Abstract：
:The ocular surface has the challenging responsibility of maintaining a clear moist refractive surface while protecting the eye from exogenous pathogens and the environment. Homeostasis of the ocular surface, including its innate immune components, is altered in ocular surface disease states. In this review, we focus on antimicrobial peptides and the role they play in the immune response of the ocular surface during healthy states and dry eye diseases. Antimicrobial peptides are of special interest to the study of the ocular surface because of their various roles that include microbial threat neutralization, wound healing, and immune modulation. This review explores current literature on antimicrobial peptides in ocular surface diseases and discusses their therapeutic potential in ocular surface diseases and dry eye.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Eshac Y,Redfern RL,Aakalu VKdoi
10.3390/ijms22020721subject
Has Abstractpub_date
2021-01-13 00:00:00issue
2issn
1422-0067pii
ijms22020721journal_volume
22pub_type
杂志文章,评审abstract：:The natriuretic peptides (NPs) family includes a class of hormones and their receptors needed for the physiological control of cardiovascular functions. The discovery of NPs provided a fundamental contribution into our understanding of the physiological regulation of blood pressure, and of heart and kidney functions. ...
journal_title：International journal of molecular sciences
pub_type： 社论
doi：10.3390/ijms20163991
更新日期：2019-08-16 00:00:00
abstract：:In this review we discuss the development of paramagnetic liposomes incorporating MRI contrast agents and show how these are utilized in cellular imaging in vitro. Bi-functional, bi-modal imaging paramagnetic liposome systems are also described. Next we discuss the upgrading of paramagnetic liposomes into bi-modal ima...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms11041759
更新日期：2010-04-15 00:00:00
abstract：:Hepcidin-25 was identified as the main iron regulator in the human body, and it by binds to the sole iron-exporter ferroportin. Studies showed that the N-terminus of hepcidin is responsible for this interaction, the same N-terminus that encompasses a small copper(II)-binding site known as the ATCUN (amino-terminal Cu(...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19082271
更新日期：2018-08-02 00:00:00
abstract：:For patients with end-stage renal disease requiring hemodialysis, their vascular access is both their lifeline and their Achilles heel. Despite being recommended as primary vascular access, the arteriovenous fistula (AVF) shows sub-optimal results, with about 50% of patients needing a revision during the year followin...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20215387
更新日期：2019-10-29 00:00:00
abstract：:Idiosyncratic drug-induced liver injury (DILI) is an underreported and underestimated adverse drug reaction. Information on the documented hepatotoxicity of drugs has recently been made available by a website that can be accessed in the public domain: LiverTox (http://livertox.nlm.nih.gov). According to critical analy...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17020224
更新日期：2016-02-06 00:00:00
abstract：:Early exercise is an effective strategy for stroke treatment, but the underlying mechanism remains poorly understood. Apoptosis plays a critical role after stroke. However, it is unclear whether early exercise inhibits apoptosis after stroke. The present study investigated the effect of early exercise on apoptosis ind...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14036074
更新日期：2013-03-15 00:00:00
abstract：:Polymer-based piezoelectric biomaterials have already proven their relevance for tissue engineering applications. Furthermore, the morphology of the scaffolds plays also an important role in cell proliferation and differentiation. The present work reports on poly(hydroxybutyrate-co-hydroxyvalerate) (PHBV), a biocompat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19082149
更新日期：2018-07-24 00:00:00
abstract：:In this review, the effect of pharmaceuticals (PHRs) and personal care products (PCPs) on microalgal growth and metabolism is reported. Concentrations of various PHRs and PCPs that cause inhibition and toxicity to growths of different microalgal strains are summarized and compared. The effect of PHRs and PCPs on micro...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20102492
更新日期：2019-05-20 00:00:00
abstract：:The terpolymerization of carbon dioxide (CO₂), propylene oxide (PO), and cyclohexene oxide (CHO) were performed by both random polymerization and block polymerization to synthesize the random poly (propylene cyclohexene carbonate) (PPCHC), di-block polymers of poly (propylene carbonate⁻cyclohexyl carbonate) (PPC-PCHC)...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19123723
更新日期：2018-11-23 00:00:00
abstract：:Krüppel-like factor 4 (Klf4) plays an important role in the transition from proliferation to differentiation in a wide variety of cells. Previous studies demonstrated its critical role in the luteal transition of preovulatory granulosa cells (GCs). This study used cultured rat preovulatory GCs to investigate the mecha...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21197385
更新日期：2020-10-06 00:00:00
abstract：:Crown rot (CR), caused by various Fusarium species, is a major disease in many cereal-growing regions worldwide. Fusarium culmorum is one of the most important species, which can cause significant yield losses in wheat. A set of 126 advanced International Maize and Wheat Improvement Center (CIMMYT) spring bread wheat ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092666
更新日期：2018-09-08 00:00:00
abstract：:The last step in the biosynthesis of flavin adenine dinucleotide (FAD) is considered a target for the design of antimicrobial drugs because it is carried out by two non-homologous proteins in eukaryotic and prokaryotic organisms. Monofunctional FMN: adenylyltransferases (FMNAT) in Eukarya and FMNAT modules of bifuncti...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21103738
更新日期：2020-05-25 00:00:00
abstract：:The micronutrients vitamins B9 and B12 act as methyl donors in the one-carbon metabolism involved in transmethylation reactions which critically influence epigenetic mechanisms and gene expression. Both vitamins are essential for proper development, and their deficiency during pregnancy has been associated with a wide...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20205097
更新日期：2019-10-14 00:00:00
abstract：:Metal often causes delayed-type hypersensitivity reactions, which are possibly mediated by accumulating T cells in the inflamed skin, called irritant or allergic contact dermatitis. However, accumulating T cells during development of a metal allergy are poorly characterized because a suitable animal model is unavailab...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17010087
