Involvement of Satellite Cell Activation via Nitric Oxide Signaling in Ectopic Orofacial Hypersensitivity.


:: The mechanical head-withdrawal threshold (MHWT) was significantly reduced following inferior alveolar nerve transection (IANX) in rats. Nitrate and nitrite synthesis was dramatically increased in the trigeminal ganglion (TG) at 6 h after the IANX. The relative number of neuronal nitric oxide synthase (nNOS)-immunoreactive (IR) cells was significantly higher in IANX rats compared to sham-operated and N-propyl-L-arginine (NPLA)-treated IANX rats. On day 3 after NPLA administration, the MHWT recovered considerably in IANX rats. Following L-arginine injection into the TG, the MHWT was significantly reduced within 15 min, and the mean number of TG cells encircled by glial fibrillary acidic protein (GFAP)-IR cells was substantially higher. The relative number of nNOS-IR cells encircled by GFAP-IR cells was significantly increased in IANX rats. In contrast, after NPLA injection into the TG, the relative number of GFAP-IR cells was considerably reduced in IANX rats. Fluorocitrate administration into the TG significantly reduced the number of GFAP-IR cells and prevented the MHWT reduction in IANX rats. The present findings suggest that following IANX, satellite glial cells are activated via nitric oxide (NO) signaling from TG neurons. The spreading satellite glial cell activation within the TG results in mechanical hypersensitivity of face regions not directly associated with the trigeminal nerve injury.


Int J Mol Sci


Lee J,Ohara K,Shinoda M,Hayashi Y,Kubo A,Sugawara S,Asano S,Soma K,Kanno K,Ando M,Koyama R,Kimura Y,Sakanashi K,Iinuma T,Iwata K




Has Abstract


2020-02-13 00:00:00










  • Hesperidin, A Popular Antioxidant Inhibits Melanogenesis via Erk1/2 Mediated MITF Degradation.

    abstract::Regulation of melanogenesis has been the focus of treatment for hyperpigmentary skin disorders. Although hesperidin is one of the most well-known, naturally occurring flavonoids with antioxidant and anti-inflammatory effect, its anti-melanogenic effect is not known. The present study aims to determine the anti-melanog...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Lee HJ,Lee WJ,Chang SE,Lee GY

    更新日期:2015-08-07 00:00:00

  • Transcriptomics and Immunological Analyses Reveal a Pro-Angiogenic and Anti-Inflammatory Phenotype for Decidual Endothelial Cells.

    abstract:BACKGROUND:In pregnancy, excessive inflammation and break down of immunologic tolerance can contribute to miscarriage. Endothelial cells (ECs) are able to orchestrate the inflammatory processes by secreting pro-inflammatory mediators and bactericidal factors by modulating leakiness and leukocyte trafficking, via the ex...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Agostinis C,Masat E,Bossi F,Ricci G,Menegazzi R,Lombardelli L,Zito G,Mangogna A,Degan M,Gattei V,Piccinni MP,Kishore U,Bulla R

    更新日期:2019-03-31 00:00:00

  • Expression of an endo-β-1,4-glucanase gene from orpinomyces PC-2 in Pichia pastoris.

    abstract::The endo-β-1,4-glucanase gene celE from the anaerobic fungus Orpinomyces PC-2 was placed under the control of an alcohol oxidase promoter (AOX1) in the plasmid pPIC9K, and integrated into the genome of a methylotrophic yeast P. pastoris GS115 by electroporation. The strain with highest endo-β-1,4-glucanase activity wa...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Jin X,Meng N,Xia LM

    更新日期:2011-01-01 00:00:00

  • Exposure to Engineered Nanomaterials: Impact on DNA Repair Pathways.

    abstract::Some engineered nanomaterials (ENMs) may have the potential to cause damage to the genetic material in living systems. The mechanistic machinery functioning at the cellular/molecular level, in the form of DNA repair processes, has evolved to help circumvent DNA damage caused by exposure to a variety of foreign substan...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Singh N,Nelson BC,Scanlan LD,Coskun E,Jaruga P,Doak SH

    更新日期:2017-07-13 00:00:00

  • Glycomics Microarrays Reveal Differential In Situ Presentation of the Biofilm Polysaccharide Poly-N-acetylglucosamine on Acinetobacter baumannii and Staphylococcus aureus Cell Surfaces.

    abstract::The biofilm component poly-N-acetylglucosamine (PNAG) is an important virulence determinant in medical-device-related infections caused by ESKAPE group pathogens including Gram-positive Staphylococcus aureus and Gram-negative Acinetobacter baumannii. PNAG presentation on bacterial cell surfaces and its accessibility f...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Flannery A,Le Berre M,Pier GB,O'Gara JP,Kilcoyne M

