Abstract：
:Rheumatoid arthritis (RA) is a systemic, inflammatory, and autoimmune disorder. Gut microbiota play an important role in the etiology of RA. With the considerable progress made in next-generation sequencing techniques, the identified gut microbiota difference between RA patients and healthy individuals provides an updated overview of the association between gut microbiota and RA. We reviewed the reported correlation and underlying molecular mechanisms among gut microbiota, the immune system, and RA. It has become known that gut microbiota contribute to the pathogenesis of RA via multiple molecular mechanisms. The progressive understanding of the dynamic interaction between gut microbiota and their host will help in establishing a highly individualized management for each RA patient, and achieve a better efficacy in clinical practice, or even discovering new drugs for RA.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Wu X,He B,Liu J,Feng H,Ma Y,Li D,Guo B,Liang C,Dang L,Wang L,Tian J,Zhu H,Xiao L,Lu C,Lu A,Zhang Gdoi
10.3390/ijms17030431subject
Has Abstractpub_date
2016-03-22 00:00:00pages
431issue
3issn
1422-0067pii
ijms17030431journal_volume
17pub_type
杂志文章,评审abstract：:Histone acetylation plays an important role in plant growth and development. Here, we investigated the effect of sodium butyrate (NaB), a histone deacetylase inhibitor, on adventitious shoot formation from protoplast-derived calli and cotyledon explants of tobacco (Nicotiana benthamiana) and tomato (Solanum lycopersic...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228451
更新日期：2020-11-10 00:00:00
abstract：:Hepatic diseases, like viral hepatitis, autoimmune hepatitis, hereditary hemochromatosis, non-alcoholic fatty liver disease (NAFLD) and Wilson's disease, play an important role in the development of liver cirrhosis and, hence, hepatocellular carcinoma. In this review, the current treatment options and the molecular me...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms15057500
更新日期：2014-04-30 00:00:00
abstract：: Adenosine monophosphate-activated protein kinase (AMPK) is an important energy sensor which is activated by increases in adenosine monophosphate (AMP)/adenosine triphosphate (ATP) ratio and/or adenosine diphosphate (ADP)/ATP ratio, and increases different metabolic pathways such as fatty acid oxidation, glucose trans...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18020288
更新日期：2017-01-29 00:00:00
abstract：:Antimicrobial peptides (AMPs) are molecules widespread in all branches of the tree of life that participate in host defense and/or microbial competition. Due to their positive charge, hydrophobicity and amphipathicity, they preferentially disrupt negatively charged bacterial membranes. AMPs are considered an important...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21124310
更新日期：2020-06-17 00:00:00
abstract：:Although butylidenephthalide (BP) is an efficient anticancer drug, its poor bioavailability renders it ineffective for treating drug-resistant brain tumors. However, this problem is overcome through the use of noninvasive delivery systems, including intranasal administration. Herein, the bioavailability, drug stabilit...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21124408
更新日期：2020-06-21 00:00:00
abstract：:A series of anti-inflammatory derivatives containing an N-acyl hydrazone subunit (4a-e) were synthesized and characterized. Docking studies were performed that suggest that compounds 4a-e bind to cyclooxygenase (COX)-1 and COX-2 isoforms, but with higher affinity for COX-2. The compounds display similar anti-inflammat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15045821
更新日期：2014-04-04 00:00:00
abstract：:Cover crops are key determinants of the ecological stability and sustainability of continuous cropping soils. However, their agro-ecological role in differentially reshaping the microbiome structure and functioning under a degraded agroecosystem remains poorly investigated. Therefore, structural and metabolic changes ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20112619
更新日期：2019-05-28 00:00:00
abstract：:Alpha thalassaemia is highly prevalent in the plural society of Malaysia and is a public health problem. Haematological and molecular data from 5016 unrelated patients referred from various hospitals to the Institute for Medical Research for α thalassaemia screening from 2007 to 2010 were retrieved. The aims of this r...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms140918599
更新日期：2013-09-10 00:00:00