更新日期：2016-01-12 00:00:00
abstract：:In clinical practice, the metabolic syndrome can lead to multiple complications, including diabetes. It remains unclear which component of the metabolic syndrome (obesity, inflammation, hyperglycemia, or insulin resistance) has the strongest inhibitory effect on stem cells involved in beta cell regeneration. This make...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21030991
更新日期：2020-02-03 00:00:00
abstract：:Prostate cancer (PCa), an epithelial malignant tumor, is the second common cause of cancer death among males in western countries. Thus, the development of new strategies is urgently needed. Tanshinones isolated from Salvia miltiorrhiza and its synthetic analogs show various biological activities including anticancer ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184459
更新日期：2019-09-10 00:00:00
abstract：:Salinity is considered as one of the most important abiotic challenges that affect crop productivity. Plant hormones, including salicylic acid (SA), are key factors in the defence signalling output triggered during plant responses against environmental stresses. We have previously reported in peach a new SA biosynthet...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19113519
更新日期：2018-11-08 00:00:00
abstract：:Lung squamous cell carcinoma (LUSC) has a poor prognosis, in part due to poor therapeutic response and limited therapeutic alternatives. Lichens are symbiotic organisms, producing a variety of substances with multiple biological activities. (+)-Usnic acid, an important biologically active metabolite of lichens, has be...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21030876
更新日期：2020-01-29 00:00:00
abstract：:The human DNA2 (DNA replication helicase/nuclease 2) protein is expressed in both the nucleus and mitochondria, where it displays ATPase-dependent nuclease and helicase activities. DNA2 plays an important role in the removing of long flaps in DNA replication and long-patch base excision repair (LP-BER), interacting wi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18071562
更新日期：2017-07-18 00:00:00
abstract：:We show that, under in vitro conditions, the vulnerability of astroglia to hypoxia is reflected by alterations in endothelin (ET)-1 release and capacity of erythropoietin (EPO) to regulate ET-1 levels. Exposure of cells to 24 h hypoxia did not induce changes in ET-1 release, while 48-72 h hypoxia resulted in increase ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15022858
更新日期：2014-02-19 00:00:00
abstract：:Chemoradiation-based bladder preservation therapy (BPT) is currently a curative option for non-metastatic muscle-invasive bladder cancer (MIBC) patients at favorable risk or an alternative to radical cystectomy (RC) for those who are unfit for RC. In BPT, only patients who achieve complete response (CR) after chemorad...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19092777
更新日期：2018-09-15 00:00:00
abstract：:To increase the efficiency of therapy via enhancing its selectivity, the usage of gold nanorods (GNR) as a factor sensitizing cancer cells to radiation was proposed. Due to gold nanoparticles' characteristics, the smaller doses of radiation would be sufficient in the treatment, protecting the healthy tissue around the...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22010016
更新日期：2020-12-22 00:00:00
abstract：:NF-E2-related factor 2 (Nrf2) has been identified as a master regulatory factor in the protection of cells from oxidative and electrophilic stress. However, overexpression of Nrf2 in lung cancer may cause chemoresistance, as well as radioresistance. In this study, we examined the relationship between radioresistance a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17070997
更新日期：2016-06-24 00:00:00
abstract：:Microgravity is known to affect the organization of the cytoskeleton, cell and nuclear morphology and to elicit differential expression of genes associated with the cytoskeleton, focal adhesions and the extracellular matrix. Although the nucleus is mechanically connected to the cytoskeleton through the Linker of Nucle...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21186762
更新日期：2020-09-15 00:00:00
abstract：:A common problem in the immunodetection of structurally close compounds is understanding the regularities of immune recognition, and elucidating the basic structural elements that provide it. Correct identification of these elements would allow for select immunogens to obtain antibodies with either wide specificity to...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20020265
更新日期：2019-01-11 00:00:00
abstract：:Cotton fibres, as single cells arising from the seed coat, can be classified as lint and fuzz according to their final length. Gossypium arboreum is a cultivated diploid cotton species and a potential donor of the A subgenome of the more widely grown tetraploid cottons. In this study, we performed genetic studies on o...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051675
更新日期：2020-02-29 00:00:00
abstract：:Neonatal seizures are one of the most common comorbidities of neonatal encephalopathy, with seizures aggravating acute injury and clinical outcomes. Current treatment can control early life seizures; however, a high level of pharmacoresistance remains among infants, with increasing evidence suggesting current anti-sei...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21217832
更新日期：2020-10-22 00:00:00
abstract：:Wheat protein is considered a major type of food allergen in many countries including the USA. The mechanisms of allergenicity of wheat proteins are not well understood at present. Both adjuvant-based and adjuvant-free mouse models are reported for this food allergy. However, it is unclear whether the mechanisms under...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21093205
更新日期：2020-05-01 00:00:00
abstract：:Tacrolimus has been used to induce remission in patients with steroid-refractory ulcerative colitis. It poses a problem of large individual differences in dosage necessary to attain target blood concentration and, often, this leads to drug inefficacy. We examined the difference in mRNA expression levels of ATP binding...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21124347
更新日期：2020-06-18 00:00:00
abstract：:Metallothioneins have been viewed as modulators in a number of biological regulations regarding cancerous development; however, the function of metallothionein 3 (MT3) in bladder cancer is unexplored. We determined the regulatory mechanisms and potential function of MT3 in bladder carcinoma cells. Real-Time Reverse Tr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20040980
更新日期：2019-02-23 00:00:00