    更新日期:2020-04-02 00:00:00

  • The NRF2 Signaling Network Defines Clinical Biomarkers and Therapeutic Opportunity in Friedreich's Ataxia.

    abstract::Friedreich's ataxia (FA) is a trinucleotide repeats expansion neurodegenerative disorder, for which no cure or approved therapies are present. In most cases, GAA trinucleotide repetitions in the first intron of the FXN gene are the genetic trigger of FA, determining a strong reduction of frataxin, a mitochondrial prot...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: La Rosa P,Bertini ES,Piemonte F

    更新日期:2020-01-30 00:00:00

  • Generation of Organized Porcine Testicular Organoids in Solubilized Hydrogels from Decellularized Extracellular Matrix.

    abstract::Cryopreservation of immature testicular tissue (ITT) prior to chemo/radiotherapy is now ethically accepted and is currently the only way to preserve fertility of prepubertal boys about to undergo cancer therapies. So far, three-dimensional culture of testicular cells isolated from prepubertal human testicular tissue w...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Vermeulen M,Del Vento F,Kanbar M,Pyr Dit Ruys S,Vertommen D,Poels J,Wyns C

    更新日期:2019-11-03 00:00:00

  • Icariin Regulates Cellular Functions and Gene Expression of Osteoarthritis Patient-Derived Human Fibroblast-Like Synoviocytes.

    abstract::Synovial inflammation plays an important role in the pathogenesis and progress of osteoarthritis (OA). There is an urgent need to find safe and effective drugs that can reduce the inflammation and regulate the pathogenesis of cytokines of the OA disease. Here, we investigated the effect of icariin, the major pharmacol...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Pan L,Zhang Y,Chen N,Yang L

    更新日期:2017-12-08 00:00:00

  • Relevance of Electrostatic Charges in Compactness, Aggregation, and Phase Separation of Intrinsically Disordered Proteins.

    abstract::The abundance of intrinsic disorder in the protein realm and its role in a variety of physiological and pathological cellular events have strengthened the interest of the scientific community in understanding the structural and dynamical properties of intrinsically disordered proteins (IDPs) and regions (IDRs). Attemp...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Bianchi G,Longhi S,Grandori R,Brocca S

    更新日期:2020-08-27 00:00:00

  • Curcumin and Photobiomodulation in Chronic Viral Hepatitis and Hepatocellular Carcinoma.

    abstract::Immune modulation is a very modern medical field for targeting viral infections. In the race to develop the best immune modulator against viruses, curcumin, as a natural product, is inexpensive, without side effects, and can stimulate very well certain areas of the human immune system. As a bright yellow component of ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Ailioaie LM,Litscher G

    更新日期:2020-09-28 00:00:00

  • Soft-MS and Computational Mapping of Oleuropein.

    abstract::Olive oil and table olives are rich sources of biophenols, which provides a unique taste, aroma and potential health benefits. Specifically, green olive drupes are enriched with oleuropein, a bioactive biophenol secoiridoid. Olive oil contains hydrolytic derivatives such as hydroxytyrosol, oleacein and elenolate from ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Gentile L,Uccella NA,Sivakumar G

    更新日期:2017-05-06 00:00:00

  • Epigenetic Suppression of the T-box Subfamily 2 (TBX2) in Human Non-Small Cell Lung Cancer.

    abstract::(1) The TBX2 subfamily of transcription factors (TBXs 2, 3, 4 and 5) are markedly down-regulated in human non-small cell lung cancer (NSCLC) and exert tumor suppressor effects in lung malignancy. Yet, mechanisms underlying suppressed expression of the TBX2 subfamily in NSCLC are elusive. Here, we interrogated probable...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Nehme E,Rahal Z,Sinjab A,Khalil A,Chami H,Nemer G,Kadara H

    更新日期:2019-03-07 00:00:00

  • Seafood Waste as Attractive Source of Chitin and Chitosan Production and Their Applications.

    abstract::Chitosan is a cationic polymer obtained by deacetylation of chitin, found abundantly in crustacean, insect, arthropod exoskeletons, and molluscs. The process of obtaining chitin by the chemical extraction method comprises the steps of deproteinization, demineralization, and discoloration. To obtain chitosan, the deace...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Santos VP,Marques NSS,Maia PCSV,Lima MAB,Franco LO,Campos-Takaki GM

    更新日期:2020-06-16 00:00:00

  • n-3 Polyunsaturated Fatty Acid Amides: New Avenues in the Prevention and Treatment of Breast Cancer.

