Abstract:
:MicroRNAs are noncoding RNA molecules of 18-25 nucleotides that regulate gene expression at the post-transcriptional levels. Recent data revealed that miR-218 played key roles in tumor metastasis. Here, we described the regulation and function of miR-218 in cervical cancer. Overexpression of miR-218 reduced the proliferation of the human cervical cancer cell line HeLa and induced cell apoptosis through the AKT-mTOR signaling pathway. In addition, it forced expression of miR-218 suppressed tumor growth in the orthotopic mouse model of HeLa cells. Furthermore, miR-218 increased chemosensitivity to cisplatin (CDDP) in vitro. Our results indicated that targeting miR-218 may provide a strategy for blocking the development of cervical cancer.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Li J,Ping Z,Ning Hdoi
10.3390/ijms131216053subject
Has Abstractpub_date
2012-11-28 00:00:00pages
16053-64issue
12issn
1422-0067pii
ijms131216053journal_volume
13pub_type
杂志文章abstract::Critical limb ischemia is the most serious form of peripheral artery disease, characterized by severe functional consequences, difficult clinical management and reduced life expectancy. The goal of this study was to investigate the miR-210 role in the neo-angiogenic response after acute limb ischemia. Complementary ap...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21010129
更新日期:2019-12-24 00:00:00
abstract::Reduced forms of ascorbate (AsA) and glutathione (GSH) are among the most important non-enzymatic foliar antioxidants in maize (Zea mays L.). The survey was aimed to evaluate impact of bird cherry-oat aphid (Rhopalosiphum padi L.) or grain aphid (Sitobion avenae F.) herbivory on expression of genes related to ascorbat...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms17030268
更新日期:2016-02-23 00:00:00
abstract::Tuberculosis (TB) is a chronic infectious disease in which prolonged, non-resolutive inflammation of the lung may lead to metabolic and neuroendocrine dysfunction. Previous studies have reported that individuals coursing pulmonary TB experience cognitive or behavioural changes; however, the pathogenic substrate of suc...
journal_title:International journal of molecular sciences
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doi:10.3390/ijms21249483
更新日期:2020-12-13 00:00:00
abstract::Chlorpyrifos (CPF) is widely used in the prevention and control of crop pests and diseases in agriculture. However, the irrational utilization of pesticides not only causes environmental pollution but also threatens human health. Compared with the conventional techniques for the determination of pesticides in soil, su...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20112817
更新日期:2019-06-10 00:00:00
abstract::Spinal cord injury is a chronic and debilitating neurological condition that is currently being managed symptomatically with no real therapeutic strategies available. Even though there is no consensus on the best time to start interventions, the chronic phase is definitely the most stable target in order to determine ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19061776
更新日期:2018-06-15 00:00:00
abstract::Currently, there is no three-dimensional structure of D-specific dehalogenase (DehD) in the protein database. We modeled DehD using ab initio technique, performed molecular dynamics (MD) simulation and docking of D-2-chloropropionate (D-2CP), D-2-bromopropionate (D-2BP), monochloroacetate (MCA), monobromoacetate (MBA)...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms131215724
更新日期:2012-11-26 00:00:00
abstract::Serum amyloid A (SAA) promotes endothelial inflammation and dysfunction that is associated with cardiovascular disease and renal pathologies. SAA is an apoprotein for high-density lipoprotein (HDL) and its sequestration to HDL diminishes SAA bioactivity. Herein we investigated the effect of co-supplementing HDL on SAA...
