Abstract：
:Present day awareness of biofilm colonization on polymeric surfaces has prompted the scientific community to develop an ever-increasing number of new materials with anti-biofilm features. However, compared to the large amount of work put into discovering potent biofilm inhibitors, only a small number of papers deal with their validation, a critical step in the translation of research into practical applications. This is due to the lack of standardized testing methods and/or of well-controlled in vivo studies that show biofilm prevention on polymeric surfaces; furthermore, there has been little correlation with the reduced incidence of material deterioration. Here an overview of the most common methods for studying biofilms and for testing the anti-biofilm properties of new surfaces is provided.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Cattò C,Cappitelli Fdoi
10.3390/ijms20153794subject
Has Abstractpub_date
2019-08-03 00:00:00issue
15issn
1422-0067pii
ijms20153794journal_volume
20pub_type
杂志文章,评审abstract：:In the elderly, whole-body health largely relies on healthy skeletal muscle, which controls body stability, locomotion, and metabolic homeostasis. Age-related skeletal muscle structural/functional deterioration is associated with a higher risk of severe comorbid conditions and poorer outcomes, demanding major socioeco...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21031010
更新日期：2020-02-04 00:00:00
abstract：:Tumor infiltration into brain tissue usually remains undetected even by high-resolution imaging. Molecular markers are used to increase diagnostic accuracy, but with limited continuous monitoring application. We evaluated the potential of circulating cell-free DNA (cfDNA) as a molecular indicator of the response to th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19061610
更新日期：2018-05-30 00:00:00
abstract：:Traumatic brain injury (TBI) can cause biochemical and metabolomic alterations in the brain tissue and serum. These alterations can be used for diagnosis and prognosis of TBI. Here, the serum concentrations of seventeen amino acids (AA) were studied for their potential utility as biomarkers of TBI. Twenty-five female,...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21051786
更新日期：2020-03-05 00:00:00
abstract：:Bacteria colonize most of the human body, and the female genital tract is not an exception. While the existence of a vaginal microbiota has been well established, the upper genital tract has been considered a sterile environment, with a general assumption that bacterial presence is associated with adverse clinical man...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20143405
更新日期：2019-07-11 00:00:00
abstract：:Sarcopenia is the degenerative loss of skeletal muscle mass and function associated with aging and occurs in the absence of any underlying disease or condition. A comparison of the age-related molecular signaling signatures of different muscles has not previously been reported. In this study, we compared the age-relat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21082862
更新日期：2020-04-20 00:00:00
abstract：:Tumours are not merely masses of abnormally proliferating cancer cells[...]. ...
journal_title：International journal of molecular sciences
pub_type： 社论
doi：10.3390/ijms19030843
更新日期：2018-03-14 00:00:00
abstract：:The role of platelet-rich plasma (PRP) in promoting the healing of bone fractures has not yet been clearly stated. The aim of this prospective clinical study was to evaluate the effectiveness of plasma rich in growth factors (PRGF, a PRP derivate) in the treatment of naturally-occurring bone fractures in dogs. With th...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20051075
更新日期：2019-03-01 00:00:00
abstract：:Starch is one of the most important storage carbohydrates in plants. Kiwifruit typically accumulate large amounts of starch during development. The fruit retain starch until commercial maturity, and its postharvest degradation is essential for consumer acceptance. The activity of genes related to starch degradation ha...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17122112
更新日期：2016-12-15 00:00:00
abstract：:Aquaporin-5 (AQP5) is a membrane water channel widely distributed in human tissues that was found up-regulated in different tumors and considered implicated in carcinogenesis in different organs and systems. Despite its wide distribution pattern and physiological importance, AQP5 short-term regulation was not reported...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms17122090
更新日期：2016-12-13 00:00:00
abstract：:Multiple myeloma (MM) is a hematologic disorder of B lymphocytes characterized by the accumulation of malignant plasma cells (PCs) in the bone marrow. The altered plasma cells overproduce abnormal monoclonal immunoglobulins and also stimulate osteoclasts. The host's immune system and microenvironment are of paramount ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21145002
更新日期：2020-07-15 00:00:00
abstract：:Reactive oxygen species (ROS) are highly reactive signaling molecules that maintain redox homeostasis in mammalian cells. Dysregulation of redox homeostasis under pathological conditions results in excessive generation of ROS, culminating in oxidative stress and the associated oxidative damage of cellular components. ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20153791
更新日期：2019-08-03 00:00:00
abstract：:Community-acquired pneumonia (CAP) places a considerable burden on society. A substantial number of pediatric and adult CAP cases are due to Streptococcus pneumoniae, but fortunately there are effective vaccines available that have a significant impact on CAP-related medical, social, and economic problems. The main ai...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms18010030
更新日期：2016-12-25 00:00:00
abstract：:It has been increasingly recognized that SNAIL1 and SNAIL2, as major EMT-inducers, might also be involved in drug resistance of cancer cells. We sought to determine a relation between SNAIL1/2, E-cadherin and N-cadherin expression, as well as ovarian cancer cells' resistance to cisplatin and EMT markers' level. Thus, ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22020980
更新日期：2021-01-19 00:00:00
abstract：:Timely and reliable distinction of sepsis from non-infectious systemic inflammatory response syndrome (SIRS) supports adequate antimicrobial therapy and saves lives but is clinically challenging. Blood transcriptional profiling promises to deliver insights into the pathomechanisms of SIRS and sepsis and to accelerate ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20092290
更新日期：2019-05-09 00:00:00
