Coutinho et al. Less Is More: Substrate Reduction Therapy for Lysosomal Storage Disorders. Int. J. Mol. Sci. 2016, 17, 1065.

abstract：:A fundamental step for cell growth and differentiation is the cell adhesion. The purpose of this study was to determine the adhesion of different cell lineages, adipose derived stromal cells, osteoblasts, and gingival fibroblast to titanium and zirconia dental implants with different surface treatments. Primary cells ...

journal_title：International journal of molecular sciences

authors： Jung S,Bohner L,Hanisch M,Kleinheinz J,Sielker S

更新日期：2020-06-09 00:00:00

abstract：:Therapeutic efficacy of cisplatin-based chemotherapy for advanced-stage urothelial carcinoma (UC) is limited by drug resistance. The nuclear factor (erythroid-derived 2)-like 2 (NRF2) pathway is a major regulator of cytoprotective responses. We investigated its involvement in cisplatin resistance in long-term cisplati...

journal_title：International journal of molecular sciences

authors： Skowron MA,Niegisch G,Albrecht P,van Koeveringe G,Romano A,Albers P,Schulz WA,Hoffmann MJ

更新日期：2017-08-02 00:00:00

abstract：:The aim of the experiment was to evaluate the effect of preconditioning based on changes in inspiratory oxygen fraction on endothelial function in the model of ischemia-reperfusion injury of the myocardium in the condition of cardiopulmonary bypass. The prospective randomized study included 32 rabbits divided into fou...

journal_title：International journal of molecular sciences

authors： Mandel IA,Podoksenov YK,Suhodolo IV,An DA,Mikheev SL,Podoksenov AY,Svirko YS,Gusakova AM,Shipulin VM,Yavorovskiy AG

更新日期：2020-07-27 00:00:00

abstract：:Borneol and menthol are terpenes that are widely used as penetration enhancers in transdermal drug delivery. To explore their penetration-enhancement effects on hydrophilic drugs, 5-fluorouracil (5-FU) was selected as a model drug. An approach that combined in vitro permeation studies and coarse-grained molecular dyna...

journal_title：International journal of molecular sciences

authors： Wang R,Wu Z,Yang S,Guo S,Dai X,Qiao Y,Shi X

更新日期：2017-12-18 00:00:00

abstract：:Growing evidence shows a close association of transposable elements (TE) with non-coding RNAs (ncRNA), and a significant number of small ncRNAs originate from TEs. Further, ncRNAs linked with TE sequences participate in a wide-range of regulatory functions. Alu elements in particular are critical players in gene regul...

journal_title：International journal of molecular sciences

authors： Hadjiargyrou M,Delihas N

更新日期：2013-06-26 00:00:00

abstract：:Levodopa (LD) is used to increase dopamine level for treating Parkinson's disease. The major metabolism of LD to produce dopamine is decarboxylation. In order to understand the metabolism of LD; the electronic structure of levodopa was investigated at the Density Functional DFT/B3LYP level of theory using the 6-311+G*...

journal_title：International journal of molecular sciences

authors： Elroby SA,Makki MS,Sobahi TR,Hilal RH

更新日期：2012-01-01 00:00:00

abstract：:Adhesion molecules are known to play an important role in endothelial activation and angiogenesis. Here we determined the functional role of IQGAP1 in the regulation of endothelial adherens junctions. VE-cadherin is found to be associated with actin filaments and thus stable, but IQGAP1 at intercellular junctions is n...

journal_title：International journal of molecular sciences

authors： Yuan Z,Zhang W,Tan W

更新日期：2013-06-27 00:00:00

abstract：:Articular cartilage is a structure lack of vascular distribution. Once the cartilage is injured or diseased, it is unable to regenerate by itself. Surgical treatments do not effectively heal defects in articular cartilage. Tissue engineering is the most potential solution to this problem. In this study, methoxy poly(e...

journal_title：International journal of molecular sciences

authors： Hsieh YH,Shen BY,Wang YH,Lin B,Lee HM,Hsieh MF

更新日期：2018-04-09 00:00:00

abstract：:Japanese encephalitis virus (JEV), a mosquito-borne flavivirus, has five genotypes (I, II, III, IV, and V). JEV genotype I circulates widely in some Asian countries. However, current JEV vaccines based on genotype III strains show low neutralizing capacities against genotype I variants. In addition, JE has no specific...

journal_title：International journal of molecular sciences

authors： Huang SH,Lien JC,Chen CJ,Liu YC,Wang CY,Ping CF,Lin YF,Huang AC,Lin CW

更新日期：2016-08-24 00:00:00

abstract：:Neuroblastoma (NB) is an aggressive, relapse-prone infancy tumor of the sympathetic nervous system and is the leading cause of death among preschool age diseases, so the search for novel therapeutic targets is crucial. Golgi phosphoprotein 3 (GOLPH3) has been reported to be involved in the development, and in the DNA ...