journal_title:International journal of molecular sciences
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更新日期:2020-02-15 00:00:00
abstract::Human endogenous retroviruses (HERVs) are genetic parasites, in-between genetics and environment. Few HERVs retain some coding capability. Sometimes, the host has the advantage of some HERV genes; conversely, HERVs may contribute to pathogenesis. The expression of HERVs depends on several factors, and is regulated epi...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20153706
更新日期:2019-07-29 00:00:00
abstract:BACKGROUND:Ras homolog gene family member A (RhoA) is involved in Wnt-5a-induced migration of gastric and breast cancer cells. We investigated the roles of RhoA and Wnt-5a in ovarian carcinoma. METHODS:RhoA and Wnt-5a mRNA and protein expression in normal fallopian tube epithelium, benign tumors, primary ovarian carci...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms141224187
更新日期:2013-12-12 00:00:00
abstract::β-adrenergic receptor (βAR) activation promotes relaxation of both vascular and airway smooth muscle cells (VSMCs and ASMCs, respectively), though the signaling mechanisms have not been fully elucidated. We previously found that the activity of Kv7.5 voltage-activated potassium channels in VSMCs is robustly enhanced b...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19082223
更新日期:2018-07-30 00:00:00
abstract::Brassinosteroids (BRs) are a class of phytohormones, which regulate various processes during plant life cycle. Intensive studies conducted with genetic, physiological and molecular approaches allowed identification of various components participating in the BR signaling-from the ligand perception, through cytoplasmic ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19092675
更新日期:2018-09-09 00:00:00
abstract::Chemotherapy is one of the most common strategies for tumor treatment but often associated with post-therapy tumor recurrence. While chemotherapeutic drugs are known to induce tumor cell senescence, the roles and mechanisms of senescence in tumor recurrence remain unclear. In this study, we used doxorubicin to induce ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22020849
更新日期:2021-01-15 00:00:00
abstract::Citalopram is a selective serotonin reuptake inhibitor, and although widely used as an antidepressant, this drug has also demonstrated interesting repairing properties leading to motor recovery and pathology amelioration in animal models of stroke and degeneration. Here, we tested the efficacy of both 7-day and 8-week...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21145062
更新日期:2020-07-17 00:00:00
abstract::Plants have evolved strategies to tightly regulate metabolism during acclimation to a changing environment. Low temperature significantly constrains distribution, growth and yield of many temperate plant species. Exposing plants to low but non-freezing temperature induces a multigenic processes termed cold acclimation...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20215411
更新日期:2019-10-30 00:00:00
abstract::Extracellular vesicles (EVs) are lipid bilayer vesicles which are released from cells and play multifaceted roles in cellular communication in health and disease. EVs can be isolated from various body fluids, including serum and plasma, and are usable biomarkers as they can inform health status. Studies on EVs are an ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22020875
更新日期:2021-01-16 00:00:00
abstract::Goat's milk is a rich source of bioactive compounds (peptides, conjugated linoleic acid, short chain fatty acids, monounsaturated and polyunsaturated fatty acids, polyphenols such as phytoestrogens and minerals among others) that exert important health benefits. However, goat's milk composition depends on the type of ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21155530
更新日期:2020-08-01 00:00:00
abstract::The chloromethyl-functionalized polystyrene is the most commonly used ammonium cation precursor for making anion exchange resins (AER) and membranes (AEM). However, the chloromethylation of polystyrene or styrene involves highly toxic and carcinogenic raw materials (e.g., chloromethyl ether) and the resultant ammonium...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21249404
更新日期:2020-12-10 00:00:00
abstract::Metastatic spread represents the leading cause of disease-related mortality among cancer patients. Many cancer patients suffer from metastatic relapse years or even decades after radical surgery for the primary tumor. This clinical phenomenon is explained by the early dissemination of cancer cells followed by a long p...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21197304
更新日期:2020-10-03 00:00:00