abstract：:Arterial wall remodeling underlies increased pulmonary vascular resistance and right heart failure in pulmonary arterial hypertension (PAH). None of the established vasodilator drug therapies for PAH prevents or reverse established arterial wall thickening, stiffening, and hypercontractility. Therefore, new approaches...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21239222
更新日期：2020-12-03 00:00:00
abstract：:Sequence diversity and population structures can vary widely among pathogenic bacteria species. In some species, all isolates are highly similar, whereas in others most of the isolates are distinguished easily. H. pylori is known for its wide genetic diversity amongst the various strains most especially in the genes i...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms12117459
更新日期：2011-01-01 00:00:00
abstract：:5-Fluorouracil (5-FU) is an important chemotherapeutic agent for the systemic treatment of colorectal cancer (CRC), but its effectiveness against CRC is limited by increased 5-FU resistance caused by the hypoxic tumor microenvironment. The purpose of our study was to assess the feasibility of using quinacrine (QC) to ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20184366
更新日期：2019-09-05 00:00:00
abstract：:Superparamagnetic iron oxide nanoparticles (SPIONs) have attracted great attention in many biomedical fields and are used in preclinical/experimental drug delivery, hyperthermia and medical imaging. In this study, biocompatible magnetite drug carriers, stabilized by a dextran shell, were developed to carry tissue plas...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18091837
更新日期：2017-08-24 00:00:00
abstract：:Targeting cancer cells using chimeric-antigen-receptor (CAR-)T cells has propelled adoptive T-cell therapy (ATT) to the next level. A plentitude of durable complete responses using CD19-specific CAR-T cells in patients suffering from various lymphoid malignancies resulted in the approval by the food and drug administr...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20235942
更新日期：2019-11-26 00:00:00
abstract：:Placental inflammation and dysfunction during pregnancy are associated with short- and long-term adverse outcomes for the offspring. However, the mechanisms of vascular protection at the feto-placental interface are still poorly investigated. The high-density lipoprotein (HDL) associated sphingosine-1-phosphate (S1P) ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21030789
更新日期：2020-01-25 00:00:00
abstract：BACKGROUND:Gadolinium chloride (GdCl3) has been reported to attenuate liver injury caused by a variety of toxicants. Gap junctional intercellular communication (GJIC) is thought to be essential in controlling liver homeostasis and pathology. Here we evaluate the effects of GdCl3 on functional GJIC and connexin expressi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20153748
更新日期：2019-07-31 00:00:00
abstract：:The present work provides a comprehensive overview of the recent progress of research work toward developing new one dimensional (1-D) ceria (CeO(2)) nanomaterials. The review has been classified into three parts: the preparation procedures with identification of the existing different dimensional ceria nanomaterials,...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms11093226
更新日期：2010-09-13 00:00:00
abstract：:Chemical injury is partly due to free radical lipid peroxidation, which can induce oxidative stress and produce a large number of reactive oxygen species (ROS). Oxaloacetic acid is an important intermediary in the tricarboxylic acid cycle (TCA cycle) and participates in metabolism and energy production. In our study, ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19061626
更新日期：2018-05-31 00:00:00
abstract：:Lysin-motif receptor-like kinase PsK1 is involved in symbiosis initiation and the maintenance of infection thread (IT) growth and bacterial release in pea. We verified PsK1 specificity in relation to the Nod factor structure using k1 and rhizobial mutants. Inoculation with nodO and nodE nodO mutants significantly redu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20071624
更新日期：2019-04-01 00:00:00
abstract：:Manganese (Mn) is an important trace element present in human body, which acts as an enzyme co-factor or activator in various metabolic reactions. While essential in trace amounts, excess levels of Mn in human brain can produce neurotoxicity, including idiopathic Parkinson's disease (PD)-like extrapyramidal manganism ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18020300
更新日期：2017-01-30 00:00:00
abstract：:Proteins have been used as building blocks to provide various supramolecular structures in efforts to develop nano-biomaterials possessing broad biological functionalities. A series of unique structures have been obtained from the engineering of hemoproteins which contain the iron porphyrin known as heme, as a prosthe...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms22031012
更新日期：2021-01-20 00:00:00
abstract：:Heat shock proteins (Hsp) are a diverse group of constitutive and/or stress-induced molecules that are categorized into several classes on the basis of their molecular weight. Mammalian Hsp have been mostly regarded as intracellular chaperones that mediate a range of essential cellular functions, including proper fold...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms21155298
更新日期：2020-07-26 00:00:00
abstract：:Maternal overweight in pregnancy alters the metabolic environment and generates chronic low-grade inflammation. This affects fetal development and programs the offspring's health for developing cardiovascular and metabolic disease later in life. MME (membrane-metalloendopeptidase, neprilysin) cleaves various peptides ...
journal_title：International journal of molecular sciences
pub_type： 临床试验,杂志文章
doi：10.3390/ijms21030834
更新日期：2020-01-28 00:00:00
abstract：:Synovial inflammation plays an important role in the pathogenesis and progress of osteoarthritis (OA). There is an urgent need to find safe and effective drugs that can reduce the inflammation and regulate the pathogenesis of cytokines of the OA disease. Here, we investigated the effect of icariin, the major pharmacol...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18122656
更新日期：2017-12-08 00:00:00
abstract：:Ventricular arrhythmia (VA) is a major component of sudden cardiac death (SCD). To investigate the expression of brain natriuretic peptide (BNP), endothelin-1 (ET-1), and transforming growth factor-beta 1 (TGF-β1) during VA, we established a rat model of VA induced by BaCl2 solution through a microinjector pump. PD142...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20235845
更新日期：2019-11-21 00:00:00
