Abstract:
:Methylation of several lysine residues of histones is a crucial mechanism for relatively long-term regulation of genomic activity. Recent molecular biological studies have demonstrated that the function of histone methylation is more diverse and complex than previously thought. Moreover, studies using newly available genomics techniques, such as exome sequencing, have identified an increasing number of histone lysine methylation-related genes as intellectual disability-associated genes, which highlights the importance of accurate control of histone methylation during neurogenesis. However, given the functional diversity and complexity of histone methylation within the cell, the study of the molecular basis of histone methylation-related neurodevelopmental disorders is currently still in its infancy. Here, we review the latest studies that revealed the pathological implications of alterations in histone methylation status in the context of various neurodevelopmental disorders and propose possible therapeutic application of epigenetic compounds regulating histone methylation status for the treatment of these diseases.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Kim JH,Lee JH,Lee IS,Lee SB,Cho KSdoi
10.3390/ijms18071404subject
Has Abstractpub_date
2017-06-30 00:00:00issue
7issn
1422-0067pii
ijms18071404journal_volume
18pub_type
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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更新日期:2017-10-01 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19071915
更新日期:2018-06-29 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19082261
更新日期:2018-08-01 00:00:00
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journal_title:International journal of molecular sciences
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doi:10.3390/ijms21082869
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17060913
更新日期:2016-06-09 00:00:00
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21010322
更新日期:2020-01-03 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21186598
更新日期:2020-09-09 00:00:00
abstract::Alzheimer's disease (AD) is the leading cause of dementia worldwide. It involves progressive impairment of cognitive function. A growing number of neuroprotective compounds have been identified with potential anti-AD properties through in vitro and in vivo models of AD. Quercetin, a natural flavonoid contained in a wi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21020493
更新日期:2020-01-13 00:00:00
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journal_title:International journal of molecular sciences
pub_type: 杂志文章
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journal_title:International journal of molecular sciences
pub_type: 临床试验,杂志文章,多中心研究
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
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更新日期:2018-05-12 00:00:00
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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journal_title:International journal of molecular sciences
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更新日期:2020-08-23 00:00:00