Involvement of Satellite Cell Activation via Nitric Oxide Signaling in Ectopic Orofacial Hypersensitivity.


:: The mechanical head-withdrawal threshold (MHWT) was significantly reduced following inferior alveolar nerve transection (IANX) in rats. Nitrate and nitrite synthesis was dramatically increased in the trigeminal ganglion (TG) at 6 h after the IANX. The relative number of neuronal nitric oxide synthase (nNOS)-immunoreactive (IR) cells was significantly higher in IANX rats compared to sham-operated and N-propyl-L-arginine (NPLA)-treated IANX rats. On day 3 after NPLA administration, the MHWT recovered considerably in IANX rats. Following L-arginine injection into the TG, the MHWT was significantly reduced within 15 min, and the mean number of TG cells encircled by glial fibrillary acidic protein (GFAP)-IR cells was substantially higher. The relative number of nNOS-IR cells encircled by GFAP-IR cells was significantly increased in IANX rats. In contrast, after NPLA injection into the TG, the relative number of GFAP-IR cells was considerably reduced in IANX rats. Fluorocitrate administration into the TG significantly reduced the number of GFAP-IR cells and prevented the MHWT reduction in IANX rats. The present findings suggest that following IANX, satellite glial cells are activated via nitric oxide (NO) signaling from TG neurons. The spreading satellite glial cell activation within the TG results in mechanical hypersensitivity of face regions not directly associated with the trigeminal nerve injury.


Int J Mol Sci


Lee J,Ohara K,Shinoda M,Hayashi Y,Kubo A,Sugawara S,Asano S,Soma K,Kanno K,Ando M,Koyama R,Kimura Y,Sakanashi K,Iinuma T,Iwata K




Has Abstract


2020-02-13 00:00:00










  • Chemical Defoliant Promotes Leaf Abscission by Altering ROS Metabolism and Photosynthetic Efficiency in Gossypium hirsutum.

    abstract::Chemical defoliation is an important part of cotton mechanical harvesting, which can effectively reduce the impurity content. Thidiazuron (TDZ) is the most used chemical defoliant on cotton. To better clarify the mechanism of TDZ promoting cotton leaf abscission, a greenhouse experiment was conducted on two cotton cul...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Jin D,Wang X,Xu Y,Gui H,Zhang H,Dong Q,Sikder RK,Yang G,Song M

    更新日期:2020-04-15 00:00:00

  • Dietary Supplementation with Lactobacillus casei Alleviates Lipopolysaccharide-Induced Liver Injury in a Porcine Model.

    abstract::This study aims to determine whether Lactobacillus casei (L. casei) could relieve liver injury in piglets challenged with lipopolysaccharide (LPS). Piglets were randomly allocated into one of the three groups: control, LPS, and L. casei. The control and LPS groups were fed a corn- and soybean meal-based diet, whereas ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Zhao D,Wu T,Yi D,Wang L,Li P,Zhang J,Hou Y,Wu G

    更新日期:2017-11-26 00:00:00

  • Effects of calorie restriction and IGF-1 receptor blockade on the progression of 22Rv1 prostate cancer xenografts.

    abstract::Calorie restriction (CR) inhibits prostate cancer progression, partially through modulation of the IGF axis. IGF-1 receptor (IGF-1R) blockade reduces prostate cancer xenograft growth. We hypothesized that combining calorie restriction with IGF-1R blockade would have an additive effect on prostate cancer growth. Severe...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Galet C,Gray A,Said JW,Castor B,Wan J,Beltran PJ,Calzone FJ,Elashoff D,Cohen P,Aronson WJ

    更新日期:2013-07-03 00:00:00

  • Muscle-Saturated Bioactive Lipids Are Increased with Aging and Influenced by High-Intensity Interval Training.

