Diverging Concepts and Novel Perspectives in Regenerative Medicine.


:Regenerative medicine has rapidly evolved, due to progress in cell and molecular biology allowing the isolation, characterization, expansion, and engineering of cells as therapeutic tools. Despite past limited success in the clinical translation of several promising preclinical results, this novel field is now entering a phase of renewed confidence and productivity, marked by the commercialization of the first cell therapy products. Ongoing issues in the field include the use of pluripotent vs. somatic and of allogenic vs. autologous stem cells. Moreover, the recognition that several of the observed beneficial effects of cell therapy are not due to integration of the transplanted cells, but rather to paracrine signals released by the exogenous cells, is generating new therapeutic perspectives in the field. Somatic stem cells are outperforming embryonic and induced pluripotent stem cells in clinical applications, mainly because of their more favorable safety profile. Presently, both autologous and allogeneic somatic stem cells seem to be equally safe and effective under several different conditions. Recognition that a number of therapeutic effects of transplanted cells are mediated by paracrine signals, and that such signals can be found in extracellular vesicles isolated from culture media, opens novel therapeutic perspectives in the field of regenerative medicine.


Int J Mol Sci


Muraca M,Piccoli M,Franzin C,Tolomeo AM,Jurga M,Pozzobon M,Perilongo G




Has Abstract


2017-05-09 00:00:00










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    abstract::We evaluated the association between prostate cancer non-coding RNA 1 (PRNCR1) polymorphisms and the risk of developing gastric cancer (GC) and GC subgroups in Korea. A case-control study was conducted with 437 GC patients and 357 healthy controls using a TaqMan genotyping assay. A chi-squared test, binary logistic re...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Hong JH,Jin EH,Kang H,Chang IA,Lee SI,Sung JK

    更新日期:2019-07-08 00:00:00

  • Association between toll-like receptor 4 expression and neural stem cell proliferation in the hippocampus following traumatic brain injury in mice.

    abstract::Whether or how neural stem cells (NSCs) respond to toll-like receptor 4 (TLR4) in an inflammatory environment caused by traumatic brain injury (TBI) has not been understood. In the present study, association between TLR4 expression and NSCs proliferation in the hippocampus was investigated in a mouse model of TBI usin...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Ye Y,Xu H,Zhang X,Li Z,Jia Y,He X,Huang JH

    更新日期:2014-07-17 00:00:00

  • Surface-Modified Poly(l-lactide-co-glycolide) Scaffolds for the Treatment of Osteochondral Critical Size Defects-In Vivo Studies on Rabbits.

    abstract::Poly(l-lactide-co-glycolide) (PLGA) porous scaffolds were modified with collagen type I (PLGA/coll) or hydroxyapatite (PLGA/HAp) and implanted in rabbits osteochondral defects to check their biocompatibility and bone tissue regeneration potential. The scaffolds were fabricated using solvent casting/particulate leachin...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Krok-Borkowicz M,Reczyńska K,Rumian Ł,Menaszek E,Orzelski M,Malisz P,Silmanowicz P,Dobrzyński P,Pamuła E

    更新日期:2020-10-13 00:00:00

  • Toward Drug-Like Multispecific Antibodies by Design.

    abstract::The success of antibody therapeutics is strongly influenced by their multifunctional nature that couples antigen recognition mediated by their variable regions with effector functions and half-life extension mediated by a subset of their constant regions. Nevertheless, the monospecific IgG format is not optimal for ma...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Sawant MS,Streu CN,Wu L,Tessier PM

    更新日期:2020-10-12 00:00:00

  • Effect of Roasting Levels and Drying Process of Coffea canephora on the Quality of Bioactive Compounds and Cytotoxicity.

    abstract::Coffee is a popular drink consumed all over the world. Besides its long-recognized stimulant effect, it has important nutritional and health effects. However, the type of bean processing modifies the composition of brewed coffee and possibly its bioactivity. In this study, extracts obtained from green and roasted bean...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Bauer D,Abreu J,Jordão N,Rosa JSD,Freitas-Silva O,Teodoro A

    更新日期:2018-10-31 00:00:00

  • Impressic Acid Attenuates the Lipopolysaccharide-Induced Inflammatory Response by Activating the AMPK/GSK3β/Nrf2 Axis in RAW264.7 Macrophages.

    abstract::Inflammatory diseases are caused by excessive inflammation from pro-inflammatory mediators and cytokines produced by macrophages. The Nrf2 signaling pathway protects against inflammatory diseases by inhibiting excessive inflammation via the regulation of antioxidant enzymes, including HO-1 and NQO1. We investigated th...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Lee GH,Kim JY,Jin SW,Pham TH,Park JS,Kim CY,Choi JH,Han EH,Kim YH,Jeong HG