abstract：:Mango is affected by different decline disorders causing significant losses to mango growers. In the United Arab Emirates (UAE), the pathogen was isolated from all tissues sampled from diseased trees affected by Lasiodiplodia theobromae. Symptoms at early stages of the disease included general wilting appearance of ma...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18102086
更新日期：2017-10-20 00:00:00
abstract：:A psychrotolerant bacterium, strain T-3 (identified as Psychrobacter piscatorii), that exhibited an extraordinarily high catalase activity was isolated from the drain pool of a plant that uses H(2)O(2) as a bleaching agent. Its cell extract exhibited a catalase activity (19,700 U·mg protein(-1)) that was higher than t...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13021733
更新日期：2012-01-01 00:00:00
abstract：:Glucose-6-phosphate dehydrogenase (G6PD) deficiency in humans causes severe disease, varying from mostly asymptomatic individuals to patients showing neonatal jaundice, acute hemolysis episodes or chronic nonspherocytic hemolytic anemia. In order to understand the effect of the mutations in G6PD gene function and its ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17050787
更新日期：2016-05-21 00:00:00
abstract：:Merging targeted systemic gene delivery and systemic chemotherapy against cancer, chemovirotherapy, has the potential to improve chemotherapy and gene therapy treatments and overcome cancer resistance. We introduced a bacteriophage (phage) vector, named human adeno-associated virus (AAV)/phage or AAVP, for the systemi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21217867
更新日期：2020-10-23 00:00:00
abstract：:Cynoglossus semilaevis is an important economic fish species and has long been cultivated in China. Since the completion of its genome and transcriptome sequencing, genes relating to C. semilaevis development have been extensively studied. R-spondin 3 (Rspo3) is a member of the R-spondin family. It plays an important ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19071915
更新日期：2018-06-29 00:00:00
abstract：:Phenolic compounds, which are secondary plant metabolites, are considered an integral part of the human diet. Physiological properties of dietary polyphenols have come to the attention in recent years. Especially, proanthocyanidins (ranging from dimers to decamers) have demonstrated potential interactions with biologi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020376
更新日期：2017-02-10 00:00:00
abstract：:The vast majority of marketed drugs are orally administrated. As such, drug absorption is one of the important drug metabolism and pharmacokinetics parameters that should be assessed in the process of drug discovery and development. A nonlinear quantitative structure-activity relationship (QSAR) model was constructed ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21103582
更新日期：2020-05-19 00:00:00
abstract：:Zinc (Zn) and iron (Fe) are essential but are sometimes deficient in humans, while cadmium (Cd) is toxic if it accumulates in the liver and kidneys at high levels. All three are contained in the grains of rice, a staple cereal. Zn and Fe concentrations in rice grains harvested under different levels of soil/hydroponic...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms160819111
更新日期：2015-08-13 00:00:00
abstract：:According to recent estimates, 2%-15% of couples are sterile, and approximately half of the infertility cases are attributed to male reproductive factors. However, the reasons remain undefined in approximately 25% of male infertility cases, and most infertility cases exhibit spermatogenic defects. Numerous genes invol...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18010097
更新日期：2017-01-05 00:00:00
abstract：:Pulmonary arterial hypertension (PAH) is a rare disease caused by pulmonary vascular remodeling. Current vasodilator treatments have substantially improved patients' survival. This improved survival has led to the appearance of complications related to conditions previously underdiagnosed or even ignored, such as pulm...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21072509
更新日期：2020-04-04 00:00:00
abstract：:Phytoalexins are antimicrobial substances of low molecular weight produced by plants in response to infection or stress, which form part of their active defense mechanisms. Starting in the 1950's, research on phytoalexins has begun with biochemistry and bio-organic chemistry, resulting in the determination of their st...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms140714136
更新日期：2013-07-08 00:00:00
