Abstract：
:Homeodomain-interacting protein kinase 2 (HIPK2) is a serine/threonine kinase that phosphorylates and activates the apoptotic program through interaction with diverse downstream targets including tumor suppressor p53. HIPK2 is activated by genotoxic stimuli and modulates cell fate following DNA damage. The DNA damage response (DDR) is triggered by DNA lesions or chromatin alterations. The DDR regulates DNA repair, cell cycle checkpoint activation, and apoptosis to restore genome integrity and cellular homeostasis. Maintenance of the DDR is essential to prevent development of diseases caused by genomic instability, including cancer, defects of development, and neurodegenerative disorders. Recent studies reveal a novel HIPK2-mediated pathway for DDR through interaction with chromatin remodeling factor homeodomain protein 1γ. In this review, we will highlight the molecular mechanisms of HIPK2 and show its functions as a crucial DDR regulator.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Kuwano Y,Nishida K,Akaike Y,Kurokawa K,Nishikawa T,Masuda K,Rokutan Kdoi
10.3390/ijms17101638subject
Has Abstractpub_date
2016-09-27 00:00:00issue
10issn
1422-0067pii
ijms17101638journal_volume
17pub_type
杂志文章,评审abstract：:A comprehensive proteome map of T-lymphoblastic leukemia cells and its alterations after daunorubicin, doxorubicin and mitoxantrone treatments was monitored and evaluated either by paired comparison with relevant untreated control and using multivariate classification of treated and untreated samples. With the main fo...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms131215536
更新日期：2012-11-22 00:00:00
abstract：:Ca2+ signaling has been involved in controling critical cellular functions such as activation of proteases, cell death, and cell cycle control. The endoplasmatic reticulum plays a significant role in Ca2+ storage inside the cell, but mitochondria have long been recognized as a fundamental Ca2+ pool. Protozoan parasite...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms22010469
更新日期：2021-01-05 00:00:00
abstract：:Heterogeneous nuclear ribonucleoproteins (hnRNPs) are structurally and functionally distinct proteins containing specific domains and motifs that enable the proteins to bind certain nucleotide sequences, particularly those found in human telomeres. In human malignant cells (HMCs), hnRNP-A1-the most studied hnRNP-is an...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20030745
更新日期：2019-02-10 00:00:00
abstract：:Ile-Ala-Val-Pro-Gly-Glu-Val-Ala (IAVPGEVA), Ile-Ala-Val-Pro-Thr-Gly-Val-Ala (IAVPTGVA) and Leu-Pro-Tyr-Pro (LPYP), three peptides deriving from soy glycinin hydrolysis, are known to regulate cholesterol metabolism in human hepatic HepG2 cells. We have recently demonstrated that the mechanism of action involves the act...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161126029
更新日期：2015-11-16 00:00:00
abstract：:Lysinuric protein intolerance (LPI) is a rare autosomal disease caused by defective cationic amino acid (CAA) transport due to mutations in SLC7A7, which encodes for the y+LAT1 transporter. LPI patients suffer from a wide variety of symptoms, which range from failure to thrive, hyperammonemia, and nephropathy to pulmo...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20215294
更新日期：2019-10-24 00:00:00
abstract：:The emergence of the novel coronavirus in Wuhan, China, which causes severe respiratory tract infections in humans (COVID-19), has become a global health concern. Most coronaviruses infect animals but can evolve into strains that cross the species barrier and infect humans. At the present, there is no single specific ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21072272
更新日期：2020-03-25 00:00:00
abstract：:Pinellia ternata is an important traditional Chinese medicinal plant. The growth of P. ternata is sensitive to high temperatures. To gain a better understanding of heat stress responses in P. ternata, we performed a comparative proteomic analysis. P. ternata seedlings were subjected to a temperature of 38 °C and sampl...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms141020614
