2019-01-27 00:00:00
abstract::Epidermal growth factor receptor (EGFR) and the mutant EGFRvIII are major focal points in current concepts of targeted cancer therapy for glioblastoma multiforme (GBM), the most malignant primary brain tumor. The receptors participate in the key processes of tumor cell invasion and tumor-related angiogenesis and their...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18061295
更新日期:2017-06-18 00:00:00
abstract::Ghrelin is a hormone predominantly produced in and secreted from the stomach. Ghrelin is involved in many physiological processes including feeding, the stress response, and in modulating learning, memory and motivational processes. Ghrelin does this by binding to its receptor, the growth hormone secretagogue receptor...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18040859
更新日期:2017-04-19 00:00:00
abstract::Regulation of synaptically located ionotropic receptors is thought to be the main mechanism by which anaesthetics cause unconsciousness. An alternative explanation, which has received much less attention, is that of primary anaesthetic disruption of brain metabolism via suppression of mitochondrial proteins. In this p...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21134703
更新日期:2020-07-01 00:00:00
abstract::Maurizio Battino, Ph.D., Associate Professor of Biochemistry in the Department of Clinical Sciences, Faculty of Medicine, Università Politecnica delle Marche (Italy), is the Director of the Centre for Health and Nutrition, Universidad Europea del Atlantico (Santander, Spain) and Director of Nutrition and Health projec...
journal_title:International journal of molecular sciences
pub_type: 面试
doi:10.3390/ijms17071038
更新日期:2016-07-05 00:00:00
abstract::The present study was performed to investigate the effects of chronic administration of nonylphenol (NP) on the expression of inflammation-related genes in the brains of mice. NP was given orally by gavages at 0, 50, 100, and 200 mg/kg/d. The expression of inflammatory enzymes, inducible nitric oxide synthase (iNOS) a...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms9101977
更新日期:2008-10-01 00:00:00
abstract:BACKGROUND:The aim of this review was to evaluate the adjunctive effect of autologous platelet concentrates (APCs) for the treatment of furcation defects, in terms of scientific quality of the clinical trials and regeneration parameters assessment. METHODS:A systematic search was carried out in the electronic database...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,meta分析
doi:10.3390/ijms20061347
更新日期:2019-03-17 00:00:00
abstract::The design, construction and initial tests on a combined laser light scattering and synchrotron X-ray scattering instrument can cover studies of length scales from atomic sizes in Angstroms to microns and dynamics from microseconds to seconds are presented. In addition to static light scattering (SLS), dynamic light s...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms160510016
更新日期:2015-05-04 00:00:00