Abstract：
:Ca2+ signaling has been involved in controling critical cellular functions such as activation of proteases, cell death, and cell cycle control. The endoplasmatic reticulum plays a significant role in Ca2+ storage inside the cell, but mitochondria have long been recognized as a fundamental Ca2+ pool. Protozoan parasites such as Plasmodium falciparum, Toxoplasma gondii, and Trypanosoma cruzi display a Ca2+ signaling toolkit with similarities to higher eukaryotes, including the participation of mitochondria in Ca2+-dependent signaling events. This review summarizes the most recent knowledge in mitochondrial Ca2+ signaling in protozoan parasites, focusing on the mechanism involved in mitochondrial Ca2+ uptake by pathogenic protists.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Scarpelli PH,Pecenin MF,Garcia CRSdoi
10.3390/ijms22010469subject
Has Abstractpub_date
2021-01-05 00:00:00issue
1issn
1422-0067pii
ijms22010469journal_volume
22pub_type
杂志文章,评审abstract：:The only curative treatment for hepatic failure is liver transplantation. Unfortunately, this treatment has several major limitations, as for example donor organ shortage. A previous report demonstrated that transplantation of induced pluripotent stem cells without reprogramming factor c-Myc (3-genes iPSCs) attenuates...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13033598
更新日期：2012-01-01 00:00:00
abstract：:Manganese (Mn) is an important trace element present in human body, which acts as an enzyme co-factor or activator in various metabolic reactions. While essential in trace amounts, excess levels of Mn in human brain can produce neurotoxicity, including idiopathic Parkinson's disease (PD)-like extrapyramidal manganism ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020300
更新日期：2017-01-30 00:00:00
abstract：:The p38α mitogen-activated protein kinase (MAPK) has become an attractive target for the treatment of many diseases such as rheumatoid arthritis, inflammatory bowel disease and Crohn's disease. In this paper, 3D-QSAR and molecular docking studies were performed on 59 p38α MAPK inhibitors. Comparative molecular field a...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms11093357
更新日期：2010-09-17 00:00:00
abstract：:Reactive oxygen species (ROS) are involved in many important processes, including the growth, development, and responses to the environments, in rice (Oryza sativa) and Magnaporthe oryzae. Although ROS are known to be critical components in rice⁻M. oryzae interactions, their regulations and pathways have not yet been ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20051191
更新日期：2019-03-08 00:00:00
abstract：:The mechanical component in the pathophysiology of dry eye disease (DED) deserves attention as an important factor. The lubrication deficit induced impaired mechano-transduction of lid pressure to the ocular surfaces may lead to the dysregulation of homeostasis in the epithelium, with sensations of pain and secondary ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21124333
更新日期：2020-06-18 00:00:00
abstract：:The emergence of antibiotic-resistant strains in facultative anaerobic Gram-positive coccal bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA), is a global health issue. Typically, MRSA strains are found associated with institutions like hospitals but recent data suggest that they are becoming more p...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16047851
更新日期：2015-04-08 00:00:00
abstract：:Obesity is an important aspect of the metabolic syndrome and is often associated with chronic inflammation. In this context, inflammation of organs participating in energy homeostasis (such as liver, adipose tissue, muscle and pancreas) leads to the recruitment and activation of macrophages, which secrete pro-inflamma...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms22010330
更新日期：2020-12-30 00:00:00
abstract：:Findings from previous studies reporting the levels of serum brain-derived neurotrophic factor (BDNF) in patients with Alzheimer's disease (AD) and individuals with mild cognitive impairment (MCI) have been conflicting. Hence, we performed a meta-analysis to examine the aggregate levels of serum BDNF in patients with ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,meta分析
doi：10.3390/ijms20020257
更新日期：2019-01-10 00:00:00
abstract：:Leaf senescence is a highly-programmed developmental process regulated by an array of multiple signaling pathways. Our group previously reported that overexpression of the protein phosphatase-encoding gene SSPP led to delayed leaf senescence and significantly enhanced cytokinin responses. However, it is still unclear ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20082043
更新日期：2019-04-25 00:00:00
abstract：:Lifestyle-related disorders, such as the metabolic syndrome, have become a primary risk factor for the development of liver pathologies that can progress from hepatic steatosis, hepatic insulin resistance, steatohepatitis, fibrosis and cirrhosis, to the most severe condition of hepatocellular carcinoma (HCC). While th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19030921
更新日期：2018-03-20 00:00:00
abstract：:Cotton is one of the most economically important crops in the world, and it is exposed to various abiotic stresses during its lifecycle, especially salt stress. However, the molecular mechanisms underlying cotton tolerance to salt stress are still not fully understood due to the complex nature of salt response. Theref...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20215244
更新日期：2019-10-23 00:00:00
abstract：:Diabetes is associated with a two to three-fold increase in risk of cardiovascular disease. However, intensive glucose-lowering therapy aiming at reducing HbA1c to a near-normal level failed to suppress cardiovascular events in recent randomized controlled trials. HbA1c reflects average glucose level rather than glyce...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms151018381
更新日期：2014-10-13 00:00:00
abstract：:Transforming growth factor β (TGFβ) is a secreted growth and differentiation factor that influences vital cellular processes like proliferation, adhesion, motility, and apoptosis. Regulation of the TGFβ signaling pathway is of key importance to maintain tissue homeostasis. Perturbation of this signaling pathway has be...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms22020476
更新日期：2021-01-06 00:00:00
abstract：:Early diagnosis of cirrhosis and hepatocellular carcinoma (HCC) due to chronic Hepatitis C (CHC) remain clinical priorities. In this pilot study, we assessed serum microRNA (miRNA) expression to distinguish cirrhosis and HCC, alone and in combination with the aminotransferase-to-platelet ratio (APRI), Fibrosis 4 (FIB-...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20040864