更新日期：2013-10-15 00:00:00
abstract：:The relationship between antiphospholipid antibodies (aPL) and autoimmune haemolytic anaemia (AIHA) has never been systematically addressed. The aim of this study is to assess the link between aPL and AIHA in adult systemic lupus erythematosus (SLE) and antiphospholipid syndrome (APS). This study performed an EMBASE/P...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21114120
更新日期：2020-06-09 00:00:00
abstract：:Over 70 different genetic variants with a significant association with rheumatoid arthritis (RA) have been discovered. Anti-citrullination protein antibodies (ACPA)-positive RA variants are more well-defined than their ACPA-negative counterparts. The human leukocyte antigen, HLA-DRB1 locus remains the prime suspect in...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17060900
更新日期：2016-06-08 00:00:00
abstract：:Axitinib is an orally available inhibitor of tyrosine kinases, with high specificity for vascular endothelial growth factor receptors (VEGFRs) 1, 2, and 3. It is approved for the treatment of advanced renal cell carcinoma and is in phase II clinical trials for recurrent glioblastoma (GBM). GBM is a brain tumor peculia...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041490
更新日期：2020-02-21 00:00:00
abstract：:Regulation of melanogenesis has been the focus of treatment for hyperpigmentary skin disorders. Although hesperidin is one of the most well-known, naturally occurring flavonoids with antioxidant and anti-inflammatory effect, its anti-melanogenic effect is not known. The present study aims to determine the anti-melanog...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160818384
更新日期：2015-08-07 00:00:00
abstract：:The stem cells of neurogenesis and carcinogenesis share many properties, including proliferative rate, an extensive replicative potential, the potential to generate different cell types of a given tissue, and an ability to independently migrate to a damaged area. This is also evidenced by the common molecular principl...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21051691
更新日期：2020-03-01 00:00:00
abstract：:Ramie (Boehmeria nivea L. Gaud), commonly known as China grass, is a perennial bast fiber plant of the Urticaceae. In China, ramie farming, industry, and trade provide income for about five million people. Drought stress severely affects ramie stem growth and causes a dramatic decrease in ramie fiber production. There...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms16023493
更新日期：2015-02-04 00:00:00
abstract：:Merkel cell carcinomas (MCCs) are rare, aggressive, cutaneous neuroendocrine tumours, approximately 80% of which are caused by the genomic integration of Merkel cell polyomavirus (MCPyV). MCPyV-positive MCCs carry poor prognosis in approximately 70% of cases, highlighting the need for greater understanding of the onco...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218222
更新日期：2020-11-03 00:00:00
abstract：:The discovery of cell-free fetal DNA molecules in plasma of pregnant women has created a paradigm shift in noninvasive prenatal testing (NIPT). Circulating cell-free DNA in maternal plasma has been increasingly recognized as an important proxy to detect fetal abnormalities in a noninvasive manner. A variety of approac...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18020453
更新日期：2017-02-20 00:00:00
abstract：:A series of diketopyrrolopyrrole-based small molecules have been designed to explore their optical, electronic, and charge transport properties as organic solar cell(OSCs) materials. The calculation results showed that the designed molecules can lower the band gap and extend the absorption spectrum towards longer wave...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms160920326
更新日期：2015-08-27 00:00:00
abstract：:Melatonin is a pleiotropic molecule with many cellular and systemic actions, including chronobiotic effects. Beneficial effects are widely documented concerning the treatment of neoplastic diseases in vivo as well as reductions in viability of cultured cells from melanoma, one of the most aggressive cancers in humans....