abstract：:Citral is well known for its antimicrobial, antifungal, and insecticidal activities. Natural sesquiterpene α-methylenelactones also exhibit a broad spectrum of biological activities. The aim of the study was to explore the effect of structural changes to citral molecules on citral behavior-modifying activity towards M...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21218029
更新日期：2020-10-28 00:00:00
abstract：:One of the major current trends in cancer immunotherapy is the blockade of immune checkpoint proteins that negatively regulate the immune response. This has been achieved through antibodies blocking PD-1/PD-L1 and CTLA-4/CD80/CD86 interactions. Such antibodies have revolutionized oncological therapy and shown a new wa...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21228876
更新日期：2020-11-23 00:00:00
abstract：:Overexpression of Sonic Hedgehog signaling (Shh) pathway molecules is associated with invasiveness and recurrence in breast carcinoma. Therefore, inhibition of the Shh pathway downstream molecule Glioma-associated Oncogene Homolog (Gli) was investigated for its ability to reduce progression and invasiveness of patient...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19051375
更新日期：2018-05-05 00:00:00
abstract：:The sugar beet monosomic addition line M14 is a unique germplasm that contains genetic materials from Beta vulgaris L. and Beta corolliflora Zoss, and shows tolerance to salt stress. Our study focuses on exploring the molecular mechanism of the salt tolerance of the sugar beet M14. In order to identify differentially ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18040847
更新日期：2017-04-18 00:00:00
abstract：:Esophageal cancer remains a challenging disease due to limited treatment options and poor prognosis. In recent years, immune checkpoint inhibitors (ICI) have been proven to be safe and effective in the treatment of highly lethal malignancies, such as non-small cell lung cancer and melanoma. Recent clinical trials also...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21051658
更新日期：2020-02-28 00:00:00
abstract：:Metallothioneins have been viewed as modulators in a number of biological regulations regarding cancerous development; however, the function of metallothionein 3 (MT3) in bladder cancer is unexplored. We determined the regulatory mechanisms and potential function of MT3 in bladder carcinoma cells. Real-Time Reverse Tr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20040980
更新日期：2019-02-23 00:00:00
abstract：:The Prostate Health Index (PHI) has been used increasingly in the context of prostate cancer (PCa) diagnostics since 2010. Previous studies have shown an association between PHI and a tumor volume of >0.5 cm³. The aim of this study was to investigate the correlation between PHI and tumor volume as well as the Gleason ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18030488
更新日期：2017-02-24 00:00:00
abstract：:With the avalanche of biological sequences generated in the postgenomic age, molecular science is facing an unprecedented challenge, i.e., how to timely utilize the huge amount of data to benefit human beings. Stimulated by such a challenge, a rapid development has taken place in molecular science, particularly in the...
journal_title：International journal of molecular sciences
pub_type： 社论
doi：10.3390/ijms151120072
更新日期：2014-11-04 00:00:00
abstract：:Calcium (Ca2+) plays an important role in regulating the differentiation and function of osteoclasts. Calcium oscillations (Ca oscillations) are well-known phenomena in receptor activator of nuclear factor kappa B ligand (RANKL)-induced osteoclastogenesis and bone resorption via calcineurin. Many modifiers are involve...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms22010180
更新日期：2020-12-26 00:00:00
abstract：:This study describes the simple synthesis of new (quinazolin-4-ylamino) methylphosphonates via microwave irradiation. Substituted-2-aminobenzonitrile reacted with 1,1-dimethoxy-N,N-dimethylmethanamine at a reflux condition to obtain N'-(substituted-2-cyanophenyl)-N,N-dimethylformamidine (1). The subsequent reaction of...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13066730
更新日期：2012-01-01 00:00:00
abstract：:Breast cancer is a common malignancy threatening women's health around the world. Despite improved treatments for different subtypes of breast tumors that have been put forward, there still exists a poor therapeutic response and prognosis. Magnetic fields, as a non-invasive therapy, have shown anti-tumor effects in vi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21082952
更新日期：2020-04-22 00:00:00
