Abstract：
:Henrin A (1), a new ent-kaurane diterpene, was isolated from the leaves of Pteris henryi. The chemical structure was elucidated by analysis of the spectroscopic data including one-dimensional (1D) and two-dimensional (2D) NMR spectra, and was further confirmed by X-ray crystallographic analysis. The compound was evaluated for its biological activities against a panel of cancer cell lines, dental bacterial biofilm formation, and HIV. It displayed anti-HIV potential with an IC50 value of 9.1 µM (SI = 12.2).
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Li WF,Wang J,Zhang JJ,Song X,Ku CF,Zou J,Li JX,Rong LJ,Pan LT,Zhang HJdoi
10.3390/ijms161126071subject
Has Abstractpub_date
2015-11-24 00:00:00pages
27978-87issue
11issn
1422-0067pii
ijms161126071journal_volume
16pub_type
杂志文章abstract：:To date, viruses are reported to be responsible for more than 15% of all tumors worldwide. The oncogenesis could be influenced directly by the activity of viral oncoproteins or by the chronic infection or inflammation. The group of human oncoviruses includes Epstein–Barr virus (EBV), human papillomavirus (HPV), ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19041217
更新日期：2018-04-17 00:00:00
abstract：:Intravenous administration of high-dose ascorbic acid (AA) has been reported as a treatment for cancer patients. However, cancer patients with renal failure cannot receive this therapy because high-dose AA infusion can have side effects. To solve this problem, we evaluated the antitumor activity of a lipophilic stable...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19020535
更新日期：2018-02-10 00:00:00
abstract：:In wheat, flag leaf, stem, chaff and awns contribute to grain filling through photosynthesis and/or re-mobilization. Environmental and genetic effects on the relative contribution of each organ were examined by analyzing the consequences of sink-source manipulations (shading and excision) and by comparing carbon isoto...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19010056
更新日期：2017-12-25 00:00:00
abstract：:Innate and adaptive immunity are both involved in acute and chronic inflammatory processes. The main cellular players in the innate immune system are macrophages, mast cells, dendritic cells, neutrophils, eosinophils, and natural killer (NK), which offer antigen-independent defense against infection. Helicobacter pylo...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17010109
更新日期：2016-01-15 00:00:00
abstract：:DNA topoisomerase II (TOP2) activity involves a normally transient double-strand break intermediate in which the enzyme is coupled to DNA via a 5'-phosphotyrosyl bond. However, etoposide and other topoisomerase drugs poison the enzyme by stabilising this enzyme-bridged break, resulting in the accumulation of TOP2-DNA ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19072056
更新日期：2018-07-14 00:00:00
abstract：:The increasing prevalence of inflammatory diseases and the adverse effects associated with the long-term use of current anti-inflammatory therapies prompt the identification of alternative approaches to reestablish immune balance. Apigenin, an abundant dietary flavonoid, is emerging as a potential regulator of inflamm...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17030323
更新日期：2016-03-01 00:00:00
abstract：:A psychrotolerant bacterium, strain T-3 (identified as Psychrobacter piscatorii), that exhibited an extraordinarily high catalase activity was isolated from the drain pool of a plant that uses H(2)O(2) as a bleaching agent. Its cell extract exhibited a catalase activity (19,700 U·mg protein(-1)) that was higher than t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13021733
更新日期：2012-01-01 00:00:00
abstract：:Polysaccharides from Morchella esculenta have been proven to be functional and helpful for humans. The purpose of this study was to investigate the chemical structure and anti-proliferating and antitumor activities of a Morchella esculenta polysaccharide (MEP) extracted by pulsed electric field (PEF) in submerged ferm...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17060986
更新日期：2016-06-22 00:00:00
abstract：:Ganoderma lucidum is widely recognized as a medicinal basidiomycete. It was previously reported that the plant hormone methyl jasmonate (MeJA) could induce the biosynthesis of ganoderic acids (GAs), which are the main active ingredients of G. lucidum. However, the regulatory mechanism is still unclear. In this study, ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246116
更新日期：2019-12-04 00:00:00
abstract：:Tumor angiogenesis is one of the major hallmarks of tumor progression. Nobiletin is a natural flavonoid isolated from citrus peel that has anti-angiogenic activity. Steroid receptor coactivator (Src) is an intracellular tyrosine kinase so that focal adhesion kinase (FAK) binds to Src to play a role in tumor angiogenes...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18050935
更新日期：2017-04-30 00:00:00
abstract：:Pancreatic ductal adenocarcinoma is one of the most lethal human cancers. Its precursor lesions include pancreatic intra-epithelial neoplasia, mucinous cystic neoplasm, and intraductal papillary mucinous neoplasm (IPMN). IPMNs usually present as an incidental finding at imaging in 2.6% of the population and, according...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21176386
更新日期：2020-09-02 00:00:00
abstract：:The development of neural circuits is a complex process that relies on the proper navigation of axons through their environment to their appropriate targets. While axon-environment and axon-target interactions have long been known as essential for circuit formation, communication between axons themselves has only more...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21145170
更新日期：2020-07-21 00:00:00
abstract：:The astA gene encoding an alternative sulfate transporter was originally cloned from the genome of the Japanese Aspergillus nidulans isolate as a suppressor of sulfate permease-deficient strains. Expression of the astA gene is under the control of the sulfur metabolite repression system. The encoded protein transports...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21207727
更新日期：2020-10-19 00:00:00
abstract：:The Bromeliaceae family is one of the most morphologically diverse families with a pantropical distribution. To schedule an appropriate flowering time for bromeliads, ethylene is commonly used to initiate flower development in adult plants. However, the mechanism by which ethylene induces flowering in adult bromeliads...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17030303
更新日期：2016-02-27 00:00:00