    abstract::Ceramide and diacylglycerol are linked to insulin resistance in rodents, but in humans the data are inconsistent. Insulin resistance is frequently observed with aging, but the role of ceramide and diacylglycerol is not clarified. Training improves metabolic health and, therefore, we aimed to elucidate the influence of...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Søgaard D,Baranowski M,Larsen S,Taulo Lund M,Munk Scheuer C,Vestergaard Abildskov C,Greve Dideriksen S,Dela F,Wulff Helge J

    更新日期:2019-03-12 00:00:00

  • Real-Time 3D Imaging and Inhibition Analysis of Various Amyloid Aggregations Using Quantum Dots.

    abstract::Amyloidosis refers to aggregates of protein that accumulate and are deposited as amyloid fibrils into plaques. When these are detected in organs, they are the main hallmark of Alzheimer's disease, Parkinson's disease, and other related diseases. Recent medical advances have shown that many precursors and proteins can ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Lin X,Galaqin N,Tainaka R,Shimamori K,Kuragano M,Noguchi TQP,Tokuraku K

    更新日期:2020-03-13 00:00:00

  • Predicting the Functional Impact of CDH1 Missense Mutations in Hereditary Diffuse Gastric Cancer.

    abstract::The role of E-cadherin in Hereditary Diffuse Gastric Cancer (HDGC) is unequivocal. Germline alterations in its encoding gene (CDH1) are causative of HDGC and occur in about 40% of patients. Importantly, while in most cases CDH1 alterations result in the complete loss of E-cadherin associated with a well-established cl...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Melo S,Figueiredo J,Fernandes MS,Gonçalves M,Morais-de-Sá E,Sanches JM,Seruca R

    更新日期:2017-12-12 00:00:00

  • Investigating the Role of VDR and Megalin in Semi-Selectivity of Side-Chain Modified 19-nor Analogs of Vitamin D.

    abstract::1,25-dihydroxyvitamin D3 (1,25D3) is implicated in many cellular functions, including cell proliferation and differentiation, thus exerting potential antitumor effects. A major limitation for therapeutic use of 1,25D3 are potent calcemic activities. Therefore, synthetic analogs of 1,25D3 for use in anticancer therapy ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Berkowska K,Corcoran A,Grudzień M,Jakuszak A,Chodyński M,Kutner A,Marcinkowska E

    更新日期:2019-08-26 00:00:00

  • Molecular Changes Concomitant with Vascular System Development in Mature Galls Induced by Root-Knot Nematodes in the Model Tree Host Populus tremula × P. alba.

    abstract::One of the most striking features occurring in the root-knot nematode Meloidogyne incognita induced galls is the reorganization of the vascular tissues. During the interaction of the model tree species Populus and M. incognita, a pronounced xylem proliferation was previously described in mature galls. To better charac...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Baldacci-Cresp F,Behr M,Kohler A,Badalato N,Morreel K,Goeminne G,Mol A,de Almeida Engler J,Boerjan W,El Jaziri M,Baucher M

    更新日期:2020-01-09 00:00:00

  • Cardiotonic Steroids-A Possible Link Between High-Salt Diet and Organ Damage.

    abstract::High dietary salt intake has been listed among the top ten risk factors for disability-adjusted life years. We discuss the role of endogenous cardiotonic steroids in mediating the dietary salt-induced hypertension and organ damage. ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Paczula A,Wiecek A,Piecha G

    更新日期:2019-01-30 00:00:00

  • 3D-Reconstructed Retinal Pigment Epithelial Cells Provide Insights into the Anatomy of the Outer Retina.

    abstract::The retinal pigment epithelium (RPE) is located between the neuroretina and the choroid, and plays a critical role in vision. RPE cells internalise outer segments (OS) from overlying photoreceptors in the daily photoreceptor renewal. Changes to RPE structure are linked with age and retinopathy, which has been describe...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Keeling E,Chatelet DS,Tan NYT,Khan F,Richards R,Thisainathan T,Goggin P,Page A,Tumbarello DA,Lotery AJ,Ratnayaka JA

    更新日期:2020-11-09 00:00:00

  • Chromatin structure following UV-induced DNA damage-repair or death?

