Abstract：
:Decades of study on the role of mitochondria in living cells have evidenced the importance of the 18 kDa mitochondrial translocator protein (TSPO), first discovered in the 1977 as an alternative binding site for the benzodiazepine diazepam in the kidneys. This protein participates in a variety of cellular functions, including cholesterol transport, steroid hormone synthesis, mitochondrial respiration, permeability transition pore opening, apoptosis, and cell proliferation. Thus, TSPO has become an extremely attractive subcellular target for the early detection of disease states that involve the overexpression of this protein and the selective mitochondrial drug delivery. This special issue was programmed with the aim of summarizing the latest findings about the role of TSPO in eukaryotic cells and as a potential subcellular target of diagnostics or therapeutics. A total of 9 papers have been accepted for publication in this issue, in particular, 2 reviews and 7 primary data manuscripts, overall describing the main advances in this field.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Denora N,Natile Gdoi
10.3390/ijms18122640subject
Has Abstractpub_date
2017-12-06 00:00:00issue
12issn
1422-0067pii
ijms18122640journal_volume
18pub_type
社论abstract：:Although the genetic alteration of CUB and Sushi multiple domains 1 (CSMD1) is known to be associated with poor prognosis in several cancers, there is a lack of clinical relevance in head and neck cancer. The aim of this study was to offer insight into the clinical significance of CSMD1, utilizing a multimodal approac...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19123996
更新日期：2018-12-12 00:00:00
abstract：:Consumption of a high-fat diet (HFD) promotes the development of obesity, a disease resulting from an imbalance between energy intake and energy expenditure. Brown adipose tissue (BAT) has thermogenic capacity that burns calories to produce heat, and it is a potential target for the treatment and prevention of obesity...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19041095
更新日期：2018-04-06 00:00:00
abstract：:Although poly(2-hydroxyethyl methacrylate) (pHEMA) and polyethylene glycol methacrylate (PEGMA) have been demonstrated to inhibit bacterial adhesion, no study has compared antibacterial adhesion when salivary pellicle is coated on polymethyl methacrylate (PMMA) grafted with pHEMA and on PMMA grafted with PEGMA. In thi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19092764
更新日期：2018-09-14 00:00:00
abstract：:Mast cells are pluripotent leukocytes that reside in the mucosa and connective tissue. Recent studies show an increased prevalence of cardiovascular disease among patients with mastocytosis, which is a hematological disease that is characterized by the accumulation of mast cells due to clonal proliferation. This assoc...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20143395
更新日期：2019-07-10 00:00:00
abstract：:The introduction of glyphosate-resistant (GR) crops revolutionized weed management; however, the improper use of this technology has selected for a wide range of weeds resistant to glyphosate, referred to as superweeds. We characterized the high glyphosate resistance level of an Amaranthus hybridus population (GRH)-a ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20102396
更新日期：2019-05-15 00:00:00
abstract：:The genetic diversity and population genetic structure of 252 accessions from 21 Prunus sibirica L. populations were investigated using 10 ISSR, SSR, and SRAP markers. The results suggest that the entire population has a relatively high level of genetic diversity, with populations HR and MY showing very high diversity...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms15010377
更新日期：2013-12-31 00:00:00
abstract：:The basic helix-loop helix (bHLH) transcription factor has been inferred to play an important role in blue and purple grain traits in common wheat, but to date, its overexpression has not been reported. In this study, the bHLH transcription factor ThMYC4E, the candidate gene controlling the blue grain trait from Th. P...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21010137
更新日期：2019-12-24 00:00:00
abstract：:Due to role of the Keap1-Nrf2 protein-protein interaction (PPI) in protecting cells from oxidative stress, the development of small molecule inhibitors that inhibit this interaction has arisen as a viable approach to combat maladies caused by oxidative stress, such as cancers, neurodegenerative disease and diabetes. T...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20184445
更新日期：2019-09-10 00:00:00
