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Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis.

Abstract：

:2-Piperidineethanol (1) and its corresponding N-protected aldehyde (2) were used for the synthesis of several natural and synthetic compounds. The existence of a stereocenter at position 2 of the piperidine skeleton and the presence of an easily-functionalized group, such as the alcohol, set 1 as a valuable starting material for enantioselective synthesis. Herein, are presented both synthetic and enzymatic methods for the resolution of the racemic 1, as well as an overview of synthesized natural products starting from the enantiopure 1.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Perdicchia D,Christodoulou MS,Fumagalli G,Calogero F,Marucci C,Passarella D

doi

10.3390/ijms17010017

subject

Has Abstract

pub_date

2015-12-24 00:00:00

issue

1

issn

1422-0067

pii

ijms17010017

journal_volume

17

pub_type

杂志文章,评审

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