Abstract：
: Adenosine monophosphate-activated protein kinase (AMPK) is an important energy sensor which is activated by increases in adenosine monophosphate (AMP)/adenosine triphosphate (ATP) ratio and/or adenosine diphosphate (ADP)/ATP ratio, and increases different metabolic pathways such as fatty acid oxidation, glucose transport and mitochondrial biogenesis. In this sense, AMPK maintains cellular energy homeostasis by induction of catabolism and inhibition of ATP-consuming biosynthetic pathways to preserve ATP levels. Several studies indicate a reduction of AMPK sensitivity to cellular stress during aging and this could impair the downstream signaling and the maintenance of the cellular energy balance and the stress resistance. However, several diseases have been related with an AMPK dysfunction. Alterations in AMPK signaling decrease mitochondrial biogenesis, increase cellular stress and induce inflammation, which are typical events of the aging process and have been associated to several pathological processes. In this sense, in the last few years AMPK has been identified as a very interesting target and different nutraceutical compounds are being studied for an interesting potential effect on AMPK induction. In this review, we will evaluate the interaction of the different nutraceutical compounds to induce the AMPK phosphorylation and the applications in diseases such as cancer, type II diabetes, neurodegenerative diseases or cardiovascular diseases.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Marín-Aguilar F,Pavillard LE,Giampieri F,Bullón P,Cordero MDdoi
10.3390/ijms18020288subject
Has Abstractpub_date
2017-01-29 00:00:00issue
2issn
1422-0067pii
ijms18020288journal_volume
18pub_type
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journal_title：International journal of molecular sciences
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更新日期：2020-10-25 00:00:00
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更新日期：2018-12-26 00:00:00
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更新日期：2017-03-22 00:00:00
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更新日期：2014-09-05 00:00:00
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更新日期：2015-10-22 00:00:00
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pub_type： 已发布勘误
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更新日期：2019-08-26 00:00:00
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更新日期：2019-04-17 00:00:00
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更新日期：2017-02-24 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2017-07-18 00:00:00
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更新日期：2020-02-13 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2020-09-19 00:00:00
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更新日期：2020-12-05 00:00:00
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pub_type： 杂志文章
doi：10.3390/ijms19113301
更新日期：2018-10-24 00:00:00