    abstract::In eukaryotes, DNA is compacted into a complex structure known as chromatin. The unravelling of DNA is a crucial step in DNA repair, replication, transcription and recombination as this allows access to DNA for these processes. Failure to package DNA into the nucleosome, the individual unit of chromatin, can lead to g...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Farrell AW,Halliday GM,Lyons JG

    更新日期:2011-01-01 00:00:00

  • Insight in Adhesion Protein Sialylation and Microgravity Dependent Cell Adhesion-An Omics Network Approach.

    abstract::The adhesion behavior of human tissue cells changes in vitro, when gravity forces affecting these cells are modified. To understand the mechanisms underlying these changes, proteins involved in cell-cell or cell-extracellular matrix adhesion, their expression, accumulation, localization, and posttranslational modifica...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Bauer TJ,Gombocz E,Wehland M,Bauer J,Infanger M,Grimm D

    更新日期:2020-03-04 00:00:00

  • Identification and Functional Characterization of Tissue-Specific Terpene Synthases in Stevia rebaudiana.

    abstract::In addition to the well-known diterpenoid steviol glycosides, Stevia rebaudiana (Stevia) produces many labdane-type diterpenoids and a wide range of mono- and sesquiterpenoids. However, biosynthesis of mono- and sesquiterpenoids in Stevia remains unknown. Here we analyzed the extracts of Stevia leaves, flowers, stems,...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Dhandapani S,Kim MJ,Chin HJ,Leong SH,Jang IC

    更新日期:2020-11-13 00:00:00

  • Hydroxyapatite Formation Coexists with Amyloid-like Self-Assembly of Human Amelogenin.

    abstract::Tooth enamel is formed in an extracellular environment. Amelogenin, the major component in the protein matrix of tooth enamel during the developing stage, could assemble into high molecular weight structures, regulating enamel formation. However, the molecular structure of amelogenin protein assembly at the functional...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Zhang J,Wang J,Ma C,Lu J

    更新日期:2020-04-22 00:00:00

  • Biological Responses to Cadmium Stress in Liverwort Conocephalum conicum (Marchantiales).

    abstract::Oxidative damage (production and localization of reactive oxygen species) and related response mechanisms (activity of antioxidant enzymes), and induction of Heat Shock Protein 70 expression, have been studied in the toxi-tolerant liverwort Conocephalum conicum (Marchantiales) in response to cadmium stress using two c...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Maresca V,Lettieri G,Sorbo S,Piscopo M,Basile A

    更新日期:2020-09-04 00:00:00

  • Evaluation of Seven Different RNA-Seq Alignment Tools Based on Experimental Data from the Model Plant Arabidopsis thaliana.

    abstract::Quantification of gene expression is crucial to connect genome sequences with phenotypic and physiological data. RNA-Sequencing (RNA-Seq) has taken a prominent role in the study of transcriptomic reactions of plants to various environmental and genetic perturbations. However, comparative tests of different tools for R...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Schaarschmidt S,Fischer A,Zuther E,Hincha DK

    更新日期:2020-03-03 00:00:00

  • The Application of Curve Fitting on the Voltammograms of Various Isoforms of Metallothioneins-Metal Complexes.

    abstract::The translation of metallothioneins (MTs) is one of the defense strategies by which organisms protect themselves from metal-induced toxicity. MTs belong to a family of proteins comprising MT-1, MT-2, MT-3, and MT-4 classes, with multiple isoforms within each class. The main aim of this study was to determine the behav...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Merlos Rodrigo MA,Molina-López J,Jimenez Jimenez AM,Planells Del Pozo E,Adam P,Eckschlager T,Zitka O,Richtera L,Adam V

    更新日期:2017-03-11 00:00:00

  • Phenotypic Screen with the Human Secretome Identifies FGF16 as Inducing Proliferation of iPSC-Derived Cardiac Progenitor Cells.

