Abstract:
:Reactive oxygen species (ROS) are highly reactive signaling molecules that maintain redox homeostasis in mammalian cells. Dysregulation of redox homeostasis under pathological conditions results in excessive generation of ROS, culminating in oxidative stress and the associated oxidative damage of cellular components. ROS and oxidative stress play a vital role in the pathogenesis of acute kidney injury and chronic kidney disease, and it is well documented that increased oxidative stress in patients enhances the progression of renal diseases. Oxidative stress activates autophagy, which facilitates cellular adaptation and diminishes oxidative damage by degrading and recycling intracellular oxidized and damaged macromolecules and dysfunctional organelles. In this review, we report the current understanding of the molecular regulation of autophagy in response to oxidative stress in general and in the pathogenesis of kidney diseases. We summarize how the molecular interactions between ROS and autophagy involve ROS-mediated activation of autophagy and autophagy-mediated reduction of oxidative stress. In particular, we describe how ROS impact various signaling pathways of autophagy, including mTORC1-ULK1, AMPK-mTORC1-ULK1, and Keap1-Nrf2-p62, as well as selective autophagy including mitophagy and pexophagy. Precise elucidation of the molecular mechanisms of interactions between ROS and autophagy in the pathogenesis of renal diseases may identify novel targets for development of drugs for preventing renal injury.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Kaushal GP,Chandrashekar K,Juncos LAdoi
10.3390/ijms20153791subject
Has Abstractpub_date
2019-08-03 00:00:00issue
15issn
1422-0067pii
ijms20153791journal_volume
20pub_type
杂志文章,评审abstract::As the majority of experimental studies suggest cadmium being metalloestrogen, we examined cadmium/breast cancer (BC) association by histological and tumor receptor subtype in 509 invasive BC patients and 1170 controls. Urinary cadmium was determined by atomic absorption spectrometry, and categorized using tertiles of...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20123029
更新日期:2019-06-21 00:00:00
abstract::Due to their large spectrum of bioactive properties, much attention has recently been drawn to phlorotannins-i.e., phenolic compounds characteristic from brown macroalgae. This study aimed to evaluate the antioxidant and anti-inflammatory properties of F. vesiculosus phlorotannin extracts and purified fractions. Overa...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21186897
更新日期:2020-09-20 00:00:00
abstract::Regenerative medicine has rapidly evolved, due to progress in cell and molecular biology allowing the isolation, characterization, expansion, and engineering of cells as therapeutic tools. Despite past limited success in the clinical translation of several promising preclinical results, this novel field is now enterin...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms18051021
更新日期:2017-05-09 00:00:00
abstract::Evodiamine (Evo), a major alkaloid compound isolated from the dry unripened fruit of Evodia fructus, has a wide range of pharmacological activities. The present study sought to explore the neuroprotective effects of Evo in l-glutamate (l-Glu)-induced apoptosis of HT22 cells, and in a d-galactose and aluminum trichlori...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19051527
更新日期:2018-05-21 00:00:00
abstract::During plant-pathogen interactions, plants have to relocate their resources including energy to defend invading organisms; as a result, plant growth and development are usually reduced. Arabidopsis signal responsive1 (AtSR1) has been documented as a negative regulator of plant immune responses and could serve as a pos...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19061764
更新日期:2018-06-14 00:00:00
abstract::Benign prostate hyperplasia (BPH) is one of the most common urological problems in mid-aged to elderly men. Risk factors of BPH include family history, obesity, type 2 diabetes, and high oxidative stress. The main medication classes for BPH management are alpha blockers and 5α-reductase inhibitors. However, these conv...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19041137
更新日期:2018-04-10 00:00:00
abstract::This study was performed to elucidate the molecular function of the synoviocyte proliferation-associated in collagen-induced arthritis (CIA) 1/serum amyloid A-like 1 (SPACIA1/SAAL1) in mice CIA, an animal model of rheumatoid arthritis (RA), and human RA-synovial fibroblasts (RASFs). SPACIA1/SAAL1-deficient mice were g...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19123828
更新日期:2018-11-30 00:00:00
