Abstract：
:The solute carrier (SLC) family-38 of transporters has eleven members known to transport amino acids, with glutamine being a common substrate for ten of them, with SLC38A9 being the exception. In this study, we examine the subcellular localization of SNAT10 in several independent immortalized cell lines and stem cell-derived neurons. Co-localization studies confirmed the SNAT10 was specifically localized to secretory organelles. SNAT10 is expressed in both excitatory and inhibitory neurons in the mouse brain, predominantly in the endoplasmic reticulum, and in the Golgi apparatus. Knock-down experiments of SNAT10, using Slc38a10-specific siRNA in PC12 cells reduced nascent protein synthesis by more than 40%, suggesting that SNAT10 might play a role in signaling pathways that regulate protein synthesis, and may act as a transceptor in a similar fashion to what has been shown previously for SLC38A2 (SNAT2) and SNAT9(SLC38A9).
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Tripathi R,Hosseini K,Arapi V,Fredriksson R,Bagchi Sdoi
10.3390/ijms20246265subject
Has Abstractpub_date
2019-12-12 00:00:00issue
24issn
1422-0067pii
ijms20246265journal_volume
20pub_type
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