Abstract：
:Leaf senescence is a highly-programmed developmental process regulated by an array of multiple signaling pathways. Our group previously reported that overexpression of the protein phosphatase-encoding gene SSPP led to delayed leaf senescence and significantly enhanced cytokinin responses. However, it is still unclear how the delayed leaf senescence phenotype is associated with the enhanced cytokinin responses. In this study, we introduced a cytokinin receptor AHK3 knockout into the 35S:SSPP background. The phenotypic analysis of double mutant revealed that AHK3 loss-of-function reversed the delayed leaf senescence induced by SSPP. Moreover, we found the hypersensitivity of 35S:SSPP to exogenous cytokinin treatment disappeared due to the introduction of AHK3 knockout. Collectively, our results demonstrated that AHK3-mediated cytokinin signaling is required for the delayed leaf senescence caused by SSPP overexpression and the detailed mechanism remains to be further elucidated.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Wang Y,Zhang X,Cui Y,Li L,Wang D,Mei Y,Wang NNdoi
10.3390/ijms20082043subject
Has Abstractpub_date
2019-04-25 00:00:00issue
8issn
1422-0067pii
ijms20082043journal_volume
20pub_type
杂志文章abstract：:Fibrotic diseases, such as liver, pulmonary and renal fibrosis, are common end-stage conditions and represent a major global health problem. Furthermore, effective therapeutic measures are presently unavailable. Extracellular matrix accumulation is the most prominent characteristic in the pathogenesis of fibrotic dise...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms14010226
更新日期：2012-12-21 00:00:00
abstract：:Circulating microRNAs (miRNAs) hold great potential as novel diagnostic markers for acute coronary syndrome (ACS). This study sought to identify plasma miRNAs that are differentially expressed in young ACS patients (mean age of 38.5 ± 4.3 years) and evaluate their diagnostic potentials. Small RNA sequencing (sRNA-seq)...
journal_title：International journal of molecular sciences
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更新日期：2018-05-15 00:00:00
abstract：:Winter's advent invokes physiological adjustments that permit temperate ectotherms to cope with stresses such as food shortage, water deprivation, hypoxia, and hypothermia. We used liquid chromatography (LC) in combination with tandem mass spectrometry (MS/MS) quantitative isobaric (iTRAQ™) peptide mapping to assess v...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
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journal_title：International journal of molecular sciences
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更新日期：2012-11-26 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2018-01-30 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-07-12 00:00:00
abstract：:The recombinant baculovirus has been widely used as an efficient tool to mediate gene delivery into mammalian cells but has barely been used in fish cells. In the present study, we constructed a recombinant baculovirus containing the dual-promoter cytomegalovirus (CMV) and white spot syndrome virus (WSSV) immediate-ea...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19123767
更新日期：2018-11-27 00:00:00
abstract：:Duloxetine (DLX) is a potent drug investigated for the treatment of depression and urinary incontinence. DLX is extensively metabolized in the liver by two P450 isozymes, CYP2D6 and CYP1A2. Propolis (PPL) is one of the popular functional foods known to have effects on activities of CYPs, including CYP1A2. Due to the h...
journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2019-05-30 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms15010545
更新日期：2014-01-06 00:00:00
abstract：:Spinal cord injury (SCI) results in neuronal and glial death and the loss of axons at the injury site. Inflammation after SCI leads to the inhibition of tissue regeneration and reduced neuronal survival. In addition, the loss of axons after SCI results in functional loss below the site of injury accompanied by neurona...
journal_title：International journal of molecular sciences
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更新日期：2014-07-25 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2013-08-22 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17101596
更新日期：2016-09-27 00:00:00
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journal_title：International journal of molecular sciences
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doi：10.3390/ijms20235860
更新日期：2019-11-22 00:00:00
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journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020452
更新日期：2017-02-20 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2017-01-26 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2015-11-19 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-04-16 00:00:00