journal_title：International journal of molecular sciences

authors： Ognibene M,Podestà M,Garaventa A,Pezzolo A

更新日期：2019-09-25 00:00:00

abstract：:The bone-derived hormone fibroblast growth factor 23 (FGF23) acts in concert with parathyroid hormone (PTH) and the active vitamin D metabolite calcitriol in the regulation of calcium (Ca) and phosphate (P) homeostasis. More factors are being identified to regulate FGF23 levels and the endocrine loops between the thre...

journal_title：International journal of molecular sciences

authors： Mace ML,Olgaard K,Lewin E

更新日期：2020-11-20 00:00:00

abstract：:Four new labdane-type diterpenoids: hedychicoronarin (1), peroxycoronarin D (2), 7β-hydroxycalcaratarin A (3), and (E)-7β-hydroxy-6-oxo-labda-8(17),12-diene-15,16-dial (4), have been isolated from the rhizomes of Hedychium coronarium, together with 13 known compounds (5-17). The structures of these new compounds were ...

journal_title：International journal of molecular sciences

authors： Chen JJ,Ting CW,Wu YC,Hwang TL,Cheng MJ,Sung PJ,Wang TC,Chen JF

更新日期：2013-06-25 00:00:00

abstract：:Antimicrobial peptides have been identified as one of the alternatives to the extensive use of common antibiotics as they show a broad spectrum of activity against human pathogens. Among these is Chionodracine (Cnd), a host-defense peptide isolated from the Antarctic icefish Chionodracohamatus, which belongs to the fa...

journal_title：International journal of molecular sciences

authors： Borocci S,Della Pelle G,Ceccacci F,Olivieri C,Buonocore F,Porcelli F

更新日期：2020-02-19 00:00:00

abstract：:A bacterial strain EMS with the capability of degrading microcystins (MCs) was isolated from Lake Taihu, China. The bacterium was tentatively identified as a Stenotrophomonas sp. The bacterium could completely consume MC-LR and MC-RR within 24 hours at a concentration of 0.7 microg/mL and 1.7 microg/mL, respectively. ...

journal_title：International journal of molecular sciences

authors： Chen J,Hu LB,Zhou W,Yan SH,Yang JD,Xue YF,Shi ZQ

更新日期：2010-03-02 00:00:00

abstract：:This study explored the inhibiting effect and mechanism of myricanol on lung adenocarcinoma A549 xenografts in nude mice. Forty nude mice with subcutaneous A549 xenografts were randomly divided into five groups: high-dose myricanol (40 mg/kg body weight) group; middle-dose myricanol (20 mg/kg body weight) group; low-d...

journal_title：International journal of molecular sciences

authors： Dai G,Tong Y,Chen X,Ren Z,Ying X,Yang F,Chai K

更新日期：2015-01-26 00:00:00

abstract：:Applications of laser therapy, including low-level laser therapy (LLLT), phototherapy and photodynamic therapy (PDT), have been proven to be beneficial and relatively less invasive therapeutic modalities for numerous diseases and disease conditions. Using specific types of laser irradiation, specific cellular activiti...

journal_title：International journal of molecular sciences

authors： Kushibiki T,Hirasawa T,Okawa S,Ishihara M

更新日期：2013-06-27 00:00:00

abstract：BACKGROUND:Recently a greater interest in tissue engineering for the treatment of large bone defect has been reported. The aim of the present systematic review and meta-analysis was to investigate the effectiveness of dental pulp stem cells and synthetic block complexes for bone defect treatment in preclinical in vivo ...

journal_title：International journal of molecular sciences

authors： Lorusso F,Inchingolo F,Dipalma G,Postiglione F,Fulle S,Scarano A

更新日期：2020-12-21 00:00:00

abstract：:Transfer RNAs (tRNAs) are key players of protein synthesis, as they decode the genetic information organized in mRNA codons, translating them into the code of 20 amino acids. To be fully active, tRNAs undergo extensive post-transcriptional modifications, catalyzed by different tRNA-modifying enzymes. Lack of these mod...

journal_title：International journal of molecular sciences

authors： Pereira M,Francisco S,Varanda AS,Santos M,Santos MAS,Soares AR

更新日期：2018-11-24 00:00:00

abstract：:Over the last few decades, vascular endothelial growth factor (VEGF) and pigment epithelium-derived factor (PEDF) have emerged as multifaceted players in not only the pathogenesis, but potential treatment, of numerous diseases. They activate diverse intracellular signaling cascades known to have extensive crosstalk, a...

journal_title：International journal of molecular sciences

authors： Falk T,Gonzalez RT,Sherman SJ

更新日期：2010-08-05 00:00:00

abstract：:The recognition of a distinct fat depot, the dermal white adipose tissue (dWAT), points out the complexity of the interaction among skin resident cells: keratinocytes, dermal fibroblasts (DFs) and adipocytes in response to physiological (diet, age) and pathological (injury) stimulations. dWAT has been recognized as a ...

journal_title：International journal of molecular sciences

authors： Walendzik K,Bukowska J,Kopcewicz M,Machcinska S,Gimble JM,Gawronska-Kozak B