更新日期：2019-02-17 00:00:00
abstract：:Short-term abiotic stress treatment before harvest can enhance the quality of horticultural crops cultivated in controlled environments. Here, we investigated the effects of combined chilling and UV-A treatment on the accumulation of phenolic compounds in kale (Brassica oleracea var. acephala). Five-week-old plants we...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20194950
更新日期：2019-10-08 00:00:00
abstract：:Phosphatidylinositol 3-kinase (PI3K) is a key enzyme that phosphorylates phosphatidylinositol at 3'-hydroxyl position of the inositol head group initiating the generation of several phosphorylated phosphatidylinositols, collectively referred to as phosphoinositides. The function of PI3K in plant senescence and ethylen...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18071533
更新日期：2017-07-15 00:00:00
abstract：:Apolipoprotein M (apoM) is a plasma apolipoprotein that mainly associates with high-density lipoproteins. Hence, most studies on apoM so far have investigated its effect on and association with lipid metabolism and atherosclerosis. The insight into apoM biology recently took a major turn. ApoM was identified as a carr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14034419
更新日期：2013-02-25 00:00:00
abstract：:The facilitative glucose transporter type 4 (GLUT4) is expressed in adipose and muscle and plays a vital role in whole body glucose homeostasis. In the absence of insulin, only ~1% of cellular GLUT4 is present at the plasma membrane, with the vast majority localizing to intracellular organelles. GLUT4 is retained intr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms14059963
更新日期：2013-05-10 00:00:00
abstract：:Ataxia is a common clinical feature in inherited metabolic disorders. There are more than 150 inherited metabolic disorders in patients presenting with ataxia in addition to global developmental delay, encephalopathy episodes, a history of developmental regression, coarse facial features, seizures, and other types of ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21155519
更新日期：2020-08-01 00:00:00
abstract：:Biblical references aside, restoring vision to the blind has proven to be a major technical challenge. In recent years, considerable advances have been made towards this end, especially when retinal degeneration underlies the vision loss such as occurs with retinitis pigmentosa. Under these conditions, optogenetic the...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21020522
更新日期：2020-01-14 00:00:00
abstract：:Our laboratory and others previously showed that Annexin A2 knockout (A2KO) mice had impaired blood-brain barrier (BBB) development and elevated pro-inflammatory response in macrophages, implying that Annexin A2 (AnxA2) might be one of the key endogenous factors for maintaining homeostasis of the neurovascular unit in...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20246125
更新日期：2019-12-05 00:00:00
abstract：:Determination of the thermal characteristics and temperature-dependent rheological properties of the magnetorheological elastomers (MREs) is of paramount importance particularly with regards to MRE applications. Hitherto, a paucity of temperature dependent analysis has been conducted by MRE researchers. In this study,...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20030746
更新日期：2019-02-10 00:00:00
abstract：:Chitosan is an amino polysaccharide found in nature, which is biodegradable, nontoxic and biocompatible. It has versatile features and can be used in a variety of applications including films, packaging, and also in medical surgery. Recently a possibility to diversify chitosan properties has emerged by combining it wi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12031908
更新日期：2011-01-01 00:00:00
abstract：:In the present work, we investigated the effect of non-steroidal anti-inflammatory drugs (NSAIDs) on the monophenolase and diphenolase activity of mushroom tyrosinase. The results showed that diflunisal and indomethacin inhibited both monophenolase and diphenolase activity. For monophenolase activity, the lag time was...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12063998
更新日期：2011-01-01 00:00:00
abstract：:Tuberculosis (TB) is a global epidemic caused by the infection of human macrophages with the world's most deadly single bacterial pathogen, Mycobacterium tuberculosis (M.tb). M.tb resides in a phagosomal niche within macrophages, where trace element concentrations impact the immune response, bacterial metal metabolism...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18112375
更新日期：2017-11-09 00:00:00
abstract：:Pasting properties are important characteristics of barley starch from a processing standpoint. Many studies reported the close relationship between pasting properties and malting quality, especially malt extract. However, most conclusions were derived from the correlation between pasting properties and malting qualit...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19113559
更新日期：2018-11-12 00:00:00
abstract：:Passage of apolipoprotein B-containing lipoproteins (apoB-LPs), i.e., triglyceride-rich lipoproteins (TRLs), intermediate-density lipoproteins (IDLs), and low-density lipoproteins (LDLs), through the endothelial monolayer occurs in normal and atherosclerotic arteries. Among these lipoproteins, TRLs and IDLs are apoE-r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19113593
更新日期：2018-11-14 00:00:00
abstract：:Although mitochondrial dysfunction has been implicated in aging, physical function decline, and several age-related diseases, an accessible and affordable measure of mitochondrial health is still lacking. In this study we identified the proteomic signature of muscular mitochondrial oxidative capacity in plasma. In 165...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21249540
更新日期：2020-12-15 00:00:00
abstract：:MicroRNAs have been identified as key regulators of gene expression and thus their potential in disease diagnostics, prognosis and therapy is being actively pursued. Deregulation of microRNAs in cerebral pathogenesis has been reported to a limited extent in both animal models and human. Due to the complexity of the pa...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15011418
更新日期：2014-01-20 00:00:00
abstract：:Wrist osteoarthritis (OA) is one of the most common conditions encountered by hand surgeons with limited efficacy of non-surgical treatments. The purpose of this study is to describe the Platelet-Rich Plasma (PRP) mixed-microfat biological characteristics of an experimental Advanced Therapy Medicinal Product (ATMP) ne...
journal_title：International journal of molecular sciences
pub_type： 临床试验,杂志文章
doi：10.3390/ijms20051111
更新日期：2019-03-05 00:00:00
