Abstract:
:Interleukin (IL)-4 and -13 are structurally and functionally related cytokines sharing common receptor subunits. They regulate immune responses and, moreover, are involved in the pathogenesis of a variety of human neoplasms. Three different receptors have been described for IL-4, but only IL-4 receptor type II (IL-4Rα/IL-13Rα1) is expressed in solid tumors. While IL-13 can also bind to three different receptors, IL-13 receptor type I (IL-4Rα/IL-13Rα1/IL-13Rα2) and type II (IL-4Rα/IL-13Rα1) are expressed in solid tumors. After receptor binding, IL-4 and IL-13 can mediate tumor cell proliferation, survival, and metastasis in gastric or colon cancer. This review summarizes the results about the role of IL-4/IL-13 and their receptors in gastric and colon cancer.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Song X,Traub B,Shi J,Kornmann Mdoi
10.3390/ijms22020727subject
Has Abstractpub_date
2021-01-13 00:00:00issue
2issn
1422-0067pii
ijms22020727journal_volume
22pub_type
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