MiR-218 impairs tumor growth and increases chemo-sensitivity to cisplatin in cervical cancer.

Abstract:

:MicroRNAs are noncoding RNA molecules of 18-25 nucleotides that regulate gene expression at the post-transcriptional levels. Recent data revealed that miR-218 played key roles in tumor metastasis. Here, we described the regulation and function of miR-218 in cervical cancer. Overexpression of miR-218 reduced the proliferation of the human cervical cancer cell line HeLa and induced cell apoptosis through the AKT-mTOR signaling pathway. In addition, it forced expression of miR-218 suppressed tumor growth in the orthotopic mouse model of HeLa cells. Furthermore, miR-218 increased chemosensitivity to cisplatin (CDDP) in vitro. Our results indicated that targeting miR-218 may provide a strategy for blocking the development of cervical cancer.

journal_name

Int J Mol Sci

authors

Li J,Ping Z,Ning H

doi

10.3390/ijms131216053

subject

Has Abstract

pub_date

2012-11-28 00:00:00

pages

16053-64

issue

12

issn

1422-0067

pii

ijms131216053

journal_volume

13

pub_type

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