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14023901
更新日期：2013-02-14 00:00:00
abstract：:The mammalian target of rapamycin (mTOR) is the central regulator of mammalian cell growth, and is essential for the formation of two structurally and functionally distinct complexes: mTORC1 and mTORC2. mTORC1 can sense multiple cues such as nutrients, energy status, growth factors and hormones to control cell growth ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms17101636
更新日期：2016-09-29 00:00:00
abstract：:Cynoglossus semilaevis is an important economic fish species and has long been cultivated in China. Since the completion of its genome and transcriptome sequencing, genes relating to C. semilaevis development have been extensively studied. R-spondin 3 (Rspo3) is a member of the R-spondin family. It plays an important ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19071915
更新日期：2018-06-29 00:00:00
abstract：:The d-galactose (d-gal)-injected animal model, which is typically established by administering consecutive subcutaneous d-gal injections to animals for approximately six or eight weeks, has been frequently used for aging research. In addition, this animal model has been demonstrated to accelerate aging in the brain, k...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17010098
更新日期：2016-01-13 00:00:00
abstract：:Grape hyacinth (Muscari spp.) is a popular ornamental plant with bulbous flowers noted for their rich blue color. Muscari species have been thought to accumulate delphinidin and cyanidin rather than pelargonidin-type anthocyanins because their dihydroflavonol 4-reductase (DFR) does not efficiently reduce dihydrokaempf...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20194743
更新日期：2019-09-24 00:00:00
abstract：:Overabundance of extracellular matrix resulting from hyperproliferation of keloid fibroblasts (KFs) and dysregulation of apoptosis represents the main pathophysiology underlying keloids. High-mobility group box 1 (HMGB1) plays important roles in the regulation of cellular death. Suppression of HMGB1 inhibits autophagy...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20174134
更新日期：2019-08-24 00:00:00
abstract：:Larix olgensis Henry is an important coniferous species found in plantation forests in northeastern China, but it is vulnerable to pathogens. Nitric oxide (NO) is an important molecule involved in plant resistance to pathogens. To study the regulatory role of NO at the transcriptional level, we characterized the trans...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms161226117
更新日期：2015-12-02 00:00:00
abstract：:In the absence of visible mucosal damage, it is hypothesized that the esophageal mucosal barrier is functionally impaired in patients with non-erosive reflux disease (NERD). The aim of the present study was to perform an exploratory analysis of the mucosal barrier in NERD compared to erosive esophagitis (EE) and contr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18051091
更新日期：2017-05-19 00:00:00
abstract：:The selective binding of six (S)-quinuclidine-triazoles and their (R)-enantiomers to nicotinic acetylcholine receptor (nAChR) subtypes α3β4 and α7, respectively, were analyzed by in silico docking to provide the insight into the molecular basis for the observed stereospecific subtype discrimination. Homology modeling ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21176189
更新日期：2020-08-27 00:00:00
abstract：:A distinct G-protein coupled receptor that senses changes in extracellular Zn2+, ZnR/GPR39, was found in cells from tissues in which Zn2+ plays a physiological role. Most prominently, ZnR/GPR39 activity was described in prostate cancer, skin keratinocytes, and colon epithelial cells, where zinc is essential for cell g...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms19020439
更新日期：2018-02-01 00:00:00
abstract：:Endoplasmic reticulum stress (ERS) is one of the mechanisms of apoptotic cell death. Inhibiting the apoptosis induced by ERS may be a novel therapeutic target in cardiovascular diseases. Icariin, a flavonoid isolated from Epimedium brevicornum Maxim, has been demonstrated to have cardiovascular protective effects, but...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140917845
更新日期：2013-08-30 00:00:00
abstract：:Matrix metalloproteinase-1 (MMP-1) is one of the most widely studied enzymes involved in collagen degradation. Mutations of specific residues in the MMP-1 hemopexin-like (HPX) domain have been shown to modulate activity of the MMP-1 catalytic (CAT) domain. In order to reveal the structural and conformational effects o...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17101727
更新日期：2016-10-14 00:00:00
abstract：BACKGROUND:Although it has been previously demonstrated that acute inflammation can promote the tumor growth of a sub-tumorigenic dose of melanoma cells through of 5-lipoxygenase inflammatory pathway and its product leukotriene B4, and also that the peritumoral treatment with eicosapentaenoic acid and its product, leuk...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20153765
更新日期：2019-08-01 00:00:00
abstract：:Cysteine cathepsins are lysosomal enzymes belonging to the papain family. Their expression is misregulated in a wide variety of tumors, and ample data prove their involvement in cancer progression, angiogenesis, metastasis, and in the occurrence of drug resistance. However, while their overexpression is usually associ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20143602
更新日期：2019-07-23 00:00:00