abstract:BACKGROUND:This study aims to investigate: (a) the putative association between the presence of microcalcifications and the expression of both epithelial-to-mesenchymal transition and bone biomarkers, (b) the role of microcalcifications in the breast osteoblast-like cells (BOLCs) formation, and (c) the association betw...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20225633
更新日期:2019-11-11 00:00:00
abstract::The development of immune checkpoint inhibitors (ICIs) has drastically altered the landscape of cancer treatment. Since approval of the first ICI for the treatment of advanced melanoma in 2011, several therapeutic agents have been Food and Drug Administration (FDA)-approved for multiple cancers, and hundreds of clinic...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21051594
更新日期:2020-02-26 00:00:00
abstract::DExD (DDX)- and DExH (DHX)-box RNA helicases, named after their Asp-Glu-x-Asp/His motifs, are integral to almost all RNA metabolic processes in eukaryotic cells. They play myriad roles in processes ranging from transcription and mRNA-protein complex remodeling, to RNA decay and translation. This last facet, translatio...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21124402
更新日期:2020-06-20 00:00:00
abstract::NF-E2-related factor 2 (NRF2) is a basic leucine zipper transcription factor, a master regulator of redox homeostasis regulating a variety of genes for antioxidant and detoxification enzymes. NRF2 was, therefore, initially thought to protect the liver from oxidative stress. Recent studies, however, have revealed that ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21155378
更新日期:2020-07-29 00:00:00
abstract::Molecular Dynamics is a method of choice for membrane simulations and the rising of coarse-grained forcefields has opened the way to longer simulations with reduced calculations times. Here, we present an elastic network, SAHBNET (Surface Accessibility Hydrogen-Bonds elastic NETwork), that will maintain the structure ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms140611510
更新日期:2013-05-30 00:00:00
abstract::Fertility preservation for prepubertal boys relies exclusively on cryopreservation of immature testicular tissue (ITT) containing spermatogonia as the only cells with reproductive potential. Preclinical studies that used a nude mice model to evaluate the development of human transplanted ITT were characterized by impo...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20235833
更新日期:2019-11-20 00:00:00
abstract::Liquid water is considered to be a peculiar example of glass forming materials because of the possibility of giving rise to amorphous phases with different densities and of the thermodynamic anomalies that characterize its supercooled liquid phase. In the present work, literature data on the density of bulk liquid wat...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21197269
更新日期:2020-10-01 00:00:00
abstract::Here is presented an investigation of the use of normal modes in protein-protein docking, both in theory and in practice. Upper limits of the ability of normal modes to capture the unbound to bound conformational change are calculated on a large test set, with particular focus on the binding interface, the subset of r...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms11103623
更新日期:2010-09-28 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) is one of the most lethal malignancies, and thus better understanding of its molecular pathology is crucial for us to devise more effective treatment of this deadly disease. As cancer cell line remains a convenient starting point for discovery and proof-of-concept studies, here ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20184473
更新日期:2019-09-10 00:00:00
abstract::The interaction between programmed cell death protein (PD-1) and its ligand (PD-L1) is one of the main pathways used by some tumors to escape the immune response. In recent years, immunotherapies based on the use of antibodies against PD-1/PD-L1 have been postulated as a great promise for cancer treatment, increasing ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20092296
更新日期:2019-05-09 00:00:00
abstract::The concept of "Sweet Immunity" postulates that sugar metabolism and signaling influence plant immune networks. In this study, we tested the potential of commercially available inulin-type fructans to limit disease symptoms caused by Botrytis cinerea in lettuce. Spraying mature lettuce leaves, with inulin-type fructan...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20051052
更新日期:2019-02-28 00:00:00
abstract::Plants encounter a variety of mechanical stimuli during their growth and development. It is currently believed that mechanosensitive ion channels play an essential role in the initial perception of mechanical force in plants. Over the past decade, the study of Piezo, a mechanosensitive ion channel in animals, has made...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22010467
