Amphiphilic DNA Organic Hybrids: Functional Materials in Nanoscience and Potential Application in Biomedicine.

abstract：:RNA interference (RNAi) has emerged as a powerful tool for studying target identification and holds promise for the development of therapeutic gene silencing. Recent advances in RNAi delivery and target selection provide remarkable opportunities for translational medical research. The induction of RNAi relies on small...

journal_title：International journal of molecular sciences

authors： Fujita Y,Kuwano K,Ochiya T

更新日期：2015-03-06 00:00:00

abstract：:NAC (NAM, ATAF1/2, and CUC2) transcription factors play important roles in many biological processes, and mainly bind to the NACRS with core sequences "CACG" or "CATGTG" to regulate gene expression. However, whether NAC proteins can bind to other motifs without these core sequences remains unknown. In this study, we e...

journal_title：International journal of molecular sciences

authors： He L,Xu J,Wang Y,Yang K

更新日期：2018-10-21 00:00:00

abstract：:It is generally known that heat shock protein 27 (HSP27) is phosphorylated through p38 mitogen-activated protein (MAP) kinase. We have previously reported that HSP27 is released from human platelets associated with collagen-induced phosphorylation. In the present study, we conducted an investigation into the effect of...

journal_title：International journal of molecular sciences

authors： Tokuda H,Kuroyanagi G,Tsujimoto M,Matsushima-Nishiwaki R,Akamatsu S,Enomoto Y,Iida H,Otsuka T,Ogura S,Iwama T,Kojima K,Kozawa O

更新日期：2016-05-14 00:00:00

abstract：:Platelets and platelet microparticles (PMPs) play a key role in the pathophysiology of vascular disorders such as coronary artery disease and stroke. In atherosclerosis, for example, the disruption of the plaque exposes endogenous agonists such as collagen, which activates platelets. Platelet hyper-activation and the ...

journal_title：International journal of molecular sciences

authors： Ed Nignpense B,Chinkwo KA,Blanchard CL,Santhakumar AB

更新日期：2019-12-24 00:00:00

abstract：:Gibberellin (GA) is a key signal molecule inducing differentiation of tracheary elements, fibers, and xylogenesis. However the molecular mechanisms underlying the effect of GA on xylem elongation and secondary wall development in tree species remain to be determined. In this study, Betula platyphylla (birch) seeds wer...

journal_title：International journal of molecular sciences

authors： Guo H,Wang Y,Liu H,Hu P,Jia Y,Zhang C,Wang Y,Gu S,Yang C,Wang C

更新日期：2015-09-23 00:00:00

abstract：:The activating leukocyte immunoglobulin-like receptors (LILRAs) play an important role in innate immunity. However, most of the LILRA members have not been characterized in avian species including chickens. The present study is the first attempt at cloning, structural analysis and functional characterization of two LI...

journal_title：International journal of molecular sciences

authors： Truong AD,Rengaraj D,Hong Y,Tran HTT,Dang HV,Nguyen VK,Lillehoj HS,Hong YH

更新日期：2018-09-11 00:00:00

abstract：:CD4+T-lymphocytes are relevant in the pathogenesis of rheumatoid arthritis (RA), however, their potential involvement in early RA remains elusive. Methotrexate (MTX) is a commonly used disease-modifying antirheumatic drug (DMARD), but its mechanism has not been fully established. In 47 new-onset DMARD-naïve RA patient...

journal_title：International journal of molecular sciences

authors： Monserrat Sanz J,Bohórquez C,Gómez AM,Movasat A,Pérez A,Ruíz L,Diaz D,Sánchez AI,Albarrán F,Sanz I,Álvarez-Mon M

更新日期：2020-09-18 00:00:00

abstract：:Colorectal cancer is a major healthcare concern worldwide. Many experimental and clinical studies have been conducted to date to discover agents that help in the prevention of this disease. Chronic inflammation in colonic mucosa and obesity, and its related metabolic abnormalities, are considered to increase the risk ...

journal_title：International journal of molecular sciences

authors： Shirakami Y,Ohnishi M,Sakai H,Tanaka T,Shimizu M

更新日期：2017-04-26 00:00:00

abstract：:Apocynin, also known as acetovanillone, is a natural organic compound structurally related to vanillin. Apocynin is known to be an inhibitor of NADPH (Nicotinamide adenine dinucleotide phosphate) oxidase activity and is highly effective in suppressing the production of superoxide. The neuroprotective effects of apocyn...

journal_title：International journal of molecular sciences

authors： Lee SH,Choi BY,Kho AR,Jeong JH,Hong DK,Kang DH,Kang BS,Song HK,Choi HC,Suh SW

更新日期：2018-10-09 00:00:00

abstract：:Hybrid magnetorheological elastomers (hMREs) were manufactured based on silicone rubber, silicone oil, carbonyl iron microparticles, graphene nanoparticles and cotton fabric. Using the hMREs, flat capacitors (FCs) were made. Using the installation described in this paper, the electrical capacitance and the coefficient...