    abstract::Over the last decades a renewed interest in n-3 very long polyunsaturated fatty acids (PUFAs), derived mainly from fish oils in the human diet, has been observed because of their potential effects against cancer diseases, including breast carcinoma. These n-3 PUFAs mainly consist of eicosapentaenoic acid (EPA) and doc...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Giordano C,Plastina P,Barone I,Catalano S,Bonofiglio D

    更新日期:2020-03-26 00:00:00

  • The Molecular Mechanism of Perillaldehyde Inducing Cell Death in Aspergillus flavus by Inhibiting Energy Metabolism Revealed by Transcriptome Sequencing.

    abstract::Perillaldehyde (PAE), an essential oil in Perilla plants, serves as a safe flavor ingredient in foods, and shows an effectively antifungal activity. Reactive oxygen species (ROS) accumulation in Aspergillus flavus plays a critical role in initiating a metacaspase-dependent apoptosis. However, the reason for ROS accumu...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Pan C,Li YX,Yang K,Famous E,Ma Y,He X,Geng Q,Liu M,Tian J

    更新日期:2020-02-23 00:00:00

  • Bioinformatics Approaches for Fetal DNA Fraction Estimation in Noninvasive Prenatal Testing.

    abstract::The discovery of cell-free fetal DNA molecules in plasma of pregnant women has created a paradigm shift in noninvasive prenatal testing (NIPT). Circulating cell-free DNA in maternal plasma has been increasingly recognized as an important proxy to detect fetal abnormalities in a noninvasive manner. A variety of approac...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Peng XL,Jiang P

    更新日期:2017-02-20 00:00:00

  • Review of PIP2 in Cellular Signaling, Functions and Diseases.

    abstract::Phosphoinositides play a crucial role in regulating many cellular functions, such as actin dynamics, signaling, intracellular trafficking, membrane dynamics, and cell-matrix adhesion. Central to this process is phosphatidylinositol bisphosphate (PIP2). The levels of PIP2 in the membrane are rapidly altered by the acti...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Mandal K

    更新日期:2020-11-06 00:00:00

  • iTRAQ-Based Quantitative Proteomic Analysis of Embryogenic and Non-embryogenic Calli Derived from a Maize (Zea mays L.) Inbred Line Y423.

    abstract::Somatic embryos (SE) have potential to rapidly form a whole plant. Generally, SE is thought to be derived from embryogenic calli (EC). However, in maize, not only embryogenic calli (EC, can generate SE) but also nonembryogenic calli (NEC, can't generate SE) can be induced from immature embryos. In order to understand ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Liu B,Shan X,Wu Y,Su S,Li S,Liu H,Han J,Yuan Y

    更新日期:2018-12-12 00:00:00

  • RNA interference in mammalia cells by RNA-3'-PNA chimeras.

    abstract::The discovery of siRNAs as the mediators of RNA interference has led to an increasing interest in their therapeutic applications. Chemical modifications are introduced into siRNAs to optimize the potency, the stability and the pharmacokinetic properties in vivo. Here, we synthesize and test the effects of RNA-3'-PNA c...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Potenza N,Moggio L,Milano G,Salvatore V,Di Blasio B,Russo A,Messere A

    更新日期:2008-03-01 00:00:00

  • Comparative Transcriptome Analysis Provides Novel Insight into Morphologic and Metabolic Changes in the Fat Body during Silkworm Metamorphosis.

    abstract::The fat body plays key roles in energy storage and utilization as well as biosynthetic and metabolic activities in insects. During metamorphosis from larva to pupa, the fat body undergoes dramatic changes in morphology and metabolic processes. However, the genetic basis underlying these changes has not been completely...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Peng J,Li Z,Yang Y,Wang P,Zhou X,Zhao T,Guo M,Meng M,Zhang T,Qian W,Xia Q,Cheng D,Zhao P

    更新日期:2018-11-09 00:00:00

  • CPP-Assisted Intracellular Drug Delivery, What Is Next?

    abstract::For the past 20 years, we have witnessed an unprecedented and, indeed, rather miraculous event of how cell-penetrating peptides (CPPs), the naturally originated penetrating enhancers, help overcome the membrane barrier that has hindered the access of bio-macromolecular compounds such as genes and proteins into cells, ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Ye J,Liu E,Yu Z,Pei X,Chen S,Zhang P,Shin MC,Gong J,He H,Yang VC

    更新日期:2016-11-14 00:00:00

  • New Aspects of Lipotoxicity in Nonalcoholic Steatohepatitis.

    abstract::NASH is becoming increasingly common worldwide because of the growing global prevalence of obesity and consequently NAFLD. Unfortunately, the mechanism of progression of NAFLD to NASH and then cirrhosis is not completely understood. Several factors, including insulin resistance, inflammation, oxidative stress, lipotox...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Mendez-Sanchez N,Cruz-Ramon VC,Ramirez-Perez OL,Hwang JP,Barranco-Fragoso B,Cordova-Gallardo J