abstract::Dendritic cells (DCs) are heterogeneous groups of innate immune cells, which orchestrate immune responses by presenting antigens to cognate T cells and stimulating other types of immune cells. Although the term 'DCs' generally represent highly mixed subsets with functional heterogeneity, the classical definition of DC...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19010042
更新日期:2017-12-23 00:00:00
abstract::The ability to respond flexibly to changing environmental circumstances is a hallmark of goal-directed behavior, and compromised flexibility is associated with a wide range of psychiatric conditions in humans, such as addiction and stress-related disorders. To identify neural circuits and transmitter systems implicate...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20123098
更新日期:2019-06-25 00:00:00
abstract::Sortase A (SrtA) is a membrane-associated enzyme that anchors surface-exposed proteins to the cell wall envelope of Gram-positive bacteria such as Staphylococcus aureus. As SrtA is essential for Gram-positive bacterial pathogenesis but dispensable for microbial growth or viability, SrtA is considered a favorable targe...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21228601
更新日期:2020-11-14 00:00:00
abstract::Stimulation of thermogenesis in brown adipose tissue (BAT) could have far-reaching health benefits in combatting obesity and obesity-related complications. Apolipoprotein A-IV (ApoA-IV), produced by the gut and the brain in the presence of dietary lipids, is a well-known short-term satiating protein. While our previou...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22031221
更新日期:2021-01-27 00:00:00
abstract::The cholinergic efferent network from the medial septal nucleus to the hippocampus has an important role in learning and memory processes. This cholinergic projection can generate theta oscillations in the hippocampus to efficiently encode novel information. Hippocampal cholinergic neurostimulating peptide (HCNP) indu...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20215367
更新日期:2019-10-28 00:00:00
abstract::Metformin is a biguanide drug that has been used to treat type 2 diabetes mellitus for more than 60 years. The United Kingdom Prospective Diabetic Study (UKPDS) has shown metformin to improve mortality rates in diabetes patients, and recent studies suggest metformin has additional effects in treating cancer, obesity, ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19102863
更新日期:2018-09-21 00:00:00
abstract::The scanning speed of atomic force microscopes continues to advance with some current commercial microscopes achieving on the order of one frame per second and at least one reaching 10 frames per second. Despite the success of these instruments, even higher frame rates are needed with scan ranges larger than are curre...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19041044
更新日期:2018-03-31 00:00:00
abstract::The composition of IL-23R complex is similar to that of the IL-12 receptor (IL-12R) complex with a shared IL-12R-β1 chain. The IL-12R-β1 heterodimerizes with IL-23R and IL-12R-β2 to form IL-23R and IL-12R complexes, respectively. The IL-12R-β2 has been shown to function as a tumor suppressor gene and apoptotic inducer...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms141224656
更新日期:2013-12-18 00:00:00
abstract::Thymidylate synthase (TYMS) enzyme is an anti-cancer target given its role in DNA biosynthesis. TYMS inhibitors (e.g., 5-Fluorouracil) can lead to drug resistance through an autoregulatory mechanism of TYMS that causes its overexpression. Since G-quadruplexes (G4) can modulate gene expression, we searched for putative...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21145028
更新日期:2020-07-16 00:00:00
abstract::The cytostatic agent hydroxyurea (HU) has proven to be beneficial for a variety of conditions in the disciplines of oncology, hematology, infectious disease and dermatology. It disrupts the S phase of the cell cycle by inhibiting the ribonucleotide reductase enzyme, thus blocking the transformation of ribonucleotides ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms19123986
更新日期:2018-12-11 00:00:00
abstract::Evodiamine (Evo), a major alkaloid compound isolated from the dry unripened fruit of Evodia fructus, has a wide range of pharmacological activities. The present study sought to explore the neuroprotective effects of Evo in l-glutamate (l-Glu)-induced apoptosis of HT22 cells, and in a d-galactose and aluminum trichlori...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19051527
更新日期:2018-05-21 00:00:00
abstract::Understanding the molecular mechanisms of skeletal myoblast differentiation is essential for studying muscle developmental biology. In our previous study, we reported that knockdown of myocyte enhancer factor 2A (MEF2A) inhibited myoblast differentiation. Here in this study, we further identified that MEF2A controlled...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20112748
更新日期:2019-06-04 00:00:00