更新日期：2020-11-25 00:00:00

abstract：:Present day awareness of biofilm colonization on polymeric surfaces has prompted the scientific community to develop an ever-increasing number of new materials with anti-biofilm features. However, compared to the large amount of work put into discovering potent biofilm inhibitors, only a small number of papers deal wi...

journal_title：International journal of molecular sciences

authors： Cattò C,Cappitelli F

更新日期：2019-08-03 00:00:00

abstract：:Reptiles are a rare model object for space research. However, some reptile species demonstrate effective adaptation to spaceflight conditions. The main scope of this review is a comparative analysis of reptile experimental exposure in weightlessness, demonstrating the advantages and shortcomings of this model. The des...

journal_title：International journal of molecular sciences

authors： Gulimova V,Proshchina A,Kharlamova A,Krivova Y,Barabanov V,Berdiev R,Asadchikov V,Buzmakov A,Zolotov D,Saveliev S

更新日期：2019-06-20 00:00:00

abstract：:We have originally reported that colony-forming units granulocyte/macrophage (CFU-GM) formation is an in vitro feature of chronic myelomonocytic leukemia (CMML) and a strong predictor for short survival. Elucidation of the molecular basis underlying this in vitro phenomenon could be helpful to define molecular feature...

journal_title：International journal of molecular sciences

authors： Geissler K,Jäger E,Barna A,Gurbisz M,Graf T,Graf E,Nösslinger T,Pfeilstöcker M,Machherndl-Spandl S,Stauder R,Zebisch A,Sill H,Öhler L,Kusec R,Hörmann G,Valent P

更新日期：2020-08-22 00:00:00

abstract：:The aim of the present pilot study was the identification of micro-RNA changes over time during the development and progression of type 2 diabetes (T2D) in Zucker diabetic fatty rats (ZDF rats). T2D is a complex metabolic disorder that is characterized, inter alia, by progressive failure of pancreatic β cells to produ...

journal_title：International journal of molecular sciences

authors： Delic D,Eisele C,Schmid R,Luippold G,Mayoux E,Grempler R

更新日期：2016-05-03 00:00:00

abstract：:Aquaporins (AQPs) are among the best structural-characterized membrane proteins, fulfilling the role of allowing water flux across cellular membranes. Thus far, 34 single amino acid polymorphisms have been reported in HUMSAVAR for human aquaporins as disease-related. They affect AQP2, AQP5 and AQP8, where they are ass...

journal_title：International journal of molecular sciences

authors： Calvanese L,D'Auria G,Vangone A,Falcigno L,Oliva R

更新日期：2018-05-25 00:00:00

abstract：:Membrane traffic plays a pivotal role in virulence in the enteric protozoan parasite Entamoeba histolytica. EhRab8A small GTPase is a key regulator of membrane traffic at the endoplasmic reticulum (ER) of this protist and is involved in the transport of plasma membrane proteins. Here we identified the binding proteins...

journal_title：International journal of molecular sciences

authors： Hanadate Y,Saito-Nakano Y,Nakada-Tsukui K,Nozaki T

更新日期：2018-11-30 00:00:00

abstract：:Drought stress is a major obstacle to agriculture. Although many studies have reported on plant drought tolerance achieved via genetic modification, application of plant growth-promoting rhizobacteria (PGPR) to achieve tolerance has rarely been studied. In this study, the ability of three isolates, including Bacillus ...

journal_title：International journal of molecular sciences

authors： Wang DC,Jiang CH,Zhang LN,Chen L,Zhang XY,Guo JH

更新日期：2019-12-12 00:00:00

abstract：:Decades of study on the role of mitochondria in living cells have evidenced the importance of the 18 kDa mitochondrial translocator protein (TSPO), first discovered in the 1977 as an alternative binding site for the benzodiazepine diazepam in the kidneys. This protein participates in a variety of cellular functions, i...

journal_title：International journal of molecular sciences

authors： Denora N,Natile G

更新日期：2017-12-06 00:00:00

abstract：:Inflammation is associated with the development of insulin resistance in Type 2 diabetes mellitus. In the present study, mouse FL83B cells were treated with tumor necrosis factor-alpha (TNF-α) to induce insulin resistance, and then co-incubated with a fraction from wax apple fruit extract (FWFE). This fraction signifi...

journal_title：International journal of molecular sciences

authors： Shen SC,Chang WC,Chang CL

更新日期：2012-01-01 00:00:00

abstract：:Inflammatory bowel diseases (IBD) are chronic, inflammatory processes that affect the gastrointestinal tract and are mainly represented by ulcerative colitis (UC) and Crohn's disease (CD). Omega 3 (ω3) fatty acids (eicosapentanoic acid and docosahexaenoic acid) show an indispensable role in the inflammatory processes ...

journal_title：International journal of molecular sciences

authors： Marton LT,Goulart RA,Carvalho ACA,Barbalho SM

更新日期：2019-09-30 00:00:00