Abstract：
:Cystic fibrosis is an inherited multi-organ disorder caused by mutations in the CFTR gene. Patients with this disease exhibit characteristic abnormalities in the levels of unsaturated fatty acids in blood and tissue. Recent studies have uncovered an underlying biochemical mechanism for some of these changes, namely increased expression and activity of fatty acid desaturases. Among other effects, this drives metabolism of linoeate to arachidonate. Increased desaturase expression appears to be linked to cystic fibrosis mutations via stimulation of the AMP-activated protein kinase in the absence of functional CFTR protein. There is evidence that these abnormalities may contribute to disease pathophysiology by increasing production of eicosanoids, such as prostaglandins and leukotrienes, of which arachidonate is a key substrate. Understanding these underlying mechanisms provides key insights that could potentially impact the diagnosis, clinical monitoring, nutrition, and therapy of patients suffering from this deadly disease.
journal_name
Int J Mol Scijournal_title
International journal of molecular sciencesauthors
Seegmiller ACdoi
10.3390/ijms150916083subject
Has Abstractpub_date
2014-09-11 00:00:00pages
16083-99issue
9issn
1422-0067pii
ijms150916083journal_volume
15pub_type
杂志文章,评审abstract：:The protein phosphatase PP2A is essential for the control of integrated eukaryotic cell functioning. Several cellular and developmental events, e.g., plant growth regulator (PGR) mediated signaling pathways are regulated by reversible phosphorylation of vesicle traffic proteins. Reviewing present knowledge on the rele...
journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2021-01-19 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2014-01-09 00:00:00
abstract：:Short-term abiotic stress treatment before harvest can enhance the quality of horticultural crops cultivated in controlled environments. Here, we investigated the effects of combined chilling and UV-A treatment on the accumulation of phenolic compounds in kale (Brassica oleracea var. acephala). Five-week-old plants we...
journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,评审
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更新日期：2014-11-18 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
pub_type： 杂志文章,随机对照试验
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2015-08-27 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2013-05-30 00:00:00
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更新日期：2019-03-03 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2017-09-21 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2016-04-14 00:00:00
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journal_title：International journal of molecular sciences
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更新日期：2018-08-02 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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更新日期：2019-02-01 00:00:00
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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journal_title：International journal of molecular sciences
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