    更新日期:2021-01-14 00:00:00

  • Intergeneric Relationships within the Early-Diverging Angiosperm Family Nymphaeaceae Based on Chloroplast Phylogenomics.

    abstract::The order Nymphaeales, consisting of three families with a record of eight genera, has gained significant interest from botanists, probably due to its position as a basal angiosperm. The phylogenetic relationships within the order have been well studied; however, a few controversial nodes still remain in the Nymphaeac...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: He D,Gichira AW,Li Z,Nzei JM,Guo Y,Wang Q,Chen J

    更新日期:2018-11-28 00:00:00

  • New Insights into Mechanisms and Functions of Chemokine (C-X-C Motif) Receptor 4 Heteromerization in Vascular Smooth Muscle.

    abstract::Recent evidence suggests that C-X-C chemokine receptor type 4 (CXCR4) heteromerizes with α1A/B-adrenoceptors (AR) and atypical chemokine receptor 3 (ACKR3) and that CXCR4:α1A/B-AR heteromers are important for α₁-AR function in vascular smooth muscle cells (VSMC). Structural determinants for CXCR4 heteromerization and ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Evans AE,Tripathi A,LaPorte HM,Brueggemann LI,Singh AK,Albee LJ,Byron KL,Tarasova NI,Volkman BF,Cho TY,Gaponenko V,Majetschak M

    更新日期:2016-06-20 00:00:00

  • Hepatocellular Carcinoma-The Influence of Immunoanatomy and the Role of Immunotherapy.

    abstract::Hepatocellular carcinoma (HCC) is a leading cause of cancer-related morbidity and mortality worldwide. Most patients are diagnosed with advanced disease, limiting their options for treatment. While current treatments are adequate for lower staged disease, available systemic treatments are limited, with marginal benefi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Patel K,Lamm R,Altshuler P,Dang H,Shah AP

    更新日期:2020-09-15 00:00:00

  • DNA repair gene XRCC4 codon 247 polymorphism modified diffusely infiltrating astrocytoma risk and prognosis.

    abstract::The DNA repair gene X-ray cross-complementary group 4 (XRCC4), an important caretaker of the overall genome stability, is thought to play a major role in human tumorigenesis. We investigated the association between an important polymorphic variant of this gene at codon 247 (rs373409) and diffusely infiltrating astrocy...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Lin ZH,Chen JC,Wang YS,Huang TJ,Wang J,Long XD

    更新日期:2013-12-27 00:00:00

  • Can We Prevent Mitochondrial Dysfunction and Diabetic Cardiomyopathy in Type 1 Diabetes Mellitus? Pathophysiology and Treatment Options.

    abstract::Type 1 diabetes mellitus is a disease involving changes to energy metabolism. Chronic hyperglycemia is a major cause of diabetes complications. Hyperglycemia induces mechanisms that generate the excessive production of reactive oxygen species, leading to the development of oxidative stress. Studies with animal models ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Cieluch A,Uruska A,Zozulinska-Ziolkiewicz D

    更新日期:2020-04-19 00:00:00

  • In-Silico Identified New Natural Sortase A Inhibitors Disrupt S. aureus Biofilm Formation.

    abstract::Sortase A (SrtA) is a membrane-associated enzyme that anchors surface-exposed proteins to the cell wall envelope of Gram-positive bacteria such as Staphylococcus aureus. As SrtA is essential for Gram-positive bacterial pathogenesis but dispensable for microbial growth or viability, SrtA is considered a favorable targe...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Thappeta KRV,Zhao LN,Nge CE,Crasta S,Leong CY,Ng V,Kanagasundaram Y,Fan H,Ng SB

    更新日期:2020-11-14 00:00:00

  • In Vitro Induction of Trained Innate Immunity by bIgG and Whey Protein Extracts.

    abstract::Bovine immunoglobulin G (bIgG) was previously shown to enhance innate immune responses to toll-like receptor (TLR) stimulation, via induction of trained immunity. In this study, we investigated whether minimally processed dairy streams with high levels of whey proteins as potential infant nutrition ingredients could a...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Hellinga AH,Tsallis T,Eshuis T,Triantis V,Ulfman LH,Neerven RJJV

    更新日期:2020-11-28 00:00:00

  • Insect Transcription Factors: A Landscape of Their Structures and Biological Functions in Drosophila and beyond.

    abstract::Transcription factors (TFs) play essential roles in the transcriptional regulation of functional genes, and are involved in diverse physiological processes in living organisms. The fruit fly Drosophila melanogaster, a simple and easily manipulated organismal model, has been extensively applied to study the biological ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Guo Z,Qin J,Zhou X,Zhang Y