    abstract::Paracrine factors can induce cardiac regeneration and repair post myocardial infarction by stimulating proliferation of cardiac cells and inducing the anti-fibrotic, antiapoptotic, and immunomodulatory effects of angiogenesis. Here, we screened a human secretome library, consisting of 923 growth factors, cytokines, an...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Jennbacken K,Wågberg F,Karlsson U,Eriksson J,Magnusson L,Chimienti M,Ricchiuto P,Bernström J,Ding M,Ross-Thriepland D,Xue Y,Peiris D,Aastrup T,Tegel H,Hober S,Sivertsson Å,Uhlén M,Strömstedt PE,Davies R,Holmberg Sch

    更新日期:2019-11-30 00:00:00

  • Loss of Response Gene to Complement 32 (RGC-32) in Diabetic Mouse Retina Is Involved in Retinopathy Development.

    abstract::Diabetic retinopathy (DR) is a severe and recurrent microvascular complication in diabetes. The multifunctional response gene to complement 32 (RGC-32) is involved in the regulation of cell cycle, proliferation, and apoptosis. To investigate the role of RGC-32 in the development of DR, we used human retinal microvascu...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Liao WL,Lin JM,Liu SP,Chen SY,Lin HJ,Wang YH,Lei YJ,Huang YC,Tsai FJ

    更新日期:2018-11-17 00:00:00

  • The Impact of IPTG Induction on Plasmid Stability and Heterologous Protein Expression by Escherichia coli Biofilms.

    abstract::This work assesses the effect of chemical induction with isopropyl β-D-1-thiogalactopyranoside (IPTG) on the expression of enhanced green fluorescent protein (eGFP) by planktonic and biofilm cells of Escherichia coli JM109(DE3) transformed with a plasmid containing a T7 promoter. It was shown that induction negatively...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Gomes L,Monteiro G,Mergulhão F

    更新日期:2020-01-16 00:00:00

  • Protective Effects of Cardamom in Isoproterenol-Induced Myocardial Infarction in Rats.

    abstract::Cardamom is a popular spice that has been commonly used in cuisines for flavor since ancient times. It has copious health benefits such as improving digestion, stimulating metabolism, and exhibits antioxidant and anti-inflammatory effects. The current study investigated the effect of cardamom on hemodynamic, biochemic...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Goyal SN,Sharma C,Mahajan UB,Patil CR,Agrawal YO,Kumari S,Arya DS,Ojha S

    更新日期:2015-11-17 00:00:00

  • Nano-ZnO-Induced Drought Tolerance Is Associated with Melatonin Synthesis and Metabolism in Maize.

    abstract::The applications of ZnO nanoparticles in agriculture have largely contributed to crop growth regulation, quality enhancement, and induction of stress tolerance, while the underlying mechanisms remain elusive. Herein, the involvement of melatonin synthesis and metabolism in the process of nano-ZnO induced drought toler...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Sun L,Song F,Guo J,Zhu X,Liu S,Liu F,Li X

    更新日期:2020-01-25 00:00:00

  • Intracerebroventricular Treatment with 2-Hydroxypropyl-β-Cyclodextrin Decreased Cerebellar and Hepatic Glycoprotein Nonmetastatic Melanoma Protein B (GPNMB) Expression in Niemann-Pick Disease Type C Model Mice.

    abstract::Niemann-Pick disease type C (NPC) is a recessive hereditary disease caused by mutation of the NPC1 or NPC2 gene. It is characterized by abnormality of cellular cholesterol trafficking with severe neuronal and hepatic injury. In this study, we investigated the potential of glycoprotein nonmetastatic melanoma protein B ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Fukaura M,Ishitsuka Y,Shirakawa S,Ushihama N,Yamada Y,Kondo Y,Takeo T,Nakagata N,Motoyama K,Higashi T,Arima H,Kurauchi Y,Seki T,Katsuki H,Higaki K,Matsuo M,Irie T