journal_title：International journal of molecular sciences

authors： Bica I,Bunoiu OM

更新日期：2019-08-27 00:00:00

abstract：:Thrombin is an essential procoagulant and profibrotic mediator. However, its implication in tuberculous pleural effusion (TBPE) remains unknown. The effusion thrombin and plasminogen activator inhibitor-1 (PAI-1) levels were measured among transudative pleural effusion (TPE, n = 22) and TBPE (n = 24) patients. Pleural...

journal_title：International journal of molecular sciences

authors： Hsieh CY,Sheu JR,Yang CH,Chen WL,Tsai JH,Chung CL

更新日期：2019-10-13 00:00:00

abstract：:Spontaneous beating of the heart pacemaker, the sinoatrial node, is generated by sinoatrial node cells (SANC) and caused by gradual change of the membrane potential called diastolic depolarization (DD). Submembrane local Ca2+ releases (LCR) from sarcoplasmic reticulum (SR) occur during late DD and activate an inward N...

journal_title：International journal of molecular sciences

authors： Vinogradova TM,Tagirova Sirenko S,Lakatta EG

更新日期：2018-07-25 00:00:00

abstract：:(-)-Epigallocatechin gallate (EGCG) and curcumin are two naturally derived agents that have been widely investigated worldwide. They exhibit their anti-tumor effects in many types of cancers. In the current study, the effect of the combination of the two agents on non-small cell lung cancer (NSCLC) cells was investiga...

journal_title：International journal of molecular sciences

authors： Zhou DH,Wang X,Yang M,Shi X,Huang W,Feng Q

更新日期：2013-06-05 00:00:00

abstract：:Plants encounter a variety of mechanical stimuli during their growth and development. It is currently believed that mechanosensitive ion channels play an essential role in the initial perception of mechanical force in plants. Over the past decade, the study of Piezo, a mechanosensitive ion channel in animals, has made...

journal_title：International journal of molecular sciences

authors： Fang X,Liu B,Shao Q,Huang X,Li J,Luan S,He K

更新日期：2021-01-05 00:00:00

abstract：:Interleukin-18 (IL-18) is a multi-functional immuno-mediator in the development and progression of many types of infectious and inflammatory diseases. In this study, we evaluated the contribution of IL-18 genotypes to renal cell carcinoma (RCC) in Taiwan via the genotyping of IL-18 -656 (A/C), -607 (A/C), and -137 (G/...

journal_title：International journal of molecular sciences

authors： Chang WS,Shen TC,Yeh WL,Yu CC,Lin HY,Wu HC,Tsai CW,Bau DT

更新日期：2019-03-28 00:00:00

abstract：:Polyphenolic compounds contained in cherry extract (CE) are well known for their antioxidant and anti-inflammatory properties. Unfortunately, most of these natural compounds have low oral bioavailability, reducing their widespread use. Here, different concentrations of polyphenol-rich CE from Tuscany (Italy), encapsul...

journal_title：International journal of molecular sciences

authors： Beconcini D,Fabiano A,Di Stefano R,Macedo MH,Felice F,Zambito Y,Sarmento B

更新日期：2019-04-10 00:00:00

abstract：:Ammonium trichloro[1,2-ethanediolato-O,O']-tellurate (AS101) is the most important synthetic Te compound from the standpoint of its biological activity. It is a potent immunomodulator with a variety of potential therapeutic applications and antitumoral action in several preclinical and clinical studies. An experimenta...

journal_title：International journal of molecular sciences

authors： Vázquez-Tato MP,Mena-Menéndez A,Feás X,Seijas JA

更新日期：2014-02-21 00:00:00

abstract：:Radiotherapy for brain tumors induces neuronal DNA damage and may lead to neurodegeneration and cognitive deficits. We investigated the mechanisms of radiation-induced neuronal cell death and the role of miR-711 in the regulation of these pathways. We used in vitro and in vivo models of radiation-induced neuronal cell...

journal_title：International journal of molecular sciences

authors： Sabirzhanov B,Makarevich O,Barrett JP,Jackson IL,Glaser EP,Faden AI,Stoica BA

更新日期：2020-07-23 00:00:00

abstract：:We previously reported that oral formulations containing indomethacin nanoparticles (IND-NPs) showed high bioavailability, and, consequently, improved therapeutic effects and reduced injury to the small intestine. However, the pathway for the transintestinal penetration of nanoparticles remained unclear. Thus, in this...

journal_title：International journal of molecular sciences

authors： Ishii M,Fukuoka Y,Deguchi S,Otake H,Tanino T,Nagai N

更新日期：2019-01-22 00:00:00

abstract：:Melanocytes in the skin play an indispensable role in the pigmentation of skin and its appendages. It is well known that the embryonic origin of melanocytes is neural crest cells. In adult skin, functional melanocytes are continuously repopulated by the differentiation of melanocyte stem cells (McSCs) residing in the ...

