Abstract：
:Colorectal cancer is a major healthcare concern worldwide. Many experimental and clinical studies have been conducted to date to discover agents that help in the prevention of this disease. Chronic inflammation in colonic mucosa and obesity, and its related metabolic abnormalities, are considered to increase the risk of colorectal cancer. Therefore, treatments targeting these factors might be a promising strategy to prevent the development of colorectal cancer. Among a number of functional foods, various phytochemicals, including tea catechins, which have anti-inflammatory and anti-obesity properties, and medicinal agents that ameliorate metabolic disorders, might also be beneficial in the prevention of colorectal cancer. In this review article, we summarize the strategies for preventing colorectal cancer by targeting obesity-related disorders and inflammation through nutraceutical and pharmaceutical approaches, and discuss the mechanisms of several phytochemicals and medicinal drugs used in basic and clinical research, especially focusing on the effects of green tea catechins.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Shirakami Y,Ohnishi M,Sakai H,Tanaka T,Shimizu Mdoi
10.3390/ijms18050908subject
Has Abstractpub_date
2017-04-26 00:00:00issue
5issn
1422-0067pii
ijms18050908journal_volume
18pub_type
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更新日期：2012-10-16 00:00:00
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journal_title：International journal of molecular sciences
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