abstract：:Water limitation represents the main environmental constraint affecting crop yield worldwide. Photosynthesis is a primary drought target, resulting in over-reduction of the photosynthetic electron transport chain and increased production of reactive oxygen species in plastids. Manipulation of chloroplast electron dist...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21197199
更新日期：2020-09-29 00:00:00
abstract：:Idiopathic pulmonary fibrosis (IPF) is a progressive, fibrotic interstitial pneumonia with high mortality. Melatonin, a hormone predominantly secreted by the pineal gland, has been reported to participate in the process of IPF. However, the mechanisms underlying the effect of melatonin in pulmonary fibrosis have not b...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19041118
更新日期：2018-04-09 00:00:00
abstract：:Molecular testing offers more objective information in the diagnosis and personalized decision making for thyroid nodules. In Korea, as the BRAF V600E mutation is detected in 70-80% of thyroid cancer specimens, its testing in fine-needle aspiration (FNA) cytology specimens alone has been used for the differential diag...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21165629
更新日期：2020-08-06 00:00:00
abstract：:Genomic selection (GS) is a strategy to predict the genetic merits of individuals using genome-wide markers. However, GS prediction accuracy is affected by many factors, including missing rate and minor allele frequency (MAF) of genotypic data, GS models, trait features, etc. In this study, we used one wheat populatio...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms21041342
更新日期：2020-02-17 00:00:00
abstract：:Contrast-induced acute kidney injury (CI-AKI) is the third most common cause of hospital associated kidney damage. Potential mechanisms of CI-AKI may involve diminished renal hemodynamics, inflammatory responses, and direct cytotoxicity. The hypothesis for this study is that diatrizoic acid (DA) induces direct cytotox...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20174074
更新日期：2019-08-21 00:00:00
abstract：:In excitable tissues, the endogenous dipeptide carnosine (CAR, β-Ala-l-His) sustains homeostatic responses to various challenges. By eliciting hypoglycemic effects via actions on the autonomic nervous system and protection of pancreatic beta-cells, CAR is also relevant in diabetes. We investigated the expression of ge...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19061713
更新日期：2018-06-09 00:00:00
abstract：:Among popular crops, plum (Prunus domestica L.) has received special attention due to its health-promoting properties. The seasonality of this fruit makes it impossible to consume it throughout the year, so new products in a powder form may offer an alternative to fresh consumption and may be used as high-quality natu...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18010176
更新日期：2017-01-17 00:00:00
abstract：:Thirteen polyphenolics were isolated from fresh pods of Caesalpinia pulcherrima using various methods of column chromatography. The structures of these polyphenolics were elucidated as gallic acid (1), methyl gallate (2), 6-O-galloyl-d-glucoside (3), methyl 6-O-galloyl-β-d-glucoside (4), methyl 3,6-di-O-galloyl-α-d-gl...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms13056073
更新日期：2012-01-01 00:00:00
abstract：:An inflammatory milieu breaks down the cartilage matrix and induces chondrocyte apoptosis, resulting in cartilage destruction in patients with cartilage degenerative diseases, such as rheumatoid arthritis or osteoarthritis. Because of the limited regenerative ability of chondrocytes, defects in cartilage are irreversi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms151121270
更新日期：2014-11-17 00:00:00
abstract：:Stem cell-based therapy is a promising approach to treat cartilage lesions and clinical benefits have been reported in a number of studies. However, the efficacy of cell injection procedures may be impaired by cell manipulation and damage as well as by cell dissemination to non-target tissues. To overcome such issues,...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms19113322
更新日期：2018-10-25 00:00:00
abstract：:Since 2003, several loss-of-function mutations in the HCN4 gene, which encodes the HCN4 protein, have been associated with sinus node dysfunction. In human sinoatrial node (SAN), HCN4 is the most abundant of the four isoforms of the HCN family. Tetramers of HCN subunits constitute the ion channels that conduct the hyp...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms16023071
更新日期：2015-01-29 00:00:00