    更新日期:2018-11-21 00:00:00

  • Molecular characterization of Tob1 in muscle development in pigs.

    abstract::Cell proliferation is an important biological process during myogenesis. Tob1 encoded a member of the Tob/BTG family of anti-proliferative proteins. Our previous LongSAGE (Long Serial Analysis of Gene Expression) analysis suggested that Tob1 was differentially expressed during prenatal skeletal muscle development. In ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Yuan J,Cao JY,Tang ZL,Wang N,Li K

    更新日期:2011-01-01 00:00:00

  • Melatonin Deficiency Confers Tolerance to Multiple Abiotic Stresses in Rice via Decreased Brassinosteroid Levels.

    abstract::Melatonin has long been recognized as a positive signaling molecule and potent antioxidant in plants, which alleviates damage caused by adverse conditions such as salt, cold, and heat stress. In this study, we found a paradoxical role for melatonin in abiotic stress responses. Suppression of the serotonin N-acetyltran...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Hwang OJ,Back K

    更新日期:2019-10-18 00:00:00

  • Effect of long-term dietary arginyl-fructose (AF) on hyperglycemia and HbA1c in diabetic db/db mice.

    abstract::We have previously reported that Amadori compounds exert anti-diabetic effects by lowering sucrose-induced hyperglycemia in normal Sprague-Dawley rats. In the present study we extended our recent findings to evaluate whether α-glucosidase inhibitor arginyl-fructose (AF) lowers blood glucose level in diabetic db/db mic...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Lee KH,Ha KS,Jo SH,Lee CM,Kim YC,Chung KH,Kwon YI

    更新日期:2014-05-12 00:00:00

  • Pharmacological Chaperones: A Therapeutic Approach for Diseases Caused by Destabilizing Missense Mutations.

    abstract::The term "pharmacological chaperone" was introduced 20 years ago. Since then the approach with this type of drug has been proposed for several diseases, lysosomal storage disorders representing the most popular targets. The hallmark of a pharmacological chaperone is its ability to bind a protein specifically and stabi...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Liguori L,Monticelli M,Allocca M,Hay Mele B,Lukas J,Cubellis MV,Andreotti G

    更新日期:2020-01-13 00:00:00

  • Escherichia coli O157:H7 F9 Fimbriae Recognize Plant Xyloglucan and Elicit a Response in Arabidopsis thaliana.

    abstract::Fresh produce is often a source of enterohaemorrhagic Escherichia coli (EHEC) outbreaks. Fimbriae are extracellular structures involved in cell-to-cell attachment and surface colonisation. F9 (Fml) fimbriae have been shown to be expressed at temperatures lower than 37 °C, implying a function beyond the mammalian host....

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Holmes A,Rossez Y,Wright KM,Hedley PE,Morris J,Willats WGT,Holden NJ

    更新日期:2020-12-19 00:00:00

  • Short Tandem Repeat Expansions and RNA-Mediated Pathogenesis in Myotonic Dystrophy.

    abstract::Short tandem repeat (STR) or microsatellite, expansions underlie more than 50 hereditary neurological, neuromuscular and other diseases, including myotonic dystrophy types 1 (DM1) and 2 (DM2). Current disease models for DM1 and DM2 propose a common pathomechanism, whereby the transcription of mutant DMPK (DM1) and CNB...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Sznajder ŁJ,Swanson MS

    更新日期:2019-07-09 00:00:00

  • Angiotensin II, Hypercholesterolemia, and Vascular Smooth Muscle Cells: A Perfect Trio for Vascular Pathology.

    abstract::Cardiovascular disease is the leading cause of morbidity and mortality in the Western and developing world, and the incidence of cardiovascular disease is increasing with the longer lifespan afforded by our modern lifestyle. Vascular diseases including coronary heart disease, high blood pressure, and stroke comprise t...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: St Paul A,Corbett CB,Okune R,Autieri MV

    更新日期:2020-06-25 00:00:00

  • Osteoporosis: From Molecular Mechanisms to Therapies 2.0.

    abstract::Osteoporosis is a common skeletal disorder, occurring as a result of an imbalance between bone resorption and bone formation, with bone breakdown exceeding bone building. Bone resorption inhibitors, e.g., bisphosphonates, have been designed to treat osteoporosis. Teriparatide, an anabolic agent, stimulates bone format...

    journal_title:International journal of molecular sciences

    pub_type: 社论


    authors: Tang CH

    更新日期:2020-10-28 00:00:00

  • Chemically Bonding of Amantadine with Gardenamide A Enhances the Neuroprotective Effects against Corticosterone-Induced Insults in PC12 Cells.

