Abstract：
:Chalcones are precursors of flavonoid biosynthesis in plants. Both flavonoids and chalcones are intensively investigated because of a large spectrum of their biological activities. Among others, anticancer and antiangiogenic effects account for the research interest of these substances. Because of an essential role in cancer growth and metastasis, angiogenesis is considered to be a promising target for cancer treatment. Currently used antiangiogenic agents are either synthetic compounds or monoclonal antibodies. However, there are some limitations of their use including toxicity and high price, making the search for new antiangiogenic compounds very attractive. Nowadays it is well known that several natural compounds may modulate basic steps in angiogenesis. A lot of studies, also from our lab, showed that phytochemicals, including polyphenols, are potent modulators of angiogenesis. This review paper is focused on the antiangiogenic effect of flavonoids and chalcones and discusses possible underlying cellular and molecular mechanisms.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Mirossay L,Varinská L,Mojžiš Jdoi
10.3390/ijms19010027subject
Has Abstractpub_date
2017-12-22 00:00:00issue
1issn
1422-0067pii
ijms19010027journal_volume
19pub_type
杂志文章,评审abstract：:Chondrocytes of the growth plate undergo apoptosis during the process of endochondral ossification, as well as during the progression of osteoarthritis. Although the regulation of this process is not completely understood, alterations in the precisely orchestrated programmed cell death during development can have cata...
journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2020-09-11 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2019-01-11 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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