    更新日期:2018-07-13 00:00:00

  • Different storage conditions influence biocompatibility and physicochemical properties of iron oxide nanoparticles.

    abstract::Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted increasing attention in many biomedical fields. In magnetic drug targeting SPIONs are injected into a tumour supplying artery and accumulated inside the tumour with a magnet. The effectiveness of this therapy is thus dependent on magnetic properties, s...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Zaloga J,Janko C,Agarwal R,Nowak J,Müller R,Boccaccini AR,Lee G,Odenbach S,Lyer S,Alexiou C

    更新日期:2015-04-24 00:00:00

  • Identification and Comparative Analysis of CBS Domain-Containing Proteins in Soybean (Glycine max) and the Primary Function of GmCBS21 in Enhanced Tolerance to Low Nitrogen Stress.

    abstract::Nitrogen is an important macronutrient required for plant growth, and is a limiting factor for crop productivity. Improving the nitrogen use efficiency (NUE) is therefore crucial. At present, the NUE mechanism is unclear and information on the genes associated with NUE in soybeans is lacking. cystathionine beta syntha...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Hao Q,Shang W,Zhang C,Chen H,Chen L,Yuan S,Chen S,Zhang X,Zhou X

    更新日期:2016-04-26 00:00:00

  • Inhibitory Effect of Alisma canaliculatum Ethanolic Extract on NF-κB-Dependent CXCR3 and CXCL10 Expression in TNFα-Exposed MDA-MB-231 Breast Cancer Cells.

    abstract::CXC motif chemokine ligand 10 (CXCL10) and its receptor CXC motif chemokine receptor 3 (CXCR3), play important roles in the motility of breast cancer cells. Alisma canaliculatum is a herb that has been used as a traditional medicine for thousands of years in Korea and China. Whether A. canaliculatum inhibits the motil...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Choi J,Ahn SS,Lim Y,Lee YH,Shin SY

    更新日期:2018-09-03 00:00:00

  • Pro-Resolving Molecules-New Approaches to Treat Sepsis?

    abstract::Inflammation is a complex response of the body to exogenous and endogenous insults. Chronic and systemic diseases are attributed to uncontrolled inflammation. Molecules involved in the initiation of inflammation are very well studied while pathways regulating its resolution are insufficiently investigated. Approaches ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Buechler C,Pohl R,Aslanidis C

    更新日期:2017-02-23 00:00:00

  • Modulatory Effects of Exogenously Applied Polyamines on Postharvest Physiology, Antioxidant System and Shelf Life of Fruits: A Review.

    abstract::Polyamines (PAs) are natural compounds involved in many growth and developmental processes in plants, and, specifically in fruits, play a vital role regulating its development, ripening and senescence processes. Putrescine (PUT), spermine (SPE), and spermidine (SPD) are prominent PAs applied exogenously to extend shel...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Sharma S,Pareek S,Sagar NA,Valero D,Serrano M

    更新日期:2017-08-17 00:00:00

  • Analysis of Centranthera grandiflora Benth Transcriptome Explores Genes of Catalpol, Acteoside and Azafrin Biosynthesis.

    abstract::Cardiovascular diseases (CVDs) are a major cause of health loss in the world. Prevention and treatment of this disease by traditional Chinese medicine is a promising method. Centranthera grandiflora Benth is a high-value medicinal herb in the prevention and treatment of CVDs; its main medicinal components include irid...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Zhang X,Li C,Wang L,Fei Y,Qin W

    更新日期:2019-11-29 00:00:00

  • Molecular motors and apical CFTR traffic in epithelia.

    abstract::Intracellular protein traffic plays an important role in the regulation of Cystic Fibrosis Transmembrane Conductance Regulator (CFTR) chloride channels. Microtubule and actin-based motor proteins direct CFTR movement along trafficking pathways. As shown for other regulatory proteins such as adaptors, the involvement o...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Kravtsov DV,Ameen NA

    更新日期:2013-05-03 00:00:00

  • Mitochondrial Quality Control in Age-Related Pulmonary Fibrosis.

    abstract::Idiopathic pulmonary fibrosis (IPF) is age-related interstitial lung disease of unknown etiology. About 100,000 people in the U.S have IPF, with a 3-year median life expectancy post-diagnosis. The development of an effective treatment for pulmonary fibrosis will require an improved understanding of its molecular patho...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Roque W,Cuevas-Mora K,Romero F

    更新日期:2020-01-18 00:00:00