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Major Challenges and Potential Microenvironment-Targeted Therapies in Glioblastoma.

Abstract：

:Glioblastoma (GBM) is considered one of the most malignant, genetically heterogeneous, and therapy-resistant solid tumor. Therapeutic options are limited in GBM and involve surgical resection followed by chemotherapy and/or radiotherapy. Adjuvant therapies, including antiangiogenic treatments (AATs) targeting the VEGF-VEGFR pathway, have witnessed enhanced infiltration of bone marrow-derived myeloid cells, causing therapy resistance and tumor relapse in clinics and in preclinical models of GBM. This review article is focused on gathering previous clinical and preclinical reports featuring major challenges and lessons in GBM. Potential combination therapies targeting the tumor microenvironment (TME) to overcome the myeloid cell-mediated resistance problem in GBM are discussed. Future directions are focused on the use of TME-directed therapies in combination with standard therapy in clinical trials, and the exploration of novel therapies and GBM models for preclinical studies. We believe this review will guide the future of GBM research and therapy.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Arbab AS,Rashid MH,Angara K,Borin TF,Lin PC,Jain M,Achyut BR

doi

10.3390/ijms18122732

subject

Has Abstract

pub_date

2017-12-16 00:00:00

issue

12

issn

1422-0067

pii

ijms18122732

journal_volume

18

pub_type

杂志文章,评审

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