abstract：:Aerobic metabolism occurs in a background of oxygen radicals and reactive oxygen species (ROS) that originate from the incomplete reduction of molecular oxygen in electron transfer reactions. The essential role of aerobic metabolism, the generation and consumption of ATP and other high energy phosphates, sustains a ba...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms12106469
更新日期：2011-01-01 00:00:00
abstract：:A bacterial strain EMS with the capability of degrading microcystins (MCs) was isolated from Lake Taihu, China. The bacterium was tentatively identified as a Stenotrophomonas sp. The bacterium could completely consume MC-LR and MC-RR within 24 hours at a concentration of 0.7 microg/mL and 1.7 microg/mL, respectively. ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms11030896
更新日期：2010-03-02 00:00:00
abstract：:Kynurenine aminotransferase isozymes (KATs 1-4) are members of the pyridoxal-5'-phosphate (PLP)-dependent enzyme family, which catalyse the permanent conversion of l-kynurenine (l-KYN) to kynurenic acid (KYNA), a known neuroactive agent. As KATs are found in the mammalian brain and have key roles in the kynurenine pat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17060946
更新日期：2016-06-15 00:00:00
abstract：:Nicotine addiction is a severe public health problem. The aim of this study was to investigate the alterations in key neurotransmissions after 60 days of withdrawal from seven weeks of intermittent cigarette smoke, e-cigarette vapours, or an e-cigarette vehicle. In the nicotine withdrawal groups, increased depressive ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22020599
更新日期：2021-01-09 00:00:00
abstract：:We first demonstrated that long-term increased polyamine (spermine, spermidine, putrescine) intake elevated blood spermine levels in mice and humans, and lifelong consumption of polyamine-rich chow inhibited aging-associated increase in aberrant DNA methylation, inhibited aging-associated pathological changes, and ext...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20051254
更新日期：2019-03-12 00:00:00
abstract：:A successful example of self-assembly in a biological system is that DNA can be an excellent agent to self-assemble into desirable two and three-dimensional nanostructures in a well-ordered manner by specific hydrogen bonding interactions between the DNA bases. The self-assembly of DNA bases have played a significant ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms15021901
更新日期：2014-01-27 00:00:00
abstract：:Maintenance of genome integrity is a key process in all organisms. DNA polymerases (Pols) are central players in this process as they are in charge of the faithful reproduction of the genetic information, as well as of DNA repair. Interestingly, all eukaryotes possess a large repertoire of polymerases. Three protein c...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20194814
更新日期：2019-09-27 00:00:00
abstract：:Members of neuropeptide B/W signaling system have been predominantly detected and mapped within the CNS. In the rat, this system includes neuropeptide B (NPB), neuropeptide W (NPW) and their specific receptor NPBWR1. This signaling system has a wide spectrum of functions including a role in modulation of inflammatory ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21217827
更新日期：2020-10-22 00:00:00
abstract：:The present study gives an overview of the binding energetics of the homologous heterodimers of cruzipain-chagasin based on the binding energy (ΔGb) prediction obtained with FoldX. This analysis involves a total of 70 homologous models of the cruzipain-chagasin complex which were constructed by homology from the combi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20061320
更新日期：2019-03-15 00:00:00
abstract：:Ovarian follicle steroidogenesis associated with embryo quality results in a successful pregnancy. Each follicle consists of an oocyte surrounded by granulosa cells, which secrete several steroid and peptide hormones. Follicles harvested from women who conceived after assisted reproductive therapy (ART) had significan...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21103592
更新日期：2020-05-19 00:00:00
abstract：:Bisphenol A (BPA) is a widespread pollutant threatening the ecosystem and human health. An effective BPA degrader YC-JY1 was isolated and identified as Sphingobium sp. The optimal temperature and pH for the degradation of BPA by strain YC-JY1 were 30 °C and 6.5, respectively. The biodegradation pathway was proposed ba...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21103588
更新日期：2020-05-19 00:00:00
abstract：:There has been a great interest in application of nanoparticles as biomaterials for delivery of therapeutic molecules such as drugs and genes, and for tissue engineering. In particular, biopolymers are suitable materials as nanoparticles for clinical application due to their versatile traits, including biocompatibilit...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms14011629
更新日期：2013-01-14 00:00:00
abstract：:A unique feature of bioactive food ingredients is their broad antioxidant function. Antioxidants having a wide spectrum of chemical structure and activity beyond basic nutrition; display different health benefits by the prevention and progression of chronic diseases. Functional food components are capable of enhancing...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18102050
更新日期：2017-09-25 00:00:00
abstract：:Since myeloproliferative neoplasms (MPN) pose a significant risk for vascular and thrombotic complications, cytoreductive therapies, such as hydroxyurea (HU), interferon (IFN) inhibitors, and Janus kinase (JAK) inhibitors are recommended for patients at high risk. However, these agents also place patients at increased...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21113900
更新日期：2020-05-30 00:00:00
abstract：:Hybrid materials constituted by peptides and synthetic polymers have nowadays a great interest since they can combine the properties and functions of each constitutive block, being also possible to modify the final characteristics by using different topologies. Poly(l-lactide-b-l-phenylalanine) copolymers with various...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms150813247
更新日期：2014-07-29 00:00:00
abstract：:The involvement of microRNAs in the control of repressors of human γ-globin gene transcription has been firmly demonstrated, as described for the miR-486-3p mediated down-regulation of BCL11A. On the other hand, we have reported that miR-210 is involved in erythroid differentiation and, possibly, in γ-globin gene up-r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18122530
更新日期：2017-11-26 00:00:00