    更新日期:2021-01-05 00:00:00

  • Exploration of the Esophageal Mucosal Barrier in Non-Erosive Reflux Disease.

    abstract::In the absence of visible mucosal damage, it is hypothesized that the esophageal mucosal barrier is functionally impaired in patients with non-erosive reflux disease (NERD). The aim of the present study was to perform an exploratory analysis of the mucosal barrier in NERD compared to erosive esophagitis (EE) and contr...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Rinsma NF,Farré R,Troost FJ,Elizalde M,Keszthelyi D,Helyes Z,Masclee AA,Conchillo JM

    更新日期:2017-05-19 00:00:00

  • Actions of Inonotus obliquus against Hyperuricemia through XOD and Bioactives Screened by Molecular Modeling.

    abstract::Inonotus obliquus is an edible mushroom and also a remedy against various diseases, especially metabolic syndrome. In this paper we report the actions of an ethanol extract of I. obliquus (IOE) against hyperuricemia in hyperuricemic mice, and the screen of bioactives. The extract (IOE) was prepared by extracting I. ob...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Yong T,Chen S,Liang D,Zuo D,Diao X,Deng C,Wu Y,Hu H,Xie Y,Chen D

    更新日期:2018-10-18 00:00:00

  • Methyl Donor Deficiency during Gestation and Lactation in the Rat Affects the Expression of Neuropeptides and Related Receptors in the Hypothalamus.

    abstract::The micronutrients vitamins B9 and B12 act as methyl donors in the one-carbon metabolism involved in transmethylation reactions which critically influence epigenetic mechanisms and gene expression. Both vitamins are essential for proper development, and their deficiency during pregnancy has been associated with a wide...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Saber Cherif L,Pourié G,Geoffroy A,Julien A,Helle D,Robert A,Umoret R,Guéant JL,Bossenmeyer-Pourié C,Daval JL

    更新日期:2019-10-14 00:00:00

  • QTL Mapping Reveals the Relationship between Pasting Properties and Malt Extract in Barley.

    abstract::Pasting properties are important characteristics of barley starch from a processing standpoint. Many studies reported the close relationship between pasting properties and malting quality, especially malt extract. However, most conclusions were derived from the correlation between pasting properties and malting qualit...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Wang J,Yang J,Hua W,Wu X,Zhu J,Shang Y,Zhou M

    更新日期:2018-11-12 00:00:00

  • Cancer stem cells: biological functions and therapeutically targeting.

    abstract::Almost all tumors are composed of a heterogeneous cell population, making them difficult to treat. A small cancer stem cell population with a low proliferation rate and a high tumorigenic potential is thought to be responsible for cancer development, metastasis and resistance to therapy. Stem cells were reported to be...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Ciurea ME,Georgescu AM,Purcaru SO,Artene SA,Emami GH,Boldeanu MV,Tache DE,Dricu A

    更新日期:2014-05-09 00:00:00

  • Molecular Regulation of Differentiation in Early B-Lymphocyte Development.

    abstract::B-lymphocyte differentiation is one of the best understood developmental pathways in the hematopoietic system. Our understanding of the developmental trajectories linking the multipotent hematopoietic stem cell to the mature functional B-lymphocyte is extensive as a result of efforts to identify and prospectively isol...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Sigvardsson M

    更新日期:2018-06-30 00:00:00

  • Overexpression of ABCB1 Transporter Confers Resistance to mTOR Inhibitor WYE-354 in Cancer Cells.

    abstract::The overexpressing ABCB1 transporter is one of the key factors leading to multidrug resistance (MDR). Thus, many ABCB1 inhibitors have been found to be able to overcome ABCB1-mediated MDR. However, some inhibitors also work as a substrate of ABCB1, which indicates that in order to achieve an effective reversal dosage,...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Wang J,Yang DH,Yang Y,Wang JQ,Cai CY,Lei ZN,Teng QX,Wu ZX,Zhao L,Chen ZS

    更新日期:2020-02-19 00:00:00