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Synthesis and properties of poly(L-lactide)-b-poly (L-phenylalanine) hybrid copolymers.

Abstract：

:Hybrid materials constituted by peptides and synthetic polymers have nowadays a great interest since they can combine the properties and functions of each constitutive block, being also possible to modify the final characteristics by using different topologies. Poly(l-lactide-b-l-phenylalanine) copolymers with various block lengths were synthesized by sequential ring-opening polymerization of l-lactide and the N-carboxyanhydride of l-phenylalanine. The resulting block copolymers were characterized by NMR spectrometry, IR spectroscopy, gel permeation chromatography, MALDI-TOF and UV-vis, revealing the successful incorporation of the polyphenylalanine (PPhe) peptide into the previously formed poly(l-lactide) (PLLA) polymer chain. X-ray diffraction and DSC data also suggested that the copolymers were phase-separated in domains containing either crystalline PLLA or PPhe phases. A peculiar thermal behavior was also found by thermogravimetric analysis when polyphenylalanine blocks were incorporated into polylactide.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Planellas M,Puiggalí J

doi

10.3390/ijms150813247

subject

Has Abstract

pub_date

2014-07-29 00:00:00

pages

13247-66

issue

8

issn

1422-0067

pii

ijms150813247

journal_volume

15

pub_type

杂志文章

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