更新日期:2021-01-05 00:00:00
abstract::Recombinant human fibroblast growth factor 10 (rhFGF-10) is frequently used to treat patients with skin injuries. It can also promote hair growth. However, the effective application of rhFGF-10 is limited because of its poor stability and transdermal absorption. In this study, polymerase chain reaction (PCR) and South...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms18102177
更新日期:2017-10-18 00:00:00
abstract::The forced swim stress test (FST) is widely used for screening pharmacological or non-pharmacological strategies with potential antidepressant activities. Recent data have suggested that repeated FST for five consecutive days (i.e., 5d-RFSS) could be used to generate a robust depressive-like phenotype in mice. However...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms22020937
更新日期:2021-01-19 00:00:00
abstract::A coherence between thyroid dysfunction and breast cancer incidence exists. Thyroid hormone metabolites bind to TAAR1 (trace amine-associated receptor 1) and through that modulate the serotonergic and dopaminergic system. Catecholamines themselves are synthesized by the L-dopa decarboxylase (DDC). The aim of our study...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21249565
更新日期:2020-12-15 00:00:00
abstract::Chemosensitivity is a crucial feature for all tumours so that they can be successfully treated, but the huge heterogeneity of these diseases, to be intended both inter- and intra-tumour, makes it a hard-to-win battle. Indeed, this genotypic and phenotypic variety, together with the adaptability of tumours, results in ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20071776
更新日期:2019-04-10 00:00:00
abstract::Lysophosphatidylcholines are a group of bioactive lipids heavily investigated in the context of inflammation and atherosclerosis development. While present in plasma during physiological conditions, their concentration can drastically increase in certain inflammatory states. Lysophosphatidylcholines are widely regarde...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21124501
更新日期:2020-06-24 00:00:00
abstract:BACKGROUND:The alkaloid 8-hydroxyquinoline (8HQ) is well-known for various biological activities, including antioxidant effects and especially for the formation of coordination complexes with various transition metals, such as iron, amongst others. Therefore, 8HQ was extensively explored as a promising antineurodegener...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19123917
更新日期:2018-12-07 00:00:00
abstract::Wheat protein is considered a major type of food allergen in many countries including the USA. The mechanisms of allergenicity of wheat proteins are not well understood at present. Both adjuvant-based and adjuvant-free mouse models are reported for this food allergy. However, it is unclear whether the mechanisms under...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms21093205
更新日期:2020-05-01 00:00:00
abstract::Transforming growth factor beta 3 (TGFβ3) promotes tenogenic differentiation and may enhance tendon regeneration in vivo. This study aimed to apply TGFβ3 absorbed in decellularized equine superficial digital flexor tendon scaffolds, and to investigate the bioactivity of scaffold-associated TGFβ3 in an in vitro model. ...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms20215474
更新日期:2019-11-03 00:00:00
abstract::Leaf senescence represents the final stage of leaf development and is regulated by diverse internal and environmental factors. Jasmonates (JAs) have been demonstrated to induce leaf senescence in several species; however, the mechanisms of JA-induced leaf senescence remain largely unknown in tomato plants (Solanum lyc...
journal_title:International journal of molecular sciences
pub_type: 杂志文章
doi:10.3390/ijms19113673
更新日期:2018-11-20 00:00:00
abstract::Natural killer (NK) cells are innate lymphoid cells that play a pivotal role in tumor surveillance. Exosomes are nanovesicles released into the extracellular environment via the endosomal vesicle pathway and represent an important mode of intercellular communication. The ability of anticancer chemotherapy to enhance t...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms20030611
更新日期:2019-01-31 00:00:00
abstract::Chimeric Antigen Receptor (CAR)-T cell therapy is an exciting development in the field of cancer immunology, wherein immune T-cells from patients are collected, engineered to create 'CAR'-T cells, and infused back into the same patient. Currently, two CAR-T-cell-based therapies, Tisagenlecleucel and Axicabtagene cilol...
journal_title:International journal of molecular sciences
pub_type: 杂志文章,评审
doi:10.3390/ijms21113906
更新日期:2020-05-30 00:00:00