abstract：:Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine involved in the promotion and progression of cancer, including triple negative breast cancer cells. Thus, there is significant interest in understanding the molecular signaling pathways that connect TNF-α with the survival of tumor cells. In our experi...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms14010411
更新日期：2012-12-24 00:00:00
abstract：:Compelling evidence supports a tight link between oxidative stress and protein aggregation processes, which are noticeably involved in the development of proteinopathies, such as Alzheimer's disease, Parkinson's disease, and prion disease. The literature is tremendously rich in studies that establish a functional link...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20163896
更新日期：2019-08-09 00:00:00
abstract：:Growing evidence shows a close association of transposable elements (TE) with non-coding RNAs (ncRNA), and a significant number of small ncRNAs originate from TEs. Further, ncRNAs linked with TE sequences participate in a wide-range of regulatory functions. Alu elements in particular are critical players in gene regul...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms140713307
更新日期：2013-06-26 00:00:00
abstract：:Borneol and menthol are terpenes that are widely used as penetration enhancers in transdermal drug delivery. To explore their penetration-enhancement effects on hydrophilic drugs, 5-fluorouracil (5-FU) was selected as a model drug. An approach that combined in vitro permeation studies and coarse-grained molecular dyna...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18122747
更新日期：2017-12-18 00:00:00
abstract：:Cystic fibrosis is an inherited multi-organ disorder caused by mutations in the CFTR gene. Patients with this disease exhibit characteristic abnormalities in the levels of unsaturated fatty acids in blood and tissue. Recent studies have uncovered an underlying biochemical mechanism for some of these changes, namely in...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms150916083
更新日期：2014-09-11 00:00:00
abstract：:Carotenoid cleavage dioxygenases (CCDs) selectively catalyze carotenoids, forming smaller apocarotenoids that are essential for the synthesis of apocarotenoid flavor, aroma volatiles, and phytohormone ABA/SLs, as well as responses to abiotic stresses. Here, 19, 11, and 10 CCD genes were identified in Nicotiana tabacum...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20225796
更新日期：2019-11-18 00:00:00
abstract：:Epigenetics is defined as the heritable phenotypic changes which do not involve alterations in the DNA sequence, including histone modifications, non-coding RNAs, and DNA methylation. Recently, much attention has been paid to the role of hypoxia-mediated epigenetic regulation in cancer, pulmonary hypertension, adaptat...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms20122937
更新日期：2019-06-15 00:00:00
abstract：:Recent advances in the field of RNA research have provided compelling evidence implicating microRNA (miRNA) and long non-coding RNA molecules in many diverse and substantial biological processes, including transcriptional and post-transcriptional regulation of gene expression, genomic imprinting, and modulation of pro...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms13010840
更新日期：2012-01-01 00:00:00
abstract：:Stable five-coordinate Pt(II) complexes have been highlighted as a promising and original platform for the development of new cytotoxic drugs. Their interaction with proteins has been scarcely studied. Here, the reactivity of the five-coordinate Pt(II) compound [Pt(I)(Me) (dmphen)(olefin)] (Me = methyl, dmphen = 2,9-d...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms20030520
更新日期：2019-01-26 00:00:00
abstract：:Apoptosis, also called programmed cell death, is an orderly cellular suicide program that is critical for the development, immune regulation and homeostasis of a multi-cellular organism. Failure to control this process can lead to serious human diseases, including many types of cancer, neurodegenerative diseases, and ...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
doi：10.3390/ijms13044807
更新日期：2012-01-01 00:00:00
abstract：:High-density genetic linkage maps of crop species are particularly useful in detecting qualitative and quantitative trait loci for important agronomic traits and in improving the power of classical approaches to identify candidate genes. The aim of this study was to develop a high-density genetic linkage map in a duru...
journal_title：International journal of molecular sciences
pub_type： 杂志文章
doi：10.3390/ijms18061329
更新日期：2017-06-21 00:00:00