journal_title：International journal of molecular sciences

authors： Mull AN,Zolekar A,Wang YC

更新日期：2015-12-21 00:00:00

abstract：:Interleukin (IL)-4 and -13 are structurally and functionally related cytokines sharing common receptor subunits. They regulate immune responses and, moreover, are involved in the pathogenesis of a variety of human neoplasms. Three different receptors have been described for IL-4, but only IL-4 receptor type II (IL-4Rα...

journal_title：International journal of molecular sciences

authors： Song X,Traub B,Shi J,Kornmann M

更新日期：2021-01-13 00:00:00

abstract：:Androgens have been known to inhibit cutaneous wound healing in men and male mice. However, in children with major burn injuries, a synthetic androgen was reported clinically to improve wound healing. The aim of this study is to investigate the role of dihydrotestosterone (DHT) as a new therapeutic approach in treatin...

journal_title：International journal of molecular sciences

authors： Shi H,Lo TH,Ma D,Condor B,Lesmana B,Parungao RJ,Tsai KH,Kim S,Chen HT,Silveira PA,Li Z,Cooper MS,Simanainen U,Handelsman DJ,Maitz PK,Wang Y

更新日期：2020-08-28 00:00:00

abstract：:Interleukin (IL)-10, an anti-inflammatory cytokine, is expressed in the brain and can inhibit microglial activation. Herein, we utilized lipopolysaccharide (LPS)-induced inflammatory Parkinson's disease (PD) cell model to determine whether microglia and astrocytes are necessary targets for IL-10 neuroprotection. Prima...

journal_title：International journal of molecular sciences

authors： Zhu Y,Chen X,Liu Z,Peng YP,Qiu YH

更新日期：2015-12-28 00:00:00

abstract：:Neurodegenerative disorders can induce modifications of several proteins; one of which is ceruloplasmin (Cp), a ferroxidase enzyme found modified in the cerebrospinal fluid (CSF) of neurodegenerative diseases patients. Cp modifications are caused by the oxidation induced by the pathological environment and are usually...

journal_title：International journal of molecular sciences

authors： Zanardi A,Alessio M

更新日期：2021-01-11 00:00:00

abstract：:For many years, it was of interest to identify the sequences encoding the two melatonin receptors (MT₁ and MT₂) from various species. After publishing the basic molecular characterization of the human, rat, mouse, sheep, and platypus MT₁, MT₂, or Mel1c receptors, we began cloning the genes from other animals, such as ...

journal_title：International journal of molecular sciences

authors： Gautier C,Dufour E,Dupré C,Lizzo G,Caignard S,Riest-Fery I,Brasseur C,Legros C,Delagrange P,Nosjean O,Simonneaux V,Boutin JA,Guenin SP

更新日期：2018-07-04 00:00:00

abstract：:Kinetic studies of the early events in cytochrome c folding are reviewed with a focus on the evidence for folding intermediates on the submillisecond timescale. Evidence from time-resolved absorption, circular dichroism, magnetic circular dichroism, fluorescence energy and electron transfer, small-angle X-ray scatteri...

journal_title：International journal of molecular sciences

authors： Goldbeck RA,Chen E,Kliger DS

更新日期：2009-04-01 00:00:00

abstract：:Papillary thyroid cancer (PTC) is the most common tumor subtype of thyroid cancer. However, not all PTCs are responsive to current surgical and radioiodine treatment. The well-established clinical prognostic factors include tumor size, lymph node/distal metastasis, and extrathyroidal invasion. The RET/PTC-RAS-BRAF lin...

journal_title：International journal of molecular sciences

authors： Chou CK,Liu RT,Kang HY

更新日期：2017-03-15 00:00:00

abstract：:Cardiovascular disease (CVD) is the main cause of death globally and responsible for the second highest number of deaths in Canada. Medical advancements in the treatment of CVD have led to patients living longer with CVD but often progressing to another condition called heart failure (HF). As a result, HF has emerged ...

journal_title：International journal of molecular sciences

authors： Dyck GJB,Raj P,Zieroth S,Dyck JRB,Ezekowitz JA

更新日期：2019-02-19 00:00:00

abstract：:Compelling evidence supports a tight link between oxidative stress and protein aggregation processes, which are noticeably involved in the development of proteinopathies, such as Alzheimer's disease, Parkinson's disease, and prion disease. The literature is tremendously rich in studies that establish a functional link...

journal_title：International journal of molecular sciences

authors： Lévy E,El Banna N,Baïlle D,Heneman-Masurel A,Truchet S,Rezaei H,Huang ME,Béringue V,Martin D,Vernis L

更新日期：2019-08-09 00:00:00

abstract：:Trichoderma reesei is a biotechnologically important filamentous fungus with the remarkable ability to secrete large amounts of enzymes, whose production is strongly affected by both the carbon and nitrogen sources. While the carbon metabolism regulators are extensively studied, the regulation of enzyme production by ...

journal_title：International journal of molecular sciences

authors： Qian Y,Sun Y,Zhong L,Sun N,Sheng Y,Qu Y,Zhong Y

更新日期：2019-08-22 00:00:00