Abstract：
:The outer and inner dynein arms (ODAs and IDAs) are composed of multiple subunits including dynein heavy chains possessing a motor domain. These complex structures are preassembled in the cytoplasm before being transported to the cilia. The molecular mechanism(s) controlling dynein arms' preassembly is poorly understood. Recent evidence suggests that canonical R2TP complex, an Hsp-90 co-chaperone, in cooperation with dynein axonemal assembly factors (DNAAFs), plays a crucial role in the preassembly of ODAs and IDAs. Here, we have summarized recent data concerning the identification of novel chaperone complexes and their role in dynein arms' preassembly and their association with primary cilia dyskinesia (PCD), a human genetic disorder.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Fabczak H,Osinka Adoi
10.3390/ijms20246174subject
Has Abstractpub_date
2019-12-07 00:00:00issue
24issn
1422-0067pii
ijms20246174journal_volume
20pub_type
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