Abstract：
:Osteoporosis represents the most common bone disease worldwide and results in a significantly increased fracture risk. Extrinsic and intrinsic factors implicated in the development of osteoporosis are also associated with delayed fracture healing and impaired bone regeneration. Based on a steadily increasing life expectancy in modern societies, the global implications of osteoporosis and impaired bone healing are substantial. Research in the last decades has revealed several molecular pathways that stimulate bone formation and could be targeted to treat both osteoporosis and impaired fracture healing. The identification and development of therapeutic approaches modulating bone formation, rather than bone resorption, fulfils an essential clinical need, as treatment options for reversing bone loss and promoting bone regeneration are limited. This review focuses on currently available and future approaches that may have the potential to achieve these aims.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Russow G,Jahn D,Appelt J,Märdian S,Tsitsilonis S,Keller Jdoi
10.3390/ijms20010083subject
Has Abstractpub_date
2018-12-26 00:00:00issue
1issn
1422-0067pii
ijms20010083journal_volume
20pub_type
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abstract：:n/a. ...
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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