    abstract::Two amantadine (ATD)-gardenamide A (GA) ligands have been designed and synthesized. The bonding of ATD with GA through a methylene carbonyl brigde (L1) enhances the neuroprotective effect against corticosterone (CORT)-induced impairments in PC12 cells; while the bonding through a succinyl brigde (L2) does not. L1 redu...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Zhao J,Peng L,Zheng W,Wang R,Zhang L,Yang J,Chen H

    更新日期:2015-09-21 00:00:00

  • Silencing of the Ortholog of DEFECTIVE IN ANTHER DEHISCENCE 1 Gene in the Woody Perennial Jatropha curcas Alters Flower and Fruit Development.

    abstract::DEFECTIVE IN ANTHER DEHISCENCE 1 (DAD1), a phospholipase A1, utilizes galactolipids (18:3) to generate α-linolenic acid (ALA) in the initial step of jasmonic acid (JA) biosynthesis in Arabidopsis thaliana. In this study, we isolated the JcDAD1 gene, an ortholog of Arabidopsis DAD1 in Jatropha curcas, and found that it...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Xu CJ,Zhao ML,Chen MS,Xu ZF

    更新日期:2020-11-24 00:00:00

  • Targeting TGF-β Signaling in Kidney Fibrosis.

    abstract::Renal fibrosis is the final common pathway of numerous progressive kidney diseases, and transforming growth factor-β (TGF-β) has an important role in tissue fibrosis by up-regulating matrix protein synthesis, inhibiting matrix degradation, and altering cell-cell interaction. Many strategies targeting TGF-β, including ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Isaka Y

    更新日期:2018-08-27 00:00:00

  • Unravelling the Effects of the Mutation m.3571insC/MT-ND1 on Respiratory Complexes Structural Organization.

    abstract::Mammalian respiratory complex I (CI) biogenesis requires both nuclear and mitochondria-encoded proteins and is mostly organized in respiratory supercomplexes. Among the CI proteins encoded by the mitochondrial DNA, NADH-ubiquinone oxidoreductase chain 1 (ND1) is a core subunit, evolutionary conserved from bacteria to ...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Iommarini L,Ghelli A,Tropeano CV,Kurelac I,Leone G,Vidoni S,Lombes A,Zeviani M,Gasparre G,Porcelli AM

    更新日期:2018-03-07 00:00:00

  • Contribution of Impaired Insulin Signaling to the Pathogenesis of Diabetic Cardiomyopathy.

    abstract::Diabetic cardiomyopathy (DCM) has emerged as a relevant cause of heart failure among the diabetic population. Defined as a cardiac dysfunction that develops in diabetic patients independently of other major cardiovascular risks factors, such as high blood pressure and coronary artery disease, the underlying cause of D...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Zamora M,Villena JA

    更新日期:2019-06-11 00:00:00

  • Immortalization of Porcine 11β-Hydroxysteroid Dehydrogenase Type 1-Transgenic Liver Cells Using SV40 Large T Antigen.

    abstract::Cortisol is a steroid hormone essential to the maintenance of homeostasis that is released in response to stress and low blood glucose concentration. Cortisol is converted from cortisone by 11βhydroxysteroid dehydrogenase type 1 (HSD11B1). It has been reported that too much cortisol or overexpression of HSD11B1 induce...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Kang HY,Choi YK,Jeong YI,Choi KC,Hyun SH,Hwang WS,Jeung EB

    更新日期:2017-12-05 00:00:00

  • Gene Therapy for Pancreatic Diseases: Current Status.

    abstract::The pancreas is a key organ involved in digestion and endocrine functions in the body. The major diseases of the pancreas include pancreatitis, pancreatic cancer, cystic diseases, pancreatic divisum, islet cell tumors, endocrine tumors, diabetes mellitus, and pancreatic pain induced by these diseases. While various th...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章,评审


    authors: Kamimura K,Yokoo T,Terai S

    更新日期:2018-10-31 00:00:00

  • Ruscogenin Attenuates Cerebral Ischemia-Induced Blood-Brain Barrier Dysfunction by Suppressing TXNIP/NLRP3 Inflammasome Activation and the MAPK Pathway.

    abstract::Ruscogenin, an important steroid sapogenin derived from Ophiopogon japonicus, has been shown to inhibit cerebral ischemic injury. However, its potential molecular action on blood-brain barrier (BBB) dysfunction after stroke remains unclear. This study aimed to investigate the effects of ruscogenin on BBB dysfunction a...

    journal_title:International journal of molecular sciences

    pub_type: 杂志文章


    authors: Cao G,Jiang N,Hu Y,Zhang Y,Wang G,Yin M,Ma X,Zhou K,Qi J,Yu B,Kou J

    更新日期:2016-08-29 00:00:00